2,184 results match your criteria: "University Hospitals Derby & Burton NHS Foundation Trust[Affiliation]"

Article Synopsis
  • - Stevens-Johnson syndrome (SJS) is a severe condition that leads to severe skin and mucous membrane damage, marked by skin cell death and peeling.
  • - The case report focuses on a young adult who developed atypical SJS as a complication of an infection, highlighting its rarity.
  • - The goal is to expand awareness and knowledge about atypical SJS among healthcare professionals, especially in cases that present with mucosal rashes linked to infections.
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Glucagon-like Peptide-1 Receptor Agonists: New Evidence of Kidney and Cardiovascular Protection From the FLOW and SELECT Trials.

Am J Kidney Dis

January 2025

Centre for Kidney Research and Innovation, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom; University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom.

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Aims/hypothesis: People with diabetes-related foot ulcers (DFUs) have high mortality rates. This analysis assesses the impact of selected risk factors on short-term mortality using a population registered in the National Diabetes Foot Care Audit (NDFA).

Methods: Mortality rates at 12, 26 and 52 weeks was assessed in people with a new DFU registered by a specialist diabetes footcare service in the NDFA in England and Wales between April 2017 and March 2022.

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Well-leg compartment syndrome is a rare and severe complication that occurs after prolonged surgery in the lithotomy position. This review outlines the presentation, diagnosis, and management of well-leg compartment syndrome after colorectal surgery. A comprehensive and systematic search of various electronic databases was conducted.

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Introduction: We describe the identification and management of general population screen-detected type 1 diabetes (T1D) and share learnings for best practice.

Research Design And Methods: Children diagnosed with T1D through a general population screening initiative, the EarLy Surveillance for Autoimmune diabetes (ELSA) study, were reviewed and described.Parents provided written, informed consent for inclusion in the case series.

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Sex dependence of postoperative pulmonary complications - A post hoc unmatched and matched analysis of LAS VEGAS.

J Clin Anesth

December 2024

Amsterdam University Medical Center, Department of Anaesthesiology, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands; Amsterdam University Medical Center, Department of Intensive Care, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands.

Article Synopsis
  • The study aimed to investigate whether there are differences in postoperative pulmonary complications (PPCs) between males and females following surgery under general anesthesia, using data from the LAS VEGAS study involving 146 hospitals across 29 countries.
  • A total of 9,697 patients were analyzed in two cohorts: an unmatched cohort (55.1% female, 44.9% male) and a matched cohort (50% female and male), finding no significant differences in PPC rates between the genders in both cohorts.
  • The study concluded that, in this international patient population, the incidence of PPCs did not differ significantly between males and females, as well as noting comparable hospital stays and mortality rates.*
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Article Synopsis
  • * The guideline committee included various professionals, such as patients, radiologists, and hand surgeons, to ensure comprehensive input.
  • * Recommendations suggest that acute UCL injuries be assessed through clinical evaluation and imaging, with treatment options ranging from non-surgical methods for stable cases to possible surgical repair for those with significant joint laxity.
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Background: Gastro-oesophageal reflux (GOR) affects nearly half of infants. Parents play a crucial role in management but more understanding of their attitudes and experiences is needed to inform future education, support and research. This study aims to explore parental experiences, attitudes and understanding of the symptoms, diagnosis and management of infant GOR.

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Article Synopsis
  • Contractures, which are common after a stroke and can limit joint movement and cause additional problems, may be managed through assistive technologies to facilitate recovery and rehabilitation.
  • The study aimed to evaluate the effects of various assistive devices on managing contractures in stroke patients by reviewing randomized controlled trials.
  • Seven studies were included in the review, with five undergoing meta-analysis, focusing primarily on the effectiveness of assistive technology compared to standard therapy, showing beneficial outcomes for joint range of motion.
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Aim: There is a paucity of evidence regarding the national introduction of newer bariatric metabolic surgery procedures. This study assessed the impact of introducing one-anastomosis gastric bypass (OAGB) in bariatric surgical practice in the UK on 30-day postoperative morbidity and early postoperative weight loss.

Methods: Patients who underwent primary BMS in the UK National Bariatric Surgical Registry (2010-2019) were identified.

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Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia.

J Infect

November 2024

National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, UK; Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Objectives: We aimed to determine the prevalence of and risk factors for nasopharyngeal and oral pneumococcal carriage in adults with community-acquired pneumonia (CAP), and the relationship between carried and disease-causing serotypes.

Methods: Between 2016 and 2018, nasopharyngeal swabs, oral-fluid, and urine were collected from hospitalised adults recruited into a prospective cohort study of CAP. Pneumococcal carriage was detected by semi-quantitative real-time PCR of direct and culture-enriched nasopharyngeal swabs and culture-enriched oral-fluid.

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Introduction: Computed Tomography (CT) chest, abdomen and pelvis research demonstrates a relationship between vertical phantom positioning and radiation dose. Moving the phantom closer or further from the x-ray source results in magnification or minimisation of the localiser. As automatic tube current modulation (ATCM) algorithms use localisers to estimate patient size and calculate required tube current, magnification or minimisation results in the incorrect provision of radiation dose.

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Cryptic population structure and insecticide resistance in Anopheles gambiae from the southern Democratic Republic of Congo.

Sci Rep

September 2024

Unit of Entomology, Department of Parasitology, Institut National de Recherche Biomédicale, 5345 Avenue De La Démocratie, Gombe, Kinshasa, République Démocratique du Congo.

Article Synopsis
  • The Democratic Republic of Congo has a big problem with malaria, and it's important to know how mosquitoes that spread it are affected by insecticides, especially since they mainly use treated nets to fight the disease.
  • Scientists studied mosquitoes from three different areas in southern Congo and found that many of these mosquitoes are becoming resistant to the insecticides used on the nets, especially in the Kimpese area.
  • By looking at the genetic makeup of these mosquitoes, they discovered differences between some populations, suggesting that resistance is connected to certain genes, and a specific gene in Kimpese might be a key factor for understanding this resistance better.
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Background: The methodologies for clinical research trials are evolving to greater usage of social media platforms, providing opportunities to incorporate smart technologies in their delivery. Research Nurses should consider how they can utilise platforms for public engagement in trials.

Aim: To explore the experiences of social media platforms and clinical research trials in a healthy population group, to gain insight into how clinical researchers can utilise these platforms professionally and ethically.

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Aim: The aim of this study was to assess the short-term outcomes of robotic colorectal surgery implemented through a structured, standardized training pathway in five colorectal centres in the United Kingdom.

Method: A multicentre retrospective observational study was conducted, involving 523 consecutive patients who underwent robotic colorectal resection between 2015 and 2019. All participating centres followed the European Academy of Robotic Colorectal Surgery training pathway.

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Introduction: Digital surgical wound monitoring for patients at home is becoming an increasingly common method of wound follow-up. This regular monitoring improves patient outcomes by detecting wound complications early and enabling treatment to start before complications worsen. However, reviewing the digital data creates a new and additional workload for staff.

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Objectives: This study aimed to understand the lived experiences of patients on the anterior cruciate ligament reconstruction (ACLR) pathway up to 3 months before, 3 months after and 1 year after surgery. Study objectives were to explore (1) patient experiences of preoperative and postoperative treatment, (2) views of/involvement in prehabilitation and (3) sources and consistency of healthcare advice.

Design: Semi-structured interviews analysed using reflexive thematic analysis.

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Article Synopsis
  • - Severe ADAMTS13 deficiency (<10 iu/dL) is a key indicator of thrombotic thrombocytopenic purpura (TTP), leading to serious health issues like microthrombi and platelet aggregation.
  • - The article explores the consequences of low ADAMTS13 levels not only during acute TTP episodes but also in patients during clinical remission, indicating ongoing risks.
  • - Research indicates that low ADAMTS13 activity may also affect vascular health in diseases beyond TTP, suggesting potential benefits from recombinant ADAMTS13 therapy in treating other thrombotic conditions.
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Background: Although one objective of NHS 111 is to ease the strain on urgent and emergency care services, studies suggest the telephone triage service may be contributing to increased demand. Moreover, while parents and caregivers generally find NHS 111 satisfactory, concerns exist about its integration with the healthcare system and the appropriateness of advice. This study aimed to analyse the advice provided in NHS 111 calls, the duration between the call and ED attendance, and the outcomes of such attendances made by children and young people (C&YP).

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Birth tourism, the practice of a woman travelling out of her country of residence to another country to give birth, is common globally. Despite this, there is limited literature on the motivations and experiences of women who gave birth abroad. This study aims to address this gap by seeking to understand the motivations for and experiences of childbirth abroad among Nigerian women.

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Article Synopsis
  • The study investigates the management of primary aneurysmal bone cysts (ABCs), using methods like comprehensive curettage, hydrogen peroxide lavage, and non-vascularized strut fibular grafting, analyzed through 20 cases mostly involving young males.
  • Results showed a high average Musculoskeletal Tumor Society (MSTS) score of 91.55%, reflecting positive functional outcomes, with non-vascularized fibular grafts providing effective stabilization and quicker recovery.
  • The findings support the proposed treatment approach as a reliable option for ABC management, emphasizing improved patient outcomes and functional recovery while considering factors like age and lesion characteristics.
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Background: The efficacy and safety of endovascular thrombectomy (EVT) beyond 6 hours from stroke onset for patients with large vessel occlusion (LVO) selected without CT perfusion(CTP) or MR imaging(MRI) is undetermined. We conducted a systematic review and meta-analysis of the current literature comparing outcomes for late presenting patients with LVO treated by best medical management (BMM) with those selected for EVT based only on non-contrast CT(NCCT)/CT angiography(CTA) (without CTP or MRI).

Methods: PRISMA guidelines were employed.

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Introduction: The international recruitment of healthcare workers remains a UK strategy to manage workforce gaps and maintain service delivery. Although not a new phenomenon, this has been exacerbated by chronic shortages. There is a need to profile the current international recruits and identify individual motivators to understand the opportunities for future recruitment and retention initiatives.

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