4,277 results match your criteria: "University Hospitals Coventry & Warwickshire NHS Trust[Affiliation]"
J Thorac Oncol
December 2024
Department of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK; Leeds Institute of Health Sciences, University of Leeds, Leeds, UK. Electronic address:
Introduction: Low dose CT (LDCT) screening for lung cancer reduces lung cancer mortality, but there is a lack of international consensus regarding the optimal eligibility criteria for screening. The Yorkshire Lung Screening Trial (YLST) was designed to evaluate lung cancer screening (LCS) implementation and a primary objective was prospective evaluation of 3 pre-defined eligibility criteria.
Methods: Individuals who had ever smoked, aged 55-80yrs, who responded to written invitation, underwent telephone risk assessment and if eligible by at least one criteria (PLCO≥1.
J Plast Reconstr Aesthet Surg
November 2024
NIHR Oxford Biomedical Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, Botnar Research Centre, Windmill Road, Oxford OX3 7HE, UK.
Background: Partial extensor tendon lacerations of the hand and forearm are common. There is a lack of evidence to guide their management and it is also unclear at what threshold surgeons would consider repair necessary. This study aimed to identify national surgical management of partial extensor tendon lacerations of the hand and forearm (zones 2-8) and assess surgeons' willingness to randomise in a future trial.
View Article and Find Full Text PDFJ Gerontol A Biol Sci Med Sci
December 2024
Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method.
View Article and Find Full Text PDFCochrane Database Syst Rev
December 2024
Department of Trauma & Orthopaedics, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK.
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To determine the benefits and harms of injury prevention programmes on anterior cruciate ligament injuries.
View Article and Find Full Text PDFClin Endocrinol (Oxf)
December 2024
Res Consortium, Andover, UK.
Introduction: There continues to be much discussion around optimisation of thyroid hormone status in hypothyroid individuals. We here looked the way that free T4(FT4) and thyroid-stimulating hormone (TSH) related to each other in a large laboratory sample of people who underwent a thyroid function test (TFT), split between those on levothyroxine replacement (monitoring test) and those who underwent a test to check for thyroid hormone imbalance (diagnostic test; not on levothyroxine).
Methods: TFT test (FT4/TSH) results were extracted from the Salford Royal Hospital Laboratory Information Management System during 2009-2012.
Br J Anaesth
December 2024
School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Cureus
November 2024
Vascular Surgery, University Hospitals Leicester, Leicester, GBR.
The carotid web is a rare fibromuscular dysplasia disease of the internal carotid artery wall. It is a cause of thromboembolic stroke in a demographic of patients generally younger than those with atherosclerotic carotid artery disease. It is easy to miss the diagnosis without a high index of suspicion.
View Article and Find Full Text PDFJ Clin Med
November 2024
Department Oral and Maxillofacial Surgery, University Hospital Zürich, 8032 Zürich, Switzerland.
Panfacial fractures are complex fractures involving multiple regions of the facial skeleton and may require multiple surgeries over a relatively short period. They are often associated with polytrauma and other injuries including neurotrauma, which require either immediate (ATLS) airway management, prolonged intubation, or repeated intubations for staged surgeries. The choice of airway for the surgical management of these fractures is difficult, as an assessment of the occlusion is required, and the central nasal complex and/or skull base may be involved, making classical orotracheal or nasotracheal intubation problematic.
View Article and Find Full Text PDFJ Clin Med
November 2024
Surgical Research Unit, Odense University Hospital, 5700 Svendborg, Denmark.
: Colon capsule endoscopy (CCE) is becoming more widely available across Europe, but its uptake is slow due to the need for follow-up colonoscopy for therapeutic procedures and biopsies, which impacts its cost-effectiveness. One of the major factors driving the conversion to colonoscopy is the detection of excess polyps in CCE that cannot be matched during subsequent colonoscopy. The capsule's rocking motion, which can lead to duplicate reporting of the same polyp when viewed from different angles, is likely a key contributor.
View Article and Find Full Text PDFCells
December 2024
Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology, Hannover Medical School, 30625 Hannover, Germany.
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, due in part to early invasion and metastasis, which in turn involves epithelial-mesenchymal transition (EMT) of the cancer cells. Prompted by the discovery that two PDAC cell lines of the quasi-mesenchymal subtype (PANC-1, MIA PaCa-2) exhibit neuroendocrine differentiation (NED), we asked whether NED is associated with EMT. Using real-time PCR and immunoblotting, we initially verified endogenous expressions of various NED markers, i.
View Article and Find Full Text PDFBackground: Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in patients suffering from stroke. Intermittent pneumatic compression devices (IPCs) and geko™ devices are used to reduce the risk of VTE in patients who have suffered an acute stroke. Correct use of the devices is essential for achieving the reduced risk of VTE.
View Article and Find Full Text PDFCureus
November 2024
Trauma and Orthopaedics, Northern Care Alliance NHS Foundation Trust, Manchester, GBR.
This review examines the roles and responsibilities of educational and clinical supervisors in the UK postgraduate medical education system, focusing on their impact on trainee doctors' educational experiences and professional development. Guidance from the General Medical Council and the Department of Health underscores the importance of consistent supervision in various clinical settings. Educational supervisors are critical in helping trainees establish clear, competency-based goals, engage in career planning, and develop resilience.
View Article and Find Full Text PDFTranspl Int
November 2024
Centre for Evidence in Transplantation, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Hepatobiliary Surg Nutr
December 2024
Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
The robotic platform enables surgeons to operate with a similar level of freedom and control as in open surgery, while still providing the patient with the benefits of a minimally invasive approach. More centres continue to adopt robotic liver surgery however standardized training materials and consensus on the surgical technique are currently lacking. The availability of a standardized surgical protocol could benefit the further dissemination of the robotic approach while promoting safe and effective operating techniques.
View Article and Find Full Text PDFFront Public Health
December 2024
Public Health, Birmingham City Council, Birmingham, United Kingdom.
Introduction: Birmingham has a significantly higher type-II diabetes prevalence than the national average. This study aimed to investigate the association of socioeconomic deprivation and ethnicity on the risk of diabetes in Birmingham.
Methods: Data were included from 108,514 NHS Health Checks conducted in Birmingham between 2018 and 2023.
Eur Heart J Case Rep
December 2024
Department of Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK.
Arch Dis Child Educ Pract Ed
December 2024
Neonatology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, Coventry, UK
Int J Soc Psychiatry
December 2024
Cornwall Intellectual Disability Equitable Research, Cornwall Partnership NHS Foundation Trust, Truro, UK.
Background: There has been significant reduction in inpatient beds for people with intellectual disability and/or autism (PwID/A) in the UK in the last decade following high profile national scandals in specialist psychiatric hospitals. To reduce inappropriate admissions a new strategy (Blue-Light, an emergency multi-disciplinary meeting to prevent admission to hospital) was introduced. However, there is no research on the influence of Blue-Light on crisis management for PwID/A.
View Article and Find Full Text PDFJAMA
December 2024
Warwick Medical School, Clinical Trials Unit, University of Warwick, Coventry, United Kingdom.
J Vasc Nurs
December 2024
Centre for Physical Activity, Sport and Exercise Sciences, Institute of Health and Wellbeing, Coventry University, Coventry, UK; Department of Sport and Exercise Sciences, Institute of Sport, Manchester Metropolitan University, Manchester, UK.
Introduction: The WALKSTRONG trial includes a programme of community walking and home-based circuit training which has been developed for people with intermittent claudication (IC). The aim of the present study was to determine the acceptability of the programme for those who took part, by gleaning their opinions and experiences.
Methods: All participants eligible for the WALKSTRONG trial were approached regarding completing a semi-structured interview, selected from three groups: A) programme completers, B) programme withdrawers and C) programme decliners.
J Clin Oncol
December 2024
Champalimaud Foundation, Lisbon, Portugal.
Arthroplasty
December 2024
University Hospitals Coventry & Warwickshire NHS Trust, Coventry, CV2 2DX, UK.
Background: Predicting the success of a Debridement, Antibiotics, and Implant Retention (DAIR) procedure for periprosthetic joint infection (PJI) for hip and knee joint arthroplasty remains a challenge. A failed DAIR might adversely affect the outcome of any future revision surgery for PJI. Hence, the ability to identify and optimize factors predictive of DAIR success would help target the procedure to the appropriate patient cohort and avoid unnecessary surgery for patients where a DAIR is unlikely to eradicate infection.
View Article and Find Full Text PDFBr J Psychiatry
December 2024
Cornwall Intellectual Disability Equitable Research (CIDER), Cornwall Partnership NHS Foundation Trust, Truro, UK; and CIDER, Peninsula School of Medicine, University of Plymouth, UK.
Eur Spine J
December 2024
Department of Neurosurgery, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham, B15 2TH, UK.
Purpose: Cauda Equina Syndrome (CES) is a rare surgical emergency. The implications for loss of quality of life through delayed management are high, though no clinical symptom is pathognomonic in its diagnosis. We describe how machine learning based algorithms can be used in triaging patients with suspected CES (CES-S).
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