Transanal full-thickness excision for rectal neoplasm: is it advisable to leave the defect open?

Purpose: After a full-thickness total wall excision of a rectal tumor, suturing the defect is generally recommended. Recently, due to various contradictory studies, there is a trend to leave the defects open. Therefore, this study aimed to determine whether leaving the defect open is an adequate management strategy compared with suturing it closed based on postoperative outcomes and recurrences.

Information in Spanish on YouTube about Covid-19 vaccines.

Our objective was to analyze the sources, characteristics, tone, and content of the most viewed YouTube videos in Spanish about Covid-19 vaccines. In February 2021, a search was carried out on YouTube using the terms "Vacuna Covid," "Vacuna coronavirus," and "Vacuna Covid19." Associations between tone, source, and others variables (e.

YouTube as a Source of Influenza Vaccine Information in Spanish.

Our objective was to analyze the information in Spanish on YouTube about the influenza vaccine. In August 2020, a search was conducted on YouTube using the terms "Vacuna gripe", "Vacuna influenza", and "Vacuna gripa". Associations between the type of authorship, country of publication, and other variables (such as tone, hoaxes, and vaccination recommendations) were studied via univariate analysis.

Information in Spanish on the Internet about the Prevention of COVID-19.

. Our objective was to analyze the evolution of the information in Spanish online about the prevention of the coronavirus disease 2019 (COVID-19). .

Characteristics of YouTube Videos in Spanish on How to Prevent COVID-19.

Objective: To analyze the characteristics of YouTube videos in Spanish on the basic measures to prevent coronavirus disease 2019 (COVID-19).

Methods: On 18 March 2020, a search was conducted on YouTube using the terms "Prevencion Coronavirus" and "Prevencion COVID-19". We studied the associations between the type of authorship and the country of publication with other variables (such as the number of likes and basic measures to prevent COVID-19 according to the World Health Organization, among others) with univariate analysis and a multiple logistic regression model.

Assessment of Health Information About COVID-19 Prevention on the Internet: Infodemiological Study.

Background: The internet is a large source of health information and has the capacity to influence its users. However, the information found on the internet often lacks scientific rigor, as anyone may upload content. This factor is a cause of great concern to scientific societies, governments, and users.

Characteristics of YouTube videos about the meningococcal B vaccine (4CMenB).

YouTube has become a large source of health information, and it has the capacity to influence users: for instance, regarding their vaccination habits. The aim of our study was to analyze the characteristics of the videos published on YouTube about the meningococcal B vaccine (4CMenB, Bexsero®). A search was made on YouTube using the keyword "Bexsero.

Rare Variants in 48 Genes Account for 42% of Cases of Epilepsy With or Without Neurodevelopmental Delay in 246 Pediatric Patients.

In order to characterize the genetic architecture of epilepsy in a pediatric population from the Iberian Peninsula (including the Canary Islands), we conducted targeted exome sequencing of 246 patients with infantile-onset seizures with or without neurodevelopmental delay. We detected 107 variants in 48 different genes, which were implicated in neuronal excitability, neurodevelopment, synaptic transmission, and metabolic pathways. In 104 cases (42%) we detected variant(s) that we classified as pathogenic or likely pathogenic.

A numerical-experimental protocol to characterize corneal tissue with an application to predict astigmatic keratotomy surgery.

Tonometers are intended to determine the intraocular pressure (IOP) and the quality of corneal tissue. In contrast to the physiological state of stress of the cornea, tonometers induce non-physiological bending stress. Recently, the use of a single experiment to calibrate a set of corneal mechanical properties was suggested to be an ill-posed problem.

Impact on Morbidity, Mortality, and Length of Stay of Hospital-Acquired Infections by Resistant Microorganisms.

Background: Infections by multidrug-resistant organisms (MDROs) are a global threat and are particularly common in hospitals. This study was performed to assess the impact of hospital-acquired infections caused by MDROs on morbidity, mortality, and length of hospital stay.

Methods: This was a retrospective cohort study.

Colorectal surgery and surgical site infection: is a change of attitude necessary?

Introduction: Surgical site infection (SSI) can be as high as 30% in patients undergoing colorectal surgery and is associated with an increase in morbidity and mortality. The aim of this study is to evaluate the impact of a set of simple preventive measures that have resulted in a reduction in surgical site infection in colorectal surgery.

Applied Method: Prospective study with two groups of patients treated in the colorectal unit of the "Clinico Universitario Lozano Blesa" hospital in Zaragoza.

Skin coverage in frostbite injuries: experimental study.

Objective: Dermal grafting after secondary wound healing constitutes the mainstay of management in cold injury tissue defects, displacing the use of local flaps. We present an experimental study in which the following treatments for frostbite defects are compared: guided wound healing, partial-thickness skin grafts and cutaneous flaps, which by definition posses an independent vascular supply.

Material And Methods: A dorsal defect in the rabbit leg was created using a cold injury model.

NSAIDs-induced gastrointestinal damage. Review.

Non-steroidal anti-inflammatory drugs (NSAIDs), along with analgesics, are the most widely prescribed medication in the world. However, NSAIDs cause numerous side effects, being the gastrointestinal (GI) events the most common ones with an increase of risk of serious GI complications between 2.5- and 5-fold, as compared with individuals not taking NSAIDs.

NSAID-induced gastrointestinal damage: current clinical management and recommendations for prevention.

Gastrointestinal toxicity is a common adverse effect of traditional non-steroidal anti-inflammatory drugs (NSAIDs) and patients at risk should receive prevention therapies. Selective cyclooxygenase-2 (COX-2) inhibitors (coxibs) are safer to the gastrointestinal tract than traditional NSAIDs. Current prevention strategies in patients who need NSAIDs should also take into account the presence of cardiovascular risk factors, as coxibs and probably most traditional NSAIDs increase the incidence of serious cardiovascular events.

Periprosthetic bone remodeling. A finite elementstudy of the influence of the implant design.

Remodeling periprosthetic femoral bone after total hip arthroplasty has been studied extensively. Finite element (FE) analysis, together with mathematical remodeling theories, has predicted that femoral bone-mineral density decreases proximally after total hip arthroplasty. There is significant controversy concerning the clinical consequences of bone remodeling such as the reduction in bone strength, the possibility of a cement mantle fracture, the aseptic loosening of the implant, or the appearance of a periprosthetic fracture, which could threaten the survival of the hip prosthesis.

Deforming chondrosarcoma of the fingers secondary to a long-term enchondromatosis of 28 years.

Enchondromatosis of the hand in the context of the Oilier disease is an infrequent pathologie associated with a high rate of malignancy. In this work, we present a case with multiple enchondromas affecting mainly the fourth and fifth rays of the hand, and with multiple ipsilateral lesions in the foot, sacroiliac joint and iliac bone. This patient is, in addition, an unusual case for a long-term progression (28 years), serious deforming appearance and for the double malignant degeneration to chondrosarcoma of the affected fingers.

Finite element study of intramedullary osteosynthesis in the treatment of trochanteric fractures of the hip: Gamma and PFN.

The ongoing debate surrounding the surgical treatment of trochanteric hip fractures, particularly unstable fractures, has led to continuous changes in the design of well-established implants and to the development of new ones. The goal of this paper was to use a finite element simulation to compare the biomechanical behaviour of two intramedullary implants most often used at the University Hospital of Zaragoza: the standard Gamma nail (Howmedica) and the proximal femoral nail (PFN, Stratec). The main focus was on the displacements of the fracture focus and the stress distributions along the femur and the implant.

3D finite element analysis of the gamma nail and dhs plate in trochanteric hip fractures.

Objective: The finite element method (FEM) was used to evaluate the short-term mechanical stability of trochanteric fractures treated by two types of implants: the Gamma" nail (Howmedica) and the Dynamic Hip Screw, DHS" (Synthes).

Methods: The displacement and stress distributions of bone and implants were computed using a complete 3D FE model.

Results: The main conclusion is that proximal stable femoral fractures can be treated correctly with the Gamma Nail and DHS.

Use of an introducer sheath for colonic stent placement.

We describe a technical modification of Wallstent implantation for the treatment of malignant rectosigmoid and descending colonic obstructions. The modification is the routine placement of an introducer sheath via the rectum before stent implantation in order to straighten the rectosigmoid region. This device facilitates catheter and guide wire manipulations and obtaining specimen biopsies for histopathological studies.

Adverse reaction of acetaminophen as an alternative analgesic in A.A.S. Triad.

The syndrome of A.A.S.