Angiotensin-converting enzyme inhibitor-induced angioedema and hereditary angioedema: a comparison study of attack severity.

Objective There appears to be differences in the clinical presentation of hereditary angioedema (HAE) and angiotensin-converting enzyme inhibitor-induced (ACE-I) angioedema (AE). The aim of this study was to compare the clinical characteristics of these two AE forms. Methods We conducted a retrospective study of consecutive patients with HAE or ACE-I AE.

Stability of Hydrocortisone Preservative-Free Oral Solutions.

Objectives: The physical and chemical stability of a preservative-free oral solution of hydrocortisone succinate was studied at different pH values and storage temperatures.

Methods: Oral solutions of hydrocortisone 1 mg/mL were prepared by dissolving hydrocortisone succinate powder in citrate buffers at pH 4.0, 5.

Stability of oxaliplatin in infusion bags containing 5% dextrose injection.

Purpose: The stability of oxaliplatin in infusion bags containing 5% dextrose injection was studied.

Methods: Solutions of oxaliplatin 0.7 mg/mL were prepared in polyolefin infusion bags containing 5% dextrose injection and stored at 3-7 degrees C in a lightproof bag, at 20-24 degrees C with continuous exposure to artificial light, and at 20-24 degrees C with continuous exposure to fluorescent light in a lightproof bag.

Stability of levamisole oral solutions prepared from tablets and powder.

Purpose: To study the stability of levamisole oral solutions (25 mg/mL) prepared from powder and tablets stored at 4 +/- 3 degrees C and 23 +/- 2 degrees C in amber glass prescription bottles.

Methods: Levamisole 25 mg/mL solutions were prepared from commercially available 50-mg tablets or from pure powder in sterile water. Levamisole concentrations were determined in duplicate by a stability-indicating HPLC method at 0, 1, 2, 3, 4, 7, 14, 30, 60 and 90 days.

Permeation risks with peracetic acid and hydrogen peroxide sterilizing agent inside ambulatory pumps.

The sterilizing agent commonly used to sterilize materials for an isolator is a peracetic acid (PA) and hydrogen peroxide (HP) mixture. The permeation of this agent through ambulatory pumps should reveal a potential toxic risk for the patient and a stability modification of the drug by a pH change. Six wrapped and six unwrapped ambulatory pumps from each laboratory were introduced in the transfer chamber for the sterilizing process over 2 h 45 min.

Stability of doxorubicin combined with Radioselectan, a contrast agent, for chemoembolization.

Objective: To assess the stability of doxorubicin combined with Radioselectan.

Methods: Solutions of doxorubicin 5 mg/mL were prepared from commercially available 50 mg powder with 10 mL of Radioselectan. They were stored in glass syringes at 4, 25 and 45 degrees C.

Stability of sulfadiazine oral liquids prepared from tablets and powder.

Purpose: To assess the stability of sulfadiazine (SDZ) oral liquids prepared from tablets and powder at two temperatures.

Methods: Solutions of SDZ 200 mg/mL were prepared from commercially available 500 mg tablets and powder in sterile water for irrigation. They were stored in amber glass bottles at 4 degrees C and 23 degrees C.

Stability of cyclophosphamide and mesna admixtures in polyethylene infusion bags.

Background: Cyclophosphamide (CYP) is used to treat cancers in combination with mesna to prevent cystitis. The use of extemporaneously prepared admixtures of these drugs must be supported by documentation of their chemical stability.

Objective: To evaluate the chemical stability of CYP and mesna admixtures in dextrose 5% polyethylene infusion bags.