2,505 results match your criteria: "University Hospital of Heraklion.[Affiliation]"

Colorectal liver metastasis (CRLM) is a disease entity that warrants special attention due to its high frequency and potential curability. Identification of "high-risk" patients is increasingly popular for risk stratification and personalization of the management pathway. Traditional regression-based methods have been used to derive prediction models for these patients, and lately, focus has shifted to artificial intelligence-based models, with employment of variable supervised and unsupervised techniques.

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  • - The study examines the effectiveness of anti-Xa level monitoring for thromboprophylaxis in medical inpatients at a Greek hospital, highlighting the rising rates of venous thromboembolism (VTE) and the need for precise dosing.
  • - Out of 150 patients, a significant number showed non-prophylactic anti-Xa levels, particularly underweight and severely obese individuals, signaling critical gaps in current treatment protocols.
  • - Key factors influencing anti-Xa levels were identified as body weight, cancer, and the Charlson Comorbidity Index, suggesting a need for personalized anticoagulation strategies to improve patient outcomes.
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BTK drives neutrophil activation for sterilizing antifungal immunity.

J Clin Invest

May 2024

Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America.

We describe a previously-unappreciated role for Bruton's tyrosine kinase (BTK) in fungal immune surveillance against aspergillosis, an unforeseen complication of BTK inhibitors (BTKi) used for treating B-cell lymphoid malignancies. We studied BTK-dependent fungal responses in neutrophils from diverse populations, including healthy donors, BTKi-treated patients, and X-linked agammaglobulinemia patients. Upon fungal exposure, BTK was activated in human neutrophils in a TLR2-, Dectin-1-, and FcγR-dependent manner, triggering the oxidative burst.

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Although routine intra-abdominal drain insertion following surgery represents a common practice worldwide, its utility has been questioned during the last decades. Several comparative studies have failed to document significant benefits from routine draining, and drain insertion has been correlated with various complications as well. Drain-related complications include, but are not limited, to infection, bleeding, and tissue erosion.

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Data on COVID-19 mortality among patients in intensive care units (ICUs) from Eastern and/or Southern European countries, including Greece, are limited. The purpose of this study was to evaluate the ICU mortality trends among critically ill COVID-19 patients during the first two years of the pandemic in Greece and to further investigate if certain patients' clinical characteristics contributed to this outcome. We conducted a multi-center retrospective observational study among five large university hospitals in Greece, between February 2020 and January 2022.

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Diphtheria and Tetanus Immunity Status among Greek Adults: Results from a Nationwide Seroprevalence Study.

Vaccines (Basel)

April 2024

Department of Respiratory Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, BIOPOLIS, 41110 Larissa, Greece.

Diphtheria and tetanus could lead to serious morbidity. We aimed to evaluate immunity levels by measuring specific IgG antibodies for diphtheria and tetanus in serum samples from a nationally expanded sample of the Greek population. A geographically stratified sampling approach based on regional units (NUTS level 2) was applied by considering variables such as age group (30-80+) and sex.

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Interleukin antagonists for atopic dermatitis: a new era of therapy.

Expert Opin Investig Drugs

June 2024

Faculty of Medicine, First Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Andreas Sygros Hospital, Athens, Greece.

Article Synopsis
  • Recent advances in understanding the immunopathogenesis of atopic dermatitis (AD) have led to the development of new immune-based therapies, particularly interleukin (IL) antagonists like dupilumab and tralokinumab, which are now approved for use in Europe.
  • This review examines the role of various interleukins in AD's development and assesses the efficacy and safety of newer and investigational IL-antagonists for treating moderate-to-severe forms of the condition.
  • Although current IL-4 and IL-13 inhibitors show promise for quick flare control and long-term relief, more research is needed on additional IL-inhibitors and real-world effectiveness, alongside establishing predictive biomarkers for personalized treatment plans.
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Respiratory drive is defined as the intensity of respiratory centers output during the breath and is primarily affected by cortical and chemical feedback mechanisms. During the involuntary act of breathing, chemical feedback, primarily mediated through CO, is the main determinant of respiratory drive. Respiratory drive travels through neural pathways to respiratory muscles, which execute the breathing process and generate inspiratory flow (inspiratory flow-generation pathway).

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  • This study compares two surgical methods, Hartmann's procedure (HP) and resection with primary anastomosis (RPA), for treating acute left-sided colonic emergencies among 1215 patients from 204 centers globally.
  • Results showed that while HP was the more common treatment (57.3%), RPA was favored for younger patients with fewer health issues and those needing surgery sooner.
  • The study concluded that although HP is still widely used, RPA might be the better option, emphasizing the importance of patient characteristics and surgeon experience in determining treatment choice.
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  • Von-Hippel-Lindau (VHL) is a genetic disorder that leads to tumors and cysts in various organs, and this case discusses a 23-year-old woman with VHL who developed rare gastric neuroendocrine tumors (gNENs) while also suffering from chronic autoimmune gastritis (CAG).
  • The gNENs observed in this patient showed characteristics similar to those typically seen in VHL-related tumors, despite gNENs not being commonly associated with VHL.
  • The findings suggest that the formation of clear-cell gNENs might be influenced more by CAG rather than just VHL, highlighting the importance of careful monitoring of such tumors in patients before ruling out VHL disease
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Adolescents often experience insufficient sleep and have unhealthy sleep habits. Our aim was to investigate the sleep patterns of secondary education students in Heraklion, Crete, Greece and their association with school performance and health habits. We conducted a community-based cross-sectional study with 831 students aged 13-19 years who completed an online self-reported questionnaire related to sleep and health habits.

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Purpose: To examine hemodynamic and functional connectivity alterations and their association with neurocognitive and mental health indices in patients with chronic mild traumatic brain injury (mTBI).

Methods: Resting-state functional MRI (rs-fMRI) and neuropsychological assessment of 37 patients with chronic mTBI were performed. Intrinsic connectivity contrast (ICC) and time-shift analysis (TSA) of the rs-fMRI data allowed the assessment of regional hemodynamic and functional connectivity disturbances and their coupling (or uncoupling).

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In steady state, intestinal subepithelial myofibroblasts form a thin layer below the basement membrane. Unlike the rest of the stromal cells in the lamina propria, they express tensile proteins, guide epithelial regeneration, and sense luminal microbiota. Upon inflammation in inflammatory bowel disease (IBD), they express activation markers, accept trophic signaling by infiltrating neutrophils and macrophages, and are activated by cytokines from helper T cells to produce a narrow spectrum of cytokines and a wider spectrum of chemokines, attract cells of innate and adaptive immunity, orchestrate inflammatory responses, and qualitatively and quantitatively modify the extracellular matrix.

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Purpose: The aim of this study is to compare the outcomes of vascular anastomosis using loupes magnification versus operative microscope magnification in reconstructive surgery.

Methods: We performed a systematic review of MEDLINE (via PubMed), Scopus and Cochrane Library database according to the PRISMA guidelines. Comparative studies between the two techniques and single arm studies reporting on loupes reconstruction were included.

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The state of emergency medicine in Greece: at critical momentum.

Int J Emerg Med

April 2024

Department of Emergency Medicine, Yale University School of Medicine, 464 Congress Avenue, Suite 260, New Haven, CT, USA.

Greece is a parliamentary republic in southeastern Europe populated by over 10 million permanent residents: 9 million reside on the mainland, with almost 4 million in the greater Athens area. The remaining 1 million populate the over 1200 Greek islands. In addition, more than 160,000 asylum-seekers reached Greece in 2022, and more than 25 million tourists have visited Greece in the last two years.

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Article Synopsis
  • * In 2022/2023, extensive community-based research was conducted, gathering insights from 1,756 caregivers, 1,201 youth, 404 teachers, and 475 health professionals through surveys and focus groups.
  • * The resulting dataset, which includes quantitative and qualitative findings, is publicly available and aims to guide future research and training in mental health, potentially serving as a model for similar initiatives in other countries.
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Purpose: A number of studies suggest that older patients may have reduced or no benefit from the addition of oxaliplatin to fluoropyrimidines as adjuvant chemotherapy for stage III colon cancer (CC).

Materials And Methods: We studied the prognostic impact of age, as well as treatment adherence/toxicity patterns according to age, in patients with stage III CC who received 3 or 6 months of infusional fluorouracil, leucovorin, and oxaliplatin/capecitabine and oxaliplatin (CAPOX) on the basis of data collected from trials from the ACCENT and IDEA databases. Associations between age and time to recurrence (TTR), disease-free survival (DFS), overall survival (OS), survival after recurrence (SAR), and cancer-specific survival (CSS) were assessed by a Cox model or a competing risk model, stratified by studies and adjusted for sex, performance status, T and N stage, and year of enrollment.

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Infective Endocarditis by Species-A Narrative Review.

Medicina (Kaunas)

February 2024

School of Medicine, University of Crete, 71003 Heraklion, Greece.

Bacteria belonging to the genus are thin, capnophilic, Gram-negative bacilli with tapered ends that include nine species that are isolated from the mouth of humans and animals and, from a phylogenetical perspective, they belong to the family . Two more species, namely and have been recovered from a periapical abscess and human and animal infections, respectively. spp.

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: Self-management programs are essential for increasing COPD patient participation and autonomy in making appropriate decisions about their chronic condition. The present study aimed to assess the impact of COPD self-management interventions on quality of life, functional status, patient education, depression, and anxiety in primary care. : We conducted a randomized controlled trial recruiting patients with COPD (GOLD A and B) from four primary care centers in Crete, Greece, with one intervention group ( = 40) receiving self-management educational support and one control group ( = 80) receiving usual care.

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Objectives: To collect real-world data about the knowledge and self-perception of young radiologists concerning the use of contrast media (CM) and the management of adverse drug reactions (ADR).

Methods: A survey (29 questions) was distributed to residents and board-certified radiologists younger than 40 years to investigate the current international situation in young radiology community regarding CM and ADRs. Descriptive statistics analysis was performed.

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Greece opened its points of entry on July 1, 2020, with specific guidelines for travellers arriving by sea, air or land. The aim of this article is to examine the effect of tourism on the long term course of the Coronavirus Disease 2019 (COVID-19) pandemic during the pre-vaccination era (June to December 2020) on the popular Greek island of Crete. To achieve this, a cross-sectional serosurvey, repeated at monthly intervals, was conducted to compare the seroprevalence in Crete with seroprevalence in the mainland of Greece.

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Radiomics feature reproducibility: The elephant in the room.

Eur J Radiol

June 2024

Department of Medical Imaging, University Hospital of Heraklion, Heraklion, Crete, Greece; Department of Radiology, School of Medicine, University of Crete, Heraklion, Crete, Greece; Computational Biomedicine Laboratory, Institute of Computer Science, Foundation for Research and Technology (FORTH), Heraklion, Crete, Greece; Division of Radiology, Department for Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden. Electronic address:

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Objective: Although there is growing evidence that ultrasonography is superior to X-ray for rib fractures' detection, X-ray is still indicated as the most appropriate method. This has partially been attributed to a lack of studies using an appropriate reference modality. We aimed to compare the diagnostic accuracy of ultrasonography and X-ray in the detection of rib fractures, considering CT as the reference standard.

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