2,504 results match your criteria: "University Hospital of Heraklion.[Affiliation]"

Introduction: The aim of this prospective study was to evaluate the impact of hemodialysis (HD) on myocardial injury, of both right and left ventricle function as well as their association with venous oxygen saturation (ScvO2) alterations.

Material And Methods: We included in the study stable consecutive patients with end-stage renal disease (ESRD) undergoing regular HD. Right and left ventricular speckle-tracking echocardiographies were performed in all patients.

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Article Synopsis
  • Terson's syndrome (TS) is an eye condition linked to subarachnoid hemorrhage (SAH) that can cause vision problems, but its details are not well understood.
  • A 52-year-old man who had a severe headache and SAH developed TS three weeks later, resulting in blurred vision, and required successful surgical treatment.
  • This case highlights the need for increased awareness among medical professionals about TS as a potential complication of SAH, emphasizing the importance of early diagnosis and treatment for better outcomes.
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Objectives: We conducted a systematic review and meta-analysis of current publications on the potential role of non-contrast-enhanced computed tomography (NCCT) radiomics as a prognostic indicator in patients with intracerebral hemorrhage (ICH).

Methods: We systematically searched PubMed, EMBASE, and the Web of Science from inception until January 8, 2024. Studies with NCCT-based radiomics features for predicting the prognostic outcomes of ICH patients were included.

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: Antibiotic (AB) therapy is the first step in managing hidradenitis suppurativa (HS). Knowledge of the local patterns of antimicrobial resistance is paramount for the appropriate selection of antimicrobials. This study aimed to assess the occurrence of antibiotic resistance in patients with HS.

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This study provides a comparative analysis of 243 Methicillin-resistant (MRSA) isolated strains from Greece and Romania, focusing on their epidemiology and antibiotic resistance patterns. Laboratory procedures included phenotypic and automated identification methods, susceptibility testing, DNA isolation, and PCR for detecting antibiotic resistance genes (, ). Our study results show significant regional differences.

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The parasellar region is the anatomical area around the sella turcica that represents a crucial crossroad for important adjacent structures. Several distinct tumors can primarily originate from this area, the most common being meningiomas, gliomas, embryonal cell tumors, germ cell tumors, and craniopharyngiomas. In addition, a number of systemic and inflammatory disorders can also affect the parasellar region, most commonly involving the pituitary.

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Infective endocarditis (IE) is a disease that may cause significant morbidity and mortality. IE is classically caused by Gram-positive microorganisms; however, Gram-negative bacteria may seldom also be the cause. species cause zoonosis and may also infect humans, mainly causing gastrointestinal infection by or invasive disease by , such as bacteremia, sepsis, meningitis, or vascular infection.

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Background: it is widely accepted that living in the digital transformation era, the need to develop and update new professional skills and tools in health sectors is crucially important. Therefore, this study aimed to explore the reliability and validity of the Digital Competence Indicators tool in assessing the digital skills of Greek health professionals.

Methods: in this cross-sectional study, 494 health professionals, including doctors (175) and registered nurses (319) working in four Greek hospitals were recruited and willingly participated using a convenience-sampling method.

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Epidemiology of Invasive Fungal Diseases: A 10-Year Experience in a Tertiary Pediatric Hematology-Oncology Department in Greece.

J Fungi (Basel)

July 2024

Department of Pediatric Hematology-Oncology & Autologous Hematopoietic Stem Cell Transplantation Unit, University Hospital of Heraklion & Laboratory of Blood Diseases and Childhood Cancer Biology, School of Medicine, University of Crete, 71003 Heraklion, Greece.

Article Synopsis
  • Advances in pediatric cancer treatment have improved outcomes for infectious diseases, but invasive fungal diseases (IFDs) still pose significant health risks for high-risk patients.
  • A retrospective study from 2013-2022 in Crete found a 7.8% prevalence of IFDs among pediatric patients, with the most common being invasive pulmonary aspergillosis and candidemia.
  • Key risk factors for developing IFDs included prolonged ICU stay, extensive antimicrobial use, and fungal colonization, with an overall mortality rate of 16.7% among those affected.
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Impact of comorbidities on patient-reported outcomes in psoriatic arthritis: the case of endometriosis.

Rheumatol Int

September 2024

Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, University Campus of Voutes, Heraklion, 71003, Greece.

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Precise classification of sarcomas is crucial to optimal clinical management. In this prospective, multicenter, observational study within the Hellenic Group of Sarcoma and Rare Cancers (HGSRC), we assessed the effect of expert pathology review, coupled with the application of molecular diagnostics, on the diagnosis and management of sarcoma patients. Newly diagnosed sarcoma patients were addressed by their physicians to one of the two sarcoma pathologists of HGSRC for histopathological diagnostic assessment.

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Background: The wide range of R0 resection rates (R0RR) and incomplete resection rates (IRR) observed with conventional cold snare polypectomy (CCSP) emphasizes the necessity for technique enhancement. The COLDWATER study aimed to compare underwater cold snare polypectomy (UCSP) to CCSP for 5-10-mm colorectal polyps, focusing on comprehensive histopathological evaluation, efficacy, and safety.

Methods: This was a randomized, single-blind, controlled trial comparing UCSP to CCSP for non-pedunculated colorectal polyps of size 5-10 mm.

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A 1-year follow-up study on checkpoint inhibitor-induced colitis: results from a European consortium.

ESMO Open

July 2024

Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy; First Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

Background: Data regarding the clinical outcome of patients with immune checkpoint inhibitor (ICI)-induced colitis are scant. We aimed to describe the 12-month clinical outcome of patients with ICI-induced colitis.

Materials And Methods: This was a retrospective, European, multicentre study.

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Article Synopsis
  • The EADV Task Forces analyzed the Health-Related Quality of Life (HRQoL) measurement in urticaria treatment, highlighting the Dermatology Life Quality Index as the most commonly used tool in clinical trials.
  • Many trials lacked specific numeric results on HRQoL changes, complicating comparisons and conclusions across studies.
  • The study suggests favoring HRQoL instruments that include minimal clinically significant difference (MCID) data for better relevance in clinical practice rather than just relying on statistically significant changes.
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Prediction of Anastomotic Leakage in Esophageal Cancer Surgery: A Multimodal Machine Learning Model Integrating Imaging and Clinical Data.

Acad Radiol

December 2024

Department for Clinical Science, Intervention and Technology (CLINTEC), Division of Radiology, Karolinska Institutet, Stockholm, Sweden; Medical Radiation Physics and Nuclear Medicine, Section for Nuclear Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden. Electronic address:

Article Synopsis
  • The study focuses on developing a machine-learning model to predict anastomotic leakage (AL) after esophagectomy for esophageal cancer, as this complication poses significant risks post-surgery.
  • 471 patients' preoperative CT and clinical data were analyzed to create and test the model using an XGBoost algorithm, with performance metrics measured using ROC curves.
  • The model showed a noteworthy accuracy, achieving a 79.2% area under the curve, which can aid in identifying patients at risk of AL, particularly where clinical indicators suggest low probability.*
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Article Synopsis
  • - AI can help improve medical imaging by making predictions, but it can also have problems with bias, which means it might make mistakes based on unfair information.
  • - Even though AI might reduce human errors, it can sometimes learn these biases itself, which can lead to harm in patient care.
  • - The authors conducted a review to help doctors and scientists understand and fix bias in AI to make sure it works better and is safer for patients.
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Background: Merkel cell carcinoma (MCC) is a rare, aggressive, cutaneous tumour with high mortality and frequently delayed diagnosis. Clinically, it often manifests as a rapidly growing erythematous to purple nodule usually located on the lower extremities or face and scalp of elderly patients. There is limited available data on the dermoscopic findings of MCC, and there are no specific features that can be used to definitively diagnose MCC.

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People living with HIV-HCV co-infection comprise a target group for HCV-micro-elimination. We conducted an HCV cascade of care (CoC) for HIV-HCV co-infected individuals living in Greece and investigated factors associated with different HCV-CoC stages. We analyzed data from 1213 participants from the Athens Multicenter AIDS Cohort Study.

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Central Line-Associated Bloodstream Infection Due to : Case Report and Literature Review on Pediatric Infections.

Microorganisms

June 2024

Department of Pediatric Hematology-Oncology, Laboratory of Blood Diseases and Childhood Cancer Biology, University Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Greece.

is an opportunistic pathogen causing lifethreatening infections in humans, particularly in immunocompromised patients, neonates and the elderly. We report a case of central line-associated bloodstream infection by in a 2.5-year-old girl with acute lymphoblastic leukemia successfully treated with a combination of piperacillin/tazobactam and amikacin.

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Respiratory disorders significantly impact adolescents' health, often resulting in hospital admissions. Meteorological elements such as wind patterns have emerged as potential contributors to respiratory symptoms. However, it remains uncertain whether fluctuations in wind characteristics over extended periods have a tangible impact on respiratory health, particularly in regions characterized by distinct annual wind patterns.

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Infections in Humans-A Narrative Review.

Antibiotics (Basel)

June 2024

School of Medicine, University of Crete, 71003 Heraklion, Greece.

species (formerly known as ) are Gram-positive filamentous bacteria in the family Promicromonosporaceae and are more commonly found in sewage and soil. The present study aimed to identify all the published cases of species infections in the literature, describe the epidemiological, clinical, and microbiological characteristics, and provide data regarding its antimicrobial resistance, treatment, and outcomes. A narrative review was performed based on a PubMed and Scopus database search.

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Comment on "beyond physical pain: A large-scale cohort study on endometriosis trends and mental health correlates".

J Psychosom Res

September 2024

Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, Heraklion, Greece; Department of Internal Medicine, University Hospital of Heraklion, Heraklion, Greece. Electronic address:

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Ataxia-telangiectasia (A-T) is an autosomal-recessive disorder caused by pathogenic variants (PVs) of the ATM gene, predisposing children to hematological malignancies. We investigated their characteristics and outcomes to generate data-based treatment recommendations. In this multinational, observational study we report 202 patients aged ≤25 years with A-T and hematological malignancies from 25 countries.

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