815 results match your criteria: "University Hospital of Campania "L. Vanvitelli"[Affiliation]"

Background: Recently, the PORT-C and LUNG-ART trials, which evaluated the role of postoperative radiation therapy (PORT), have significantly altered the treatment landscape for NSCLC pN2 patients who previously underwent surgery. In response, the Italian Association of Radiotherapy and Oncology Thoracic Oncology study group has initiated an observational multicenter trial to assess both acute and late toxicities of PORT in pN2 NSCLC patients treated with modern techniques.

Methods: Data on NSCLC patients submitted to PORT after radical surgery treated between 2015 and 2020 in six Italian Centers were collected.

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Introduction: Acute pancreatitis (AP) is a common disease, and several scores aim to assess its prognosis. Our study aims to automatically recognize mild AP from computed tomography (CT) images in patients with acute abdominal pain but uncertain diagnosis from clinical and serological data through Radiomic model based on formal methods (FMs).

Methods: We retrospectively reviewed the CT scans acquired with Dual Source 256-slice CT scanner (Somatom Definition Flash; Siemens Healthineers, Erlangen, Germany) of 80 patients admitted to the radiology unit of Antonio Cardarelli hospital (Naples) with acute abdominal pain.

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Background: The recent advances in precision oncology for lung cancer treatment has focused attention on the importance of obtaining appropriate specimens for tissue diagnosis as well as comprehensive molecular profiling. CT scan-guided biopsies and bronchoscopy are currently the main procedures employed for tissue sampling. However, growing evidence suggests that ultrasound-guided biopsies may represent an effective as well as safe approach in this diagnostic area.

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Clinical cases referring to the EACTS/STS Guidelines for diagnosing and treating acute and chronic syndromes of the aortic organ aim to assist physicians in selecting the best management strategies for individual patients with a given condition. These expert opinions consider the impact on patient outcomes as well as the risk-benefit ratio of different diagnostic or therapeutic methods. These cases serve as a vital tool to aid physicians in making decisions in their daily practice.

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Oropouche virus infection: What internal medicine physicians should know.

Eur J Intern Med

October 2024

Department of Precision Medicine, University of Campania 'L. Vanvitelli', and Unit of Internal Medicine and Transplants, AORN Ospedali dei Colli-Monaldi Hospital, Naples, Italy. Electronic address:

Article Synopsis
  • The text indicates that clinical insights do not need additional requirements or prerequisites for understanding.
  • It suggests that the information provided is straightforward and accessible.
  • This implies that anyone can grasp the essential concepts without needing specialized knowledge.
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Bardet-Biedl syndrome improved diagnosis criteria and management: Inter European Reference Networks consensus statement and recommendations.

Eur J Hum Genet

November 2024

CINBIO, Universidad de Vigo, Grupo de Investigación en Enfermedades Raras, Instituto de Investigación Sanitaria Galicia Sur (IIS Galicia Sur), Vigo, Spain.

Four European Reference Networks (ERN-EYE, ERKNet, Endo-ERN, ERN-ITHACA) have teamed up to establish a consensus statement and recommendations for Bardet-Biedl syndrome (BBS). BBS is an autosomal recessive ciliopathy with at least 26 genes identified to date. The clinical manifestations are pleiotropic, can be observed in utero and will progress with age.

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The Challenge of Managing Atrial Fibrillation during Pregnancy.

Rev Cardiovasc Med

October 2023

Cardiology Department, Grande Ospedale Metropolitano, GOM, AO Bianchi Melacrino Morelli, 89124 Reggio Calabria, Italy.

Article Synopsis
  • * Treating AF in pregnant women is tricky since medications can pose risks to both mother and baby; thus, strategies like electrical cardioversion and beta-blockers are preferred for safety and effectiveness.
  • * Collaboration among healthcare professionals in a "Pregnancy-Heart Team" enhances patient care, but more research is necessary to establish the best treatment approaches for managing AF in pregnancy.
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Genomic Profiling for Predictive Treatment Strategies in Fibrotic Interstitial Lung Disease.

Biomedicines

June 2024

UOC Pneumotisiologia Federico II, A.O.R.N. Monaldi-Cotugno-CTO Piazzale Ettore Ruggieri, 80131 Napoli, Italy.

Article Synopsis
  • Idiopathic pulmonary fibrosis (IPF) is commonly seen as the main type of progressive fibrotic interstitial lung disease (f-ILD), but other forms can also show a similar progressive pattern.
  • Using genomic signatures in clinical settings for f-ILD patients may help identify those at high risk for progression and improve personalized treatment.
  • The review highlights ongoing research in IPF and other pulmonary fibrosis types linked to immune disorders, and discusses future research directions in understanding these diseases better.
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Aim: To provide guidance for follow-up and monitoring of children and adolescents identified as positive to islet autoantibodies (IA) in the general population screening for type 1 diabetes (T1D) in Italy.

Methods: Detection of IA helps to diagnose pre-symptomatic T1D, prevent diabetic ketoacidosis (DKA) and identify persons for new therapies to delay symptomatic diabetes. Italy recently became the first country to approve by law a general autoantibody screening program for T1D and celiac disease in all children and adolescents (age 1-17yr).

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  • A Loeys-Dietz syndrome patient underwent mitral valve repair and replacement of the aortic root and valve, revealing a previously misdiagnosed Morgagni hernia during a preoperative CT scan.
  • The Morgagni hernia was found to contain omentum and was compressing the right ventricle, complicating the patient’s condition.
  • Intraoperative observations revealed abnormal blood flow back into the left ventricle, later attributed to major aorto-pulmonary collateral arteries, highlighting the need to consider these congenital features in diagnosis and surgical treatment.
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Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with 20% of patients presenting with metastatic disease at diagnosis. TGF-β signaling plays a crucial role in various cellular processes, including growth, differentiation, apoptosis, epithelial-mesenchymal transition (EMT), regulation of the extracellular matrix, angiogenesis, and immune responses. TGF-β signals through SMAD proteins, which are intracellular molecules that transmit TGF-β signals from the cell membrane to the nucleus.

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Background: The growing understanding of cancer biology and the establishment of new treatment modalities has not yielded the expected results in terms of survival for Laryngeal Squamous Cell Cancer (LSCC). Early diagnosis, as well as prompt identification of patients with high risk of relapse would ensure greater chance of therapeutic success. However, this goal remains a challenge due to the absence of specific biomarkers for this neoplasm.

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Ultrasound features of cutaneous myiasis: a rare case in a child.

J Ultrasound

July 2024

Department of Radiology, AORN "Santobono-Pausilipon", Via Posillipo 226, Naples, Italy.

Cutaneous myiasis is an infestation of the skin with larvae of some dipteran species. Among humans, Dermatobia hominis is the most frequently encountered dipteran responsible for cutaneous myiasis. This insect is endemic to tropical and subtropical regions, consequently, individuals travelling from non-endemic areas are most susceptible to infection due to a lack of prior exposure.

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Article Synopsis
  • Central nervous system tumors are significant in children due to their prevalence and effects on health, highlighting the need for advanced imaging techniques to assess these conditions more thoroughly.* -
  • Recent advances in magnetic resonance imaging (MRI) techniques, including radiomics and artificial intelligence, are enhancing the characterization, grading, and prognosis of pediatric brain tumors beyond traditional visual assessment.* -
  • A review of relevant literature from 2008 to 2024 identified 63 studies that explore the roles of radiomics and AI in improving the management of pediatric brain tumors through more detailed and quantitative imaging analysis.*
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Background: Pancreatic cancer (PC) first-line therapy often consists of polychemotherapy regimens, but choosing a second-line therapy after disease progression, especially following first-line FOLFIRINOX, remains a clinical challenge. This study presents results from a large, multicenter, retrospective analysis of Italian patients with metastatic PC (mPC) treated with Nab-paclitaxel/Gemcitabine (AG) as second or later line of treatment. Main objective of the study is to identify prognostic factors that could inform treatment decisions.

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Background: The aim of this study is to report the preliminary real-word clinical and hemodynamic performance from the MANTRA study in patients undergoing aortic valve replacement with Perceval PLUS sutureless valve.

Methods: MANTRA is an ongoing "umbrella" prospective, multi-center, international post-market study to collect real-life safety and performance data on Corcym devices (Corcym S.r.

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Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia.

Front Endocrinol (Lausanne)

June 2024

Department of Women's and Children's Health, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Ancona, 'Salesi Hospital', Ancona, Italy.

Article Synopsis
  • * Hypoglycemia continues to be a major concern for those using insulin therapy, prompting the need for evidence-based recommendations for its recognition, treatment, and management among pediatric diabetologists.
  • * The guidelines suggest raising blood glucose levels above 70 mg/dL using oral glucose, with specific dosages tailored for different treatment settings, and they include practical flow charts to assist in clinical decision-making, aiming for a global applicability.
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Article Synopsis
  • - The study investigates whether illegal toxic waste discharge can cause a new reproductive condition called morpho-epigenetic pathozoospermia in young men who typically have normal sperm quality.
  • - Findings reveal that exposure to environmental contaminants can lead to serious sperm defects and an increase in low-quality circular RNA in the seminal plasma of men living in heavily polluted areas.
  • - The research involved semen samples from 160 healthy men, split between those from a contaminated region in Italy ('Land of Fires') and a control group, highlighting significant differences in sperm quality attributed to environmental pollution.
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Rethinking the role of trazodone in the different depressive dimensions.

Expert Rev Neurother

July 2024

Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Centre, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

Introduction: The efficacy of trazodone for several psychopathologic dimensions of depression has been shown in the literature. Trazodone has been widely used in some clinical contexts (e.g.

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Background: The severe acute respiratory syndrome Coronarovirus-2 associated still causes a significant number of deaths and hospitalizations mainly by the development of respiratory failure. We aim to validate lung ultrasound score in order to predict mortality and the severity of the clinical course related to the need of respiratory support.

Methods: In this prospective multicenter hospital-based cohort study, all adult patients with diagnosis of SARS-CoV-2 infection, performed by real-time reverse transcription polymerase chain reaction were included.

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Background And Aims: We aimed to characterize the epidemiologic and comorbidities profiles of patients with chronic Hepatitis D (CHD) followed in clinical practice in Italy and explored their interferon (IFN) eligibility.

Methods: This was a cross-sectional study of the PITER cohort consisting of consecutive HBsAg-positive patients from 59 centers over the period 2019-2023. Multivariable analysis was performed by logistic regression model.

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: High-flow nasal cannula (HFNC) therapy has emerged as a promising treatment modality for interstitial lung disease (ILD)-related respiratory failure. This systematic review aims to evaluate the efficacy and safety of HFNC therapy in patients with ILDs. A comprehensive literature search was conducted using major electronic databases to identify relevant studies investigating the use of HFNC therapy in ILD patients with respiratory failure.

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Unlabelled: Patients with COVID-19 have coagulation and platelet disorders, with platelet alterations and thrombocytopenia representing negative prognostic parameters associated with severe forms of the disease and increased lethality.

Methods: The aim of this study was to study the expression of platelet glycoprotein IIIa (CD61), playing a critical role in platelet aggregation, together with TRL-2 as a marker of innate immune activation.

Results: A total of 25 patients were investigated, with the majority (24/25, 96%) having co-morbidities and dying from a fatal form of SARS-CoV-2(+) infection (COVID-19+), with 13 men and 12 females ranging in age from 45 to 80 years.

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