3 results match your criteria: "University Hospital of Bordeaux (CHU Bordeaux - Pellegrin Hospital)[Affiliation]"
Widening of myelin lamellae in polyneuropathy with immunoglobulin-M monoclonal gammopathy, without activity against myelin-associated glycoprotein, responsive to treatment.
Neuromuscul Disord
August 2022
Department of Neurology, Nerve-Muscle Unit, AOC National Reference Center for Neuromuscular Disorders, ALS Center, University Hospital of Bordeaux (CHU Bordeaux - Pellegrin Hospital), place Amélie Raba-Léon, Bordeaux 33000, France. Electronic address:
Article Synopsis
- *The patient also has immunoglobulin-M monoclonal gammopathy but lacks antibodies against known myelin antigens.
- *Nerve biopsy showed unusual changes in myelin, and treatment with plasma exchanges and rituximab was effective, indicating an autoimmune cause for the condition.*
Are Miller Fisher syndrome and CANDA due to a paranodopathy?
J Neurol Sci
July 2022
Department of Neurology, Nerve-Muscle Unit, AOC National Reference Center for Neuromuscular Disorders, ALS Center, University Hospital of Bordeaux (CHU Bordeaux - Pellegrin Hospital), Place Amélie Raba-Léon, 33000 Bordeaux, SM, France. Electronic address:
Article Synopsis
- This study investigates the pathological features of acute and chronic ataxic peripheral neuropathy, focusing on the node of Ranvier in nerve biopsies from two patients with different conditions: Miller Fisher syndrome (acute) and chronic ataxic neuropathies with disialosyl antibodies (CANDA).
- Findings reveal that both patients exhibit lesions indicative of "paranodopathy," where the immune response negatively affects myelin and surrounding nerve structures.
- The research concludes that immune-mediated peripheral neuropathies can be categorized as nodoparanodopathies, which involve various clinical presentations and may contribute to nerve damage through mechanisms related to anti-disialosyl antibodies.
CIDP and hemopathies, an underestimated association.
J Neurol Sci
October 2021
Department of Neurology, National Reference Center for 'Rare Peripheral Neuropathies', University Hospital of Limoges (CHU Limoges - Dupuytren Hospital), 2 avenue Martin Luther King, 87042 Limoges, France. Electronic address:
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated and treatable disease that may be associated with various systemic conditions. Our objective is to describe the clinical, electrophysiological and pathological data of a series of patients with both CIDP and hemopathy. In this retrospective study, we analyzed 21 patients with CIDP and various hemopathies (malignant or not), consecutively observed for almost five years.
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