3 results match your criteria: "University Hospital of Bonn (UKB)[Affiliation]"
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Genome Med
January 2021
Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Background: The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory distress syndrome, respiratory failure, and death. Reports on a dysregulated immune system in the severe cases call for a better characterization and understanding of the changes in the immune system.
View Article and Find Full Text PDFTLR agonists enhance responsiveness of inflammatory innate immune cells in HLA-B*57-positive HIV patients.
J Mol Med (Berl)
January 2021
Department of Internal Medicine I, University Hospital of Bonn (UKB), Venusberg-Campus 1, 53127, Bonn, Germany.
HLA-B*57 affects the course of HIV infection. Under antiretroviral therapy, its effects cannot be explained by outstandingly efficient T cell responses alone but may also involve cells of innate immunity. Studying in vitro stimulation with Pam3CSK4, E.
View Article and Find Full Text PDFRole of regulatory T cells and checkpoint inhibition in hepatocellular carcinoma.
Cancer Immunol Immunother
December 2019
Department I of Internal Medicine, University Hospital of Bonn (UKB), Venusberg-Campus-1, 53127, Bonn, Germany.
Article Synopsis
- Immune checkpoint inhibitors show potential for treating advanced hepatocellular carcinoma (HCC), but it's unclear how they work since HCC cells don't express the usual inhibitory molecules.
- The study examined the role of regulatory T cells (Tregs) in HCC, finding that Tregs in these patients express checkpoint molecules and produce inhibitory factors, affecting the immune response.
- The research suggested that blocking the PD-L1/PD-1 pathway can improve the effectiveness of immune responses against HCC by counteracting the inhibitory effects of Tregs, indicating a possible new therapeutic strategy.