380 results match your criteria: "University Hospital of Asturias[Affiliation]"

Disease activity indices used in axial spondyloarthritis perform similarly in real-life clinical settings.

J Rheumatol

January 2025

R. Queiro, M.D., Ph.D, Rheumatology Division, Central University Hospital of Asturias, Oviedo, Spain; Department of Medicine. Oviedo University School of Medicine, Oviedo, Spain; Translational Immunology Division. Health Research Institute of the Principality of Asturias (ISPA), Oviedo-Spain.

Objective: Monitoring of axial spondyloarthritis (axSpA) activity using validated indices (BASDAI/ASDAS) is widely recommended but rarely followed in practice. The reasons, although varied, may be found in the scarcity of studies comparing the performance of these indices in daily practice. Here we compare the performance of activity indices in clinical practice.

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Introduction: Retrograde ejaculation (RE) consists of the reflux backwards, towards the bladder, of the ejaculate, during the emission phase of ejaculation, causing a total or partial absence of sperm emission, with the consequent diversion of semen into the bladder during the emission phase of ejaculation. Evaluating the ejaculate may not be sufficient for identifying RE in some patients. Hence, the management of infertility may involve the use of invasive methods such as epididymal fluid retrieval or testicular biopsy.

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Faecal Metabolome Profiles in Individuals Diagnosed with Hyperplastic Polyps and Conventional Adenomas.

Int J Mol Sci

December 2024

Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), 33011 Oviedo, Spain.

Colorectal cancer (CRC) development is a gradual process in which progressive histological alterations of the intestinal mucosa damage occur over years. This process can be influenced by modifiable external factors such as lifestyle and diet. Most CRC cases (>80%) originate from conventional adenomas through the adenomatous pathway and usually harbour dysplastic cells, whereas the serrated pathway is less frequent (<20% cases) and comprises hyperplastic polyps and other polyps containing dysplastic cells.

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Objective: The relationship between different power equations and the severity of acute respiratory distress syndrome (ARDS) remains unclear. This study aimed to evaluate various power equations: total mechanical power, total elastic power (comprising elastic static and elastic dynamic power), and resistive power, in a cohort of mechanically ventilated patients with and without ARDS. Bayesian analysis was employed to refine estimates and quantify uncertainty by incorporating a priori distributions.

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C-reactive protein thresholds for discriminating active disease in psoriatic arthritis may be different in early versus established disease.

Clin Exp Rheumatol

December 2024

Rheumatology Division, Central University Hospital of Asturias, Oviedo; Department of Medicine, Oviedo University School of Medicine, Oviedo; and Translational Immunology Division, Biohealth Research Institute of the Principality of Asturias (ISPA), Oviedo, Spain.

Objectives: Inflammatory biomarkers such as C-reactive protein (CRP) lack discriminatory capacity to detect active disease in psoriatic arthritis (PsA). Our aim was to find CRP thresholds capable of discriminating active disease in both early and established PsA.

Methods: We included a total of 345 PsA patients (215 early-onset not exposed to high-impact therapies and 130 with established disease under biologics and oral targeted therapies).

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Purpose: The main objectives were to study differences between the first and the fourth cycle in dosimetry variables in patients treated for neuroendocrine tumours with four cycles of [Lu]Lu-DOTA-TATE, as well as to look for absorbed dose-effect correlations aiming to help individualise and optimise this therapy for future patients.

Material And Methods: SPECT/CT based dosimetry of tumour lesions and kidneys was performed in the first and the fourth cycles of the [Lu]Lu-DOTA-TATE treatments for 17 patients from 2020 to 2023. Clinical variables of interest were collected in order to look for correlations with some dosimetry variables.

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The Spanish Society of Pneumology and Thoracic Surgery (SEPAR) and the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) have developed together Clinical Practice Guidelines (GPC) on the management of people affected by tuberculosis (TB) resistant to drugs with activity against Mycobacterium tuberculosis. These clinical practice guidelines include the latest updates of the SEPAR regulations for the diagnosis and treatment of drug-resistant TB from 2017 to 2020 as the starting point. The methodology included asking relevant clinical questions based on PICO methodology, a literature search focusing on each question, and a systematic and comprehensive evaluation of the evidence, with a summary of this evidence for each question.

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Obesity and smoking have been related to increased disease activity in axial spondyloarthritis (axSpA), but these associations might vary depending on the composite index chosen to assess disease activity. We aimed to check this possibility. Three hundred and thirty consecutive patients were recruited from the monographic axSpA unit of a university center.

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Protective Effect of High Adherence to Mediterranean Diet on the Risk of Incident Type-2 Diabetes in Subjects with MAFLD: The Di@bet.es Study.

Nutrients

November 2024

Centro de Investigaciónn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain.

: Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) increases the risk of Type-2 Diabetes (T2DM). The Mediterranean diet (MD) has shown advantages in the management of MAFLD and preventing co-morbidities; however, its relationship with T2DM development in MAFLD has been less investigated. We aimed to evaluate the association of MD adherence with the risk of incident T2DM in the Spanish adult population with MAFLD and according to their weight gain at 7.

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Complications Related to the Securement Device in Peripheral Intravenous Catheters: A Randomized Study.

J Infus Nurs

November 2024

Author Affiliations: Navarra's Health Research Institute (IdiSNA), Pamplona, Navarra, Spain ; Public University of Navarre, Pamplona, Spain ; University Hospital of Navarra, Pamplona, Spain ; Central University Hospital of Asturias, Asturias, Spain.

Studies have not demonstrated the effectiveness of the different types of dressings in reducing the rate of complications. The purpose of this study was to determine which type of dressing is most beneficial in reducing the rate of complications. A total of 281 patients requiring a peripheral intravenous catheter were randomized to receive partially reinforced dressings or fully reinforced dressings (dressings with integral catheter securement).

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Article Synopsis
  • A study investigated how fiber and probiotic supplements can help protect against colon damage and gut microbiota changes caused by harmful substances (PhIP and DSS) in male Fischer-344 rats.* -
  • The results showed that while PhIP and DSS caused significant inflammation and damage to the colon, fiber reduced this damage and inflammation, and probiotics increased colon length.* -
  • Additionally, fiber shifted the gut microbiota toward less inflammation, contrasting with the negative changes seen after exposure to PhIP and DSS without supplements.*
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Background/objectives: In recent years, a possible connection between HLA-Cw6 and a distinctive cardiometabolic (CM) profile in patients with psoriatic disease (PsD) has been proposed, although there is still little support for this. Our aim was to further investigate this possible association by studying a large population of PsD patients.

Methods: For this study, three different cohorts of patients with PsD were analyzed: two with a majority of cutaneous psoriasis, pooled n: 600, and a third with only psoriatic arthritis-PsA-cases, n: 340.

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Article Synopsis
  • Myxedema coma often involves reduced consciousness and low body temperature, potentially linked to thyroid issues, especially in patients with head trauma and central hormone deficiencies.
  • A 52-year-old man with head trauma exhibited symptoms like drowsiness and hypotension, with initial tests showing normal TSH levels but low ACTH and FT4, and his condition worsened before improving with medication.
  • The case highlights the importance of assessing both TSH and FT4 levels for diagnosing central hypothyroidism, as relying solely on TSH might lead to overlooked conditions in patients showing hormone deficiency symptoms post-trauma.
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The gut microbiota is a key and primary stimulus for the development of a host's immune system. The early establishment of the gut microbiota is affected by several perinatal factors but little is known about their influence on shaping normal immune development and, consequently, on the programming of future health. The analysis of different immune compounds is well-documented in serum samples; however, their presence in faecal samples has not been studied, and this information could be valuable in early life.

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Radioactive seed localization technique with 125-I in inguinal endometriosis.

Rev Esp Med Nucl Imagen Mol (Engl Ed)

September 2024

Department of Nuclear Medicine, Hospital Clínic Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.

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Article Synopsis
  • * A 55-year-old male patient was diagnosed with HMSC, confirmed through various techniques, including immunohistochemistry (IHC) and genetic testing (PCR and RNA ISH), leading to successful treatment via surgery and radiotherapy.
  • * Whole exome sequencing (WES) identified 38 gene mutations and provided insights into possible personalized therapy targets, while no mutations were found to suggest drug response according to established databases.
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Breast cancer (BC) recurrence, defined as the reappearance of cancer in the ipsilateral breast after primary treatment, poses significant challenges in clinical management. Despite advances in treatment, recurrence rates persist, ranging from 0.6 to 1.

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PROMISing results for inhaled antibiotics in bronchiectasis.

Lancet Respir Med

October 2024

Pneumology Department, Bellvitge University Hospital, University of Barcelona, Bellvitge Biomedical Research Institute, Network Research Center for Respiratory Diseases, Barcelona, Spain.

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Background: Muscle ultrasound is increasingly popular thanks to its advantages over other techniques. However, its usefulness in the diagnosis of sarcopenia in older adults with aortic stenosis (AS) has not been studied to date.

Objectives: to analyze the prevalence of sarcopenia using muscle ultrasound and its impact on the health outcomes in older patients with AS.

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The ability of F-FDG positron emission tomography (PET) to track disease activity and treatment response in patients with Ankylosing Spondylitis (AS) or Psoriatic Arthritis (PsA) remains unclear. Here, we assessed whether F-FDG uptake is a marker of disease activity and treatment response in AS or PsA, and explored the ability of F-FDG to predict treatment response. Patients with AS (n = 16) or PsA (n = 8) who were scheduled to initiate treatment with biologics were recruited.

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Longitudinal systolic function following aortic valve replacement in the PARTNER 2 trial and registry.

Eur Heart J Cardiovasc Imaging

November 2024

Department of Cardiology, Québec Heart and Lung Institute, Laval University, Québec City, Québec G1V-4G5, Canada.

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During the last years, there has been an increasing research interest in the analysis of biological fluids requiring non-invasive sampling for biomedical and clinical applications. In this work, we have focused on the nasal exudate with the aim of investigating the potential use of this fluid to know the role of iron in stroke and also for diagnosis. Potential differences in the nasal exudate, collected in swabs, from diagnosed hemorrhagic stroke, ischemic stroke, and control groups were investigated with regard to total iron by inductively coupled plasma-mass spectrometry, iron fractionation studies by size exclusion chromatography together with post-column isotope dilution analysis, and four proteins containing iron (ferritin, transferrin, lactoferrin, and ferroportin) with ELISA kits.

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