8,898 results match your criteria: "University Hospital of "Tor Vergata"[Affiliation]"

Background/objective: Optimal vitamin D levels are required for bone health and proper functionality of the nervous, musculoskeletal and immune systems. The objective of this study was to assess the efficacy and safety profiles of new weekly calcifediol formulations with the potential to improve adherence and outcome.

Methods: A Phase II-III, double-blind, randomized, multicentre trial (EudraCT 2020-001099-14 and NCT04735926).

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Artificial intelligence applied to time-lapse microscopy may revolutionize embryo selection in IVF by automating data collection and standardizing the assessments. In this context, blastocyst expansion dynamics, although being associated with reproductive fitness, have been poorly studied. This retrospective study (N = 2184 blastocysts from 786 cycles) exploited both technologies to picture the association between embryo and inner-cell-mass (ICM) area in µm, the ICM/Trophectoderm ratio, and the zona pellucida thickness in µm (zp-T) at sequential blastocyst expansion stages, with (i) euploidy and (ii) live-birth per transfer (N = 548 transfers).

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: Division of the pulmonary ligament is standard in lower lobectomies, but its application in upper lobectomies remains controversial due to potential complications like atelectasis and bronchial kinking. This retrospective matched cohort study aimed to evaluate the efficacy and safety of ligament resection in upper lobectomies for oncological purposes. : From January 2015 to December 2020, 988 patients who underwent minimally invasive upper lobectomies across multiple centers were identified.

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Intraductal papillary mucinous neoplasms (IPMNs) display four histological subtypes: gastric foveolar, pancreaticobiliary, intestinal, and oncocytic. All of these subtypes harbor a different risk of cancer development. The clinical impact of these subtypes concerning the occurrence of high-grade dysplasia (HGD)/cancer (C) in specific morphological types, such as branch-duct (BD), main-duct (MD), and mixed-type (MT) IPMNs, has been less investigated.

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Article Synopsis
  • Human umbilical cord blood serum (HUCBS) shows promise as an effective treatment for severe ocular surface disorders (OSDs) by speeding up healing and reducing inflammation, benefiting patients who haven't found relief through standard therapies.
  • A study of 49 patients with various severe OSDs was conducted at San Marco Hospital in Italy, categorizing patients based on causes like rheumatologic diseases and graft-versus-host disease.
  • Results indicated significant improvement in multiple assessments, including patient-reported outcomes and clinical evaluations, demonstrating the potential of HUCBS in treating resistant cases of OSDs.
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ApoE: The Non-Protagonist Actor in Neurological Diseases.

Genes (Basel)

October 2024

Clinical Neurochemistry Unit and Biobank, IRCCS Santa Lucia Foundation, Via Ardeatina, 306/354, 00179 Rome, Italy.

Article Synopsis
  • - ApoE is a glycoprotein critical for lipid transport and metabolism, with the E4 allele being a known risk factor for Alzheimer's disease and potentially other neurological disorders like Parkinson's disease and brain trauma.
  • - Recent findings suggest that the E4 allele is linked to worse clinical outcomes in various neurological conditions, mainly through its role in processes like amyloid-β accumulation and neuroinflammation.
  • - This review aims to summarize the role of ApoE in neurodegenerative diseases and discuss the ethical considerations surrounding genetic testing for APOE variants, emphasizing its clinical significance.
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Identifying the Bundle/Care Development Process in Clinical Risk Management: A Systematic Review.

Healthcare (Basel)

November 2024

Research and International Relations Unit, Italian National Agency for Regional Healthcare Services, 00187 Rome, Italy.

Background: A bundle is a set of three to five evidence-based interventions designed to improve the quality and outcomes of care processes. Numerous international studies have evaluated the effectiveness of Bundles/Care Bundles (BCB) in reducing morbidity and mortality. The Institute for Healthcare Improvement (IHI) has defined the concept of a bundle but has not outlined the development process.

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To evaluate neurogenic bladder and bowel dysfunction (NBBD) in children with cerebral palsy (CP) and acquired brain injury (ABI), a condition considered less frequent in those patients than in children with spinal cord injury (SCI), and to study the relationship between NBBD and disability grade in this population. We retrospectively reviewed the clinical data of all patients (aged 3-18 years old) admitted during a three-month observation in our neurorehabilitation department. Data collected were as follows: demographic parameters; disability status (Wee-FIM Scale, Gross Motor Function Classification System (GMFCS) and the Communication Function Classification System); and gastrointestinal and urological symptoms (diaries, Bristol scale, Pad Test and International Consultation on Incontinence Modular Questionnaire).

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(1) Background: Helmet Continuous Positive Airway Pressure (H-CPAP) has primarily been used in intensive care settings to treat moderate-to-severe bronchiolitis in infants. We aim to report on the feasibility of H-CPAP for selected infants with bronchiolitis in a pediatric ward. (2) Methods: A retrospective, observational, consecutive case series was studied of 26 patients who received H-CPAP on the pediatric ward from October 2022 to February 2023, including a description of patient outcomes and costs.

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Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal.

Biol Direct

November 2024

State Key Laboratory of Radiation Medicine and Protection, Medical College, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, Institutes for Translational Medicine of Soochow University, Suzhou, China.

Osteoporosis, a metabolic disorder, remains challenging to treat due to limited understanding of its underlying mechanism. The annual cycle of "cyclic physiological osteoporosis (CPO)" and its full reversal in male deer represents a unique natural model for studying this condition. Deer antlers, weighing up to 25 kg/pair, derive over 60% of their mineral contents from deer skeleton during mineralization.

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Article Synopsis
  • * In the experiment, urine was either aspirated from the bladder or leaked through the ureter into the peritoneum of seven minipigs, with samples taken at 4 and 10 hours for analysis of inflammatory response.
  • * Results show that while urine in the peritoneum causes bowel distention, there was no significant inflammatory response in the visceral peritoneum within the 10-hour observation period, leading to questions about other mechanisms affecting bowel distention.
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Background: The juxta-anastomotic stenosis (JAS) represents the major complication of arteriovenous fistula (AVF) during the first months after the surgery and the approach to JAS can be surgical or radiological.

Methods: From 01/02/2016 to 31/12/2020, a total of 976 radiocephalic fistulas have been performed. The 15.

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Aim: To meta-analyze the utility of transarterial radioembolization (TARE) in patients with liver metastatic breast cancer (BC), based on the objective response rate (ORR) and disease control rate (DCR).

Methods: A literature search was performed retrieving studies with (1) at least 10 patients with liver metastatic BC treated with TARE and (2) adequate information to derive ORR and DCR. The ORR is the ratio between patients with liver lesions showing complete response (CR) or partial response (PR) over the total number of patients treated with TARE; the DCR is the ratio between patients with CR, PR, or stable disease (SD) over the total number of patients treated with TARE.

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Article Synopsis
  • Acute myeloid leukemia (AML) is a complex type of blood cancer mainly affecting older adults, who often have poor outcomes due to their overall health and other medical issues.
  • Recent studies have uncovered important molecular and biological factors related to AML, leading to improved treatment options for older patients.
  • The article reviews the latest advancements in understanding and treating AML, focusing on how these developments are changing care for older adults with the disease.
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Article Synopsis
  • - Growth hormone treatment has evolved from using pituitary-derived GH for specific cases of GH deficiency to recombinant human GH (rhGH), which is now approved for various disorders beyond just GH deficiency.
  • - RhGH significantly helps improve short stature in GH-deficient patients and has positive effects on metabolic and bone health, with long-term safety studies showing encouraging results, particularly for those with isolated GHD.
  • - New long-acting rhGH formulations are being developed to enhance adherence to treatment and lessen the burden on patients, while ongoing surveillance is needed for safety in higher doses or other clinical conditions.
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Background: The ongoing COVID-19 pandemic has infected more than 500 million people worldwide. Several measures have been taken to reduce the spread of the virus and the saturation of intensive care units: among them, a lockdown (LD) was declared in Italy on 9 March 2020. As a result, gyms, public parks, sports fields, outdoor play areas, schools, and multiple commercial activities have been closed.

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Background: Melanoma brain metastases represents a significant clinical challenge, frequently associated with high morbidity and mortality. Recent advancements in neuroimaging, radiation therapy, and targeted systemic therapies, specifically BRAF and MEK inhibitors, have improved the management of this condition. Nevertheless, the optimal therapeutic approach for melanoma brain metastases remains a subject of ongoing debate, with no universally accepted treatment protocol.

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Background: Prone positioning improves oxygenation in adults with acute respiratory distress syndrome (ARDS) and has been extensively applied in intensive care units (ICU) during the COVID-19 pandemic. Although some complications due to the manoeuvre are well known, brachial plexus injury after prone positioning is reported as a rare complication and the phenomenon could be either very rare or underestimated.

Aim: This study aimed to evaluate the effect of swimmer position during prone ventilation on the onset of brachial plexus injury in patients admitted to ICU for ARDS.

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Psychometric properties and clinical correlates of the Frontal Behaviour Inventory in progressive supranuclear palsy: data from the PSP-NET.

Neurol Sci

November 2024

Center for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

Objectives: Neuropsychiatric symptoms, such as apathy, disinhibition and irritability, are common in Progressive Supranuclear Palsy (PSP). The Frontal Behaviour Inventory (FBI) is a useful instrument for the evaluation of behavioural disorders in neurodegenerative diseases. The main goal of the present study was to explore the psychometric properties of the FBI in PSP.

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Background: Breast cancer (BC) constitutes a significant public health challenge in Italy, with a considerable impact on healthcare resources and societal costs. Despite advancements in diagnostics and therapies, the economic burden of BC remains substantial, necessitating a comprehensive evaluation to inform healthcare policy and resource allocation. The aim of this study is to estimate both direct health costs and social security costs related to BC.

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Clonal hematopoiesis in large granular lymphocytic leukemia.

Leukemia

November 2024

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

Past studies described occasional patients with myeloid neoplasms (MN) and coexistent large granular lymphocytic leukemia (LGLL) or T-cell clonopathy of unknown significance (TCUS), which may represent expansion of myeloid clonal hematopoiesis (CH) as triggers or targets of clonal cytotoxic T cell reactions. We retrospectively analyzed 349 LGLL/TCUS patients, 672 MN patients, and 1443 CH individuals to establish the incidence, genetic landscape, and clinical phenotypes of CH in LGLL. We identified 8% of cases overlapping with MN, while CH was found in an additional 19% of cases (CH + /LGLL) of which TET2 (23%) and DNMT3A (14%) were the most common.

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Outcomes of Mechanical Thrombectomy in Patients With Acute Basilar Artery Occlusion With Mild to Moderate Symptoms.

Neurology

December 2024

From the Department of Human Neuroscience (E.N., S.L., D.T.), Sapienza University of Rome; Stroke Unit (E.N., F.S.), Ospedale dei Castelli, Ariccia (RM); Department of NEUROFARBA (G.P.), Neuroscience Section, University of Florence; Stroke Unit (A.C., M.D.M.), Policlinico Umberto I, Sapienza University of Rome; Neurology and Stroke Unit (V.S., T.T.), S. Corona Hospital, Pietra Ligure, Italy; Interventional Neurovascular Unit (N. Limbucci), Careggi University Hospital; Careggi University Hospital (P.N.), Florence; AUSL Romagna Cesena (M.R.); Neurologia e Stroke Unit Ospedale Bufalini Cesena (M.L.); UO Neuroradiologia (M. Cosottini); Neurological Institute (G.O.), Azienda Ospedaliero Universitaria Pisana; Dipartimento di Neuroscienze (M.B.), Universitá di Torino; A.O. Cittá della Salute (P.C.), Torino; UO Neuroradiologia (S.V.); Neurologia-Stroke Unit (G. Bigliardi), Ospedale Civile di Baggiovara - AOU di Modena; UOC Neuroradiologia diagnostica e terapeutica AOU Senese (S.C.); UOC Stroke Unit AOU Senese (R.T.), Siena; Dipartimento di Biomedicina e Prevenzione - UOSD radiologia interventistica (V.D.R.); Department of Systems Medicine (M.D.), University of Rome Tor Vergata; IRCCS Istituto di Scienze Neurologiche di Bologna - UOC Neuroradiologia Ospedale Bellaria (L.S.); IRCCS Istituto di Scienze Neurologiche di Bologna (A.Z.), Department of Neurology and Stroke Center, Maggiore Hospital; UOC Neuroradiologia AOU "G. Martino" Messina (M.V.); UOSD Stroke Unit AOU "G. Martino"-Messina (P.L.L.S.); UO Neuroradiologia Ospedale Policlinico San Martino (L.C.); UO Neurologia Ospedale Policlinico San Martino (M.D.S.), Genova, Italy; Neurology Unit (I.C.), University Hospital Arcispedale S. Anna, Ferrara; Dipartimento di Scienze Biomediche (E.F.), Sperimentali e Cliniche, Neuroradiologia, Università degli Studi di Firenze, Ospedale Universitario Careggi; Unità Complessa di Neuroradiologia (R.M.), Azienda Ospedaliero-Universitaria; Dipartimento di Medicina e Chirurgia (A.P.), Università degli Studi di Parma - Programma Stroke Care, Dipartimento di Emergenza-Urgenza, Azienda Ospedaliero-Universitaria, Parma; UOSD Interventistica AOU Salerno (D.G.R.); UOC Neuroradiologia AOU Salerno (G.F.); Radiologia e Neuroradiologia diagnostica e interventistica (S.N.), IRCCS Policlinico San Matteo; UO Neurologia d'Urgenza e Stroke Unit (N. Loizzo), IRCCS Fondazione Mondino, Pavia; UO Neuroradiologia Dip Neuroscienze AZOU Ferrara (A.S.); UO Neurologia Dip Neuroscienze AZOU Ferrara (A.D.V.); Neuroradiology department ospedale di circolo- ASST Settelaghi Varese (R.A.); Stroke Unit - Azienda Ospedaliera Universitaria Integrata Verona (M. Cappellari); UO Neuroradiologia AOU Consorziale Policlinico Bari (D.S.Z.); UOC Neurologia e Stroke Unit "Puca" AOU Consorziale Policlinico Bari (M.P.); SC Neuroradiologia Diagnostica e Interventistica (L.A.), S. Corona Hospital, Pietra Ligure; UO Neuroradiologia interventistica (D.A.); Neurologia d'urgenza e Stroke Unit (S. Marcheselli), IRCCS Humanitas Research Hospital, Rozzano; UOC Neuroradiologia (M.P.G.); UOC Neurologia (G. Boero), Ospedale "SS. Annunziata", Taranto; IRCCS Neuromed (S. Mangiafico), Pozzilli (IS), Italy; Department of Clinical Neuroscience (N.A.), Karolinska Institutet, Stockholm, Sweden; Stroke Center EOC (C.W.C.), Neurocentre of Southern Switzerland; and Faculty of Biomedical Sciences (C.W.C.), Università della Svizzera Italiana, Lugano, Switzerland.

Background And Objectives: The benefit of mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) with basilar artery occlusion (BAO) and a baseline National Institute of Health Stroke Scale (NIHSS) score <10 is unclear because this subpopulation has been substantially excluded from large clinical trials. The aim of our study was to determine whether MT ± IV thrombolysis (IVT) improves functional outcomes compared with IVT alone in patients with BAO and a NIHSS score <10.

Methods: We emulated a hypothetical trial including adult patients with BAO, a baseline NIHSS score <10, and prestroke modified Rankin scale (mRS) scores 0-2, comparing MT (±IVT) with IVT alone.

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Pancreatic cancer has an increasing incidence and prevalence trend. Its prognosis is negatively affected by poor/altered nutritional status. Therefore, nutritional interventions play a critical/pivotal role at any stage.

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mRNA vaccines demonstrate impaired immunogenicity and durability in vulnerable older populations. We hypothesized that human modeling and proteomics could elucidate age-specific mRNA vaccine actions. BNT162b2-stimulation changed the plasma proteome of blood samples from young (18-50Y) and older adult (≥60Y) participants, assessed by mass spectrometry, proximity extension assay, and multiplex.

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Objectives: Oral anticoagulation therapy (OAC) is often contraindicated in patients with atrial fibrillation (AF) and cerebral amyloid angiopathy (CAA) because of the high hemorrhagic risk. Left atrial appendage occlusion (LAAO) can prevent thromboembolic events while avoiding long-term anticoagulation. However, a short period of antithrombotic therapy (AT) is still recommended after LAAO, and, therefore, it is unclear whether patients with CAA can be candidates for LAAO.

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