2,339 results match your criteria: "University Hospital and University of Helsinki[Affiliation]"
International practice patterns and perspectives on endovascular therapy for the treatment of cerebral venous thrombosis.
Int J Stroke
December 2024
Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Background: Cerebral venous thrombosis (CVT) accounts for 0.5-1% of all strokes. The role of endovascular therapy (EVT) in the management of CVT remains controversial and variations in practice patterns are not well known.
View Article and Find Full Text PDFSurgery-First for Painful Chronic Pancreatitis.
JAMA Surg
November 2024
Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Incidence and risk factors of adverse events after distal radius fracture fixation with volar locking plates: retrospective analysis of 2,790 cases.
Acta Orthop
November 2024
Department of Hand Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Article Synopsis
- A study examined the incidence and risk factors for adverse events in patients undergoing surgery for distal radius fractures (DRFs) using volar locking plates (VLPs) at Helsinki University Hospital from 2009-2019.
- Out of 2,790 cases, 16% experienced complications, with hardware issues being the most common (8.3%), alongside carpal tunnel syndrome, tendon complications, and infections.
- Identified risk factors for these adverse events included smoking, high body mass index, alcohol abuse, and specific fracture characteristics like dorsal tilt and intra-articular displacement.
Isolated Orbital Fracture - Treatment and Outcomes in a Single Tertiary Care Centre.
Craniomaxillofac Trauma Reconstr
April 2024
Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Study Design: Retrospective, questionnaire survey.
Objective: The literature lacks a consensus on treatment of isolated orbital fracture. Our aim was to explore treatment schemes and outcomes of patients with isolated orbital fracture treated at a single tertiary care centre.
Genetic analysis implicates ERAP1 and HLA as risk factors for severe Puumala virus infection.
Hum Mol Genet
November 2024
Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Tukholmankatu 8, 00290 Helsinki, Finland.
Article Synopsis
- Puumala virus (PUUV) can lead to serious illnesses like Hemorrhagic Fever with Renal Syndrome, but the genetic factors affecting disease severity in humans are not well understood.
- A genome-wide association study using data from 2227 cases helped identify significant associations at the Human Leukocyte Antigen (HLA) locus and the ERAP1 gene, which are important for immune response.
- The study found a specific genetic variant (rs26653) in the ERAP1 gene and identified associations with several HLA alleles that suggest how these genetic factors may influence susceptibility to severe PUUV infections.
Electrical burns in train climbers treated in the Helsinki Burn Centre during the last 30 years.
Scand J Trauma Resusc Emerg Med
November 2024
Helsinki Burn Centre, Department of Plastic and Reconstructive Surgery, Helsinki University Hospital and University of Helsinki, P.O. Box 800, 00029, Helsinki, Finland.
Background: Patients who climb onto the roof of a stationary train carriage and sustain a high voltage electrical injury from the overhead cables represent a rare type of electrical injury. The aim of this study was to review all the electrical burns and their outcomes in train climbers treated in the Helsinki Burn Centre during the last three decades.
Methods: 18 patients who had climbed onto the roof of a stationary electric train between November 1993 and December 2022 were included.
Correction to: Night‑time versus daytime surgical outcomes in chronic subdural hematomas: a post hoc analysis of the FINISH randomized trial.
Acta Neurochir (Wien)
November 2024
Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Bridge Hospital, HUS, Haartmaninkatu 4, Po. Box 340, 00029, Helsinki, Finland.
Predicting radiotoxic effects after BNCT for brain cancer using a novel dose calculation model.
Phys Med
December 2024
División Física Computacional y Biofísica de las Radiaciones, Comisión Nacional de Energía Atómica (CNEA), Av. General Paz 1499, B1650KNA, San Martín, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2270, C1425FQD, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address:
Purpose: The normal brain is an important dose-limiting organ for brain cancer patients undergoing radiotherapy. This study aims to develop a model to calculate photon isoeffective doses (D) to normal brain that can explain the incidence of grade 2 or higher somnolence syndrome (SS⩾2) after Boron Neutron Capture Therapy (BNCT).
Methods: A D model was constructed to find the reference photon dose that equals the Normal Tissue Complication Probability (NTCP) of the absorbed dose from BNCT.
Exploring successes, barriers, and enablers in the one-year digital Healthy Weight Coaching.
BMC Health Serv Res
November 2024
Healthy Weight Hub, Abdominal Centre, Helsinki University Hospital and University of Helsinki, Helsinki, 00290, Finland.
Introduction: Healthcare professionals' perspectives are often overlooked in the evaluation of digital weight loss interventions. Thus, we examined how healthcare professionals perceive patient success in a one-year web-based weight management program, the Healthy Weight Coaching, aiming to identify key success factors and common challenges within the coaching process.
Methods: Thematic analysis was conducted on ten semi-structured interviews with healthcare professionals from the Healthy Weight Coaching.
Clinical outcomes of pediatric kidney replacement therapy after childhood cancer-An ESPN/ERA Registry study.
Am J Transplant
November 2024
Department of Pediatric Nephrology and Transplantation, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Article Synopsis
- Cancer can lead to serious kidney issues in children requiring kidney replacement therapy (KRT), with a study identifying 287 pediatric KRT patients who had a history of cancer.
- The study showed that those whose cancer caused KRT had a longer wait for kidney transplantation compared to matched controls, with a median time of 2.4 years for cancer patients versus shorter times for controls.
- While childhood cancer survivors experienced increased mortality rates while on KRT (16% for group 1 and 23% for group 2) compared to controls, their long-term survival rates after kidney transplantation were similar to non-cancer patients.
An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns.
Am J Hum Genet
November 2024
Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA; Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address:
Article Synopsis
- Research on abdominal obesity highlighted that the rs10494217 variant in the TBX15 gene is linked to adipocyte health and the heritability of obesity.
- The frequency of this variant shows a geographical trend, decreasing from north to south, particularly evident in the Finnish population, suggesting an adaptive response to colder climates.
- Individuals with the risk allele exhibit changes in gene expression related to thermogenesis and unhealthy fat cell growth, indicating the variant's possible role in promoting abdominal obesity.
Temporal trends of catheter ablation procedures in patients with atrial fibrillation and atrial flutter: A nationwide cohort study.
Int J Cardiol Heart Vasc
December 2024
Department of Internal Medicine, Jorvi Hospital, HUS Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Background: Catheter ablation is a well-established treatment to prevent atrial fibrillation (AF) and atrial flutter (AFL) recurrences and to relieve symptoms, whereas pacemaker implantation and atrioventricular node (AVN) ablation is used for rate control when medical therapy fails.
Aims: We investigated temporal trends and patient characteristics in catheter ablation procedures for AF, AFL and AVN in Finland between 2012-2018.
Methods: Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) is a registry-based study including all patients with AF or AFL in Finland between 2012-2018.
Selection between sunitinib and ripretinib using mutation analysis for gastrointestinal stromal tumor patients progressing on imatinib.
Transl Gastroenterol Hepatol
September 2024
Department of Oncology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Association of oral frailty with falls in long-term care residents.
Eur Geriatr Med
November 2024
Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
Purpose: We investigated the relationship between oral frailty (OFr) and falls among long-term care residents.
Methods: Residents (N = 254, mean age 84 y, 79% women) participated in this longitudinal cohort study in 2018-2021. OFr was defined by six signs.
Preoperative reference values for breast cancer patients using the BREAST-Q.
Breast
December 2024
Division of Musculoskeletal and Plastic Surgery, Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Article Synopsis
- The BREAST-Q tool assesses health-related quality of life (HRQL) for new breast cancer patients, but lacks previous reference data for this group.
- In a study of 627 newly diagnosed patients, 315 (50.2%) participated, where data on HRQL was collected and analyzed based on factors like age and body mass index (BMI).
- Results showed lower scores in physical well-being compared to norms, and highlighted that increased BMI and younger age correlated with lower psychosocial, sexual well-being, and breast satisfaction.
Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis.
ACR Open Rheumatol
January 2025
University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
Objective: The objective of this study was to determine if baseline adiponectin, leptin, and resistin levels are associated with response to antirheumatic treatment in early rheumatoid arthritis (RA).
Methods: This study included 341 participants of the Nordic Rheumatic Diseases Strategy Trials and Registries trial with untreated early RA, randomized at baseline into four treatment arms: methotrexate combined with (1) prednisolone, (2) certolizumab, (3) abatacept, or (4) tocilizumab. Follow-up was up to 48 weeks.
Patient-Reported Esthetic Outcomes Following Secondary Rhinoplasty in Adult Patients with a Cleft lip and Palate.
Cleft Palate Craniofac J
November 2024
Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Objective: Secondary rhinoplasty is a frequently requested revision procedure in patients with a history of cleft lip and palate (CLP). The satisfaction of patients with the esthetic outcome of the procedure has been infrequently studied.
Design: Adult patients with CLP who had undergone a secondary rhinoplasty between 2009 and 2019 were identified in a cross-sectional cohort that had filled the FACE-Q rhinoplasty module.
Response to Letter to The Editor: Epidemiological profile of stroke in Qatar - Insights from a seven-year observational study.
J Clin Neurosci
January 2025
Department of Emergency Medicine and Services, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. Electronic address:
Cost-of-illness review of status epilepticus in Europe.
Epilepsy Behav
December 2024
Epilepsia Helsinki, European Reference Network EpiCARE, Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
The objective of this review is to give an overview of published cost of illness (COI) studies on status epilepticus (SE). This review analysed studies from 2014 onwards, focusing on direct and indirect costs of SE treatment in Europe. Searches were conducted across major databases, and studies employing various methodologies were included and systematically assessed.
View Article and Find Full Text PDFEx vivo modeling of precision immuno-oncology responses in lung cancer.
Sci Adv
November 2024
Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Article Synopsis
- Immunotherapy shows promise for cancer treatment, but individual immune responses and the lack of reliable biomarkers lead to varied patient outcomes.* -
- Researchers developed a precision ex vivo platform that combines patient-specific tumor and immune cells to explore antitumor responses and predict the effectiveness of treatments.* -
- The study identified a beneficial combination of anti-PD-1 treatment and a specific inhibitor that can overcome resistance, suggesting that tailored immunotherapy can improve personalized cancer care.*
Executive functions and processing speed in covert cerebral small vessel disease.
Eur J Neurol
January 2025
Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Background And Purpose: Executive dysfunction and slowed processing speed are central cognitive impairments in cerebral small vessel disease (cSVD). It is unclear whether the subcomponents of executive functions become equally affected and whether computerized tests are more sensitive in detecting early cognitive changes over traditional tests. The associations of specific executive abilities (cognitive flexibility, inhibitory control, working memory) and processing speed with white matter hyperintensities (WMHs) and Instrumental Activities of Daily Living (IADL) were examined.
View Article and Find Full Text PDFPerinatal and neonatal outcomes in gestational diabetes: The importance of the number of abnormal values in an oral glucose tolerance test.
Acta Obstet Gynecol Scand
January 2025
Research Unit of Clinical Medicine, Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Article Synopsis
- Gestational diabetes mellitus (GDM) is identified through abnormal results in an oral glucose tolerance test (OGTT), with a lack of clear understanding about how the number of abnormal values relates to negative birth outcomes.
- A study involving 4869 pregnant women in Finland analyzed the connection between the quantity of abnormal OGTT values and adverse perinatal and neonatal results, taking into account various health and social factors.
- Results indicated that women with two or more abnormal OGTT values had significantly higher rates of negative perinatal (35.0% vs. 27.5%) and neonatal outcomes (31.1% vs. 18.9%) compared to those with fewer or no abnormal values.
Long-Term Recurrence Risk, Metastatic Potential, and Length of Cystoscopic Surveillance of Low-Grade Non-Muscle-Invasive Bladder Cancer.
J Urol
October 2024
Division of Urology, Department of Surgery, Mount Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.
Purpose: Patients with Ta low-grade (LG) NMIBC rarely develop metastases or die of it. Long-term data are scant and length of follow-up poorly defined.
Materials And Methods: This retrospective study included 521 patients diagnosed with primary TaLG NMIBC (n = 491) or papillary urothelial neoplasm of low malignant potential (n = 30) from 1989 to 2019 at an academic center.
Aspergillus Serologic Findings and Clinical Outcomes in Patients With Bronchiectasis: Data From the European Bronchiectasis Registry.
Chest
October 2024
Royal Brompton and Harefield Hospitals and National Heart and Lung Institute, Imperial College London, London, England.
Article Synopsis
- Aspergillus species are linked to various conditions in bronchiectasis, including ABPA, AS, and increased IgG levels indicating exposure or infection.
- A study of nearly 10,000 bronchiectasis patients revealed 6.1% with ABPA, 5.7% with AS, and 8.1% with elevated Aspergillus-specific IgG levels, with these conditions associated with more severe lung issues and exacerbations.
- Long-term follow-up showed that those with raised IgG levels faced more frequent and severe exacerbations, particularly affecting patients not on inhaled corticosteroids.
The association of intraoperative electric field and neural excitation patterns of the cochlear implant with patient-related factors of age, gender, cochlear diameter, and postoperative speech measures.
Hear Res
November 2024
Department of Otorhinolaryngology-Head and Neck Surgery and Tauno Palva Laboratory, Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Purpose: To assess the relationships between the electric field (EF) and neural excitation patterns in cochlear implants (CIs) and explore their associations with the cochlear diameter, patient age and gender, and postoperative speech recognition.
Method: The intraoperative transimpedance matrix (TIM) and spread of excitation (SOE) measures were computed to obtain their 50 % widths corresponding to six electrode contacts of a lateral-wall electrode array. The measures were then analyzed for intercorrelations, associations with the cochlear diameter, as well as age and gender-related differences.