3 results match your criteria: "University Hospital and Medical Faculty of the University of Groningen[Affiliation]"
Portal and systemic serum growth factor and acute-phase response after laparotomy or partial hepatectomy in patients with colorectal liver metastases: a prognostic role for C-reactive protein and hepatocyte growth factor.
Scand J Gastroenterol
November 2004
Department of Surgery, Division of Hepato-Pancreato-Biliary Surgery & Liver Transplantation, University Hospital and Medical Faculty of the University of Groningen, 9700 RB Groningen, The Netherlands.
Background: Growth factors play a role in wound healing and tumour growth. The aim of this study was to compare the effect of partial hepatectomy (PH) and laparotomy on serum levels of growth factors and acute-phase proteins in patients with colorectal liver metastases and to correlate these levels with prognosis after PH.
Methods: Epidermal growth factor (EGF), hepatocyte growth factor (HGF), insulin like growth factor-I (IGF-I), insulin, interleukin-6 (IL-6), C-reactive protein (CRP) and serum amyloid-A (SAA) were determined in portal and systemic serum in 24 PH patients and 9 laparotomy patients.
Serum response of hepatocyte growth factor, insulin-like growth factor-I, interleukin-6, and acute phase proteins in patients with colorectal liver metastases treated with partial hepatectomy or cryosurgery.
J Hepatol
March 2001
Department of Surgery, University Hospital and Medical Faculty of the University of Groningen, The Netherlands.
Background/aims: The aim of the study was to compare the serum response of regeneration factors and acute phase proteins in patients treated with partial hepatectomy or cryosurgery.
Methods: The responses of serum hepatocyte growth factor (HGF), insulin-like growth factor-I (IGF-I) (free and total), interleukin-6 (IL-6) and the acute phase proteins, C-reactive protein (CRP) and serum amyloid A (SAA) were examined in patients with colorectal liver metastases treated with partial hepatectomy (n = 14) or cryosurgery (n = 10).
Results: In both groups, IL-6 peak levels at the end of the operation were followed by peak levels at day 1 for HGF and CRP.
Serum obtained from rats after partial hepatectomy enhances growth of cultured colon carcinoma cells.
Invasion Metastasis
April 2000
Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, University Hospital and Medical Faculty of the University of Groningen, Groningen, The Netherlands.
Tumour-bearing rats were randomized to a 70% partial hepatectomy or a sham operation. At days 1, 3 or 14, portal and systemic serum was obtained and colon carcinoma cells were cultured in the presence of 5, 10, 20 or 50% serum. Proliferation and epidermal growth factor receptor (EGFr) expression was measured in tumour cells.
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