5,051 results match your criteria: "University Hospital Wuerzburg; kai.kretzschmar@uni-wuerzburg.de.[Affiliation]"

RIFM fragrance ingredient safety assessment, 2-(3-heptyl)-1,3-dioxolane, CAS Registry Number 4359-47-1.

Food Chem Toxicol

November 2024

Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

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Article Synopsis
  • Conversions from robot-assisted partial nephrectomy to more invasive surgeries happen in about 1-5% of cases, and this study looks at what could predict these conversions.
  • The research analyzed 2,549 patients operated on by 25 surgeons, finding a 3.5% conversion rate linked to factors like older age, higher BMI, tumor size, and the surgeon’s experience.
  • The study concludes that both patient characteristics and surgical expertise significantly impact the likelihood of conversion, suggesting that better training could enhance outcomes and allow for more kidney-sparing procedures.
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Article Synopsis
  • - The study aimed to analyze factors affecting postoperative renal function (PRF) following robot-assisted partial nephrectomy for patients with multiple kidney tumors, using data from 132 surgeries and assessing both patient and surgical influences on outcomes.
  • - Key findings included that most patients had two tumors, the average surgery lasted 175 minutes, and that the majority of surgeries met trifecta criteria, indicating successful outcomes in terms of cancer control, renal preservation, and complications.
  • - Factors such as warm ischemia time, body mass index (BMI), and preoperative kidney function were found to impact kidney function loss post-surgery, with BMI and comorbidities being significant predictors of acute kidney injury during hospitalization.
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  • Anxiety disorders are common and typically treated with cognitive behavioral therapy and medication, but some patients don’t respond well to these methods.
  • A clinical trial involving 76 individuals with acrophobia tested the effectiveness of intermittent theta burst stimulation (iTBS) combined with virtual reality exposure therapy, finding a significant reduction in phobic symptoms.
  • However, the study concluded that iTBS did not provide additional benefits over a placebo version, suggesting the need for more personalized TMS approaches and further research to optimize treatment.
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RIFM fragrance ingredient safety assessment, dibenzyl ether, CAS Registry number 103-50-4.

Food Chem Toxicol

December 2024

Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

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RIFM fragrance ingredient safety assessment, (4-methylphenoxy)acetaldehyde, CAS Registry Number 67845-46-9.

Food Chem Toxicol

December 2024

Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

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RIFM fragrance ingredient safety assessment, cinnamyl cinnamate, CAS Registry Number 122-69-0.

Food Chem Toxicol

December 2024

Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

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Assessment of hemodynamic parameters by PiCCO and PAC in patients treated with the Impella CP.

J Intensive Care Soc

November 2024

Department of Internal Medicine I, Medical Intensive Care Unit, University Hospital, University of Wuerzburg, Wuerzburg, Germany.

In 28 patients supported by an Impella pump (Impella CP, Abiomed Inc., Danvers, MA), hemodynamic measurements by PiCCO (PULSION Medical Systems SE, Feldkirchen, Germany) and pulmonary artery catheter (PAC or Swan-Ganz Catheter; Edwards Lifescience, Unterschleissheim, Germany) were compared. There was a significant positive correlation of cardiac output (CO;  = 0.

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Intermittent theta burst stimulation to the left prefrontal cortex enhances extinction learning but not extinction recall.

Behav Brain Res

February 2025

Center of Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Wuerzburg, Margarete-Hoeppel-Platz 1, Wuerzburg 97080, Germany. Electronic address:

Article Synopsis
  • * The study tested intermittent theta burst stimulation (iTBS) on 50 participants over three days, measuring fear responses during various learning and testing phases to see if iTBS could help reduce fear.
  • * Results showed that active iTBS reduced fear responses during extinction learning, but there were no significant effects observed during later recovery or reinstatement tests, indicating limited effectiveness for improving extinction memory.
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Accurate classification of cells in bronchoalveolar lavage (BAL) fluid is essential for the assessment of lung disease in pneumology and critical care medicine. However, the effectiveness of BAL fluid analysis is highly dependent on individual expertise. Our research is focused on improving the accuracy and efficiency of BAL cell classification using the "You Only Look Once" (YOLO) algorithm to reduce variability and increase the accuracy of cell detection in BALF analysis.

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Plate or Arthroplasty for complex Mason Type-III Radial Head Fractures? Mid-to-long term results from a blinded outcome assessor study.

Injury

November 2024

Department of Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Wuerzburg, Wuerzburg, Germany; Trauma-, Shoulder- and Reconstructive Surgery, Sports Medicine and Sports Traumatology, Clinic Rummelsberg, Schwarzenbruck, Germany.

Background: The surgical treatment of radial head fractures like Mason type III comminuted radial head fractures is challenging and controversial. Whether to use open reduction and internal fixation (ORIF) or radial head arthroplasty (RHA) as treatment methods is under constant debate.

Methods: We retrospectively analyzed clinical and radiographic mid- to long-term results of 42 patients with a mean follow-up time of 4.

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Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) presents significant challenges for affected children and adolescents, their social environment, and treating physicians, due to its profound impact on quality of life and the lack of causal therapeutic approaches. One crucial aspect of care that has been missing for these patients is comprehensive education for both them and their social circles.

Objective: This study protocol aims to outline the goals, study design, execution, and evaluation of the subproject within the BAYNET FOR ME/CFS project.

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Article Synopsis
  • Treosulfan is an important treatment in allogeneic haematopoietic stem cell transplantation (allo-HSCT) for children, offering lower toxicity than traditional drugs.
  • Researchers studied the effects of treosulfan on 83 pediatric patients to see how it impacts survival, graft failure, and graft-versus-host disease.
  • The results showed no significant correlation between treosulfan exposure and clinical outcomes or toxicity, indicating that standardized dosing is effective for pediatric allo-HSCT.
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RIFM fragrance ingredient safety assessment, zingerone, CAS Registry Number 122-48-5.

Food Chem Toxicol

December 2024

Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

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RIFM fragrance ingredient safety assessment, 2-ethoxy-4-[(1-methylethoxy)methyl] phenol, CAS Registry number 96840-56-1.

Food Chem Toxicol

December 2024

Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

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Irisin, an exercise-induced myokine, is known to be able to regulate bone metabolism. However, the underlying mechanisms regarding the effects of irisin on senile osteoporosis have not been fully elucidated. Here, we demonstrated that irisin can inhibit bone mass loss and bone microarchitecture alteration in senile osteoporosis mouse model.

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Objective: The precise segmentation of kidneys from a 2D ultrasound (US) image is crucial for diagnosing and monitoring kidney diseases. However, achieving detailed segmentation is difficult due to US images' low signal-to-noise ratio and low-contrast object boundaries.

Methods: This paper presents an approach called deep supervised attention with multi-loss functions (MLAU-Net) for US segmentation.

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Assessing localization of the transient receptor potential vanilloid-1 (TRPV1) in skin nerve fibers is crucial for understanding its role in peripheral neuropathy and pain. However, information on the specificity and sensitivity of TRPV1 antibodies used for immunofluorescence (IF) on human skin is currently lacking. To find a reliable TRPV1 antibody and IF protocol, we explored antibody candidates from different manufacturers, used rat DRG sections and human skin samples for screening and human TRPV1-expressing HEK293 cells for further validation.

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Update to RIFM fragrance ingredient safety assessment, diethyl malonate, CAS registry number 105-53-3.

Food Chem Toxicol

December 2024

Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

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Update to RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6.

Food Chem Toxicol

December 2024

Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

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RIFM fragrance ingredient safety assessment, cyclohexanone 1,3-butylene glycol ketal, CAS Registry Number 6413-26-9.

Food Chem Toxicol

December 2024

Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

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