203 results match your criteria: "University Hospital System[Affiliation]"

Background: In the current era of rapid technological development, digital technology is progressively transforming the medical field. In palliative care, its integration is an inevitable trend, offering new possibilities for improving care delivery and patient outcomes.

Objective: This study aimed to review the application of digital technologies in palliative care, focusing on their advantages, challenges, and measurable impacts across diverse care settings.

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Introduction: French paratroopers have been deployed during airborne operations for nearly a century. Parachute operations have increased since the start of and in the Sahelo-Saharan strip. These military operations allow paratroopers to be dropped behind enemy lines.

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Article Synopsis
  • The study examined the effectiveness of serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for predicting acute kidney injury (AKI) in patients with rhabdomyolysis who visited emergency departments in France.
  • Conducted across five adult EDs, the research included 197 patients with high creatine phosphokinase levels, assessing NGAL levels upon admission and evaluating its correlation with AKI development within 48 hours.
  • Out of those studied, 29% developed AKI by day two, with NGAL showing moderate predictive ability, indicated by an area under the receiver operating characteristic curve (AUC-ROC) of 0.60, meaning further refinement and research are needed
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Biomimetics is the science of imitating nature's designs and processes to create innovative solutions for various fields, including dentistry and craniofacial reconstruction. In these areas, biomimetics involves drawing inspiration from living organisms/systems to develop new materials, techniques, and devices that closely resemble natural tissue structures and enhance functionality. This field has successfully demonstrated its potential to revolutionize craniofacial procedures, significantly improving patient outcomes.

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Anti-NMDA receptor (A-NMDAR) encephalitis is an autoimmune condition often associated with ovarian teratoma. Surgical removal of the teratoma is generally curative, and recurrence is uncommon. A 14-year-old female presented with psychiatric symptoms and was ultimately diagnosed with A-NMDAR encephalitis during a prolonged hospitalization.

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Classification of germline non-truncating variants: a new approach to interpretation.

J Med Genet

November 2024

Cancer Genetics Unit, Institut Bergonié, Bordeaux, Aquitaine, France.

Article Synopsis
  • PTEN hamartoma tumour syndrome (PHTS) includes syndromes like Cowden syndrome, with missense variants making up 30% of PHTS cases, yet their classification is complex.
  • A study from the Bergonie Institute identified 76 non-truncating variants in 166 patients, developing a new classification method using criteria like functional analysis, phenotypic features, and familial patterns.
  • The new approach successfully reclassifies 25 variants, revealing the need to update current classification standards based on multiple factors, and it requires further validation in future research.
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Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.

Clin Microbiol Infect

December 2024

OUTCOMEREA Research Group, Drancy, France; Institut National de la Santé et de la Recherche Medicale, Infection Antimicrobial Modelisation Evolution, U1137, Team Decision Science in Infectious Diseases, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat hospital, Medical and infectious diseases ICU, F75018, Paris France. Electronic address:

Article Synopsis
  • Hospital-acquired bloodstream infections (HA-BSI) in ICU patients can be life-threatening, and this study aimed to see how early adequate antibiotic treatment affects 28-day mortality rates for patients who survive at least one day after infection onset.
  • Using data from a multicenter study with 2,418 patients, researchers found that those who received adequate treatment within 24 hours had a lower 28-day mortality rate (32.8%) compared to those who were inadequately treated (40%).
  • The study concluded that inadequate antibiotic therapy within 24 hours contributes significantly to 28-day mortality, indicating that quicker treatment could greatly improve patient outcomes in cases of HA-BSI.
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French protocol for the diagnosis and management of systemic lupus erythematosus.

Rev Med Interne

September 2024

Department of Internal Medicine and Clinical immunology, Reference Centre of Autoimmune Systemic Rare Diseases of North and North-West of France (CeRAINO), Lille University, Inserm, University Hospital of Lille, Lille, France.

Because Systemic Lupus Erythematosus (SLE) is a rare disease, and due to the significant prognostic impact of early management, a diagnosis confirmed by a physician with experience in SLE is recommended, for example from an expert center. Once the diagnosis is confirmed, existing manifestations should be identified in particular, renal involvement by an assessment of proteinuria, disease activity and severity should be determined, potential complications anticipated, associated diseases searched for, and the patient's socioprofessional and family context noted. Therapeutic management of SLE includes patient education on recognizing symptoms, understanding disease progression as well as when they should seek medical advice.

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Disentangling the coping process in White rural men who carry guns.

Psychol Rep

May 2024

Department of Education and Human Services, College of Education, Lehigh University, Bethlehem, PA, USA.

Affluent White rural men have the highest rates of gun ownership in the United States. However, few studies have specifically examined reasons and motivations for gun ownership and gun behaviors in this population. Therefore, this study sought to examine the relationship between stress variables, namely masculine gender role stress, adverse childhood experiences (ACEs), and income level, and subsequent pro-gun beliefs and amount of time an individual carried a gun within this population.

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Antibiotic Duration and UTI Outcomes in Recurrent UTI Patients.

Urogynecology (Phila)

January 2025

From the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Women and Infants Hospital/Warren Alpert Medical School of Brown University, Providence, RI.

Importance: Little evidence is available to inform management of acute urinary tract infections (UTIs) in women with recurrent urinary tract infection (rUTI).

Objective: This study aimed to compare the proportion of acute UTIs with persistence/relapse or recurrence based on duration of treatment antibiotics (acute UTI guideline-consistent versus extended).

Study Design: A retrospective noninferiority study of women with rUTI was performed at an academic tertiary referral center from January 2016 to December 2020.

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Article Synopsis
  • The study focused on evaluating the correlation and concordance between different activity score indices for Polymyalgia Rheumatica (PMR), particularly including the C reactive protein polymyalgia rheumatica activity score (CRP-PMR-AS).
  • Data were analyzed from the SEMAPHORE trial, comparing the efficacy of tocilizumab to placebo in PMR patients while measuring various PMR-ASs at multiple visits.
  • Results showed an excellent correlation between the activity scores, indicating that in trials with drugs affecting CRP levels, these derived scores can be reliably used.
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Alert fatigue, a decrease in sensitivity to alerts, is a problem in the medical field. In this study, a survey was conducted on medical accidents in order to develop an alert that could be expected to reduce alert fatigue. As a result, medical accidents related to drugs are common worldwide, and the need for an alert system that can detect the implementation of medical treatment was found.

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Article Synopsis
  • Force-Based Manipulation (FBM), which includes techniques like light touch and thrust manipulation, is widely used to alleviate pain, but the specific mechanisms behind its effectiveness are not well understood.
  • A study identified 37 research gaps related to FBM by employing an international nominal group technique, with 23 gaps achieving consensus, particularly highlighting the strong influence of contextual factors and the need for studies on different pain phenotypes.
  • The findings suggest that understanding individual differences in pain response could enhance precision medicine approaches in pain management, emphasizing the importance of mechanism-based research in clinical settings.
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Article Synopsis
  • * The occurrence of HLA-B*57:01 was similar in patients with PML (6.19%) and those without (5.08%), indicating no significant difference.
  • * Clinical and biological characteristics, as well as outcomes for PML, were unaffected by the HLA-B*57:01 status among those diagnosed with PML.
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Objective: To establish priority gaps related to contextual factors (CFs) research and force-based manipulation (FBM).

Methods: A three-round Delphi following recommended guidelines for conducting and reporting Delphi studies (CREDES) involving international and interdisciplinary panelists with expertise in CFs and FBM. Round 1 was structured around two prompting questions created by the workgroup.

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Blood analysis is a ubiquitous and critical aspect of modern medicine. Analyzing blood samples requires invasive techniques, various testing systems, and samples are limited to relatively small volumes. Photoacoustic imaging (PAI) is a novel imaging modality that utilizes non-ionizing energy that shows promise as an alternative to current methods.

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Molecular Basis of Transglutaminase-2 and Muscarinic Cholinergic Receptors in Experimental Myopia: A Target for Myopia Treatment.

Biomolecules

June 2023

Eye-Academic Clinical Program, DUKE-National University of Singapore Gr Medical School, 8 College Road, Singapore 169857, Singapore.

Myopia, a prevalent refractive error disorder worldwide, is characterized by the elongation of the eye, leading to visual abnormalities. Understanding the genetic factors involved in myopia is crucial for developing therapeutic and preventive measures. Unfortunately, only a limited number of genes with well-defined functionality have been associated with myopia.

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Objective: Emerging literature suggests contextual factors are important components of therapeutic encounters and may substantially influence clinical outcomes of a treatment intervention. At present, a single consensus definition of contextual factors, which is universal across all health-related conditions is lacking. The objective of this study was to create a consensus definition of contextual factors to better refine this concept for clinicians and researchers.

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Systemic Diclofenac Sodium Reduces Postoperative rhBMP-2 Induced Neuroinflammation: A Rodent Model Study.

Spine (Phila Pa 1976)

September 2023

University Spine Centre, University Orthopaedics, Hand and Reconstructive Microsurgery Cluster, National University Hospital System, Singapore, Singapore.

Study Design: This is a basic science, animal research study.

Objective: This study aims to explore, in rodent models, the effectiveness of systemic nonsteroidal anti-inflammatory drugs in reducing recombinant human bone morphogenetic protein-2 (rhBMP-2) induced neuroinflammation.

Summary Of Background Data: rhBMP-2 is increasingly used to augment fusion in lumbar interbody fusion surgeries, although it can cause complications including postoperative radiculitis.

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Article Synopsis
  • - The COVID-19 pandemic increased psychological distress and burnout among frontline healthcare workers, particularly nurses, leading to a need for effective intervention methods.
  • - A pilot randomized trial involving 102 nurses tested the feasibility and impact of a mobile mindfulness program aimed at reducing psychological distress and burnout, comparing intervention participants with a control group on various mental health metrics over a month.
  • - Results showed that while the mindfulness intervention effectively reduced depression symptoms (as measured by the Patient Health Questionnaire-9), it did not significantly impact burnout levels, indicating limited use of the program among participants despite meeting initial feasibility targets.
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Objective: Recent studies have highlighted that systemic lupus erythematosus (SLE) is characterized by different types of symptoms: type 1 symptoms related to inflammation and disease activity and type 2 symptoms such as fatigue, anxiety-depression, and pain. Our aim was to investigate the relation between type 1 and type 2 symptoms, and their impact on health-related quality of life (HRQoL) in SLE.

Methods: A literature review was conducted about disease activity/type1 and type 2 symptoms.

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Smoking Cessation for Preoperative Optimization.

Clin Colon Rectal Surg

May 2023

Department of Surgery, Michigan Medicine, Ann Arbor, Michigan.

Cigarette smoking is associated with pulmonary and cardiovascular disease and confers increased postoperative morbidity and mortality. Smoking cessation in the weeks before surgery can mitigate these risks, and surgeons should screen patients for smoking before a scheduled operation so that appropriate smoking cessation education and resources can be given. Interventions that combine nicotine replacement therapy, pharmacotherapy, and counseling are effective to achieve durable smoking cessation.

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