143 results match your criteria: "University Hospital Munich (LMU)[Affiliation]"
Sci Rep
October 2024
Department of Radiology and Neuroradiology, Faculty of Medicine and University Hospital, University of Cologne, Kerpener Strasse 62, Cologne, 50937, Germany.
Intrasaccular flow disruption with the Woven Endobridge (WEB) has become a well-established endovascular technique for the treatment of intracranial aneurysms. This study presents our 12-year experience with the WEB and evaluates its evolving indications, procedures, and outcomes. A consecutive series of 324 aneurysms treated with WEB between 2011 and 2023 at three neurovascular centers was retrospectively analyzed and the study group was divided into four treatment periods.
View Article and Find Full Text PDFInterv Neuroradiol
December 2024
University of Cologne, Faculty of Medicine and University Hospital, Department of Radiology and Neuroradiology, Cologne, Germany.
J Clin Med
September 2024
Division of Hand, Plastic and Aesthetic Surgery, University Hospital Munich (LMU), 81377 Munich, Germany.
Free muscle flaps can develop significant postoperative edema and wound exudation, thereby increasing interstitial pressure and potentially compromising microcirculation. While concerns exist regarding negative pressure wound therapy (NPWT) to compress free flaps and hinder monitoring, recent studies have indicated a reduction in edema and an increase in blood flow. To compare microcirculation in free latissimus dorsi muscle (LDM) flaps dressed with and without NPWT.
View Article and Find Full Text PDFJ Neurosurg
August 2024
2Department of Radiology and Neuroradiology, University of Cologne, Faculty of Medicine and University Hospital, Cologne, Germany.
Interv Neuroradiol
August 2024
Institute of Neuroradiology, University Hospital Munich (LMU), Munich, Germany.
Interv Neuroradiol
July 2024
Institute of Radiology and Neuroradiology, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Objective: The Pipeline Vantage Embolization Device (PVED) is a novel coated flow diverter with reduced wire diameters to improve neoendothelialization and stent porosity. This systematic review evaluates the safety and efficacy of the PVED based on the current literature.
Methods: Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, a thorough literature search was conducted using PubMed, EMBASE, and Cochrane.
Clin Neuroradiol
December 2024
Department of Radiology and Neuroradiology, University of Cologne, Faculty of Medicine and University Hospital, Kerpener Straße 62, 50937, Cologne, Germany.
Purpose: The WEB 17 system represents the fifth generation of Woven Endobridge (WEB) flow disruptors and features a low profile with fewer wires than its predecessor, the WEB 21. The present study compares the safety and efficacy of the WEB 17 and WEB 21 for the treatment of unruptured cerebral aneurysms with 4-7 mm device sizes, which were available for both systems.
Methods: Patient and aneurysm characteristics, complications, clinical outcome and angiographic results were retrospectively analysed.
J Neurointerv Surg
May 2024
Institute of Neurointervention, Paracelsus Medical University Salzburg, Salzburg, Austria.
Background: Intrasaccular devices have become increasingly popular in the treatment of cerebral aneurysms, particularly at the bifurcation. Here we evaluate the Contour Neurovascular System, an intrasaccular device for the endovascular treatment of cerebral aneurysms, in a multicenter cohort study, the largest to the best of our knowledge.
Methods: Consecutive patients with intracranial aneurysms treated with the Contour Neurovascular System between February 2017 and October 2022 at 10 European neurovascular centers were prospectively collected and retrospectively reviewed.
Pancreas
September 2024
From the Departments of Medicine II.
Background/aim: Severity of microlithiasis- and sludge-induced pancreatitis in comparison to gallstone-induced pancreatitis has never been studied for a lack of definition.
Materials And Methods: In this retrospective cohort study, 263 patients with acute biliary pancreatitis treated at a tertiary care center from 2005 to 2021 were stratified according to the recent consensus definition for microlithiasis and sludge. The gallstone-pancreatitis cohort was compared to microlithiasis, sludge, and suspected stone passage pancreatitis cohorts in terms of pancreatitis outcome, liver function, and endosonography/endoscopic retrograde cholangiopancreatography results using one-way analysis of variance and χ 2 test.
Neuro Oncol
October 2024
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Clin Neuroradiol
September 2024
Neuroradiologische Klinik, Neurozentrum, Klinikum Stuttgart, Stuttgart, Germany.
Purpose: Recent observational studies have indicated the efficacy of stent retriever devices for the treatment of posthemorrhagic cerebral vasospasm (CVS), both by deployment and on-site withdrawal into the microcatheter (stent angioplasty, SA) and deployment followed by retraction through the target vessel similar to thrombectomy (Stent Retraction to reLieve Arterial Cerebral vaSospasm caused by SAH, Stent-ReLACSS). This article reports the findings with each application of pRESET and pRELAX in the treatment of CVS.
Methods: We retrospectively enrolled 25 patients with severe CVS following aneurysmal subarachnoid hemorrhage.
J Neurointerv Surg
April 2024
Department of Radiology and Neuroradiology, University of Cologne, Faculty of Medicine and University Hospital, Cologne, Germany.
Radiology
March 2024
From the Departments of Radiology (S.C.F., A.S.D., G.C.F., M.R.M.) and Neuroradiology (D.S., M.E.H., M.R., M.C.M., B.W., B.J.S., J.S.K.), Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany; Departments of Radiology (S.S.G., J.W.) and Neuroradiology (R.S., A.S.G.), University Hospital Munich (LMU), Munich, Germany; and German Cancer Consortium (DKTK), Partner Site Munich, and German Cancer Research Center (DKFZ), Heidelberg, Germany (B.W.).
Background Differentiating between benign and malignant vertebral fractures poses diagnostic challenges. Purpose To investigate the reliability of CT-based deep learning models to differentiate between benign and malignant vertebral fractures. Materials and Methods CT scans acquired in patients with benign or malignant vertebral fractures from June 2005 to December 2022 at two university hospitals were retrospectively identified based on a composite reference standard that included histopathologic and radiologic information.
View Article and Find Full Text PDFNeuro Oncol
May 2024
Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Background: Radiological progression may originate from progressive disease (PD) or pseudoprogression/treatment-associated changes. We assessed radiological progression in O6-methylguanine-DNA methyltransferase (MGMT) promoter-methylated glioblastoma treated with standard-of-care chemoradiotherapy with or without the integrin inhibitor cilengitide according to the modified response assessment in neuro-oncology (RANO) criteria of 2017.
Methods: Patients with ≥ 3 follow-up MRIs were included.
Radiol Artif Intell
January 2024
From the Department of Neuroradiology (M.A.M., C.J.P., H.M., M.B., G.B., P.V.), Department of Neuroradiology, Division for Computational Neuroimaging (M.A.M., C.J.P., H.M., G.B., P.V.), and Department of Neurology (W.W.), Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Department of Neurosurgery, University Hospital Munich LMU, Munich, Germany (J.C.T.); and Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland (M.W.).
Purpose To develop a fully automated device- and sequence-independent convolutional neural network (CNN) for reliable and high-throughput labeling of heterogeneous, unstructured MRI data. Materials and Methods Retrospective, multicentric brain MRI data (2179 patients with glioblastoma, 8544 examinations, 63 327 sequences) from 249 hospitals and 29 scanner types were used to develop a network based on ResNet-18 architecture to differentiate nine MRI sequence types, including T1-weighted, postcontrast T1-weighted, T2-weighted, fluid-attenuated inversion recovery, susceptibility-weighted, apparent diffusion coefficient, diffusion-weighted (low and high value), and gradient-recalled echo T2*-weighted and dynamic susceptibility contrast-related images. The two-dimensional-midsection images from each sequence were allocated to training or validation (approximately 80%) and testing (approximately 20%) using a stratified split to ensure balanced groups across institutions, patients, and MRI sequence types.
View Article and Find Full Text PDFWorld Neurosurg
March 2024
Department of Radiology and Neuroradiology, University of Cologne, Faculty of Medicine and University Hospital, Cologne, Germany.
BMC Pulm Med
October 2023
Department of Medicine V, University Hospital Munich (LMU), Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Ziemssenstr. 1, 80336, Munich, Germany.
As a result of advances in the treatment of lung cancer, the life expectancy of lung cancer patients has improved significantly, but it remains the leading cause of cancer death worldwide. For decades, most of the initial tumor biopsies have been obtained by bronchoscopy or computed tomography (CT)-guided transthoracic lung biopsy without concerning reports of cancer seeding following the latter. In this case report we discuss the patient history of a 56-year old women with low-differentiated squamous cell lung cancer who developed tumor seeding following a CT-guided transthoracic biopsy 11 months after the intervention.
View Article and Find Full Text PDFWorld Neurosurg
January 2024
Department of Radiology and Neuroradiology, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Objective: Several studies have demonstrated a high safety and efficacy profile of the Woven EndoBridge (WEB) for endovascular aneurysm treatment. However, contemporary large-scale studies of the WEB are rare. This multicenter study attempts to set a benchmark for state-of-the-art WEB treatment with consistent application of the WEB oversizing technique.
View Article and Find Full Text PDFJ Vis Exp
February 2023
Department of Medicine I, University Hospital Munich (LMU), Ludwig-Maximilians-University Munich (LMU); Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich; DZHK (German Centre for Cardiovascular Research) Partner Site Munich, Munich Heart Alliance (MHA); Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich;
Sci Rep
May 2023
Department of Neuroradiology, University Hospital Munich (LMU), Munich, Germany.
Developing new capabilities to predict the risk of intracranial aneurysm rupture and to improve treatment outcomes in the follow-up of endovascular repair is of tremendous medical and societal interest, both to support decision-making and assessment of treatment options by medical doctors, and to improve the life quality and expectancy of patients. This study aims at identifying and characterizing novel flow-deviator stent devices through a high-fidelity computational framework that combines state-of-the-art numerical methods to accurately describe the mechanical exchanges between the blood flow, the aneurysm, and the flow-deviator and deep reinforcement learning algorithms to identify a new stent concepts enabling patient-specific treatment via accurate adjustment of the functional parameters in the implanted state.
View Article and Find Full Text PDFCancers (Basel)
April 2023
Department of Diagnostic and Interventional Neuroradiology, University Hospital Munich (LMU), Marchioninistrasse 15, 81377 Munich, Germany.
Background: The aim of this study was to develop and validate radiogenomic models to predict the MDM2 gene amplification status and differentiate between ALTs and lipomas on preoperative MR images.
Methods: MR images were obtained in 257 patients diagnosed with ALTs ( = 65) or lipomas ( = 192) using histology and the MDM2 gene analysis as a reference standard. The protocols included T2-, T1-, and fat-suppressed contrast-enhanced T1-weighted sequences.
Trials
March 2023
Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Carl-Neuberg Strasse 1, 30625, Hannover, Germany.
Background: Progress of cholangitis to cholangiosepsis is a frequent observation in patients with secondary sclerosing cholangitis in critically ill patients (SSC-CIP). Adequate biliary drainage may reduce episodes of cholangiosepsis and therefore stabilize liver function and improve survival. The primary objective of the BISCIT study is to demonstrate that scheduled biliary interventions will reduce incidence of cholangiosepsis, liver transplantation, or death in patients with SSC-CIP.
View Article and Find Full Text PDFEgypt Heart J
March 2023
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Background: Despite the spontaneous regression of many cases of coronary artery fistulas (CAFs), symptomatic patients or cases with severe shunting may require therapeutic interventions. In the present study, we aimed to assess the outcome of treatment of CAFs using interventional approaches.
Methods: This retrospective cohort study was performed on 29 patients with CAFs that were referred to our tertiary center between 2009 and 2019.
Cancers (Basel)
February 2023
Department of Dermatology and National Center for Tumor Diseases, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Targeted therapy with BRAF and MEK inhibitors (BRAFi, MEKi) is one of the mainstays of melanoma treatment. When dose-limiting toxicity (DLT) is observed, an option represents the intra-class switch to a different BRAFi+MEKi combination. Currently, there is scarce evidence for this procedure.
View Article and Find Full Text PDFRadiother Oncol
June 2023
Department of Radiation Oncology and Cyberknife Center, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Cologne Lymphoma Working Group (CLWG), Cologne, Germany. Electronic address:
Background: Chimeric antigen receptor (CAR) T-cell therapy has improved the limited overall survival (OS) of patients with intensively pretreated diffuse large B-cell lymphoma (DLBCL). However, the potentially life-threatening toxicities of CAR T-cells and early relapses remain a challenge. As suggested by smaller monocentric analyses, radiotherapy (RT) in combination with CAR T-cells may have an immunomodulatory effect.
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