938 results match your criteria: "University Hospital Lausanne[Affiliation]"

Detection of OXA-23-producing Proteus mirabilis in Switzerland.

Eur J Clin Microbiol Infect Dis

December 2024

Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

Proteus mirabilis is a Gram-negative bacterium found in the environment and also forms part of the commensal flora in the gastrointestinal tract of both humans and animals. P. mirabilis can cause a wide variety of infections, however it does not harbor any intrinsic β-lactamase genes and as such usually exhibits full susceptibility to β-lactams with the exception of imipenem, to which it is naturally resistant.

View Article and Find Full Text PDF

BACKGROUND Brunneromas are among the rarest benign tumors of the upper gastrointestinal tract. They arise from the Brunner's glands and patients have a good prognosis if treated timely and radically. Because symptoms are rare, their diagnosis can be challenging, especially regarding the smaller ones.

View Article and Find Full Text PDF

Background: Ablative fractional photothermolysis serves as an excellent in vivo model for studying wound healing. The advent of non-invasive imaging devices, such as line-field confocal optical coherence tomography (LC-OCT), enhances this model by enabling detailed monitoring of skin wound healing over time. Additionally, artificial intelligence (AI)-based algorithms are revolutionizing the evaluation of clinical images by providing detailed analyses that are unfeasible manually.

View Article and Find Full Text PDF

The therapeutic aim for rheumatoid arthritis (RA) is to control disease activity and prevent radiographic progression. Various clinical scores are used to assess disease activity in RA patients. The DAS 28 score can define states of low disease activity (LDA) and remission.

View Article and Find Full Text PDF

Background: The rising prevalence of acute ischemic stroke (AIS) in young adults, particularly with undetermined pathogenesis, is a growing concern. This study assessed risk factors, treatments, and outcomes between young AIS patients with undetermined and determined pathogeneses.

Methods And Results: This was a retrospective cohort study including AIS patients aged 18 to 55 years in Switzerland, treated between 2014 and 2022.

View Article and Find Full Text PDF

Background: Most individuals on combination antiretroviral therapy (ART) have HIV plasma viral loads below the limit of detection. However, episodes of low-level viremia (LLV) are observed in subsets of individuals, risk factors and clinical significance of which remain debated.

Methods: We included participants enrolled in the Swiss HIV Cohort Study, starting ART between July 1999 and April 2023, with HIV RNA <200 copies/ml six months post ART initiation.

View Article and Find Full Text PDF

Transcriptional profile of infection in people living with HIV.

iScience

November 2024

Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.

In people with HIV-1 (PWH), (MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct clustering in MTB-infected individuals.

View Article and Find Full Text PDF

Patient and public involvement in HIV research: a mapping review and development of an online evidence map.

J Int AIDS Soc

November 2024

CLEAR Methods Center, Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

Introduction: Increasing evidence indicates the benefits of patient and public involvement (PPI) in medical research, and PPI is increasingly expected by funders and publishers. We conducted a mapping review of studies reporting examples of PPI implementation in HIV research, and developed an online evidence map to guide HIV researchers.

Methods: We systematically searched Medline and Embase up until 18 August 2024, including search terms with variations for PPI and HIV.

View Article and Find Full Text PDF

Clinical parameters of death and heart failure hospitalization in biventricular systolic dysfunction assessed via cardiac magnetic resonance.

Int J Cardiol

January 2025

Centro Cardiologico Monzino IRCCS, Milan, Italy; Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, University of Milan, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. Electronic address:

Aims: While factors associated with adverse events are well elucidated in setting of isolated left ventricular dysfunction, clinical and imaging-based prognosticators of adverse outcomes are lacking in context of biventricular dysfunction. The purpose of this study was to establish role of clinical variables in prognosis of biventricular heart failure (HF), as assessed by cardiac magnetic resonance imaging.

Methods: Study cohort consisted of 840 patients enrolled in DERIVATE registry with coexisting CMR-derived right ventricular (RV) and left ventricular (LV) dysfunction, as defined by RV and LV ejection fractions ≤45 % and ≤ 50 %, respectively.

View Article and Find Full Text PDF
Article Synopsis
  • CPPD disease is a significant cause of arthritis that can resemble other rheumatic conditions, making accurate diagnosis crucial.
  • A deep-learning algorithm was developed and tested to automatically detect CPPD features in hand radiographs, focusing specifically on certain joint areas.
  • The combined model for detecting CPPD showed strong performance metrics, with a mean AUROC of 0.86 and good sensitivity and specificity, while separate models for different joint areas had varying success rates.
View Article and Find Full Text PDF

Intramyocardial fatty infiltration lesion in sporadic inclusion body myositis: a case report.

Int J Cardiovasc Imaging

October 2024

Cardiovascular Department of Cardiology, Division of Cardiology, Lausanne University Hospital, CHUV, Rue du Bugnon 46, Lausanne, 1005, Switzerland.

Sporadic inclusion body myositis (sIBM), the most common inflammatory muscle disorder in adults over 50 years, is often misdiagnosed due to its gradual onset and its common but unspecific muscle weakness in older adults. Diagnosis relies on clinical, radiological, and pathological features. Cardiac involvement is rare, prompting this case description and a comprehensive literature analysis.

View Article and Find Full Text PDF

Ideal Time to Conduct a Pharmacokinetic Investigation After Delivery to Fully Capture the Effect of Pregnancy on Drug Exposure.

Open Forum Infect Dis

October 2024

Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.

Background: The World Health Organization is pushing to accelerate the study of new human immunodeficiency virus drugs in pregnant women. However, regulatory guidelines do not specify when to conduct pharmacokinetic studies in postpartum women. This knowledge gap carries the potential to jeopardize the outcomes and conclusions of clinical trials aiming to study the effect of pregnancy on drug exposure.

View Article and Find Full Text PDF
Article Synopsis
  • Spontaneous supratentorial intracerebral hemorrhage is a severe type of stroke with high mortality rates, and there are currently no effective treatments to improve patient outcomes.
  • This trial will assess the effects of early minimally invasive endoscopic surgery compared to the best medical treatment, focusing on functional outcomes after 6 months.
  • Conducted in Switzerland, this multicenter study aims to fill the gap in large randomized trials, potentially establishing new treatment options for this life-threatening condition.
View Article and Find Full Text PDF

Introduction: Intraoperative fluorescence guidance is a well-established surgical adjunct in high-grade glioma surgery. In contrast, the clinical use of such dyes and technology has been scarcely reported in skull base surgery.

Research Question: We aimed to systematically review the clinical applications of different fluorophores in both open and endonasal skull base surgery.

View Article and Find Full Text PDF

The REPRIEVE trial suggests that primary cardiovascular disease (CVD) prevention could be considered among people with HIV at low CVD risk. We found cisgender women with low/moderate and high CVD risk are less likely to receive statins than cisgender men. Efforts are needed to guarantee equal access to statin-based CVD prevention.

View Article and Find Full Text PDF

Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence.

Cancer Cell

September 2024

Department of Oncology, University of Lausanne, 1011 Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, 1011 Lausanne, Switzerland; Agora Cancer Research Center Lausanne, 1011 Lausanne, Switzerland; Agora Cancer Centre, University Hospital Lausanne, 1011 Lausanne, Switzerland; Lundin Brain Tumour Centre, University Hospital Lausanne, 1011 Lausanne, Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, Geneva, Switzerland. Electronic address:

Article Synopsis
  • Glioblastoma recurrence remains unavoidable even after intensive treatments, with studies showing that targeting tumor-associated macrophages can reduce tumors and improve survival.
  • However, around 50% of cases in long-term studies still saw recurrences linked to fibrotic scars, which form after multiple treatments.
  • Research identified these fibrotic areas as protective environments for surviving cancer cells, and blocking the associated signaling pathways improved outcomes in preclinical trials of anti-CSF-1R therapy.
View Article and Find Full Text PDF

Introduction: Although increasingly appreciated, little is known about the prevalence of fecal urgency, fecal incontinence and differences between patients' and physicians' perception in inflammatory bowel disease (IBD).

Methods: We performed an online patient and physician survey to evaluate the assessment, prevalence and impact of fecal urgency and incontinence in IBD.

Results: A total of 593 patients (44.

View Article and Find Full Text PDF

Background: The advent of ablative fractional photothermolysis has revolutionized laser dermatology by providing a method to produce well-standardized, precise, and repeatable microscopic lesions. These wounds typically heal within 1-3 weeks, depending on the body site, with a minimal risk of permanent scarring. This positions ablative fractional photothermolysis as an exemplary in vivo model for studying the skin's wound healing processes.

View Article and Find Full Text PDF

Objective: Overlapping chronic pain syndromes, including fibromyalgia, are heterogeneous and often treatment-resistant entities carrying significant socioeconomic burdens. Individualized treatment approaches from both a somatic and psychological side are necessary to improve patient care. The objective of this study was to identify and visualize patient clusters in refractory musculoskeletal pain syndromes through an extensive set of clinical variables, including immunologic, psychosomatic, wearable, and sleep biomarkers.

View Article and Find Full Text PDF

Background: Bleeding during laparoscopic surgery is stressful and requires immediate efficient management. Skills for complication management are rarely trained. This study aims to investigate the impact of video-assisted coaching on laparoscopic skills acquisition and performance in emergency bleeding situations.

View Article and Find Full Text PDF