10 results match your criteria: "University Hospital Larrey[Affiliation]"
Prognostic implications of mucosal and deep margin distances according to T-status in oral tongue squamous cell carcinoma: A single-center retrospective study.
Head Neck
December 2024
Department of Surgery, University Cancer Institute of Toulouse - Oncopole, Toulouse, France.
Objective: To elucidate the prognostic implications of mucosal and deep margin distances in oral tongue squamous cell carcinoma (OTSCC), and to assess a different margin cut-off value in T1-T2 versus T3-T4 tumors.
Methods: This single-center retrospective study included 223 patients who received surgery for a primary OTSCC between January 2017 and December 2021.
Results: Multivariable analysis showed that deep margin distance ≥3 mm in T1-T2 tumors and ≥5 mm in T3-T4 tumors was significantly associated with better RFS and OS.
Advanced Platelet Lysate Aerogels: Biomaterials for Regenerative Applications.
J Funct Biomater
February 2024
CIRIMAT, Université Toulouse 3 Paul Sabatier, Toulouse INP, CNRS, Université de Toulouse, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France.
Human platelet lysate (HPL), rich in growth factors, is increasingly recognized for its potential in tissue engineering and regenerative medicine. However, its use in liquid or gel form is constrained by limited stability and handling difficulties. This study aimed to develop dry and porous aerogels from HPL hydrogel using an environmentally friendly supercritical CO-based shaping process, specifically tailored for tissue engineering applications.
View Article and Find Full Text PDFVideofluoroscopic swallowing study to detect pharyngeal leak after total (pharyngo-) laryngectomy: Retrospective assessment of a single-institution protocol.
Head Neck
April 2024
Department of Surgery, University Cancer Institute of Toulouse - Oncopole, Toulouse, France.
Article Synopsis
- Researchers wanted to see how well a special swallowing test called VFSS can find leaks in the throat after surgery to remove parts of the throat and voice box.
- They looked at 248 patients who had this surgery and took the swallowing test about a week to two weeks later.
- The test was pretty good at spotting leaks; it helped prevent future problems for many patients who had a positive test result.
Oncological outcomes and prognostic factors of squamous cell carcinoma of the upper gingiva and hard palate: a retrospective study.
Eur Arch Otorhinolaryngol
October 2023
Department of Surgery, University Cancer Institute of Toulouse - Oncopole, 1 Avenue Irène Joliot-Curie, 31100, Toulouse, France.
Purpose: Despite sharing the same staging system as oral cavity cancers, upper gingiva and hard palate (UGHP) squamous cell carcinoma (SCC) have several features that make them a different entity. We aimed to analyze oncological outcomes and adverse prognostic factors of UGHP SCC, and assess an alternate T classification specific to UGHP SCC.
Methods: Retrospective bicentric study including all patients treated by surgery for a UGHP SCC between 2006 and 2021.
Transoral Robotic Surgery for Head and Neck Cancer: Advances and Residual Knowledge Gaps.
J Clin Med
March 2023
Department of Otolaryngology, Head and Neck Surgery, Toulouse University Hospital-Larrey Hospital, 24 Chemin de Pouvourville, CEDEX 9, 31059 Toulouse, France.
Article Synopsis
- - Minimally invasive surgery, particularly transoral robotic surgery (TORS), has become increasingly important in treating head and neck cancers since its FDA approval in 2009 for certain oral cavity malignancies.
- - TORS offers advantages like wristed instruments and a 3D view that improve surgical precision and comfort, making it suitable for tumor removal in complex areas of the head and neck.
- - Despite its growing use, the application of TORS must be based on strong evidence to ensure safety and effectiveness, with ongoing research needed to fill existing knowledge gaps in this field.
Paratracheal lymph node dissection during total (pharyngo-)laryngectomy: A systematic review and meta-analysis.
Oral Oncol
September 2022
Oncology & Metabolism, University of Sheffield, UK.
Objectives: The objective of this review was to determine the rate and risk factors of paratracheal lymph node (PTLN) involvement during total laryngectomy (TL) or total pharyngolaryngectomy (TPL). In addition, we aimed to assess its prognostic significance in terms of survival and peristomal recurrence.
Methods: A comprehensive electronic search was performed on PubMed, EMBASE, and CENTRAL databases.
Airway management during transoral robotic surgery for head and neck cancers: a French GETTEC group survey.
Eur Arch Otorhinolaryngol
July 2022
Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Hôpital Larrey, Toulouse, France.
Purpose: The aim of the survey was to define the indications for preventive tracheostomy in transoral robotic surgery (TORS) for head and neck cancers.
Methods: From October 2019 to January 2020, an online questionnaire was e-mailed to French surgical ENT teams with considerable experience of the TORS procedure (Gettec group). A descriptive analysis of the answers was performed.
IL-17 Mast Cell/T Helper Cell Axis in the Early Stages of Acne.
Front Immunol
January 2022
Inserm, U1037, Centre de Recherche en Cancérologie de Toulouse (CRCT), Toulouse, France.
Acne is a multifactorial disease driven by physiological changes occurring during puberty in the pilosebaceous unit (PSU) that leads to sebum overproduction and a dysbiosis involving notably . These changes in the PSU microenvironment lead to a shift from a homeostatic to an inflammatory state. Indeed, immunohistochemical analyses have revealed that inflammation and lymphocyte infiltration can be detected even in the infraclinical acneic stages, highlighting the importance of the early stages of the disease.
View Article and Find Full Text PDFTransoral robotic surgery for squamous cell carcinomas of the posterior pharyngeal wall.
Eur Arch Otorhinolaryngol
December 2017
Department of Head and Neck Surgery, University Hospital Larrey, Toulouse, France.
Posterior pharyngeal wall squamous cell carcinomas (SCCs) are rare and have an associated poor prognosis. Progress in transoral resection techniques, in particular, transoral robotic surgery (TORS), have renewed the role of surgery in their treatment. This article presents the oncological and functional results obtained by the French Group of Head and Neck Robotic Surgery for TORS for posterior pharyngeal wall SCC-curative surgery.
View Article and Find Full Text PDFClinical outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Experience of a French evaluation cooperative subgroup of GETTEC.
Head Neck
April 2016
Department of Head and Neck Surgery, Hospices Civils de Lyon, University Hospital Lyon-Nord, Lyon, France.
Background: Transoral, minimally invasive, organ preservation surgeries are increasingly used to treat laryngopharyngeal carcinomas to avoid the toxicity associated with combined chemoradiotherapy (CRT) regimens. This study investigated the efficiency, safety, and functional outcomes of using transoral robotic surgery (TORS) to perform supraglottic laryngectomy (SGL).
Methods: This was a multicenter study using a case series with planned data collection from 2009 to 2012 for patients with supraglottic squamous cell carcinomas (SCCs) who underwent an SGL using TORS.