3 results match your criteria: "University Hospital Gasthuisberg-University of Leuven[Affiliation]"
Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib.
Crit Rev Oncol Hematol
January 2022
Department of Digestive Oncology, University Hospital Gasthuisberg-University of Leuven, Leuven, Belgium.
Article Synopsis
- Fusions of NTRK genes with partner genes can create abnormal proteins that contribute to cancer development through constant activation of kinases.
- Despite varying occurrences across tumor types, the presence of NTRK fusions in multiple cancers suggests potential for creating universal treatments targeting these fusions.
- Larotrectinib, the first approved drug for treating NTRK fusion-positive cancers, provides a groundbreaking tumor-agnostic option, and expert guidelines have been established to help oncologists understand its use and NTRK fusion diagnostics in clinical practice.
Normalizing Ovulation Rate by Preferential Reduction of Hepato-Visceral Fat in Adolescent Girls With Polycystic Ovary Syndrome.
J Adolesc Health
October 2017
Pediatric & Adolescent Endocrinology, Department of Development & Regeneration, University Hospital Gasthuisberg-University of Leuven, Leuven, Belgium.
Purpose: Polycystic ovary syndrome (PCOS) is an increasingly prevalent disorder in adolescent girls, commonly presenting with hirsutism/oligomenorrhea, commonly treated with an oral contraceptive (OC), and commonly followed by oligoanovulatory subfertility. We tested whether an intervention targeting the reduction of hepato-visceral adiposity is followed by a higher ovulation rate than OC treatment.
Methods: This randomized, open-label, single-center, pilot proof-of-concept study (12 months on treatment, then 12 months off) was performed in adolescent girls with hirsutism and oligomenorrhea (PCOS by National Institutes of Health; no sexual activity; N = 36; mean age 16 years, body mass index 23.
Sweet's syndrome in a patient with Crohn's disease.
Acta Gastroenterol Belg
December 1999
Department of Internal Medicine, University Hospital Gasthuisberg University of Leuven, Belgium.
Crohn's disease is rarely associated with Sweet's syndrome. We report a 32-year old woman who presented with diarrhea, fever and disseminated erythematous plaques on the arms and the trunk. After colonoscopy with biopsies, Crohn's disease was diagnosed.
View Article and Find Full Text PDF