32 results match your criteria: "University Hospital Frankfurt and Goethe University[Affiliation]"

Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral Regurgitation.

N Engl J Med

November 2024

From the Department of Internal Medicine III (S.B., R.P.), the Institute of Medical Statistics and Computational Biology (W.M., J.F., M.H.), and Cardiothoracic Surgery (T. Wahlers), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, the Department of Cardiothoracic Surgery (T.D.) and Cardiology (P.C.S.), Jena University Hospital, Friedrich-Schiller-University of Jena, Jena, Thoracic and Cardiovascular Surgery (J.G.) and General and Interventional Cardiology/Angiology (V.R.), Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, Medical Faculty OWL, Bad Oeynhausen, the Department of Cardiology, Ulm University Heart Center, Ulm (M. Kessler, W.R.), the Faculty of Health, School of Medicine (P.B.), and Helios Klinikum Krefeld (A.B.), University Witten/Herdecke, Witten, Marienkrankenhaus (E.L.), the Department of Cardiology, University Hospital Eppendorf (E.L.), and the Department of Cardiothoracic Surgery, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (H.R.), Hamburg, the Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen (J.S.), Cardiac Surgery (T.N.), Heart Center Leipzig at Leipzig University (H.T.), and Leipzig Heart Science (H.T.), Leipzig, the Department of Cardiovascular Surgery, University Hospital Frankfurt and Goethe University Frankfurt, Frankfurt (T. Walther), University Hospital Düsseldorf and CARID (Cardiovascular Research Institute Düsseldorf), Düsseldorf (M. Kelm), Medical Clinic and Polyclinic I (J.H.) and the Department of Cardiac Surgery (C.H.), Ludwig Maximilian University Munich, Munich, Medical Clinic II, University Heart Center Lübeck, and the German Center for Cardiovascular Research (DZHK), Lübeck (I.E.), the Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim (U.F.-R.), Otto-von-Guericke-University Magdeburg, Magdeburg (A.S.), the Department of Cardiology, University Medical Center Rostock, Rostock (H.I.), the Department of Cardiology, University Medical Center Mainz (P.L., R.S.B.), and the German Center for Cardiovascular Research (DZHK) partner site Rhine Main (P.L.), Mainz, St. Franziskus Hospital, Münster (S.R.), and the Department of Cardiology, Helios Klinikum Siegburg, Siegburg (H.B.) - all in Germany.

Article Synopsis
  • A study in Germany compared two treatments for heart failure patients with secondary mitral regurgitation: transcatheter edge-to-edge repair and surgical mitral-valve repair or replacement.
  • The trial involved 210 patients and assessed outcomes like death, hospitalizations, and major adverse events, finding that transcatheter repair had similar efficacy but significantly fewer safety issues than surgery.
  • Results showed that transcatheter edge-to-edge repair was noninferior to the surgical approach, indicating it might be a safer alternative for this patient group.
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Article Synopsis
  • The study aimed to compare two techniques for valve-sparing root replacement in patients with aortic root aneurysm: aortic root remodelling and aortic valve reimplantation, utilizing a multicenter approach and propensity-score matching.* -
  • Researchers conducted a retrospective analysis of data from 2010 to 2021, selecting pairs of patients who underwent either technique to evaluate perioperative outcomes and long-term valve function.* -
  • Findings indicated that while there were no significant differences in short-term outcomes, patients who underwent remodelling faced a higher risk of needing further interventions compared to those who had reimplantation, especially if immediate postoperative valve function was suboptimal.*
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Background: Minimally invasive aortic valve replacement (AVR) via upper ministernotomy (MiniAVR) is a standard alternative to full sternotomy access. Minimally invasive cardiac surgery has been proven to provide a number of benefits to patients. The aim of this study was to compare the short- and long-term outcomes after MiniAVR versus conventional AVR via full sternotomy (FS) using a biological prosthesis in an elderly higher-risk population.

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Non-femoral focused transaxillary access in TAVI: GARY data analysis and future trends.

Clin Res Cardiol

March 2024

Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, University Hospital Ruhr-University Bochum, Bad Oeynhausen, Germany.

Background: In patients not suitable for transfemoral transcatheter aortic valve implantation (TAVI), several access strategies can be chosen.

Aim: To evaluate the use and patient outcomes of transaxillary (TAx), transapical (TA), and transaortic (TAo) as alternative access for TAVI in Germany; to further evaluate surgical cutdown vs. percutaneous TAx access.

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Introduction: Delta power is a clinically established biomarker for abnormal brain processes. However, in patients with unilateral focal epilepsy (FE) it is still not well understood, how it relates to the epileptogenic zone and to neurocognitive functioning. The aim of the present study was thus to assess how delta power relates to the affected hemisphere, whether lateralization strength differs between the patients, and how changes in delta power correlate with cognitive functioning.

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Minimally invasive direct coronary artery bypass grafting (MIDCAB) using the left internal thoracic artery to the left descending artery is a clinical routine in the treatment of coronary artery disease. Far less is known on right-sided MIDCAB (r-MIDCAB) using the right internal thoracic artery (RITA) to the right coronary artery (RCA). We aimed to present our experience in patients with complex coronary artery disease who underwent r-MIDCAB.

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Objective: Despite increased awareness of the serious epilepsy complication sudden unexpected death in epilepsy (SUDEP), a substantial population of people with epilepsy (PWE) remain poorly informed. Physicians indicate concern that SUDEP information may adversely affect patients' health and quality of life. We examined SUDEP awareness and the immediate and long-term effects of providing SUDEP information to PWE.

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We read the letter to the editor by Dr Jasinski et al. entitled "Long-term durability of valve-sparing or repair procedures in BAV-Is there room for improvement?" with great interest.

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: Aortic valve and root replacement (AVRR) is a standardised procedure to treat patients with aortic valve and root disease. In centres with a well-established aortic valve and root repair program (valve repairs and Ross operations), only patients with very complex conditions receive AVRR; this procedure uses a mechanical or biological composite valve graft (modified Bentall-de Bono procedure). The aim of the study was to evaluate the short- and long-term results after AVRR in a high-risk population with complex pathologies.

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Superficial siderosis is a consequence of repetitive bleeding into the subarachnoid space, leading to toxic iron and hemosiderin deposits on the surface of the brain and spine. The clinical and radiological phenotypes of superficial siderosis are known to manifest over long time intervals. In contrast, this study defines the "acute superficial siderosis syndrome" and illustrates typical imaging and histopathological findings of this entity.

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Background: Data on the frequency and outcome of mechanical thrombectomy (MT) for large vessel occlusion (LVO) in patients with COVID-19 is limited. Addressing this subject, we report our multicenter experience.

Methods: A retrospective cohort study was performed of consecutive acute stroke patients with COVID-19 infection treated with MT at 26 tertiary care centers between January 2020 and November 2021.

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Objectives: The aim of this study was to compare short- and longer-term outcomes of David (DV) versus Florida sleeve (FS) procedure in patients requiring valve-sparing aortic root replacement.

Methods: Between January 1996 and December 2020 285 patients received a DV procedure (median age 60 years; 26% females) and 57 patients underwent an FS procedure (median age 64 years; 19% females) in our department. Propensity score matching using patient characteristics led to 58 (DV) versus 57 (FS) patients.

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Kommerell's diverticulum is an aneurysmatic offspring of the left aberrant subclavian artery, which is a rare vascular anomaly of the aortic arch. Here, we present our less invasive approach to the repair of a symptomatic Kommerell's diverticulum in a 31-year-old patient, without the use of cardiopulmonary bypass.

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Executive deficits in neuropsychological testing differentiate between autoimmune temporal lobe epilepsy caused by limbic encephalitis and temporal lobe epilepsies with non-autoimmune etiologies.

Epilepsy Behav

October 2021

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt am Main, Germany.

Objective: Patients with temporal lobe epilepsy caused by autoimmune limbic encephalitis (AI-TLE) clinically resemble patients with temporal lobe epilepsy with non-autoimmune etiologies (NAI-TLE) but have a different prognosis and require specific adjusted therapies. The objective of this study was to investigate whether patients with these forms of TLE can be discerned by means of neuropsychological assessment.

Methods: Data from 103 patients with TLE (n = 39 with AI-TLE and n = 64 with NAI-TLE, including n = 39 with hippocampal sclerosis [HS] and n = 25 with low-grade epilepsy-associated tumors [LEAT]) and 25 healthy controls who underwent comprehensive neuropsychological assessments were analyzed retrospectively.

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