3 results match your criteria: "University Hospital Essen at the University Duisburg-Essen[Affiliation]"
Locally advanced oesophageal adenocarcinoma (EAC) remains difficult to treat because of common resistance to neoadjuvant therapy and high recurrence rates. The ecological and evolutionary dynamics responsible for treatment failure are incompletely understood. Here, we performed a comprehensive multi-omic analysis of samples collected from EAC patients in the MEMORI clinical trial, revealing major changes in gene expression profiles and immune microenvironment composition that did not appear to be driven by changes in clonal composition.
View Article and Find Full Text PDFStatins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis.
Cell Rep
November 2021
Department of Medical Oncology, West German Cancer Center, University Hospital Essen at the University Duisburg-Essen, Duisburg, Germany; German Cancer Consortium (DKTK) partner site Essen, Essen, Germany. Electronic address:
Article Synopsis
- Statins, commonly prescribed to many adults over 40, can influence cancer cell behavior, particularly in solid tumors, making it vital to study their effects on cancer and patients taking them.
- Research shows that statins can trigger a partial epithelial-to-mesenchymal transition (EMT) in cancer cells, leading to both increased ability for cancer cells to spread and a reduced chance of forming new tumors.
- The study offers a detailed understanding of how statin use impacts various stages of cancer development, progression, and metastasis, highlighting both potential risks and benefits.
Unraveling Tumor Heterogeneity by Using DNA Barcoding Technologies to Develop Personalized Treatment Strategies in Advanced-Stage PDAC.
Cancers (Basel)
August 2021
West German Cancer Center, Department of Medical Oncology, University Hospital Essen at the University Duisburg-Essen, 45147 Essen, Germany.
Tumor heterogeneity is a hallmark of many solid tumors, including pancreatic ductal adenocarcinoma (PDAC), and an inherent consequence of the clonal evolution of cancers. As such, it is considered the underlying concept of many characteristics of the disease, including the ability to metastasize, adapt to different microenvironments, and to develop therapy resistance. Undoubtedly, the high mortality of PDAC can be attributed to a high extent to these properties.
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