8,260 results match your criteria: "University Hospital Coventry & Warwickshire[Affiliation]"
Health and wellbeing of survivors of sexual violence and abuse attending sexual assault referral centres in England: the MESARCH mixed-methods evaluation.
Health Soc Care Deliv Res
October 2024
Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Article Synopsis
- One million individuals in England and Wales face sexual violence annually, with only about 30,000 accessing supportive services through sexual assault referral centres.* -
- The study evaluated care pathways for survivors through a series of sub-studies, including interviews with service providers and survivors, and highlighted the effectiveness of psychosocial interventions for mental health issues like PTSD and depression.* -
- Findings suggested that while sexual assault referral centres provide high-quality care, certain groups, such as those facing domestic abuse and some ethnic minorities, are underrepresented, emphasizing the need for better inter-agency collaboration and support.*
Imaging Glucose Metabolism and Dopaminergic Dysfunction in Sheep () Brain Using Positron Emission Tomography Imaging Reveals Abnormalities in OVT73 Huntington's Disease Sheep.
ACS Chem Neurosci
November 2024
Preclinical, Imaging, and Research Laboratories (PIRL), South Australian Health and Medical Research Institute (SAHMRI), Gilles Plains, Adelaide 5086, Australia.
Article Synopsis
- Huntington's disease (HD) is a progressive neurodegenerative condition leading to cognitive, movement, and behavioral issues, ultimately causing disability and death.
- This study evaluates the effectiveness of a transgenic sheep model (OVT73) for PET imaging to track brain metabolism and dysfunction related to HD.
- Findings reveal that younger HD sheep show increased glucose uptake in specific brain regions compared to healthy controls, while both older HD sheep displayed reduced dopamine binding potential, highlighting the potential of this model for studying HD progression.
Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial.
Trials
October 2024
Population Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
Background: Chronic kidney disease (CKD) prevalence is steadily increasing, in part due to increased multimorbidity in our aging global population. When progression to kidney failure cannot be avoided, people need unbiased information to inform decisions about whether to start dialysis, if or when indicated, or continue with holistic person-centred care without dialysis (conservative kidney management). Comparisons suggest that while there may be some survival benefit from dialysis over conservative kidney management, in people aged 80 years and over, or with multiple health problems or frailty, this may be at the expense of quality of life, hospitalisations, symptom burden and preferred place of death.
View Article and Find Full Text PDFSerological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats.
Nat Commun
October 2024
Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Article Synopsis
- Cases of H5 highly pathogenic avian influenza are increasing, with a high mortality rate of 60% in humans, although no human infections have been reported in Malaysian Borneo despite circulation in local poultry and migratory birds.
- Deforestation in coastal areas may bring humans closer to these migratory birds, raising the risk of zoonotic spillover events, where diseases jump from animals to humans.
- A recent survey of over 10,000 individuals found evidence of exposure to H5 viruses, indicating potential human contact with the virus, and emphasizes the need for enhanced surveillance of cross-species pathogen transmission in areas where humans and migratory birds interact.
A Core set of patient-reported outcome measures to measure quality of life in obesity treatment research.
Obes Rev
October 2024
Department of Science, Nederlandse Obesitas Kliniek (Dutch Obesity Clinic), Huis Ter Heide, Utrecht, The Netherlands.
The lack of standardization in patient-reported outcome measures (PROMs) has made measurement and comparison of quality of life (QoL) outcomes in research focused on obesity treatment challenging. This study reports on the results of the second and third global multidisciplinary Standardizing Quality of life measures in Obesity Treatment (S.Q.
View Article and Find Full Text PDFNational audit of patient reported experience of radical cystectomy for bladder cancer pathways.
BJUI Compass
October 2024
Bristol Urological Institute, Southmead Hospital North Bristol NHS Trust Bristol UK.
Objective: The objective of this study was to measure and describe the national patient experience of radical cystectomy (RC) pathways in the UK using the validated Cystectomy-Pathway Assessment Tool (C-PAT).
Patients And Methods: A cohort of 1081 patients who underwent RC for bladder cancer, between 1 January 2021 and 31 July 2022 at 33 UK cystectomy centres, returned completed C-PAT responses. SPSS was employed for data summary statistics, including median, interquartile range, Mann Whitney U test or Chi-square test with a 95% confidence interval to assess statistical significance between potentially associated variables.
Current management of chronic kidney disease in type-2 diabetes-A tiered approach: An overview of the joint Association of British Clinical Diabetologists and UK Kidney association (ABCD-UKKA) guidelines.
Diabet Med
October 2024
Guy's and St Thomas' Hospital London and King's College London, London, UK.
Article Synopsis
- A significant number of people with diabetes develop chronic kidney disease (CKD), which often leads to end-stage kidney disease (ESKD) and is highly associated with cardiovascular disease (CVD) mortality.
- Managing modifiable risk factors, such as hyperglycemia and hypertension, along with treating dyslipidemia is vital for patients with type 2 diabetes and CKD to reduce the risk of CVD.
- Recent clinical trials demonstrate that medications like SGLT-2 inhibitors and GLP-1 receptor agonists can help protect kidney function in these patients, informing updated clinical practice guidelines for healthcare professionals.
Phase 3 Trial of Stereotactic Body Radiotherapy in Localized Prostate Cancer.
N Engl J Med
October 2024
From the Royal Marsden Hospital (N.A., A.T., O.N.), the Institute of Cancer Research (N.A., C.G., A.T., J. Patel, E.W., J. Pugh, G.M., S. Brown, S. Burnett, E.H.), St. Bartholomew's Hospital (P.W.), and Patient and Public Representative (D.P.), London, the Mount Vernon Cancer Centre, Northwood (P.O.), the James Cook University Hospital, Middlesbrough (H.V.), University Hospitals Birmingham, Birmingham (D.F.), the Clatterbridge Cancer Centre, Birkenhead (S.T.), Queen's University Belfast, Belfast (S.J.), Churchill Hospital, Oxford (P.C.), University Hospitals of Leicester, Leicester (K.K.), Freeman Hospital, Newcastle (J.F.), University Hospitals Coventry and Warwickshire, Coventry (A.C.), Velindre Cancer Centre, Cardiff (J.S.), and Cambridge University Hospitals NHS Foundation Trust, Cambridge (A.M.) - all in the United Kingdom; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto (A.L., W.C.), and the Department of Oncology, McMaster University, Hamilton, ON (I.D.) - both in Canada; and Cancer Trials Ireland and St. Luke's Radiation Oncology Network, St. Luke's Hospital - both in Dublin (J.A.).
Article Synopsis
- A study investigated whether stereotactic body radiotherapy (SBRT) is just as effective as standard radiotherapy for treating localized prostate cancer in terms of treatment failure rates.
- The trial involved 874 men with early-stage prostate cancer, comparing SBRT (36.25 Gy in 5 sessions) to conventional radiotherapy (78 Gy in 39 sessions or 62 Gy in 20 sessions) over several weeks, focusing on the chance of being free from cancer progression after 5 years.
- Results showed that SBRT was noninferior to standard treatment, with similar success rates in preventing cancer failure (95.8% for SBRT vs. 94.6% for control) but higher rates of genitour
Development of a toolkit to help parents/caregivers manage feeding problems in autistic children: A protocol for a realist synthesis and toolkit co-design.
PLoS One
October 2024
Institute of Health and Neurodevelopment & School of Psychology, Aston University, Birmingham, United Kingdom.
Many autistic children have feeding problems, typically eating a limited range of foods. Feeding problems affect quality of life, health, and development. Research suggests that parents are often unsure when to or whether to seek help.
View Article and Find Full Text PDFThe impact of locked cabinets for automated external defibrillators (AEDs) on cardiac arrest and AED outcomes: A scoping review.
Resusc Plus
December 2024
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background: Rapid public defibrillation with automated external defibrillators (AEDs) is critical to improving out-of-hospital cardiac arrest survival. Concerns about AED theft and vandalism have led to implementing security measures, including locked cabinets. This scoping review, conducted as part of the evidence review for the International Liaison Committee on Resuscitation, explores the impact of securing AEDs in locked cabinets.
View Article and Find Full Text PDFTransplant Trial Watch.
Transpl Int
October 2024
Department of Transplant Surgery, University Hospitals Coventry & Warwickshire, Coventry, United Kingdom.
Article Synopsis
- The study aimed to evaluate the effectiveness of biodegradable temporising matrix (BTM) in reconstructing complex wounds through a systematic review and meta-analysis following PRISMA guidelines.
- It analyzed data from 26 studies involving 1153 complex wounds, finding high integration rates (92.7%) and low infection rates (12.6%) with positive scar outcomes.
- The authors concluded that BTM serves as a strong dermal template for wound reconstruction, suggesting further randomized controlled trials to strengthen the findings.
Assessment of Respiratory Health Implications of Vaping: A Systematic Review of Toxicity Mechanisms and Adverse Effects of Electronic Nicotine Delivery Systems.
Cureus
September 2024
General Medicine, Lahore General Hospital, Lahore, PAK.
E-cigarettes are thought to aid in tobacco smoking cessation, but there are concerns about their overall effectiveness and safety for the general population, particularly adults. This review aims to investigate the mechanisms of toxicity and adverse effects of e-cigarettes on the respiratory system, comparing these effects with those of conventional smoking. A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
View Article and Find Full Text PDFHuman Claustrum Connections: Robust In Vivo Detection by DWI-Based Tractography in Two Large Samples.
Hum Brain Mapp
October 2024
Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Article Synopsis
- - Despite significant research on the claustrum's role in the mammalian brain, studies on its connections in humans are limited due to its complex anatomy and challenges in imaging techniques.
- - The study used deep-learning segmentation and diffusion-weighted imaging (DWI)-based tractography on two large groups of healthy adults to explore claustrum connectivity.
- - Results showed consistent and replicable connections between the claustrum and various brain regions across different subjects, enhancing the understanding of claustrum connectivity and its implications for health and disease.
Correlation Between the Neutrophil-to-Lymphocyte Ratio and the Severity of Coronary Artery Disease in Patients With Myocardial Infarction.
Cureus
September 2024
Orthopaedic Surgery, Rawalpindi Medical University, Rawalpindi, PAK.
Article Synopsis
- This study explores the relationship between neutrophil-to-lymphocyte ratio (NLR) and the severity of coronary artery disease (CAD) in patients who have experienced a myocardial infarction, aiming to simplify the severity evaluation process compared to the complex Gensini scoring system.
- Conducted on 208 patients at Benazir Bhutto Hospital over a year, the study utilized both descriptive and inferential statistics to analyze the collected data, including Gensini and vessel scores to categorize CAD severity.
- Findings indicated that 61.53% of participants had non-severe CAD while 38.47% had severe CAD, revealing significant correlations between higher NLR values and increased CAD severity, along with various risk factors like
Changes in body composition and average daily energy expenditure of men and women during arduous extended polar travel.
PLoS One
October 2024
Department of Vascular and Renal Transplant Surgery, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom.
Weight and skin-fold measurements were made at five-day intervals during a 47-day expedition by six men and three women from the edge of the sea ice to the South Pole. From these, together with detailed manual records of the nutrition for individual participants, the average daily energy expenditure was determined before and after a resupply at approximately mid-point of the expedition. For all participants body weight fell during the expedition with the overall loss being much smaller for the three female participants (-4.
View Article and Find Full Text PDFRNA sequencing reveals molecular mechanisms of endometriosis lesion development in mice.
Dis Model Mech
October 2024
Robinson Research Institute and School of Biomedicine, The University of Adelaide, Adelaide, SA 5006, Australia.
Article Synopsis
- - The study investigates the molecular mechanisms behind endometriosis by using a mouse model with decidualized endometrial tissue injected to create endometriosis-like lesions.
- - Researchers conducted high throughput mRNA sequencing to analyze gene expression in both decidualized tissue and lesions at two time points, identifying key genes and pathways involved in the disease.
- - The findings highlight distinct gene expression patterns and suggest new potential regulators and genes not previously linked to endometriosis, indicating new avenues for understanding and researching the disease.
COVID-19 is associated with cardiac structural and functional remodelling in healthy middle-aged and older individuals.
Clin Physiol Funct Imaging
January 2025
Research Centre for Health and Life Sciences, Institute for Health and Wellbeing, Coventry University, Coventry, UK.
Background: Coronavirus disease 2019 (COVID-19) was declared a global pandemic in 2019. It remains uncertain to what extent COVID-19 effects the heart in heathy individuals. To evaluate the effect of the COVID-19 on cardiac structure and function in middle-aged and older individuals.
View Article and Find Full Text PDFSurvival rates in pregnancies complicated by twin-to-twin transfusion syndrome undergoing laser therapy: a systematic review and meta-analysis: Survival rates in twin-to-twin transfusion syndrome.
Am J Obstet Gynecol MFM
October 2024
Fetal Medicine Unit, Saint George's Hospital, London, UK; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK; Twins and Multiples Centre for Research and Clinical Excellence; Fetal Medicine Unit, Liverpool Women's Hospital, University of Liverpool, Liverpool, UK. Electronic address:
Article Synopsis
- Twin-to-twin transfusion syndrome (TTTS) can cause problems for both babies, and doctors want to understand how severe it is to help with survival rates after treatment.
- They reviewed a lot of studies to see how well both twins survive depending on the severity of TTTS, which is measured in stages.
- The results showed that around 73% of twins survive when TTTS is stage I, but the survival drops to about 48% and 53% for stages III and IV, which are more severe.
Midwives' perceptions and experiences of recommending and delivering vaccinations to pregnant women following the Covid-19 pandemic: a qualitative study.
Midwifery
January 2025
Division of Health Sciences, Warwick Medical School, University of Warwick.
Article Synopsis
- Pregnant women and their babies are more likely to get really sick if they catch an illness, but not enough women are getting vaccines for things like the flu and Covid-19 during pregnancy.
- This research looked at what midwives in the UK think about discussing vaccines with pregnant women and how they can help women decide to get vaccinated.
- The study found that midwives need clear information about vaccines and should explain why they are important so that pregnant women can make better choices about getting vaccinated.
Artistic gymnastics-specific extension of the IOC 2020 consensus statement: methods for recording and reporting of epidemiological data on injury and illness in sport.
BMJ Open Sport Exerc Med
October 2024
Department for Health, University of Bath, Bath, Bath and North East Somer, UK.
The incidence of injuries reported in artistic gymnastics varies greatly. This is partly due to inconsistencies in defining and reporting injuries in artistic gymnastics. The objective was to develop consistent definitions and methodology for reporting injuries in artistic gymnastics.
View Article and Find Full Text PDFArticle Synopsis
- * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
- * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
Expression of ten-eleven translocation 2 and glutathione-S-transferase pi in colorectal cancer patients with and without type 2 diabetes mellitus.
Folia Med (Plovdiv)
June 2024
University of Ioannina Medical School, Ioannina, Greece.
To highlight possible correlations of type 2 diabetes mellitus (T2DM) with microscopic / macroscopic characteristics of colorectal cancer tissues, along with the expression of Ten-Eleven Translocation 2 (TET2) and glutathione-S-transferase pi (GST-pi) proteins.
View Article and Find Full Text PDFPreventive drug treatments for adults with chronic migraine: a systematic review with economic modelling.
Health Technol Assess
October 2024
Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.
Article Synopsis
- Chronic migraine affects 2-4% of adults globally and recent advances in expensive medications have prompted a review of their clinical and cost-effectiveness.
- The study analyzed data from randomised controlled trials involving 7352 adults and compared six different medications, including calcitonin gene-related peptide monoclonal antibodies, Botox, and topiramate, against placebo.
- Results showed that calcitonin gene-related peptide monoclonal antibodies ranked highest in reducing headache days and improving quality of life, while topiramate was less effective compared to these newer treatments.
Are completed ReSPECT plans facilitating person-centred care? An evaluation of completed plans in UK general practice.
Resusc Plus
December 2024
Warwick Medical School, University of Warwick, Gibbet Hill, Coventry CV4 7AL, United Kingdom.
Background: The Recommended Summary Plan for Emergency Care and Treatment (ReSPECT) includes agreed clinical recommendations for a person's care in a future emergency which have been informed by discussion of the person's preferences. Previous evaluation of ReSPECT plans in acute NHS hospitals found inconsistencies in recording patient's preferences and involvement in the plan, and infrequent justification for recommendations.
Aim: To explore to what extent ReSPECT recommendations reflect individual preferences, as documented in the plan.