2,079 results match your criteria: "University Hospital Charité Humboldt-University[Affiliation]"

Trends of mapping knowledge structure and themes of cancer sonodynamic therapy: a text-mining study.

Quant Imaging Med Surg

December 2024

Department of Spine Surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background: Sonodynamic therapy (SDT) is a non-invasive cancer treatment technique stemming from photodynamic therapy (PDT) and has garnered escalated interest among researchers in recent years. Numerous aspects of cancer SDT remain contentious, and the global research trajectory within this domain remains insufficiently explored. This study seeks to delineate the comprehensive knowledge framework, developmental trends, and pivotal research focal points concerning cancer SDT.

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Diffusion-limited cytokine signaling in T cell populations.

iScience

June 2024

Biomathematics Division, Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany.

Effective immune-cell responses depend on collective decision-making mediated by diffusible intercellular signaling proteins called cytokines. Here, we designed a three-dimensional spatiotemporal modeling framework and a precise finite-element simulation setup to systematically investigate the origin and consequences of spatially inhomogeneous cytokine distributions in lymph nodes. We found that such inhomogeneities are critical for effective paracrine signaling, and they do not arise by diffusion and uptake alone, but rather depend on properties of the cell population such as an all-or-none behavior of cytokine secreting cells.

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Background: Pleural invasion (PI) is considered to be an adverse prognostic factor in non-small cell lung cancer (NSCLC). However, the prognostic roles of PI in pathologic (p)T3-4N0M0 NSCLC remain controversial. Therefore, this study aimed to evaluate the predictive value of PI in patients with pT3-4N0M0 NSCLC.

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Sleep has been demonstrated to support memory formation from early life on. The precise temporal coupling of slow oscillations (SOs) with spindles has been suggested as a mechanism facilitating this consolidation process in thalamocortical networks. Here, we investigated the development of sleep spindles and SOs and their coordinate interplay by comparing frontal, central, and parietal electroencephalogram recordings during a nap between infants aged 2-3 months ( = 31) and toddlers aged 14-17 months ( = 49).

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Telomere maintenance in neuroblastoma is linked to poor outcome and caused by either telomerase reverse transcriptase (TERT) activation or through alternative lengthening of telomeres (ALT). In contrast to TERT activation, commonly caused by genomic rearrangements or MYCN amplification, ALT is less well understood. Alterations at the ATRX locus are key drivers of ALT but only present in ∼50% of ALT tumors.

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Article Synopsis
  • This study evaluated the incidence of orofacial injuries and the use of sports mouthguards among German elite athletes aged 18-35.
  • Data was collected through questionnaires at the Institute of Applied Training Science in Leipzig, focusing on athletes’ experiences between May 2020 and April 2021.
  • Results showed that high-risk sports athletes had a significant rate of orofacial injuries (55%) and dental injuries (30%), while mouthguard use was very low across all risk categories, highlighting an urgent need for improved injury prevention strategies.
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  • Utilization of ventricular assist devices (VAD) for end-stage heart failure is advanced, but there's a need for evidence-based psychosocial support interventions post-implantation.
  • A study in Germany involved 140 patients, randomly assigned to an intervention or control group, to evaluate the impact of a new VAD support curriculum on various health outcomes.
  • Results indicated that while primary health complications were similar across both groups, the intervention significantly reduced depression in patients and showed improvements in anxiety, quality of life, social support, and self-management for those receiving the VAD intervention.
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Aims: Traditional cardiovascular (CV) biomarkers (high-sensitivity troponinT [hsTnT] and N-terminal pro-B-type natriuretic peptide [NT-proBNP]) are important to monitor cancer patients' cardiac function and to assess prognosis. Newer CV biomarkers (mid-regional pro-adrenomedullin [MR-proADM], C-terminal pro-arginine vasopressin [copeptin], and mid-regional pro-atrial natriuretic peptide [MR-proANP]) might outperform traditional biomarkers.

Methods And Results: Overall, 442 hospitalized cancer patients without significant CV disease or current infection were enrolled (61 ± 15 years, 52% male, advanced cancer stage: 85%) and concentrations of CV biomarkers were analysed.

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Secondary lymphoid organs (SLOs) provide the confined microenvironment required for stromal cells to interact with immune cells to initiate adaptive immune responses resulting in B cell differentiation. Here, we studied three patients from two families with functional hyposplenism, absence of tonsils, and complete lymph node aplasia, leading to recurrent bacterial and viral infections. We identified biallelic loss-of-function mutations in encoding the lymphotoxin beta receptor (LTβR), primarily expressed on stromal cells.

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Bridging the gender, climate, and health gap: the road to COP29.

Lancet Planet Health

December 2024

Barcelona Supercomputing Center, Barcelona, Spain; Centre on Climate Change and Planetary Health and Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK; Catalan Institution for Research and Advanced Studies, Barcelona, Spain.

Article Synopsis
  • This text discusses the importance of intersectional approaches in climate policy to address the unique health impacts of climate change on women, girls, and gender-diverse individuals, who often face compounded vulnerabilities due to systemic oppression.
  • It highlights the lack of meaningful gender and health representation in international climate governance, emphasizing that despite some progress, men still dominate decision-making roles in climate policy.
  • The text advocates for promoting gender-responsiveness in climate strategies to enhance inclusivity and effectiveness, leading to more resilient and equitable societies.
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Tactile mechanisms and afferents underlying the rat pup transport response.

Curr Biol

December 2024

Neural Systems & Behavior, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA; University of Edinburgh, Simons Initiative for the Developing Brain, 1 George Square, EH8 9JZ Edinburgh, Scotland, United Kingdom. Electronic address:

Juvenile rodents and other altricial mammals react with calming, immobility, and postural modifications to parental pickup, a set of behaviors referred to as the transport response. Here, we investigate sensory mechanisms underlying the rat transport response. Grasping rat pups in anterior neck positions evokes strong immobility and folding up of feet, whereas more posterior grasping has lesser effects on immobility and foot position.

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Effect of laterality on the postoperative survival of non-small cell lung cancer patients undergoing pneumonectomy.

Transl Lung Cancer Res

September 2024

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: Pneumonectomy is one of the important surgical methods for non-small cell lung cancer (NSCLC). This study evaluated the effects of laterality on the short- and long-term survival of NSCLC patients undergoing pneumonectomy.

Methods: We reviewed the Surveillance, Epidemiology, and End Results database to retrieve the data of patients who underwent pneumonectomy for stage I-III NSCLC from 2004 to 2015.

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Acyl-coenzyme A: cholesterol acyltransferases are enzymes which are involved in the homeostasis of cholesterol. Impaired enzyme activity is associated with the occurrence of various diseases like Alzheimer's disease, atherosclerosis, and cancers. At present, mitotane is the only inhibitor of this class of enzymes in clinical use for the treatment of adrenocortical carcinoma but associated with common and severe adverse effects.

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Article Synopsis
  • Hereditary angioedema (HAE) is a chronic disease requiring effective long-term preventive treatments, prompting a study to evaluate the safety and efficacy of garadacimab, a new medication for HAE.
  • In an interim analysis of the ongoing phase 3 VANGUARD study, involving 161 patients, most treatment-emergent adverse events (TEAEs) were mild, with injection-site reactions being the most common, and no serious complications linked to garadacimab were reported.
  • The results showed a significant reduction in HAE attacks, with 60% of patients remaining attack-free, indicating that garadacimab offers a safe and effective long-term treatment option for patients with
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Chimeric antigen receptor (CAR)-modified natural killer (NK) cells show antileukemic activity against acute myeloid leukemia (AML) in vivo. However, NK cell-mediated tumor killing is often impaired by the interaction between human leukocyte antigen (HLA)-E and the inhibitory receptor, NKG2A. Here, we describe a strategy that overcomes CAR-NK cell inhibition mediated by the HLA-E-NKG2A immune checkpoint.

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  • There are big changes in the bacteria living in the mouths and guts of people with a type of blood cancer called chronic lymphocytic leukemia (CLL) compared to healthy people.
  • The study looked at samples from patients with CLL and found some good bacteria were missing while others were too much, which could be linked to how serious their condition is.
  • The research suggests that understanding these bacterial changes might help doctors predict how quickly patients with CLL might need treatment and how the disease could progress.
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  • Researchers aim to better understand the protein-coding genome due to its importance in human health, while questioning what previous genomic studies may have overlooked regarding non-canonical open reading frames (ncORFs).
  • Over the last ten years, ncORFs have shown potential relevance in human cell types and diseases, but their impact on the human proteome was previously unclear, prompting a collaborative effort to analyze their protein-level evidence.
  • The study found that 25% of analyzed ncORFs contribute to translated proteins, resulting in over 3,000 new peptides from extensive mass spectrometry data, and established an annotation framework and public tools to support ongoing research in this area.
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Long-term memory formation for voices during sleep in three-month-old infants.

Neurobiol Learn Mem

November 2024

Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, 72076 Tübingen, DE, Germany; Center for Integrative Neuroscience, University of Tübingen, 72076 Tübingen, Germany; German Center for Mental Health (DZPG), site Tübingen, Germany. Electronic address:

The ability to form long-term memories begins in early infancy. However, little is known about the specific mechanisms that guide memory formation during this developmental stage. We demonstrate the emergence of a long-term memory for a novel voice in three-month-old infants using the EEG mismatch response (MMR) to the word "baby".

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Long-term effects of dialectical behaviour therapy for posttraumatic stress disorder and cognitive processing therapy 9 months after treatment termination.

Eur J Psychotraumatol

September 2024

Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.

The complexity of posttraumatic stress disorder (PTSD) symptoms related to childhood abuse (CA) present challenges for effective psychotherapeutic treatment. Consequently, there is great interest in the long-term effectiveness of psychological treatments for this population. This study aims to investigate the long-term outcomes of Dialectical Behaviour Therapy for PTSD (DBT-PTSD) and Cognitive Processing Therapy (CPT) 9 months after treatment termination.

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Percutaneous Transcatheter Edge-to-Edge Repair for Functional Mitral Regurgitation in Heart Failure: A Meta-Analysis of 3 Randomized Controlled Trials.

J Am Coll Cardiol

December 2024

Charité-University Medicine Berlin corporate member of Free University Berlin and Humboldt-University Berlin, Berlin, Germany; German Centre for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum Charité, Campus Benjamin Franklin, Berlin, Germany; Berlin Institute of Health, Charité-University Medicine Berlin, Berlin, Germany. Electronic address:

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Robotic-assisted extended thymectomy for large resectable thymoma: 21 years' experience.

J Thorac Cardiovasc Surg

August 2024

Department of Surgery, Competence Center of Thoracic Surgery, Charité Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

Objective: This study aims to evaluate the perioperative and midterm oncological outcomes of robotic-assisted thoracic surgery extended thymectomy for patients with large resectable thymomas compared with small thymomas.

Methods: This retrospective single-center study included 204 patients with thymomas who underwent robotic-assisted thoracic surgery extended thymectomy between January 2003 and February 2024. Patients were divided into 2 groups based on the thymoma size (5-cm threshold).

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Social support from family and friends, albeit associated with beneficial health effects, does not always help to cope with pain. This may be because humans elicit mixed expectations of social support and evaluative judgment. The present studies aimed to test whether pet dogs are a more beneficial source of support in a painful situation than human companions because they are not evaluative.

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Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence.

JAMA Netw Open

August 2024

Division of Social and Preventive Medicine, Department of Sports and Health Sciences, Intrafaculty unit of Cognitive Sciences, Faculty of Human Science, and Faculty of Health Sciences Brandenburg, Research Area Services Research and e-Health, University of Potsdam, Potsdam, Germany.

Importance: The development of an alcohol use disorder in adolescence is associated with increased risk of future alcohol dependence. The differential associations of risk factors with alcohol use over the course of 8 years are important for preventive measures.

Objective: To determine the differential associations of risk-taking aspects of personality, social factors, brain functioning, and familial risk with hazardous alcohol use in adolescents over the course of 8 years.

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