40 results match your criteria: "University Hospital Centre Toulouse[Affiliation]"

Background: Double-jaw surgeries are known to be painful and to require opioids. Maxillary (V2) and mandibular (V3) nerves block could provide adequate pain management with minimal opioid-related side effects. Our main objective was to evaluate the analgesic effect of bilateral ultrasound-guided V2 and V3 combined nerves block in patients undergoing double-jaw orthognathic surgery.

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Background: Data suggest an association between positron emission tomography/CT (PET/CT) metabolic metrics and tumor microenvironment in several malignancies, and a potential role of PET/CT to monitor response to immunotherapy.

Objective: To evaluate the correlation between tumor loco-regional extension and tumor-infiltrating lymphocyte infiltration in locally advanced cervical cancer prior to concurrent chemo-radiotherapy.The secondary objective was to assess the association between tumor-infiltrating lymphocytes and PET/CT metabolic metrics.

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Objective: To determine whether the relative measurement of birth weight (BW) and head circumference (HC) in preterm infants is associated with neurological outcomes.

Methods: The EPIPAGE-2 Study included 3473 infants born before 32 weeks' gestation, classified based on their Z-score of BW and HC on the Fenton curves as concordant (≤1 SD apart) or discordant (>1 SD difference). We defined four mutually exclusive categories: discordant smaller BW (sBW) with BW-1SD and concordant small measurement (CsM) with BW and HC concordant and both ≤-1SD.

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Corticosteroids remain the first-line treatment of immune thrombocytopenia (ITP), but increase the risk of osteoporosis and fractures. Bisphosphonates are used for the treatment of osteoporosis, but their usage among patients with ITP has not been systemically described. We investigated the risk of fractures and the use of bisphosphonates in adult patients with primary (pITP) and secondary ITP (sITP) compared with matched comparators in a nationwide registry-based cohort study.

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Background: NMF are currently poorly evaluated in therapeutic decisions. A quantification of their severity would facilitate their integration. The objective of this study was to validate an autoquestionnaire evaluating the severity of non-motor fluctuations (NMF) in Parkinson's disease (PD).

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Article Synopsis
  • - The SCHOLAR-2 study showed that patients with relapsed/refractory mantle cell lymphoma (MCL) had poor overall survival using standard care after failing a Bruton tyrosine kinase inhibitor.
  • - In the ZUMA-2 trial, the CAR T-cell therapy brexucabtagene autoleucel (brexu-cel) showed high and lasting response rates in similar patients with prior BTKi treatment.
  • - Comparing overall survival rates, brexu-cel significantly outperformed standard care across multiple statistical methods, indicating better survival outcomes for patients with R/R MCL after BTKi failure.
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Multiple molecular diagnoses in the field of intellectual disability and congenital anomalies: 3.5% of all positive cases.

J Med Genet

December 2023

Centre de Génétique et Centre de Référence Anomalies du Développement et Syndromes Malformatifs de l'interrégion Est et FHU TRANSLAD, Centre Hospitalier Universitaire de Dijon Centre de Genetique, Dijon, France.

Article Synopsis
  • - The study investigates the increasing frequency of multiple molecular diagnoses (MMDs) in individuals with congenital anomalies/intellectual disability (CA/ID) through clinical exome/genome sequencing, highlighting rates between 1.8% to 7.1% previously documented.
  • - Out of 880 positive exome sequencing diagnoses analyzed from 2014 to 2021, MMDs were found in 3.5% of cases, with additional potential MMDs identified in 4.4% of individuals, indicating their significance in disease comprehension.
  • - Emphasizing the necessity for reanalysis of sequencing data and collaboration among clinicians and biologists, the study underlines the importance of updated clinical information and enhanced bio
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Prevalence and impact of recreational drug use in patients with acute cardiovascular events.

Heart

October 2023

Department of Cardiology, Hôpital Lariboisière, Assistance Publique - Hopitaux de Paris, Université Paris Cité, INSERM U 942, Paris, France

Article Synopsis
  • The study investigated the prevalence of recreational drug use among patients admitted to intensive cardiac care units (ICCU) and its effect on major adverse events (MAEs) during hospitalization.
  • Out of 1499 patients tested, 11% were positive for recreational drugs, with cannabis being the most common, yet only 57% self-reported their use.
  • Patients using recreational drugs experienced significantly higher rates of in-hospital MAEs compared to non-users, with drugs like cannabis, cocaine, and MDMA showing independent associations with worse outcomes.
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Benralizumab for eosinophilic granulomatosis with polyangiitis.

Ann Rheum Dis

December 2023

Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hospital Cochin, Paris, France

Background: Benralizumab is effective in the treatment of eosinophilic asthma and is being investigated for the treatment of other eosinophil-associated diseases. Reports on the use of benralizumab for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA) are limited to case reports and small case series.

Methods: We conducted a multicentre, retrospective study including EGPA patients treated with off-label benralizumab.

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Over the last 10 years, there has been a rise in neurointerventional case complexity, device variety and physician distractions. Even among experienced physicians, this trend challenges our memory and concentration, making it more difficult to remember safety principles and their implications. Checklists are regarded by some as a redundant exercise that wastes time, or as an attack on physician autonomy.

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Background: Management of macroscopic local recurrence (MLR) after radical prostatectomy is a challenging situation with no standardized approach.

Objective: The objective of our study was to assess the efficacy and safety of functional image-guided salvage radiotherapy (SRT) in patients with MLR in the prostate bed.

Design, Setting, And Participants: In this international multicenter retrospective study across 16 European centers, eligible patients were initially treated by radical prostatectomy (RP) with or without pelvic lymph node dissection for localized or locally advanced adenocarcinoma of the prostate.

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Objectives: The TRI-SCORE reliably predicts in-hospital mortality after isolated tricuspid valve surgery (ITVS) on native valve but has not been tested in the setting of redo interventions. We aimed to evaluate the predictive value of the TRI-SCORE for in-hospital mortality in patients with redo ITVS and to compare its accuracy with conventional surgical risk scores.

Methods: Using a mandatory administrative database, we identified all consecutive adult patients who underwent a redo ITVS at 12 French tertiary centres between 2007 and 2017.

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Article Synopsis
  • Intravenous thrombolysis (IVT) combined with mechanical thrombectomy (MT) for patients with M2 occlusions shows a significantly better 90-day functional outcome compared to MT alone, according to a study analyzing data from the Endovascular Treatment in Ischemic Stroke (ETIS) registry.
  • The analysis included 1,132 patients, with 570 receiving prior IVT, and found that combining IVT with MT resulted in a 59.8% favorable outcome versus 44.7% for MT alone, without increasing complications.
  • These findings suggest that administering IVT prior to MT in M2 occlusions could enhance patient recovery, highlighting the potential benefits of this combined treatment approach.
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Association of intravenous thrombolysis and pre-interventional reperfusion: a post hoc analysis of the SWIFT DIRECT trial.

J Neurointerv Surg

November 2023

University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern Inselspital, University of Bern, Bern, Switzerland

Background: A potential benefit of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT) is pre-interventional reperfusion. Currently, there are few data on the occurrence of pre-interventional reperfusion in patients randomized to IVT or no IVT before MT.

Methods: SWIFT DIRECT (Solitaire With the Intention For Thrombectomy Plus Intravenous t-PA vs DIRECT Solitaire Stent-retriever Thrombectomy in Acute Anterior Circulation Stroke) was a randomized controlled trial including acute ischemic stroke IVT eligible patients being directly admitted to a comprehensive stroke center, with allocation to IVT with MT versus MT alone.

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Aims: Pharmacovigilance signals of heart failure (HF) following exposure to protein kinase inhibitors (PKIs) have been detected in recent years. Our aim was to identify the PKIs most frequently associated with the development of HF.

Methods: Using the French National Healthcare Database, all patients newly exposed to a PKI between January 2011 and June 2014 were followed up for 18 months.

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Introduction: Pharmacotherapy is an important component of the multimodal treatment of attention-deficit/hyperactivity disorder (ADHD). Cardiovascular safety of medications for ADHD is of concern from a clinical and public health standpoint. We aim to conduct a network meta-analysis (NMA) comparing the effects of available medications for ADHD on blood pressure (diastolic and systolic), heart rate and ECG parameters over the short-term and long-term treatment.

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The results of this study confirm the difficulties experienced by patients in the oral sphere. They also show that patients are able to adapt and that their demands go beyond functional rehabilitation. This work should encourage dental practitioners to be part of the overall management of the disease, involving regular checkups, preventive dental measures, and oral hygiene education.

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Patterns of opioid analgesic prescribing in cancer outpatients during the last year of life in France: A pharmacoepidemiological cohort study based on the French health insurance database.

Therapie

December 2022

Medical and Clinical Pharmacology Unit, University Hospital Centre Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France; Clinical Investigation Center (CIC) 1436, University Hospital Centre Toulouse, 31059 Toulouse cedex 9, France; Equipe Pharmacologie en Population, cohorteS, biobanqueS, PEPPS, Toulouse University, 31000 Toulouse, France.

Article Synopsis
  • - This study analyzed pain management in cancer patients during their last year of life, focusing on how often they were prescribed weak and strong opioids and what factors influenced late initiation of strong opioids.
  • - Out of 4704 cancer outpatients studied, 63.8% received opioid prescriptions, with 52.3% using weak opioids and 36.8% strong opioids, noting distinct timelines between initiation and death for each type.
  • - It was found that patients dying at home were more likely to start strong opioids late, and factors like age, social circumstances, and prior opioid use were linked to this delayed prescription, particularly for outpatient deaths.
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A 65-year-old woman reported orbital symptoms two days after her first dose and presented exacerbation of signs after the second dose of BNT162b2 mRNA vaccine. The temporal relationship between the COVID-19 vaccination and orbital symptoms suggests a probable link between SARS-CoV-2 mRNA vaccine and this orbital inflammatory disease.

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Thrombectomy in basilar artery occlusions: impact of number of passes and futile reperfusion.

J Neurointerv Surg

May 2023

Department of Diagnostic and Interventional Neuroradiology, CHRU Nancy, Nancy, Lorraine, France.

Background: The number of mechanical thrombectomy (MT) passes is strongly associated with angiographic reperfusion as well as clinical outcomes in patients with anterior circulation ischemic stroke. However, these associations have not been analyzed in patients with basilar artery occlusion (BAO). We investigated the influence of the number of MT passes on the degree of reperfusion and clinical outcomes, and compared outcome after ≤3 passes versus >3 passes.

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Article Synopsis
  • Endovascular treatment (EVT) for blocked arteries in the brain (basilar artery occlusions) doesn't always lead to good results, even if doctors successfully restore blood flow.
  • A study looked at data from stroke patients in France and found that many patients didn’t have a good recovery after treatment, even when their blood flow was restored.
  • Factors like age, stroke severity, and the type of successful blood flow restoration were important in predicting how well patients would do after treatment.
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