5 results match your criteria: "University Hospital Center Gabriel Montpied[Affiliation]"
Expert perspectives for transoral robotic versus laser surgery for supraglottic carcinomas.
Eur Arch Otorhinolaryngol
November 2024
Department of Otolaryngology-Head & Neck Surgery, Foch Hospital, Suresnes, France.
Article Synopsis
- The study aimed to gather insights from international experts on the efficacy and challenges of two minimally invasive surgical techniques, transoral laser microsurgery (TLM) and transoral robotic surgery (TORS), for treating supraglottic laryngeal tumors.
- A survey was conducted with 27 head and neck surgeons, finding that TLM generally took less setup time compared to TORS, although both techniques faced concerns about bleeding during surgery, particularly with TLM.
- Experts viewed TLM and TORS as largely equal in effectiveness, but noted that TORS offered better control over bleeding and improved visibility during the procedure.
The Identification of Large Rearrangements Involving Intron 2 of the Gene in Negative and Breast Cancer Susceptibility.
Genes (Basel)
November 2022
Department of Biology and Pathology, Laboratory of Cancer Genetics Institut Gustave Roussy, 94805 Villejuif, France.
E-cadherin, a gene product, is a calcium-dependent cell-cell adhesion molecule playing a critical role in the establishment of epithelial architecture, maintenance of cell polarity, and differentiation. Germline pathogenic variants in the gene are associated with hereditary diffuse gastric cancer (HDGC), and large rearrangements in the gene are now being reported as well. Because pathogenic variants could be associated with breast cancer (BC) susceptibility, rearrangements could also impact it.
View Article and Find Full Text PDFPostoperative SBRT in the treatment of early-stage oropharyngeal and oral cavity cancers with high-risk margins: A dosimetric comparison of volumetric modulated arc therapy with or without non-coplanar arcs and acute toxicity outcomes from the STEREOPOSTOP GORTEC 2017-03 phase 2 trial.
Clin Transl Radiat Oncol
January 2023
Department of Radiation Oncology, Centre Jean Perrin, Clermont-Ferrand, France.
Background And Purpose: The STEREO POSTOP GORTEC 2017-03 phase 2 trial (NCT03401840) evaluates postoperative stereotactic body radiotherapy (SBRT) in case of high-risk margins for pT1-T2/N0 oropharyngeal and oral cavity tumors. The present ancillary study aimed to compare the dosimetric impact of adding non-coplanar arcs to the volumetric modulated arc therapy (VMAT) technique and to evaluate acute toxicities on the first patients included in this trial.
Materials And Methods: Ten patients were included.
A multicenter prospective phase II study of postoperative hypofractionated stereotactic body radiotherapy (SBRT) in the treatment of early-stage oropharyngeal and oral cavity cancers with high risk margins: the STEREO POSTOP GORTEC 2017-03 trial.
BMC Cancer
August 2020
Department of Radiotherapy, Jean Perrin Centre, 58 rue Montalembert, BP 5026, 63011, Cedex 1, Clermont Ferrand, France.
Article Synopsis
- The study focuses on treating early-stage oropharyngeal and oral cavity cancer using a method called SBRT, especially for patients with high-risk margins after surgery.
- It’s a clinical trial involving 90 patients to see if this new radiation treatment causes fewer severe side effects over two years compared to traditional methods.
- The trial started in 2018 and will continue until January 2024, and they're checking various effects like survival rates and quality of life for the patients.
Efficacy of pentoxifylline-tocopherol-clodronate in mandibular osteoradionecrosis.
Laryngoscope
November 2020
Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Center Gabriel Montpied, Clermont-Ferrand, France.
Objectives/hypothesis: PENTOCLO treatment, associating pentoxifylline, tocopherol, and clodronate, resolves radiation-induced fibrosis. The main aim of the present study was to prospectively assess efficacy in mandibular osteoradionecrosis (ORN).
Study Design: Prospective cohort study.