16 results match your criteria: "University Hospital (AOU) of Sassari[Affiliation]"

Psoriatic arthritis (PsA), a chronic autoimmune disease of unclear aetiology, is associated with dysregulated angiogenesis due to the proliferation, migration, and differentiation of endothelial cells. Vascular endothelial growth factor (VEGF) plays a key role such that PsA patients exhibit skin and joint symptoms, e.g.

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Background: Rheumatic diseases (RDs) include a broad group of disabling conditions with different phenotypes, from autoimmune to autoinflammatory, degenerative, metabolic or mixed manifestations. With the continuous efforts to identify therapeutic targets for new biologic drugs to treat overt clinical manifestations, research is also focusing on the discovery of new biomarkers to diagnose and manage early disease stages. In this context, we conducted a systematic review and meta-analysis of Fetuin-A (FtA), a glycoprotein synthesized by the liver that participates in several biological processes and has been proposed as a biomarker for several disorders, including rheumatoid arthritis.

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Aim: Vascular endothelial growth factor (VEGF) is linked to inflammation and angiogenesis, indicating a possible role in inflammatory bowel disease (IBD) and its main clinical manifestations, Crohn's disease (CD) and ulcerative colitis (UC). This systematic review and meta-analysis investigated studies assessing circulating VEGF concentrations in IBD patients and healthy controls, considering the effect of IBD type, sample type and geographical location.

Methods: A systematic search identified 18 studies (28 group comparators) investigating 1741 IBD patients and 1291 controls.

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  • Breast cancer (BC) is the most common cancer in women and a major cause of cancer-related deaths; this systematic review and meta-analysis examined the roles of specific adipokines—resistin, omentin, and ghrelin—in BC.
  • The analysis of 11 studies indicated that BC patients had significantly higher levels of resistin compared to healthy controls, while the findings regarding omentin and ghrelin were inconclusive and showed substantial variability.
  • The study suggests that resistin may play a role in the development of BC and highlights the need for further research with larger, well-designed studies to better understand the implications of these adipokines in breast cancer pathology.
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Background: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), poses a significant challenge to health care systems because of its chronic nature and increasing global prevalence. Effective management of IBD requires accurate diagnostic tools and biomarkers. This systematic review and meta-analysis aimed to evaluate the relationship between bilirubin concentrations and IBD activity and outcomes.

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Adipose-derived stem cells (ADSCs) are promising in regenerative medicine. Their proliferation, survival and activation are influenced by specific signals within their microenvironment, also known as niche. The stem cell niche is regulated by complex interactions between multiple cell types.

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  • This systematic review and meta-analysis explores the link between haemoglobin (Hb) levels and obstructive sleep apnea syndrome (OSAS), analyzing data from various study designs.
  • A total of 27 studies with 6,499 OSAS patients and 5,199 controls were included, showing that Hb concentrations were significantly higher in OSAS patients, particularly those with severe OSAS.
  • Despite these findings, there were inconsistencies in results across some studies and the need for further research in diverse populations is emphasized due to potential bias and variability in methodologies.
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Background: Among the Pentraxins, the long Pentraxin-3 (PTX-3) is associated with several processes, particularly in the earliest phases of the innate humoral response. Increased blood PTX-3 concentrations have been observed in a wide range of conditions, from infectious to cardiovascular disorders. Since its increase is more rapid than C-reactive protein (CRP), PTX-3 can be useful to detect and monitor early inflammation.

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Background: MAURIS is an Italian multicenter, open-label, phase IIIb ongoing trial, aiming at evaluating the safety and effectiveness of atezolizumab + carboplatin/etoposide in patients with newly diagnosed, extensive-stage small-cell lung cancer (ES-SCLC). The primary objective is the safety evaluation.

Materials And Methods: Patients received atezolizumab + carboplatin/etoposide Q3W for 4-6 cycles in the induction phase, followed by atezolizumab maintenance Q3W.

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  • Neuroendocrine neoplasms (NENs) are rare tumors, and existing databases like SEER are outdated due to recent advancements in diagnostics and treatments, prompting the need for updated information.
  • In 2019, the Italian Association for Neuroendocrine Tumors (Itanet) launched a nationwide database to collect data on gastroenteropancreatic NENs from 37 Italian centers, focusing on details like age, diagnostics, tumor stage, and treatments.
  • By October 2023, the database has recorded data from 1,600 patients, with plans to reach 3,600 by the end of 2025, aiming to improve understanding of GEP-NENs and enhance patient
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Combined indices of different haematological cell types appear to be particularly promising for investigating the link between systemic inflammation and coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to assess the aggregate index of systemic inflammation (AISI), an emerging index derived from neutrophil, monocyte, platelet, and lymphocyte counts, in hospitalized COVID-19 patients with different disease severity and survival status. We searched electronic databases between the 1st of December 2019 and the 10th of June 2023 and assessed the risk of bias and the certainty of evidence.

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Cutaneous angiosarcoma (CAS) is the most common type of angiosarcoma that predominantly affects older Caucasians. The outcomes of immunotherapy in CAS are currently under investigation in relation to the expression of programmed death ligand 1 (PD-L1) and other biomarkers. We performed a systematic review and metanalysis of data from the current literature reporting on PD-L1 immunohistochemistry expression.

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Oncogenic mutations in the gene are targets of tyrosine kinase inhibitors (TKIs) in lung adenocarcinoma (LC) patients, and their search is mandatory to make decisions on treatment strategies. Liquid biopsy of circulating tumour DNA (ctDNA) is increasingly used to detect EGFR mutations, including main activating alterations (exon 19 deletions and exon 21 L858R mutation) and T790M mutation, which is the most common mechanism of acquired resistance to first- and second-generation TKIs. In this study, we prospectively compared three different techniques for mutation detection in liquid biopsies of such patients.

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Duration of Immunotherapy in Non-Small Cell Lung Cancer Survivors: A Lifelong Commitment?

Cancers (Basel)

January 2023

Medical Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori Monza, 20900 Monza, Italy.

Lung cancer is one of the most common human malignancies and the leading cause of cancer-related death worldwide. Novel therapeutic approaches, like targeted therapies against specific molecular alterations and immunotherapy, have revolutionized in the last decade the oncological outcomes in patients affected by non-small cell lung cancer (NSCLC). The advent of immunotherapy for the treatment of NSCLC has significantly improved overall and progression-free survival, as well as the patient's quality of life in comparison to traditional chemotherapy.

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Lung cancer is one of the most common and lethal cancers worldwide. Numerous medications targeting specific molecular alterations in non-small cell lung cancer have been introduced in the last decade and have revolutionized the clinical management of the disease. Their use has brought to a parallel evolution of molecular testing techniques to identify alterations in druggable molecular targets within the genetic material of the tumors.

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NGS-Based Analysis of Atypical Deep Penetrating Nevi.

Cancers (Basel)

June 2021

Section of Pathological Anatomy, Department of Health Sciences, University of Florence, 50121 Firenze, Italy.

Deep penetrating nevi (DPNs) are rare melanocytic neoplasms consisting of pigmented spindled or epithelioid melanocytes with a distinctive wedge-shaped configuration showing activation of the WNT pathway, with unusual cyto-architectural features. It is unclear whether they show a distinct genomic profile associated with a diverse metastatic potential. We describe herein a cohort of 21 atypical DPNs analyzed by next-generation sequencing using the Ion AmpliSeq™ Comprehensive Cancer Panel.

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