585 results match your criteria: "University Hospital 'ATTIKON'[Affiliation]"

Article Synopsis
  • * Out of 130 patients with definite ST, 45 underwent ICI, and the analysis found that ICI-guided management improved survival rates free of cardiac death or target lesion revascularization (CD-TLR) at 2 years to 93% compared to 73% for those not guided by ICI.
  • * The results suggest that ICI can significantly influence treatment decisions, leading to better outcomes in patients with ST, particularly by identifying the main mechanisms causing thrombosis.
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"Bubbly lung", a honeycombing variant with more favorable outcome.

Respir Investig

November 2024

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 1st St. SW Rochester, MN 55905, Rochester, MN, USA.

Background: Although radiologic honeycombing is generally associated with progressive fibrosis and a dismal prognosis, some patients display an unexpectedly indolent clinical course. We aimed to assess for variants of honeycombing associated with a more favorable prognosis.

Methods: A computer-assisted search was conducted to identify patients encountered at Mayo Clinic from 1998 to 2022 who had undergone chest CT that manifested exuberant honeycombing.

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Article Synopsis
  • The study explores the relationship between serum chloride levels and clinical outcomes in patients with acute heart failure undergoing treatment with acetazolamide, highlighting its role in renal salt sensing.
  • Results showed that low chloride levels (hypochloremia) were linked to slower recovery, longer hospital stays, and higher risks of mortality and readmissions, while high chloride levels (hyperchloremia) were also noted but less common.
  • Acetazolamide was found to improve decongestion and prevent chloride levels from dropping, aiding patients regardless of their initial serum chloride status, which suggests its potential benefits in managing heart failure.
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Article Synopsis
  • - The study evaluated the effectiveness of patiromer, a drug used to manage high potassium levels (hyperkalemia), in patients with heart failure and chronic kidney disease, especially focusing on its benefits when used alongside RAAS inhibitors.
  • - Results showed that patiromer was particularly effective in controlling serum potassium levels in patients with more advanced chronic kidney disease (CKD), without increasing the risk of adverse effects.
  • - The research concluded that patiromer allows for safer use of RAAS inhibitors in patients with heart failure, especially those with lower estimated glomerular filtration rates (eGFR), while minimizing hyperkalemia risk.
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  • Pulmonary alveolar proteinosis (PAP) is a rare lung syndrome characterized by the accumulation of proteinaceous material, leading to symptoms like progressive dyspnea and hypoxemia, with various diagnostic methods such as CT scans, bronchoalveolar lavage, and genetic testing suggested for evaluation.
  • A European Respiratory Society Task Force, comprised of diverse experts, developed evidence-based guidelines for diagnosing and managing PAP using a systematic review of literature and the GRADE approach for assessing the strength of recommendations.
  • The Task Force provided specific management recommendations, including whole lung lavage, GM-CSF therapy, and potential treatments like rituximab, alongside diagnostic approaches involving GM-CSF antibody
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Article Synopsis
  • Scientists wanted to see how different storage solutions affect blood platelets that are treated to kill germs.
  • They tested platelets stored in plasma and Platelet Additive Solutions (PAS) from the same donors and checked their health on days 1, 3, and 5.
  • Results showed that PAS kept the platelets healthier than plasma, but both types had less ability to stop bleeding over time.
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Article Synopsis
  • The study examined heart failure patients with initially low ejection fractions who later showed improvement, identifying about 20% of these individuals achieving a significant increase in heart function after 9 months.* -
  • Patients with improved ejection fraction experienced lower rates of rehospitalization and mortality compared to those with persistently low function, with consistent results found in two separate patient registries.* -
  • Five key predictors for improvement were identified: female sex, absence of ischemic heart disease, higher initial ejection fraction, and smaller heart sizes, allowing the development of a predictive model to better assess who may improve.*
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Purpose: Tetralogy of Fallot (TOF) is a congenital heart disease, and patients undergo surgical repair early in their lives. The evaluation of TOF patients is continuous through their adulthood. The use of cardiac magnetic resonance imaging (CMR) is vital for the evaluation of TOF patients.

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This study aims to create a strong binary classifier and evaluate the performance of pre-trained convolutional neural networks (CNNs) to effectively distinguish between benign and malignant ovarian tumors from still ultrasound images. The dataset consisted of 3510 ultrasound images from 585 women with ovarian tumors, 390 benign and 195 malignant, that were classified by experts and verified by histopathology. A 20% to80% split for training and validation was applied within a k-fold cross-validation framework, ensuring comprehensive utilization of the dataset.

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Ischemic bowel disease is considered a high-risk factor for infection from anaerobic bacteria, as the ischemic bowel is the perfect ground for their development. Herein, we present the case of an advance stage colon cancer patient with a rare cause of gastrointestinal bleeding and bacteremia due to , a rare anaerobic Gram-positive bacterium. The patient had presented with several episodes of hematochezia in the context of chronic superior mesenteric-portal vein tumor thrombosis and rupture of ectopic varices, and the bacteremia was an unexpected complication of the bowel ischemia due to a combination of arterial ischemia and venous congestion.

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Background: the objective of this longitudinal study (from pregnancy to the end of the sixth month postpartum) is to elucidate the association between maternal self-efficacy, defined as a mother's confidence in her ability to breastfeed, and breastfeeding outcomes.

Methods: This prospective cohort study was conducted among high-risk pregnant women (including those with conditions such as gestational diabetes, hypertension, pre-eclampsia, and other pathological medical conditions) and normal-risk pregnant women in Greece. The high-risk group included 164 women, while the normal-risk group comprised 154 women.

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Cancer begets atrial fibrillation … and vice versa?

Eur Heart J

July 2024

The Heart Failure and Cardio-Oncology Unit, Department of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens Medical School, 1 Rimini St, Athens, Greece.

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Interdepartmental miscommunication regarding radiology: Addressing chronic challenges and exploring solutions.

World J Radiol

May 2024

Orthopaedics Surgery and Sports Medicine Department, FIFA Medical Centre of Excellence, Croix-Rousse Hospital, Lyon University Hospital, Lyon 69004, France.

Effective communication and collaboration among healthcare professionals are crucial for delivering high-quality patient care. Interdepartmental miscommunication poses a significant challenge to healthcare systems, potentially undermining the quality of healthcare services provided. In the same manner, communication barriers between referring physicians and radiologists can specifically affect radiology services and patient outcomes.

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Despite the progress in the care of individuals with heart failure (HF), important sex disparities in knowledge and management remain, covering all the aspects of the syndrome, from aetiology and pathophysiology to treatment. Important distinctions in phenotypic presentation are widely known, but the mechanisms behind these differences are only partially defined. The impact of sex-specific conditions in the predisposition to HF has gained progressive interest in the HF community.

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One of the World Health Organization's targets for the 2030 viral hepatitis elimination strategy is to reduce new hepatitis C (HCV) infections. In Athens, Greece, people who inject drugs (PWID) have a high HCV prevalence, with increasing trends since the 2000s. This analysis aims to assess primary HCV incidence among PWID during 2012-2020.

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Expression of DNA Repair Genes in Ewing Sarcoma.

Cancer Diagn Progn

May 2024

Division of Pediatric Oncology, First Department of Pediatrics, Aghia Sofia Children's Hospital, Athens, Greece.

Article Synopsis
  • Ewing sarcoma is a serious cancer that mainly affects children and teens, with the EWSR1/FLI1 fusion gene being a common genetic factor, but it hasn’t been targeted for treatment or used to predict outcomes.
  • This study looked at 35 Ewing sarcoma patients to see how DNA repair mechanisms correlate with different clinical features of the disease, focusing on two DNA repair pathways: non-homologous end joining (NHEJ) and homologous recombination (HR).
  • Findings indicate that these repair pathways are disrupted in Ewing sarcoma, and low levels of the XRCC4 gene are linked to better survival, suggesting potential new targets for therapy.
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Introduction: Silent pauses are regarded as integral components of the temporal organization of speech. However, it has also been hypothesized that they serve as markers for internal cognitive processes, including word access, monitoring, planning, and memory functions. Although existing evidence across various pathological populations underscores the importance of investigating silent pauses' characteristics, particularly in terms of frequency and duration, there is a scarcity of data within the domain of post-stroke aphasia.

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Background: Several rare surfactant-related gene (SRG) variants associated with interstitial lung disease are suspected to be associated with lung cancer, but data are missing. We aimed to study the epidemiology and phenotype of lung cancer in an international cohort of SRG variant carriers.

Methods: We conducted a cross-sectional study of all adults with SRG variants in the OrphaLung network and compared lung cancer risk with telomere-related gene (TRG) variant carriers.

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Body mass index and cardiorenal outcomes in the EMPEROR-Preserved trial: Principal findings and meta-analysis with the DELIVER trial.

Eur J Heart Fail

April 2024

Department of Cardiology (CVK) of German Heart Center Charité; German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin, Berlin, Germany.

Aims: Both low and high body mass index (BMI) are associated with poor heart failure outcomes. Whether BMI modifies benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in heart failure with preserved ejection fraction (HFpEF) requires further investigation.

Methods And Results: Using EMPEROR-Preserved data, the effects of empagliflozin versus placebo on the risks for the primary outcome (hospitalization for heart failure [HHF] or cardiovascular [CV] death), change in estimated glomerular filtration rate (eGFR) slopes, change in Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS), and secondary outcomes across baseline BMI categories (<25 kg/m, 25 to <30 kg/m, 30 to <35 kg/m, 35 to <40 kg/m and ≥40 kg/m) were examined, and a meta-analysis conducted with DELIVER.

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