1,052 results match your criteria: "University Hospital "San Giovanni di Dio e Ruggi d'Aragona".[Affiliation]"

Article Synopsis
  • A multicenter study analyzed the effectiveness and safety of intravenous antiplatelet therapies, cangrelor and tirofiban, in STEMI patients undergoing PPCI at seven Italian centers.
  • The primary outcome measured was the incidence of TIMI flow < 3 after the procedure and the risk of bleeding (BARC 2-5) in patients receiving either treatment.
  • Results showed that cangrelor led to better myocardial blood flow post-PPCI compared to tirofiban, without a higher risk of significant bleeding complications.
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The aim of this systematic review was to investigate the outcomes of knee arthrodesis (KA) after periprosthetic joint infection (PJI) of the knee. Differences in clinical outcomes and complication rates among the intramedullary nailing (IMN), external fixation (EF), and compression plating (CP) procedures were compared. A total of 23 studies were included.

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Blinatumomab is a bispecific T-cell engager approved for relapsed/refractory and minimal residual disease positive B-cell Acute Lymphoblastic Leukemia. We conducted a retrospective study evaluating the outcome of Blinatumomab. The impact of clinical and treatment-related variables on cumulative incidence of relapse/progression (CIRP), event-free (EFS) and overall survival (OS) was analyzed.

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Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study.

Cardiovasc Diabetol

April 2024

Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein - Mount Sinai Diabetes Research Center (ES-DRC), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA.

Background: Hypertension and chronic kidney disease (CKD) pose significant public health challenges, sharing intertwined pathophysiological mechanisms. Prediabetes is recognized as a precursor to diabetes and is often accompanied by cardiovascular comorbidities such as hypertension, elevating the risk of pre-frailty and frailty. Albuminuria is a hallmark of organ damage in hypertension amplifying the risk of pre-frailty, frailty, and cognitive decline in older adults.

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Diagnostic Delay of Celiac Disease in Childhood.

JAMA Netw Open

April 2024

First Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Policlinico San Matteo, Pavia, Italy.

Article Synopsis
  • The study investigates the diagnostic delay experienced by pediatric patients with celiac disease across 13 referral centers in Italy, covering cases from 2010 to 2019 and analyzing data in 2023.
  • It finds that the median diagnostic delay for these patients is about 5 months, with a notable portion experiencing extreme delays of 11 months or more.
  • Factors such as age at diagnosis influence delays, with younger patients (under 3 years) generally facing shorter wait times for diagnosis.
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Liquid biopsy is a minimally invasive diagnostic tool for identification of tumor-related mutations in circulating cell-free DNA (cfDNA). The aim of this study was to investigate feasibility, sensitivity, and specificity of non-invasive prenatal test (NIPT) for identification of chromosomal abnormalities in cfDNA from a total of 77 consecutive patients with non-Hodgkin B-cell lymphomas, Hodgkin lymphoma (HL), or plasma cell dyscrasia. In this case series, half of patients had at least one alteration, more frequently in chromosome 6 (23.

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Introduction: Since COVID-19 patients are often polytreated, monitoring drug-drug interaction (DDIs) is necessary. We evaluated whether drugs used after the second COVID-19 pandemic wave were associated with DDI-related adverse events and the role of drug interaction checkers in identifying them.

Methods: The study (PROSPERO-ID: CRD42024507634) included: 1) consulting the drug interaction checkers Drugs.

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Aortopathy and aortic valve surgery in patients with bicuspid aortic valve with and without raphe.

Int J Cardiol

July 2024

Cardio-Thoracic and Vascular Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy; Department of Vascular Physiopathology, IRCCS Neuromed, Pozzilli (IS), Italy. Electronic address:

Article Synopsis
  • - The study aimed to assess how the presence of raphe (a type of anatomical feature) in patients with bicuspid aortic valve (BAV) correlates with valve dysfunction, aortopathy, and the likelihood of needing aortic valve surgery.
  • - Researchers analyzed 695 BAV patients, finding that those with raphe experienced more moderate to severe aortic stenosis and a higher prevalence of aortopathy, particularly Type B, compared to those without raphe.
  • - The results indicated that having raphe significantly raises the odds of requiring aortic valve surgery within three years, highlighting the importance of monitoring patients with this anatomical feature.
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Objective: The superior eyelid endoscopic transorbital approach (SETOA) provides a direct and short minimally invasive route to the anterior and middle skull base. Nevertheless, it uses a narrow corridor that limits its angles of attack. The aim of this study was to evaluate the feasibility and potential benefits of an "extended" conservative variant of the "standard" endoscopic transorbital approach-termed "open-door"-to enhance the exposure of lesions affecting the paramedian aspect of the anterior and middle cranial fossae.

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Article Synopsis
  • Bicuspid aortic valve (BAV) is the most common congenital heart defect in adults, but it can also lead to serious issues in children.
  • Adults with significant BAV complications before age 30 tend to have more severe symptoms, require more surgeries, and often have additional heart defects compared to those whose BAV issues arise after age 50.
  • This underscores the importance of early detection, ongoing monitoring, and focused treatment strategies for patients experiencing early complications from BAV.
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The Course of the Trochlear Nerve Presented via a 3-Dimensional Photorealistic Anatomic Model.

World Neurosurg

June 2024

Laboratory of Neuroanatomy, EBRIS Foundation, Salerno, Italy; Department of Neurosurgery, Acibadem Cityclinic University Hospital Tokuda, Sofia, Bulgaria; Department of Neurosciences, Reproductive and Odontostomatological Sciences, Neurosurgical Clinic, School of Medicine, University of Naples "Federico II", Naples, Italy; Department of Neurosurgery, San Luca Hospital, Vallo della Lucania, Salerno, Italy; Unit of Neurosurgery, University Hospital San Giovanni di Dio e Ruggi d'Aragona, University of Salerno, Salerno, Italy; Neuroanatomy Committee of the Italian Society of Neurosurgery, SINch, Italy.

Objectives: Several factors contribute to the anatomical complexity of the trochlear nerve, including small diameter, complex and longest intracranial course, deep location, and numerous neurovascular relationships. A 3-dimensional (3D) photorealistic model of the cranial nerves provides a detailed and immersive representation of the anatomy, enabling one to improve surgical planning, advanced surgical research, and training. The purpose of this work is to present a 3D photogrammetric study for a more intuitive and interactive way to explore and describe the entire course of trochlear nerve.

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Congestion is the main therapeutic target of acute heart failure (HF) treatment, and loop diuretics (LDs) are widely used drugs for this purpose. Despite their extensive use, these agents remain largely understudied in terms of modality administration, treatment duration, and escalation dose for subjects responding poorly to therapy. LDs were initially investigated in several edematous statuses such as cirrhosis, nephrotic syndrome, and congestive HF and initially approved for the treatment of cardiogenic congestion in 1966.

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Article Synopsis
  • * A significant complication of CKD is CKD-mineral and bone disorder (MBD), which disrupts bone health and mineral metabolism, causing issues like vascular calcification that are linked to increased cardiovascular risks.
  • * Effective diagnosis and treatment require understanding the connections between mineral metabolism, bone disorders, and vascular calcification, as these factors heavily impact CKD-related morbidity and mortality.
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Aim: The digital transformation of the pathology laboratory is being continuously sustained by the introduction of innovative technologies promoting whole slide image (WSI)-based primary diagnosis. Here, we proposed a real-life benchmark of a pathology-dedicated medical monitor for the primary diagnosis of renal biopsies, evaluating the concordance between the 'traditional' microscope and commercial monitors using WSI from different scanners.

Methods: The College of American Pathologists WSI validation guidelines were used on 60 consecutive renal biopsies from three scanners (Aperio, 3DHISTECH and Hamamatsu) using pathology-dedicated medical grade (MG), professional grade (PG) and consumer-off-the-shelf (COTS) monitors, comparing results with the microscope diagnosis after a 2-week washout period.

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Article Synopsis
  • - Immune-checkpoint inhibitors have significantly transformed cancer treatment by enhancing patient outcomes, but they can trigger immune-related side effects across various organs.
  • - Pulmonary complications from these treatments are common and can be severe, making accurate diagnosis complex due to diverse symptoms and imaging findings.
  • - Radiologists play a crucial role in identifying and diagnosing pulmonary complications early to evaluate their severity and help manage patient treatment effectively.
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Article Synopsis
  • Efficient predictive biomarkers are essential for the success of immune checkpoint inhibitors (ICIs) in treating non-small cell lung cancer (NSCLC), with specific focus on evaluating single nucleotide polymorphisms (SNPs) in PD-L1.
  • The SNP rs822336 shows a strong correlation with positive responses to anti-PD-1/PD-L1 therapy in NSCLC patients, outperforming other SNPs like rs2282055 and rs4143815.
  • The study reveals that rs822336 influences PD-L1 expression through its location in the gene’s promoter/enhancer region, controlled by specific transcription factors (C/EBPβ and NFIC), highlighting its potential as a novel biomarker
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Survival Predictors of Radioiodine-refractory Differentiated Thyroid Cancer Treated With Lenvatinib in Real Life.

J Clin Endocrinol Metab

September 2024

Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, ENETS Center of Excellence, Sapienza University of Rome, 00198, Rome, Italy.

Context: Lenvatinib is approved for the treatment of radioiodine-refractory differentiated thyroid cancer (RR-DTC). The definition of predictive factors of survival is incomplete.

Objective: To identify pre- and posttreatment survival predictors in a real-life cohort of RR-DTC treated with lenvatinib.

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Background: Despite numerous studies, the true scenario of hearing loss in beta-thalassaemia remains rather nebulous.

Materials And Methods: Pure tone audiometry, chelation therapy, demographics and laboratory data of 376 patients (mean age 38.5 ± 16.

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Longevity is rightly considered one of the greatest achievements of modern society, not only as a function of lifespan, but, more importantly, as a function of healthspan. There are Longevity Blue Zones (LBZs), regions around the world, such as in Okinawa, Japan; the Nicoya Peninsula, Costa Rica; Loma Linda, California; Icaria, Greece; and Ogliastra, Sardinia, that are characterized by a significant percentage of residents who live exceptionally long lives, often avoiding age-related disability to a significantly higher degree than in the Western way of life. Longevity is not a universal phenomenon, so if there are places in the world with characteristics similar to the LBZs, it is important to identify them in order to better understand what other factors, in addition to the known ones, might contribute to a long and healthy life.

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Background: Recent data indicate that end-of-life management for patients affected by acute decompensated heart failure in cardiac intensive care units is aggressive, with late or no engagement of palliative care teams.

Objective: To assess current palliative care and end-of-life practices in a contemporary Italian multicenter registry of patients with cardiogenic shock due to acute decompensated heart failure.

Methods: A survey-based approach was used to collect data on palliative care and end-of-life management practices.

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Cenobamate (CNB) is a new anti-seizure medication (ASM) recently introduced in clinical practice after approval by the FDA and EMA for the add-on treatment of focal onset seizures in adult patients. Although its mechanism of action has not been fully understood, CNB showed promising clinical efficacy in patients treated with concomitant ASMs. The accessibility of CNB could pave a way for the treatment of refractory or drug-resistant epilepsies, which still affect at least one-third of the patients under pharmacological treatment.

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Perceptions and Expectations of Youth Regarding the Respect for Their Rights in the Hospital.

Children (Basel)

February 2024

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Pediatrics Section, University of Salerno, 84081 Baronissi, Italy.

Information obtained from children themselves regarding the characteristics of the ideal hospital that ensure well-being during a hospital stay is scarce. Here, we report the opinions, perceptions, and expectations of 700 children and adolescents about their experiences, assessed through a mixed-method research approach with age-appropriate questionnaires, three open-ended questions, and an analysis of optional pictorial and textual narratives. Most children indicated that, while they acknowledged the expertise of hospital staff, they also noted several shortcomings, e.

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Background: The role for the transradial approach for mechanical thrombectomy is controversial. We sought to compare transradial and transfemoral mechanical thrombectomy in a large multicenter database of acute ischemic stroke.

Methods: The prospectively maintained Stroke Thrombectomy and Aneurysm Registry (STAR) was reviewed for patients who underwent mechanical thrombectomy for an internal carotid artery (ICA) or middle cerebral artery M1 occlusion.

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Article Synopsis
  • Tuberculosis (TB) is a major global health threat, and understanding the genetic background and drug resistance of Mycobacterium tuberculosis (MTB) is crucial for effective management of the disease.
  • A study collected 159 MTB genomes from the Campania region between 2018-2021, revealing that 81.11% belonged to lineage 4, a common strain in the area.
  • While most strains (87.4%) were drug-susceptible, 12.58% exhibited drug resistance, including 8 isoniazid-resistant and 4 multidrug-resistant cases, enhancing knowledge for future TB research and management.
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Oxidative Stress in Atopic Dermatitis and Possible Biomarkers: Present and Future.

Indian J Dermatol

January 2024

From the Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

Oxidative stress is important in the pathogenesis of atopic dermatitis (AD); it can damage keratinocytes, increase dermal inflammation, and reduce skin barrier function, the hallmarks of atopic dermatitis pathogenesis. Measuring oxidative stress is possible by identifying peripheral markers, which could have a predictive value of disease severity, disease progression and response to therapy, with a potentially significant impact on patient management. Our review explored this fascinating field of research, focusing on old and new possible biomarkers that may represent an effective tool to investigate the inflammatory-oxidative axis in AD, adding clinically important information to patient care.

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