25 results match your criteria: "University Health and Indiana University School of Medicine[Affiliation]"
Pediatr Crit Care Med
December 2024
Division of Pediatric Critical Care, Department of Pediatrics, Riley Hospital for Children at Indiana, University Health and Indiana University School of Medicine, Indianapolis, IN.
Urology
December 2024
Department of Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA; Department of Urology, Indiana University Health and Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:
Objectives: To determine whether the area deprivation index (ADI), a surrogate for socioeconomic status (SES) associated with patient residence, affected UTUC staging, recurrence rates, and mortality.
Methods: Patients undergoing radical nephroureterectomy or ureterectomy for UTUC at a single institution between February 2010 to August 2021 were classified by ADI. A 50 percentile cut-off of ADI classified patients as "advantaged" or "disadvantaged.
Circ Cardiovasc Imaging
December 2024
Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.).
Chest
November 2024
Department of Anesthesiology and Critical Care, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA.
Background: The 2023 International Pediatric Ventilator Liberation Clinical Practice Guidelines provided evidence-based recommendations to guide pediatric critical care providers on how to perform daily aspects of ventilator liberation. However, because of the lack of high-quality pediatric studies, most recommendations were conditional based on very low to low certainty of evidence.
Research Question: What are the research gaps related to pediatric ventilator liberation that can be studied to strengthen the evidence for future updates of the guidelines?
Study Design And Methods: We conducted systematic reviews of the literature in eight predefined Population, Intervention, Comparator, Outcome (PICO) areas related to pediatric ventilator liberation to generate recommendations.
J Perinatol
December 2024
Center for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Background: Daily serum creatinine monitoring protocols for acute kidney injury (AKI) are invasive and may lead to surveillance resistance. We aimed to understand if use of urine neutrophil gelatinase-associated lipocalin (uNGAL) could increase high-risk nephrotoxic medication (NTMx) associated AKI screening adherence in neonates.
Methods: Statistical process control methods prior to and post implementation were trended.
Brain Circ
June 2023
Pediatric Neurosurgery, Oklahoma University, Oklahoma Children's Hospital, Oklahoma, United States.
Spinal cord infarctions in children are rare and early magnetic resonance imaging studies are often negative. A high clinical suspicion must be maintained to identify stroke and initiate workup for underlying etiology to suggest appropriate treatment. We present two cases of spinal cord infarction without major preceding trauma.
View Article and Find Full Text PDFJAMA Pediatr
August 2023
Department of Anesthesiology and Critical Care, Children's Hospital Los Angeles, Los Angeles, California.
Importance: Extubation failure (EF) has been associated with worse outcomes in critically ill children. The relative efficacy of different modes of noninvasive respiratory support (NRS) to prevent EF is unknown.
Objective: To study the reported relative efficacy of different modes of NRS (high-flow nasal cannula [HFNC], continuous positive airway pressure [CPAP], and bilevel positive airway pressure [BiPAP]) compared to conventional oxygen therapy (COT).
Respir Care
October 2023
Division of Pediatric Critical Care, Department of Pediatrics, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis, Indiana.
Background: The Critical Care Societies Collaborative included not ordering diagnostic tests at regular intervals as one of their Choosing Wisely initiatives. A reduction in unnecessary chest radiographs (CXRs) can help reduce exposure to radiation and eliminate health care waste. We aimed to reduce daily screening CXRs in a pediatric ICU (PICU) by 20% from baseline within 4 months of implementation of CXR criteria.
View Article and Find Full Text PDFClin Lab Med
December 2022
Department of Laboratory Medicine, Deaconess Hospital, 600 Mary Street, Evansville, IN 47747, USA.
Respir Care
March 2023
Division of Pediatric Critical Care, Department of Pediatrics, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis, Indiana.
Background: Adult critical care and radiographical societies have recommended changing practice from routine screening radiographs to on-demand chest radiographs (CXRs) for stable mechanically ventilated adult patients. There are no similar recommendations for patients in the pediatric ICU. Reducing the frequency with which unneeded CXRs are obtained can decrease radiation exposure and reduce waste, a substantial contributor to rising health care costs.
View Article and Find Full Text PDFObjectives: To map the literature regarding assessment of neurocognitive outcomes in PICU survivors. Secondary objectives were to identify literature gaps and to provide data for development of a Core Outcome Measures Set in the domain.
Methods: Planned, analysis was performed of data from an over-all scoping review of Post-Intensive Care Syndrome-pediatrics (PICS-p) functional outcomes.
Ann Am Thorac Soc
January 2023
Department of Anesthesiology and Critical Care, Children's Hospital Los Angeles, Los Angeles, California.
Periextubation corticosteroids are commonly used in children to prevent upper airway obstruction (UAO). However, the best timing and dose combination of corticosteroids is unknown. To compare effectiveness of different corticosteroid regimens in preventing UAO and reintubation.
View Article and Find Full Text PDFJ Pediatr Pharmacol Ther
March 2022
Department of Pharmacy (MLK), Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis, IN.
Intravenous beta-lactam antibiotics are the most prescribed antibiotic class in US hospitalized patients of all ages; therefore, optimizing their dosing is crucial. Bactericidal killing is best predicted by the time in which beta-lactam drug concentrations are maintained above the organism's minimum inhibitory concentration (MIC), rather than achievement of a high peak concentration. As such, administration of beta-lactam antibiotics via extended or continuous infusions over a minimum of 3 hours, rather than standard infusions over approximately 30 minutes, has been associated with improved achievement of pharmacodynamic targets and improved clinical outcomes in adult medical literature.
View Article and Find Full Text PDFAm J Surg Pathol
May 2022
Department of Pathology, Indiana University Health and Indiana University School of Medicine, Indianapolis, IN.
In testicular germ cell tumors (TGCTs), components with nonspecific sarcomatous features that express keratins and glypican 3 are classified as sarcomatoid yolk sac tumor (SYST). SYST is most frequently seen in metastatic sites after chemotherapy. Like so-called "somatic-type" malignancies arising in TGCTs, SYST is markedly resistant to systemic therapy and has a more aggressive clinical course than conventional types of TGCT.
View Article and Find Full Text PDFPediatr Neurol
January 2022
Division of Child Neurology, Department of Neurology, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:
Background: Fetal cerebral sinovenous thrombosis (CSVT) and dural sinus malformation (DSM) are rare types of fetal cerebral venous pathology that are becoming increasingly recognized as fetal imaging advances. Fetal DSMs are a common source of fetal CSVT, although CSVT may occur without a DSM. The literature on these disorders is limited.
View Article and Find Full Text PDFRespir Care
December 2021
Division of Pediatric Critical Care, Department of Pediatrics, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis, Indiana.
Background: In general emergency departments, advanced airway management of pediatric patients who are critically ill has been associated with increased adverse events given the varying exposure to pediatric patients and limited resources. Previous studies have shown significant improvement of simulated pediatric airway management in general emergency departments. The aim of this retrospective study was to determine the effect of an in situ simulation-based collaborative intervention program on the actual care of pediatric airway management in general emergency departments.
View Article and Find Full Text PDFEur J Pediatr
January 2021
Department of Pediatrics, Division of Pediatric Critical Care Medicine, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, 705 Riley Hospital Drive, Phase 2, Room 4900, Indianapolis, IN, 46202-5225, USA.
Pediatric patients with hematological malignancies repeatedly undergo painful bone marrow aspirates and biopsies (BMABs) in routine care. No standard sedation regimen has been established. This study evaluated the addition of injected local lidocaine to a propofol-ketamine sedation for BMAB and its effects on propofol dosing, safety, and efficacy.
View Article and Find Full Text PDFJ Stroke Cerebrovasc Dis
August 2020
Division of Child Neurology, Department of Neurology, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, 705 Riley Hospital Dr. RI 1340, Indianapolis, IN 46202, United States. Electronic address:
ASAIO J
May 2020
From the Division of Pediatric Surgery, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis, Indiana.
J Stroke Cerebrovasc Dis
February 2020
Division of Child Neurology, Department of Neurology, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:
Background: Mechanical thrombectomy for treatment of arterial ischemic stroke (AIS) and cerebral venous thrombosis (CVT) is well-studied in adult populations, but not in children.
Methods: We report 3 new cases of pediatric stroke treated using mechanical thrombectomy. Two cases of AIS and 1 case of CVT were identified from 2018 pediatric stroke clinic records.
Female Pelvic Med Reconstr Surg
August 2018
From the Female Pelvic Medicine Reconstructive Surgery, Indiana University Health and Indiana University School of Medicine, Indianapolis, IN.
Pediatr Res
January 2017
Department of Pediatrics, Section of Critical Care, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis, Indiana.
The management of hypoplastic left heart syndrome (HLHS) has changed substantially over the past four decades. In the 1970s, children with HLHS could only be provided with supportive care. As a result, most of these unfortunate children died within the neonatal period.
View Article and Find Full Text PDFAnn Thorac Surg
January 2016
Sections of Cardiothoracic Surgery, Indiana University Health and Indiana University School of Medicine, Indianapolis, Indiana.
Background: Transcatheter aortic valve replacement (TAVR) is currently offered to patients who are high-risk candidates for conventional surgical aortic valve replacement. For the past 37 years, off-pump aortic valve bypass (AVB) has been used in elderly patients at our center for this similarly high-risk group. Although TAVR and AVB were offered to similar patients at our center, comparisons of clinical outcomes and hospital economics for each strategy were not reported.
View Article and Find Full Text PDFPediatr Crit Care Med
September 2014
1Department of Pediatrics, Division of Critical Care, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI. 2Department of Pediatrics, Section of Pediatric Critical Care Medicine, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis, IN. 3Department of Pediatrics, Division of Quantitative Health Sciences, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI. 4Department of Pediatrics, Division of Hematology, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI. 5Blood Center of Wisconsin, Milwaukee, WI. 6Department of Pediatrics, Division of Infectious Disease, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI.
Objectives: To demonstrate that low-molecular-weight heparin (enoxaparin) can be used in critically ill pediatric patients to achieve target anti-factor Xa concentrations and determine appropriate dosing corrected for age and illness severity.
Design: Retrospective cohort study.
Setting: Single tertiary level PICU.