632 results match your criteria: "University Health Systems[Affiliation]"

This study aimed to explore Singaporean fathers' perceived influence over their children's eating habits. A descriptive qualitative study design was used. Convenience sampling was used to recruit fathers of children aged 3-21 years old from a general paediatric outpatient clinic in a tertiary public hospital.

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Objectives: Fortunately, operating room deaths and unexpected deaths are infrequent occurrences. However, when they occur, the surgeon is called upon to deliver this news to family and loved ones. There is a paucity of literature on this topic and little guidance preparing cardiothoracic surgeons for this important but difficult situation.

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Background: Most Neisseria gonorrhoea (GC) and Chlamydia trachomatis (CT) infections in men who have sex with men (MSM) are diagnosed at extragenital sites. However, testing at these sites is often lacking. The purpose of this study was to determine if a standardized questionnaire administered by physicians and clinical assistants improves documentation of sex activity and increases extragenital testing and diagnoses of GC and CT among MSM.

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Adjunctive rosuvastatin for rifampicin-susceptible pulmonary tuberculosis (rs-PTB) shows no effect on microbiological or radiological outcomes in a phase IIb randomised, controlled trial (NCT04504851). We explore the impact of adjunctive rosuvastatin on 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) imaging in a sub-study of 24 participants. Changes in standardised uptake value (SUVmax, SUVmean), Total Metabolic Volume, (TMV), Total Lesion Glycolysis (TLG), cavity diameter and volume, between week 0 and week 8 post-randomisation, are evaluated.

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Aims: Women with gestational diabetes (GDM) have increased lifetime risk of developing diabetes. We aim to determine the factors contributing to poor adherence of the postpartum oral glucose tolerance test (OGTT) and identify key predictors to postpartum dysglycaemia in our Asian cohort.

Methods: We conducted a retrospective cohort study of women with high-risk GDM (n = 561).

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Teaching NeuroImage: Prognostication of X-Linked Adrenoleukodystrophy Based on the Loes Neuroimaging Score.

Neurology

December 2024

From the Khoo Teck Puat-National University Children's Medical Institute (C.Y.S.L., N.B.H.N., V.H., K.Y.L., J.B.L.), Department of Paediatrics, National University Health Systems; Department of Paediatrics (N.B.H.N., V.H., K.Y.L., J.B.L.), Yong Loo Lin School of Medicine, National University of Singapore; and Department of Diagnostic Imaging (C.Y.), National University Health System, Singapore.

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Poland, Public Health, Chaplains, Clergy, Mindfulness and Prayer.

J Relig Health

December 2024

School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.

This issue commences with a bibliometric analysis of the top 100 most cited articles on religion. It then presents the first of a two-part series relating to research from Poland and progresses to examine the relevance of religion and spirituality to public health. Finally, this issue revisits the long-established and productive discipline of healthcare chaplaincy and various factors relating to parish clergy.

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The rising prevalence of kratom use in the United States has led to increased encounters with individuals who consume kratom and those who develop Kratom Use Disorder (KUD) among healthcare professionals. This case series highlights the need for diverse treatment approaches tailored to the individual motivations for kratom consumption. Three cases are presented: one involving the progression from kratom use for energy to opioid-driven use with subsequent challenges in detoxification and transition to naltrexone necessitating buprenorphine low-dose induction for maintenance; another detailing successful inpatient detoxification using methadone and symptom-driven clonidine, followed by successful maintenance treatment with naltrexone; and a final case involving kratom consumption for pain and anxiety self-management by an individual without a history of addictive disorders, without meeting KUD criteria.

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Adult emergency resuscitative thoracotomy: A Western Trauma Association clinical decisions algorithm.

J Trauma Acute Care Surg

October 2024

From the Department of Surgery (R.T.), University of California, San Francisco, San Francisco, California; Comparative Effectiveness and Clinical Outcomes Research Center (R.C.), Riverside University Health Systems Medical Center, Moreno Valley; Loma Linda University School of Medicine (R.C.), Loma Linda, California; Scripps Memorial Hospital La Jolla (W.L.B.), La Jolla, California; University of Colorado (C.C.B.), Aurora, Colorado; University of Florida College of Medicine (C.A.C.), Gainesville, Florida; University of Maryland School of Medicine (C.F.), Baltimore, Maryland; University of Kansas Medical Center (J.L.H.), Kansas City, Kansas; University of Arizona College of Medicine-Phoenix (N.K.), Phoenix, Arizona; Methodist Dallas Medical Center (M.L.), Dallas, Texas; Division of Acute Care Surgery, Department of Surgery (M.J.M., M.S.), Los Angeles General Medical Center, Los Angeles, California; Division of Vascular Surgery and Endovascular Therapy (G.A.M.), Keck Medical Center of USC, Los Angeles, California; Division of Acute Care Surgery, Department of Surgery (L.J.M.), The University of Texas McGovern Medical School - Houston Red Duke Trauma Institute, Memorial Hermann Hospital, Houston, Texas; Medical University of South Carolina (A.R.P.), North Charleston, South Carolina; Yale School of Medicine (K.M.S.), New Haven, Connecticut; St. Joseph's Hospital and Medical Center (J.A.W.), Phoenix, Arizona; and Program in Trauma (D.M.S.), University of Maryland School of Medicine, Baltimore, Maryland.

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Immune checkpoint inhibitors in advanced gastroesophageal adenocarcinoma: a series of patient-level meta-analyses in different programmed death-ligand 1 subgroups.

ESMO Open

November 2024

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

Background: While the benefit of immune checkpoint inhibitors (ICI) is well established in programmed death-ligand 1 high (PD-L1) advanced gastroesophageal adenocarcinoma (GEAC), there remains significant controversy about their benefit in PD-L1 GEAC. To elucidate the benefit of ICI in PD-L1 and PD-L1 GEAC, we conducted an analysis leveraging individual patient data (IPD) extracted from Kaplan-Meier (KM) plots of pivotal trials.

Methods: KM curves from randomized clinical trials investigating the efficacy of ICI for advanced GEAC were extracted from published articles.

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A cross-sectional study on advance care planning documentation attitudes during national advance care planning week in a South-East Asian country.

BMC Palliat Care

October 2024

Division of Neurosurgery, University Surgical Centre, National University Hospital, Level 8, National University Health Systems Tower Block, 1E Kent Ridge Rd, Singapore, 119228, Republic of Singapore.

Background: Through advocacy initiatives such as roadshows during "National ACP Week", the Agency for Integrated Care (AIC) had increased advance care planning (ACP) engagement since 2011. Project Happy Apples (PHA), a community initiative project led by medical students from the National University of Singapore, also conducted a public exhibition to raise ACP awareness during this period. This study aimed to investigate and identify predictors of attitudes towards ACP documentation among 'ACP Week' respondents which may be used to formulate strategies to increase ACP documentation in Singapore.

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Challenges in the practical implementation of blood biomarkers for Alzheimer's disease.

Lancet Healthy Longev

October 2024

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address:

Blood biomarkers have emerged as accessible, cost-effective, and highly promising tools for advancing the diagnostics of Alzheimer's disease. However, transitioning from cerebrospinal fluid biomarkers to blood biomarkers-eg, to verify amyloid β pathology-requires careful consideration. This Series paper highlights the main challenges in the implementation of blood biomarkers for Alzheimer's disease in different possible contexts of use.

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Nutrition, Chronic Care, Measurement Scales and COVID-19.

J Relig Health

October 2024

School of Psychology and Public Health, La Trobe University, Melbourne, Australia.

In the year of the Olympics (Paris, 2024), this issue of JORH explores nutrition and chronic care, offers a caution regarding the use of religiosity and spiritual measurement scales, and revisits the topic of COVID-19. While the latter has been rapidly declining in terms of its global impact, each of these areas of inquiry generate a great deal of research from which humanity still has much to learn.

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Contact precautions for MRSA and VRE: where are we now? A survey of the Research Network.

Antimicrob Steward Healthc Epidemiol

September 2024

Division of Infectious Diseases, Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

Objective: Contact precautions for methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant (VRE) have limited data on efficacy and have been associated with patient harm. Still, a 2015 (SHEA) Research Network (SRN) survey showed only 7% of hospitals discontinued routine MRSA/VRE contact precautions. The study objectives were to identify the current proportion of hospitals that have discontinued routine MRSA/VRE contact precautions and motivations for change.

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Racial differences in cardiothoracic surgery letters of recommendation.

J Thorac Cardiovasc Surg

September 2024

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pa. Electronic address:

Objective: Cardiothoracic surgery lacks racial diversity. Attracting the best candidates requires valuing diversity and advancing a recruitment process that minimizes racial bias. Implicit bias in recommendation letters has been identified as an influential mechanism for lack of diversity in cardiothoracic surgery.

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Introduction: Pilot studies are important initial steps in research, providing a preliminary assessment of the practicality, feasibility, and potential challenges of a proposed study. This study attempts to assess the feasibility, practicality, and acceptability of a study that integrates a human-animal contact (HAC) questionnaire, animal biodiversity survey using acoustic analysis, and zoonotic disease investigation in animals among rural households in the Central River Region (CRR) of The Gambia. The pilot study revealed granular insights that would otherwise go unnoticed, providing vital information that directly guided the design and implementation of the subsequent full-scale study on zoonotic disease risk.

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Paraneoplastic cast nephropathy, a rare cause of acute kidney injury, is most commonly observed in cases of multiple myeloma and is characterized by the formation of intratubular casts composed of monoclonal light chains. Nonmonoclonal paraneoplastic cast nephropathy has also been reported in patients with pancreatic acinar cell carcinoma or prolactinoma. In this case report, we present a case of polyclonal cast nephropathy in a patient with metastatic acinar cell carcinoma.

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Article Synopsis
  • This study looked at three medications (dupilumab, omalizumab, and mepolizumab) to see how well they help patients with certain sinus problems reduce the need for surgery.
  • All three medications were successful in lowering surgery risks, but only dupilumab also helped reduce hospital visits and other health issues.
  • The results suggest that these medications can help patients feel better and have fewer health problems related to their sinus conditions.
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Objective: Monteggia fracture-dislocation variants have been well documented in adults, but most of the literature in the pediatric population is in the form of case reports. These injuries present differently in children due to the presence of immature radiocapitellar epiphyses and the flexibility of the joint that is more prone to subluxation, contributing to occult presentations and/or misdiagnoses. The purpose of this study is to investigate the outcomes and complications of true Monteggia fracture-dislocations compared with their variants in the pediatric population.

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Article Synopsis
  • There is a need for better second- and third-line treatments for advanced non-small-cell lung cancer (NSCLC) without driver mutations, prompting a clinical trial.
  • The trial involved 559 eligible patients with NSCLC who had failed first-line treatment and tested the effectiveness of docetaxel combined with either plinabulin or a placebo.
  • Results showed that the plinabulin group had a longer median overall survival (10.5 months) compared to the placebo group (9.4 months), with over 99% of patients experiencing treatment-related adverse events.
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Gestational diabetes (GDM), defined as glucose intolerance during pregnancy, affects one in six pregnancies globally and significantly increases a woman's lifetime risk of type 2 diabetes mellitus (T2DM). Being a relatively young group, women with GDM are also at higher risk of developing diabetes related complications (e.g.

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Epidemiology of High-Energy Distal Radius Fractures.

J Hand Surg Asian Pac Vol

October 2024

Department of Hand and Reconstructive Microsurgery, National University Health Systems, Singapore.

Article Synopsis
  • High-energy distal radius fractures, which account for 27.1% of cases studied, differ significantly from more common osteoporotic fractures in terms of demographic and injury characteristics.
  • The primary cause of these fractures is falls from height, with a higher incidence in younger males, particularly those involved in workplace accidents.
  • These injuries are often bilateral and more likely to involve additional upper extremity injuries, indicating that they require distinct clinical management strategies compared to osteoporotic fractures.
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Background: Medical students in Singapore engage in short term medical missions, locally known as Overseas Community Involvement Projects (OCIPs). Little is known about the learning outcomes of an OCIP and how this complements their medical education back home. Understanding this can help the medical educators structure the OCIP to optimise its learning value.

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