18 results match your criteria: "University Health Network. Electronic address: Eric.Horlick@uhn.ca.[Affiliation]"

Aortic Pseudodissection After Stenting of Coarctation of the Aorta.

JACC Cardiovasc Interv

October 2024

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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Transcatheter-Based Interventions for Tetralogy of Fallot Across All Age Groups.

JACC Cardiovasc Interv

May 2024

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

Article Synopsis
  • Tetralogy of Fallot (TOF) is a common congenital heart defect that causes low oxygen levels and can be treated with palliative procedures to improve oxygen saturation.
  • This review explores various catheter-based interventions suitable for different age groups, focusing on palliative treatments such as duct stenting and valvuloplasty for children.
  • It also discusses options for transcatheter pulmonary valve replacement in adults who have had surgical repairs for TOF, particularly for those with enlarged right ventricular outflow tracts.
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Gore atrial septal occluder devices as an option in patients with nickel allergy.

Rev Esp Cardiol (Engl Ed)

August 2024

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto, Canada. Electronic address:

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Article Synopsis
  • This systematic review analyzes the impact of aortic valve calcification (AVC) on outcomes following transcatheter aortic valve implantation (TAVI) by synthesizing different calcium scoring methods.
  • The review included 68 studies, emphasizing variability in calcium scoring protocols, with findings indicating a trend towards increased AVC correlating with negative TAVI outcomes.
  • Key results showed that higher AVC burdens were linked to a greater risk of complications, such as the need for a permanent pacemaker and paravalvular leaks, highlighting that AVC adversely affects TAVI success regardless of quantification techniques used.
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The natural history of an unrepaired isolated partial anomalous pulmonary venous connection(s) (PAPVC) and the absence of other congenital anomalies remains unclear. This study aimed to expand the understanding of the clinical outcomes in this population. Isolated PAPVC with an intact atrial septum is a relatively uncommon condition.

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Short- and Long-Term Outcomes in Patients With Thrombophilia Undergoing Transcatheter Closure of Patent Foramen Ovale.

JACC Cardiovasc Interv

June 2023

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

Article Synopsis
  • - The study investigates outcomes following patent foramen ovale (PFO) closure in patients with and without thrombophilia, using a large clinical database linked to population data in Ontario, Canada.
  • - A total of 669 patients were analyzed, revealing that thrombophilia was present in 26% of cases, but there were no significant differences in procedural complications, emergency visits, or long-term adverse outcomes (such as atrial fibrillation and recurrent cerebrovascular events) between the two groups.
  • - The findings suggest that patients with thrombophilia can safely undergo PFO closure without increased risk of negative outcomes, supporting their inclusion in future clinical trials.
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Background: Patent foramen ovale (PFO) is a congenital heart defect associated with an increased risk of cryptogenic stroke. We aimed to evaluate real-world outcomes of adult patients undergoing transcatheter PFO closure with the Amplatzer PFO Occluder.

Methods: In this single centre, retrospective cohort study, we linked a detailed clinical registry with provincial administrative databases to obtain short and long-term outcomes.

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Incidence of new-onset atrial fibrillation after transcatheter patent foramen ovale closure using 15 years of Ontario administrative health data.

Heart Rhythm

September 2022

Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, University Health Network (UHN), Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

Background: Individuals with patent foramen ovale (PFO) routinely undergo transcatheter closure (TC) for secondary prevention of recurrent stroke. However, some evidence suggests that TC may increase the risk of new-onset atrial fibrillation (AF).

Objective: The purpose of this study was to evaluate the risk of new-onset AF following PFO closure and to explore predictors of AF development.

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Long-Term Outcomes After Atrial Septal Defect Transcatheter Closure by Age and Against Population Controls.

JACC Cardiovasc Interv

March 2021

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, UHN, Toronto, Ontario, Canada. Electronic address:

Objectives: The long-term outcomes after transcatheter closure of atrial septal defects (ASD) in adults are reported and compared between age groups and against population control patients.

Background: ASD is the second most common lesion in congenital heart disease. Comprehensive data on long-term outcomes after ASD closure are limited.

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Percutaneous Pulmonary Valve Replacement: What a Difference a Day Makes.

J Am Coll Cardiol

December 2020

Department of Pediatric Cardiology and Intensive Care, Medical Hospital of the University of Munich, LMU Ludwig Maximilians University Munich, Munich, Germany.

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Periprocedural Outcomes of Fluoroscopy-Guided Patent Foramen Ovale Closure With Selective Use of Intracardiac Echocardiography.

Can J Cardiol

October 2020

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

Background: Recent randomized trials have confirmed the role of patent foramen ovale (PFO) closure in the secondary prevention of cryptogenic stroke. Guidelines have suggested a central role for intraprocedural imaging using intracardiac echocardiography (ICE). However, this modality may not be required to achieve safe and effective closure.

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Incidence and Outcomes of Positive Bubble Contrast Study Results After Transcatheter Closure of a Patent Foramen Ovale.

JACC Cardiovasc Interv

June 2018

Peter Munk Cardiac Centre and Toronto Congenital Cardiac Centre for Adults, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

Objectives: The aim of this study was to assess the incidence of persistently positive results on agitated saline contrast injection after patent foramen ovale (PFO) closure, the underlying mechanism, and management.

Background: Transcatheter intervention to close a PFO is reasonable in highly selected patients younger than 60 years, after a thorough cardioneurological investigation following a cryptogenic stroke, particularly in the presence of thromboembolic disease or in patients at high risk for venous thrombosis. The U.

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Percutaneous Intervention to Treat Platypnea-Orthodeoxia Syndrome: The Toronto Experience.

JACC Cardiovasc Interv

September 2016

Peter Munk Cardiac Centre and Toronto Congenital Cardiac Centre for Adults, Toronto General Hospital, University Health Network. Electronic address:

Objectives: This study reviewed a series of patients treated with transcatheter closure of septal defect to treat platypnea-orthodeoxia syndrome, with specific attention to septal characteristics and device choice.

Background: Platypnea-orthodeoxia syndrome is an uncommon condition characterized by positional dyspnea and hypoxemia due to intracardiac right-to-left shunting through a patent foramen ovale (PFO), an atrial septal defect, or pulmonary arteriovenous malformations. Percutaneous closure of such defects is the treatment of choice.

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Accidental intraventricular placement of a pericardiocentesis catheter is a rare but well-recognized complication. Failure to achieve adequate hemostasis in the ventricular wall on removal of the catheter can potentially result in fatal consequences. Here we describe a case in which a chest drain (10.

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Transcatheter Pulmonary Valve Replacement With the Edwards Sapien System: The Toronto Experience.

JACC Cardiovasc Interv

December 2015

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objectives: This study sought to review the outcomes for the Sapien and Sapien XT valves (Edwards Lifesciences, Irvine, California) for percutaneous pulmonary valve implantation (PPVI).

Background: PPVI has emerged as a viable alternative to surgery in patients with right ventricular (RV) outflow tract dysfunction. Limited data are available for the Sapien and Sapien XT valves in this setting.

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Edwards Sapien XT valve implantation in CoreValve aortic prosthesis to treat severe paravalvular regurgitation.

Int J Cardiol

July 2014

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Canada. Electronic address:

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Evolving trends in interventional cardiology: endovascular options for congenital disease in adults.

Can J Cardiol

January 2014

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada. Electronic address:

As increasing numbers of patients with congenital heart disease enter adulthood, there is a growing need for minimally invasive percutaneous interventions, primarily to minimize the number of repeated surgeries required by these patients. The use of percutaneous devices is commonplace for the treatment of simple lesions, such as atrial septal defect, patent foramen ovale, patent duct arteriosus, and abnormal vascular connections. There is also substantial experience with device closure of membranous and muscular ventricular septal defects, as well as more complex shunts such as baffle leaks after atrial switch repair and ventricular pseudoaneurysms.

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We describe 3 distinct ACHD lesions amenable to percutaneous repair: (1) venous baffle obstruction in transposition of the great arteries, (2) coronary artery fistulas, and (3) ruptured sinus of Valsalva aneurysms. For each entity, we chronicle the typical clinical scenario and indications for intervention to supplement the technical approach and potential pitfalls with treatment.

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