Patent Overview of Innovative Hyaluronic Acid-Based Hydrogel Biosensors.

Hyaluronic acid-based hydrogels are emerging as highly versatile materials for cost-effective biosensors, capable of sensitive chemical and biological detection. These hydrogels, functionalized with specific groups, exhibit sensitivity modulated by factors such as temperature, pH, and analyte concentration, allowing for a broad spectrum of applications. This study presents a patent-centered overview of recent advancements in hyaluronic acid hydrogel biosensors from 2003 to 2023.

Polysaccharide-Based Drug Carriers-A Patent Analysis.

Polysaccharide-based carriers as biomaterials for drug delivery have been inspiring scientists for years due to their exceptional characteristics, such as nontoxicity, biocompatibility, and degradability, as they are able to protect pharmaceutically active molecules and provide their controlled/modified release. This review focuses on selected drug delivery systems based on natural polymers, namely fucoidan, pullulan, dextran, and pectin, with the aim of highlighting published patent documents. The information contained in patents is very important because it is usually not published in any other document and is much less discussed as the state of the art in the scientific literature.

Deep-sea coral habitats off the north atlantic Morocco: Distribution and associated communities.

The recent decline in the health status of deep-sea habitats around the world has pushed the need to document and map their distribution to preserve them in their marine ecosystems. This work describes deep-water coral habitats (133-729 m) and their associated communities, based on nine ROV video transects. These transects cover a 171 km sub-seafloor profile within a predefined 5560 km area along the North Atlantic coast of Morocco, surveyed in 2020 as part of a coral habitat mapping study under the FAO-NANSEN programme.

Evaluation of Glycemic Control in Patients With Diabetes by a Continuous Glucose Monitoring System During the Month of Ramadan.

Introduction: Ramadan presents challenges for patients with type 2 diabetes mellitus (T2DM) who choose to fast. Maintaining good glycemic control through regular monitoring during fasting is crucial. This study aims to evaluate and compare glycemic fluctuations in fasting and non-fasting T2DM patients during Ramadan.

Multi-criteria Bayesian optimization of Empirical Mode Decomposition and hybrid filters fusion for enhanced ECG signal denoising and classification: Cardiac arrhythmia and myocardial infarction cases.

This paper introduces a new advanced model for denoising and classification of ECG signals, focusing on the use of a hybrid filter and Bayesian optimization. The hybrid filter synergistically combines enhanced empirical mode decomposition (EEMD), Chebyshev Type II filters, Butterworth, Daubechies Wavelet, and Savitzky-Golay filters, leveraging their respective advantages for effective noise reduction while preserving the essential features of the ECG signal. We employ a multi-criteria Bayesian optimization process, using cross-correlation and mean squared error (MSE) as key metrics, to refine the filter parameters to further improve the signal quality.

A Study of the Bioactive Compounds, Antioxidant Capabilities, Antibacterial Effectiveness, and Cytotoxic Effects on Breast Cancer Cell Lines Using an Ethanolic Extract from the Aerial Parts of the Indigenous Plant Coss. & Moq.

contain numerous bioactive compounds that provide several advantages, including antioxidant, antibacterial, anticancer, neuroprotective, anti-inflammatory, and antidiabetic characteristics. This study aimed to make a hydroethanolic extract from the aerial part of the plant, analyze its biochemical compounds, and test its biological activities. From HPLC-DAD analysis, cinnamic acid, sinapic acid, and vanillin bioactives were found to be the main compounds in the extract.

Screening for proline‑rich protein 11 gene expression in cervical cancer: Use as a novel diagnostic biomarker and poor prognostic factor.

Cervical cancer is the fourth most common type of cancer affecting the female population worldwide, and it is associated with a late diagnosis and a poor prognosis. It is thus imperative to improve modern diagnostic methods by searching for novel tumor biomarkers, such as proline-rich protein 11 (PRR11), the expression of which is deregulated in various types of cancer and participates in their cellular progression. However, the involvement of PRR11 in cervical cancer has not yet been fully elucidated.

Adenomatous Polyposis Coli (APC) Promoter Gene Methylation in Urine-Derived DNA: A Non-invasive Biomarker for Early Bladder Cancer Detection and Tumor Aggressiveness.

Background Bladder urothelial carcinoma (BLCA) is a major cause of morbidity and mortality worldwide, largely due to the high frequency of disease relapse and the lack of efficient endoscopic diagnostic methods. This study aimed to address this clinical gap by evaluating the potential of using adenomatous polyposis coli (APC) gene promoter methylation as a biomarker detectable in urine DNA of individuals with BLCA. Methods Methylation-specific PCR was used to determine the methylation status of the APC promoter gene in 50 bladder carcinoma patients and 50 apparently healthy individuals.

Immunogenicity of two-dose sinopharm BBIB-CorV vaccine in Morocco: One-year follow-up and neutralizing activity against severe acute respiratory syndrome coronavirus 2 variants of concern.

Background: This study aimed to evaluate the immunogenicity of a two-dose Sinopharm BBIB-CorV (Vero cells) vaccine against SARS-CoV-2, at 28 days, 6 months, and 1-year postvaccination. And assess the capacity of two-dose vaccine recipients to neutralize SARS-CoV-2 strains B.1 (Wuhan/D614G), B.

Early heart disease prediction using feature engineering and machine learning algorithms.

Heart disease is one of the most widespread global health issues, it is the reason behind around 32 % of deaths worldwide every year. The early prediction and diagnosis of heart diseases are critical for effective treatment and sickness management. Despite the efforts of healthcare professionals, cardiovascular surgeons and cardiologists' misdiagnosis and misinterpretation of test results may happen every day.

Mentha aquatica (Water Mint) as a Source of Active Pharmaceutical and Cosmetic Ingredients: A Critical Review.

Mentha aquatica L., or water mint, is an important member of the Mentha genus, and has long been used in traditional medicine, mainly to treat respiratory diseases such as the common cold. Nevertheless, although over the years many studies have shown that it's potential grows beyond this use, a review that highlights M.

Environmentally friendly PtNiCo nanocatalysts enhanced with multi-walled carbon nanotubes for sustainable methanol oxidation in an alkaline medium.

In this study, trimetallic PtNiCo/MWCNT and PtNiCo catalysts were synthesized using a microwave method to reduce the amount of precious Pt. The prepared catalysts were characterized using XRD, TEM, and EDX mapping and their electrochemical performances for methanol oxidation were investigated. The results showed that the MWCNT-supported catalyst showed 2.

Comparative Study Analysis of Epstein-Barr Virus Infection: Tissue Versus Blood Samples in Patients With Prostatic Adenocarcinoma and Its Correlation With Clinicopathological Parameters.

Prostate cancer (PCa) is the most frequently diagnosed cancer and a leading cause of cancer-related mortality in men. The diagnosis and treatment of PCa carry considerable medical, psychological, and economic implications. Among the risk factors contributing to cancer, viral infections, notably Epstein-Barr virus (EBV), play a significant role.

Detection of Staphylococcal Enterotoxins A and E and Methicillin Resistance in Strains From Moroccan Broiler Chicken Meat.

Foodborne epidemics have become a serious public health emergency worldwide. Foods of animal origin, in particular chicken meat, are considered to be potential vectors of pathogenic bacteria, particularly . This bacterium can be resistant in the form of methicillin-resistant (MRSA) or produce enterotoxins leading to food poisoning when ingested.

Assessment of water quality in wells and springs across various districts of Taza City, Morocco.

The aim of this study is to assess groundwater pollution in the city of Taza, Morocco. This was accomplished through hydrochemical and biological investigations, focusing on analyzing the physicochemical and bacteriological parameters of groundwater. Water samples were collected from wells and sources within Taza City on a monthly basis during the spring and summer of 2023.

Reassessment of Electrical and Dielectric Properties in the Borophosphate Glass System: A Promising Solid Electrolyte for High-Temperature Batteries.

This study investigates the conduction mechanism of ternary sodium borophosphate glass 30NaO-(70 - )BO-PO with 0 ≤ ≤ 35 mol % from a different perspective, focusing on previously unreported high-temperature electrical and dielectric properties for potential solid electrolytes in high-temperature batteries. The glass composition with BO/PO = 1 exhibits a conductivity of approximately 10 S/cm at 250 °C. Dielectric analysis supports this improved conduction, showing higher dielectric values and minimal energy dissipation during storage, indicating promising conductivity and favorable dielectric properties.

The Performance of GeneXpert in the Diagnosis of Lymph Node Tuberculosis: A Prospective Study Comparing GeneXpert and Culture Findings.

Background and objective Lymph node tuberculosis (LNTB) is a common manifestation of extrapulmonary tuberculosis (EPTB). GeneXpert is a rapid diagnostic molecular test that simultaneously detects tuberculosis and rifampicin (RIF) resistance. In this study, we aimed to assess the epidemiology of LNTB and diagnostic performance parameters of the GeneXpert in routine ENT practice.

Seed quality as a proxy of climate-ready orphan legumes: the need for a multidisciplinary and multi-actor vision.

In developing countries, orphan legumes stand at the forefront in the struggle against climate change. Their high nutrient value is crucial in malnutrition and chronic diseases prevention. However, as the 'orphan' definition suggests, their seed systems are still underestimated and seed production is scanty.

The impact of fatigue on people with multiple sclerosis in Morocco.

Background: Multiple sclerosis (MS), fatigue is among the leading clinical symptoms. It is one of the most disabling symptoms for most MS people.

Objectives: This research measures the prevalence of fatigue and its impact on the physical, cognitive, and psychosocial abilities of individuals with MS in Morocco.

Mathematical modelling and control approach for sustainable ecosystems in mitigating the impact of pollutants on aquatic species in rivers.

This paper focuses on the urgent issue of minimising the impact of pollutants on aquatic life in river ecosystems. Our innovative approach involves the integration of mathematical modelling and strategic control methods to counteract the negative consequences of industrial and agricultural activities. The model, developed in a one-dimensional context, captures the complex dynamics of species population and pollutant concentration.

Efficient Synthesis, Structural Characterization, Antibacterial Assessment, ADME-Tox Analysis, Molecular Docking and Molecular Dynamics Simulations of New Functionalized Isoxazoles.

This work describes the synthesis, characterization, and in vitro and in silico evaluation of the biological activity of new functionalized isoxazole derivatives. The structures of all new compounds were analyzed by IR and NMR spectroscopy. The structures of and were further confirmed by single crystal X-ray and their compositions unambiguously determined by mass spectrometry (MS).