Effects of Titanium Dioxide Nanoparticles on Porcine Prepubertal Sertoli Cells: An "" Study.

The increasing use of nanomaterials in a variety of industrial, commercial, medical products, and their environmental spreading has raised concerns regarding their potential toxicity on human health. Titanium dioxide nanoparticles (TiO NPs) represent one of the most commonly used nanoparticles. Emerging evidence suggested that exposure to TiO NPs induced reproductive toxicity in male animals.

Ageing Causes Ultrastructural Modification to Calcium Release Units and Mitochondria in Cardiomyocytes.

Ageing is associated with an increase in the incidence of heart failure, even if the existence of a real age-related cardiomyopathy remains controversial. Effective contraction and relaxation of cardiomyocytes depend on efficient production of ATP (handled by mitochondria) and on proper Ca supply to myofibrils during excitation-contraction (EC) coupling (handled by Ca release units, CRUs). Here, we analyzed mitochondria and CRUs in hearts of adult (4 months old) and aged (≥24 months old) mice.

Long-Term Exercise Reduces Formation of Tubular Aggregates and Promotes Maintenance of Ca Entry Units in Aged Muscle.

Tubular aggregates (TAs) in skeletal muscle fibers are unusual accumulation of sarcoplasmic reticulum (SR) tubes that are found in different disorders including TA myopathy (TAM). TAM is a muscular disease characterized by muscle pain, cramping, and weakness that has been recently linked to mutations in and STIM1 and ORAI1 are the two main proteins mediating store-operated Ca entry (SOCE), a mechanism activated by depletion of intracellular Ca stores (e.g.