Neuropsychological test performance in mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis.

Background: We sought to characterize the cognitive profile among individuals with mild cognitive impairment with Lewy bodies (MCI-LB) to help guide future clinical criteria.

Methods: Systematic review and meta-analysis included MCI-LB studies with cognitive data from PubMed, Embase, Web of Science, and PsycINFO (January 1990 to March 2023). MCI-LB scores were compared to controls, MCI due to Alzheimer's disease (MCI-AD), and dementia with Lewy bodies (DLB) groups with random-effects models.

Validation of the Italian consensus recommendations for the biomarker‐based etiological diagnosis of mild cognitive impairment: study design and preliminary data.

Background: In 2020, five Italian scientific societies issued diagnostic recommendations to improve the rational and combined use of biomarkers in the clinical practice of Italian memory clinics (Boccardi et al., 2020). The present project will aim to compare the most frequent diagnostic workups in three academic memory clinics before (pre‐recommendations: January 2018 ‐ December 2019) and after (post‐recommendations: October 2022 ‐ October 2023) the release of the recommendations to assess their implementation in clinical routine.

Be Divergent, Be Green! The Moderating Role of Gender in the Association Between Divergent Thinking and Pro-Environmental Behaviours in Children.

Background/objectives: The environmental crisis has begun as a daily challenge for present and forthcoming generations. This scenario highlights the need to adopt many pro-environmental strategies to avoid its adverse consequences. Consequently, it is of paramount importance to comprehend the fundamental psychological and cognitive characteristics that may encourage young children to participate in Pro-Environmental Behaviours (PEBs).

The combination of hyaluronic acids and collagen boosts human Achilles tendon-derived cell escape from inflammation and matrix remodeling in vitro.

Objective: This study explores whether hyaluronic acid (HA) of different molecular weights and collagen, given their role in tendon extracellular matrix maintenance, have a synergistic effect on human tendon-derived cells, with the aim to improve the treatment of tendinopathy.

Material: Human monocytes (CRL-9855™) and primary Achilles tendon-derived cells.

Treatment: The collagen/HA ratio was based on the formulation of the commercial food supplement TendoGenIAL™.

Substantia nigra degeneration in spinocerebellar ataxia 2 and 7 using neuromelanin-sensitive imaging.

Objective: Spinocerebellar ataxias (SCA) are neurodegenerative diseases with widespread lesions across the central nervous system. Ataxia and spasticity are usually predominant, but patients may also present with parkinsonism. We aimed to characterize substantia nigra pars compacta (SNc) degeneration in SCA2 and 7 using neuromelanin-sensitive imaging.

Alexithymia and estimated 10-year cardiovascular disease risk in healthy adults: a community-based cross-sectional study.

Background: This cohort study aimed to explore whether and to what extent alexithymia would be associated with cardiovascular disease (CVD) risk over an estimated 10-year period, over and above established clinical cofactors (i.e., depressive symptoms, quality of life, sociodemographic, anthropometric, lifestyle, and biological data), in a low-risk population of blood donors.

Garlic peel-based carbon quantum dots as a sustainable alternative for the sensitive and green spectrofluorometric quantification of molnupiravir in pharmaceutical capsules.

Searching for natural alternatives to replace environmentally harmful chemical reagents in analysis is just as crucial as finding easily accessible analytical tools. To reinforce these concepts, this study proposes a simple spectrofluorometric approach using natural carbon quantum dots (n-CQDs) as fluorescence probes for sensitive and environmentally friendly measurement of molnupiravir, an antiviral drug that was initially developed for influenza and has demonstrated potential efficacy against COVID-19. n-CQDs were synthesized using garlic peels (GP), a waste material, via a microwave-assisted method.

Association between salivary /microbiological parameters, oral health and eating habits in young athletes.

Background: Athletes' oral health can impact overall well-being and sports performance. This study aimed to evaluate the interactions between eating habits and oral health of 120 young athletes as compared to 30 age-matched individuals not practicing sports based on a questionnaire and the analysis of saliva.

Methods: One hundred twenty subjects practicing various sports activities (test group) and 30 subjects not practicing sports (control group) were selected.

Disinfection of dental root canals by cold atmospheric plasma: a systematic review and meta-analysis of dental biofilm.

Aim: The intricate structure of the tooth root canals has a role in the colonization and biofilm formation in hidden areas that are hardly reached by standard endodontic treatments. This review aims at summarizing data from and studies for a better understanding of the application of cold atmospheric plasma (CAP) for the disinfection of dental root canals.

Methods: PubMed, Scopus, and Web of Science databases were screened.

Italian XEN-Glaucoma Treatment Registry (XEN-GTR): Effectiveness and Safety at 36 Months of XEN45 Implant.

: We evaluated the 3-year effectiveness and safety of XEN45, combined or not with phacoemulsification, in patients from the Italian XEN-Glaucoma Treatment Registry. : Data from glaucoma patients who underwent XEN45 alone or combined with phacoemulsification were analyzed. Changes in intraocular pressure (IOP) and the number of ocular hypotensive medications (OHMs) were tested with repeated measures ANOVA in last observation carried forward (LOCF) and per-protocol (PP) analyses.

Survival of dental implants placed in a postgraduate educational setting: a retrospective cohort study.

Introduction: Dental implant treatment can still fail due to various factors. The aim of this retrospective cohort study was to assess the influence of operator experience in a postgraduate educational setting, as well as patient, implant, and surgical risk factors on the incidence of the dental implant failure.

Methods: The dental records of 1049 implants with a mean follow-up of 794.

DE-PASS Best Evidence Statement (BESt): A Systematic Review and Meta-analysis on the Effectiveness of Trials on Device-Measured Physical Activity and Sedentary Behaviour and Their Determinants in Children Aged 5-12 Years.

Background: To combat the high prevalence of physical inactivity among children, there is an urgent need to develop and implement real-world interventions and policies that promote physical activity (PA) and reduce sedentary behaviour (SB). To inform policy makers, the current body of evidence for children's PA/SB interventions needs to be translated.

Objectives: The current systematic review and meta-analysis aimed to identify modifiable determinants of device-measured PA and SB targeted in available intervention studies with randomized controlled trial (RCT) and controlled trial (CT) designs in children and early adolescents (5-12 years) and to quantify the effects of the interventions within their respective settings on the determinants of PA/SB and the outcomes PA and SB.

Anthropometric-based predictive equations developed with multi-component models for estimating body composition in athletes.

Purpose: Body composition can be estimated using anthropometric-based regression models, which are population-specific and should not be used interchangeably. However, the widespread availability of predictive equations in the literature makes selecting the most valid equations challenging. This systematic review compiles anthropometric-based predictive equations for estimating body mass components, focusing on those developed specifically for athletes using multicomponent models (i.

A Randomized Clinical Study of a Curcumin and Melatonin Toothpaste Against Periodontal Bacteria.

The mouth and the oropharyngeal system are home to numerous bacterial species that constitute the so-called oral microbiome and play an important role for the integrity of the oral cavity, influencing the overall health of the body, as demonstrated by several studies. The aim of this study was to evaluate the bacterial modulation potential of a toothpaste (bioredoxin) containing curcumin and melatonin. Both substances have anti-inflammatory properties, as documented in several scientific reports.

The Relationship Between Playing Formations, Team Ranking, and Physical Performance in the Serie A Soccer League.

The influence of playing formations and team ranking on the physical performance of professional soccer players is an open question that needs to be explored. The present study aimed to investigate the impact of these factors on the physical exertion of Serie A soccer players. We analyzed match data from 375 players, categorizing teams based on their final ranking and comparing performance across different playing formations.

DE-PASS Best Evidence Statement (BESt): Determinants of self-report physical activity and sedentary behaviours in children in settings: A systematic review and meta-analyses.

Previous physical activity interventions for children (5-12yrs) have aimed to change determinants associated with self-report physical activity behaviour (PAB) and/or sedentary behaviour (SB), however, the associations between these determinants and PAB/SB in different settings are uncertain. The present study aimed to identify modifiable determinants targeted in previous PAB/SB interventions for children. Intervention effects on the determinants and their associations with self-report PAB/SB were assessed across settings.

Mechanical and biocompatibility testing of zirconia and lithium disilicate ceramics: An in vitro study.

Statement Of Problem: High-translucency zirconia and lithium disilicate are among the most used materials in contemporary fixed prosthodontics because of their excellent esthetic and mechanical properties. However, their different cementation techniques, physical properties, and biocompatibility profiles can influence the clinician's choice.

Purpose: The purpose of this in vitro study was to evaluate the mechanical strength and adhesive cementation techniques for zirconia and lithium disilicate materials through mechanical testing, including compressive and pull-out tests.

Segmentation methods for quantifying X-ray Computed Tomography based biomarkers to assess hip fracture risk: a systematic literature review.

Background: The success of using bone mineral density and/or FRAX to predict femoral osteoporotic fracture risk is modest since they do not account for mechanical determinants that affect bone fracture risk. Computed Tomography (CT)-based geometric, densitometric, and finite element-derived biomarkers have been developed and used as parameters for assessing fracture risk. However, to quantify these biomarkers, segmentation of CT data is needed.

Development of novel CDK9 and CYP3A4 inhibitors for cancer therapy through field and computational approaches.

Cyclin-dependent kinase 9 (CDK9) and cytochrome P450 3A4 (CYP3A4) have emerged as promising targets in the development of anticancer drugs, presenting a consistent challenge in the quest for potent inhibitors. CDK9 inhibitors can selectively target fast-growing cancer cells by disrupting transcription elongation, which in turn hinders the production of proteins essential for cell cycle progression and survivaŚ. Understanding how CYP3A4 metabolizes specific chemotherapy drugs allows for personalized treatment plans, optimizing drug dosages according to a patient's metabolic profile.