A multimodal neuroimaging study of cerebrovascular regulation: Protocols and insights of combining electroencephalography, functional near-infrared spectroscopy, transcranial Doppler ultrasound, and physiological parameters.

The current paper describes the creation of a simultaneous trimodal neuroimaging protocol. The authors detail their methodological design for a subsequent large-scale study, demonstrate the ability to obtain the expected physiologically induced responses across cerebrovascular domains, and describe the pitfalls experienced when developing this approach. Approach: Electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and transcranial Doppler ultrasound (TCD) were combined to provide an assessment of neuronal activity, microvascular oxygenation, and upstream artery velocity, respectively.

A review: Breeding behavior and management strategies for improving reproductive efficiency in bulls.

This review focuses on bull breeding behaviors and management strategies to improve reproductive efficiency. Breeding soundness evaluations are utilized to classify a bull's physical ability and sperm quality, yet roughly 20 % of bulls fail to meet the minimum criteria. Furthermore, despite achieving the minimum criteria, few bulls in multi-sire breeding groups sire the majority of calves, indicating a need for better understanding of bull behavior that impact siring capacity, and thus, a bull's reproductive efficiency.

Type I and Type II photosensitization of DNA etheno adducts.

Photophysical and photochemical studies were carried out to examine the photoreactivity of etheno adducts, 1,N-ethenoadenine (εdA) and 1,N-ethenoguanine (εdG), in the presence of two well-known photosensitizers acting by Type I and/or Type II mechanisms such as 4-carboxybenzophenone (CBP) and rose Bengal (RB), respectively. Steady-state photolysis experiments combined with HPLC and mass spectroscopy measurements lead to photoproducts that correspond to the repaired nucleosides. To determine the mechanism of this photooxidation processes, phosphorescence spectroscopy, direct detection of singlet oxygen luminescence and laser flash photolysis were carried out.

Studying Chinook salmon in northern river ecosystems through ecological methods and Indigenous, Teslin Tlingit knowledge.

In this study, we examined Pacific salmon decline and ecosystem function through Western science and Indigenous, Teslin Tlingit knowledge. We tested relationships of riparian tree growth and nitrogen composition at the limit of Pacific salmon distribution on the Teslin Tlingit Council (TTC) Traditional Territory in Southern Yukon, studied ecosystem roles of salmon and population declines in the area, and the interactions of these processes. Within sites, tree growth was positively related to salmon escapement at all salmon-bearing sites and not at the negative (salmon-free) control site.

Synthesis and Mesomorphic Properties of Geometric and Conformation-Modulated Amphiphilic β-Cyclodextrin Liquid Crystals.

This study explores the liquid crystalline properties of novel amphiphilic β-cyclodextrin derivatives functionalized with seven oligoethylene glycol chains at the primary face, terminated with either an O-methyl or an O-cyanoethyl group, and fourteen hydrophobic aliphatic chains (elaidic or oleic acids) at the secondary face. These derivatives were designed to study the impact of chain conformation and terminal group polarity on their mesomorphic behavior. Thermal, microscopic, and X-ray diffraction studies revealed that the elaidic derivatives form columnar hexagonal mesophases, with the O-cyanoethyl derivative undergoing a slow, temperature-dependent transition to a bicontinuous cubic phase.

Biomarkers of Intestinal Permeability Are Influenced by Diet in Patients with Ulcerative Colitis-An Exploratory Study.

The disruption of the intestinal epithelial barrier leads to increased intestinal permeability (IP), allowing endotoxins and pathogens to enter the bloodstream contributing to chronic inflammation. Western diets are associated with increased IP, while diets rich in polyphenols, fiber, and omega-3 fats are linked to decreased IP. The relationship between diet, disease activity, and IP in ulcerative colitis (UC) is poorly understood.

Petrographic and Molecular Characterization of Organic-Rich Mudstones with Petroleum Generative Potential from The Lower Triassic Montney Formation, Western Canada.

The Triassic Montney Formation hosts major oil and gas resources in Western Canada. Despite significant historical development of these resources, the origin of its hydrocarbons remains unclear, partly due to limited evidence of primary organic matter within the formation. Most of the hydrocarbons in the Triassic Montney Formation are trapped in low-permeability siltstone facies.

The contribution of nonmedical opioid use to healthcare encounters for opioid overdose and use disorders among long-term users with metastatic cancer.

Purpose: Opioid misuse is increasingly recognized as a relevant problem among patients with cancer. However, the applicability of these concerns for patients with metastatic disease is complicated by shorter prognoses and greater symptom burden. This study aimed to investigate whether nonmedical opioid use (NMOU) was identified as contributing to opioid-related healthcare encounters among patients with metastatic cancer receiving long-term prescribing.

Conditional logistic individual-level models of spatial infectious disease dynamics.

Here, we introduce a novel framework for modelling the spatiotemporal dynamics of disease spread known as conditional logistic individual-level models (CL-ILM's). This framework alleviates much of the computational burden associated with traditional spatiotemporal individual-level models for epidemics, and facilitates the use of standard software for fitting logistic models when analysing spatiotemporal disease patterns. The models can be fitted in either a frequentist or Bayesian framework.

Educators' perceptions and experiences of online teaching to foster caring professions students' development of virtual caring skills: A sequential explanatory mixed-methods study.

Background: Professionals in caring disciplines have been pivotal in advancing virtual care, which leverages remote technologies to deliver effective support and services from a distance. Educators in these caring professions are required to teach students the skills and competencies needed to provide high-quality and effective care and as virtual care becomes more integral, educators must equip students in these fields with both interpersonal and technological skills, bridging traditional hands-on learning with digital literacy. However, there is a gap in evidence exploring educators' perceptions and experiences of teaching caring professions students about virtual caring skills within online environments.

Retention behavior of Hg, MeHg, thimerosal and phenylmercuric acetate on a C RP-HPLC column.

Humans are exposed to potentially toxic mercuric mercury (Hg) and methylmercury (MeHg) by the ingestion of food, to the bactericidal vaccine additive thimerosal (THI), and/or to the antifungal compound phenylmercuric acetate (PMA) which is used in some lens cleaning ophthalmic fluids. While numerous HPLC methods have been developed to separate Hg and MeHg in environmental samples (e.g.

The factor structure of the Patient Health Questionnaire-9 in stroke: A comparison with a non-stroke population.

Background: It is unclear if certain post-stroke somatic symptoms load onto items of the Patient Health Questionnaire-9 (PHQ-9), a self-report depression questionnaire. We investigated these concerns in a stroke sample using factor analysis, benchmarked against a non-stroke comparison group.

Methods: The secondary dataset constituted 787 stroke and 12,016 non-stroke participants.

A Review of Wastewater-Based Epidemiology for the SARS-CoV-2 Virus in Rural, Remote, and Resource-Constrained Settings Internationally: Insights for Implementation, Research, and Policy for First Nations in Canada.

Wastewater-based epidemiology (WBE) is regarded as a support tool for detecting and assessing the prevalence of infectious diseases at a population level. For rural, remote, and resource-constrained communities with little access to other public health monitoring tools, WBE can be a low-cost approach to filling gaps in population health knowledge to inform public health risk assessment and decision-making. This rapid review explores and discusses unique considerations of WBE in key settings, with a focus on the detection of the SARS-CoV-2 virus, which has rapidly expanded WBE infrastructure globally.

Strain of the vertebral artery during passive neck movements and spinal manipulation of the cervical spine: An observational study.

Background: Neck pain is a common condition, and a frequent treatment is chiropractic cervical spinal manipulation therapy (cSMT). However, cervical spinal manipulations have been associated with excessive cervical artery elongations, allegedly causing arterial dissection leading to stroke.

Purpose: The primary purpose of this study was to quantify the total vertebral artery elongations during cSMT, and secondarily, quantify the vertebral artery elongations during the pre-manipulative orientation of the head and neck and the subsequent elongations during the actual thrust.

Experimental and Theoretical Insights into Single Atoms, Dual Atoms, and Sub-Nanocluster Catalysts for Electrochemical CO Reduction (CORR) to High-Value Products.

Electrocatalytic carbon dioxide (CO) conversion into valuable chemicals paves the way for the realization of carbon recycling. Downsizing catalysts to single-atom catalysts (SACs), dual-atom catalysts (DACs), and sub-nanocluster catalysts (SNCCs) has generated highly active and selective CO transformation into highly reduced products. This is due to the introduction of numerous active sites, highly unsaturated coordination environments, efficient atom utilization, and confinement effect compared to their nanoparticle counterparts.

Identifying winner-takes-all emergence in random nanowire networks: an inverse problem.

Random nanowire networks (NWNs) are interconnects that enable the integration of nanoscopic building blocks (the nanowires) in a disorganized fashion, enabling the study of complex emergent phenomena in nanomaterials and built-in fault-tolerant processing functionalities; the latter can lead to advances in large-scale electronic devices that can be fabricated with no particular array/grid high-precision pattern. However, when various nanowires are assembled to form an intricate network, their individual features are somehow lost in the complex NWN frame, in line with the complexity hallmark "the whole differs from the sum of the parts". Individual nanowire materials and geometrical features can only be inferred indirectly by attempting to extract information about their initial conditions from a response function measurement.

Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice.

Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons active during an event (an engram ensemble). We examined the molecular and circuit processes mediating stress-induced threat memory overgeneralization in mice.

Enhancing disease risk gene discovery by integrating transcription factor-linked trans-variants into transcriptome-wide association analyses.

Transcriptome-wide association studies (TWAS) have been successful in identifying disease susceptibility genes by integrating cis-variants predicted gene expression with genome-wide association studies (GWAS) data. However, trans-variants for predicting gene expression remain largely unexplored. Here, we introduce transTF-TWAS, which incorporates transcription factor (TF)-linked trans-variants to enhance model building for TF downstream target genes.

The experiences of living with multiple myeloma and a palliative approach to care: A grounded theory study.

Purpose: Multiple myeloma is an incurable hematologic cancer. A palliative approach to care can be used in conjunction with curative therapy to alleviate suffering, but is underutilized in the hemato- oncology population. The purpose of this study was to explore living with multiple myeloma and individuals' experiences with, and perceptions of a palliative approach in their care.

Myélome multiple et approche palliative des soins : étude théorique ancrée dans la pratique.

Objectif: Le myélome multiple est un cancer hématologique incurable. Pour alléger la souffrance, il est possible d'employer une approche palliative en conjonction avec un traitement curatif, mais cette approche est sous-utilisée chez les patients en hémato-oncologie. L'objectif de la présente étude est d'examiner l'expérience des personnes atteintes d'un myélome multiple qui reçoivent un traitement palliatif dans le cadre de leurs soins, et de comprendre comment ils perçoivent cette approche.

Exploring the Experiences of Visiting Veterinary Service Providers in Indigenous Communities in Canada: Proposing Strategies to Support Pre-Clinical Preparation.

Many Indigenous communities in Canada lack access to veterinary services due to geography, affordability, and acceptability. These barriers negatively affect the health of animals, communities, and human-animal relationships. Canadian veterinary colleges offer veterinary services to Indigenous communities through fourth-year veterinary student rotations.

Supporting Positive Learning Experiences for Veterinary Students on Rotations in Remote Indigenous Communities in Canada.

Many health care programs in medicine, nursing, social work, and physiotherapy include practicum rotations near the end of students' studies. Increasingly, veterinary education programs also offer community-based rotations in underserved or remote communities. While these opportunities in veterinary medicine provide many learning benefits, they can also be stressful if the students do not feel adequately supported.