Prevalence and clinical impact of disseminated intravascular coagulation in acute aortic dissection: a nationwide cohort study.

Background: Acute aortic dissection is a life-threatening cardiovascular emergency with high mortality rates. Disseminated intravascular coagulation (DIC) is a critical complication in patients with acute aortic dissection; however, its incidence and impact on outcomes remain inconclusive.

Objectives: This study aimed to evaluate DIC prevalence and prognosis in patients with aortic dissection.

Barriers and facilitators for healthcare access among immigrants in Japan: a mixed methods systematic review and meta-synthesis.

Background: While Japan provides universal healthcare, immigrants may experience hampered access to healthcare. A comprehensive review of immigrant healthcare access is also lacking. This systematic review aims to examine barriers and facilitators of healthcare access among immigrants in Japan.

Nuclear factor I-C regulates intramembranous bone formation via control of FGF signalling.

Our previous studies indicate that NFI-C is essential for tooth root development and endochondral ossification. However, its exact role in calvarial intramembranous bone formation remains unclear. In this study, we demonstrate that the disruption of the gene leads to defects in intramembranous bone formation, characterized by decreased osteogenic proliferative activity and reduced osteoblast differentiation during postnatal osteogenesis.

Oral behaviors in Chinese temporomandibular disorder patients: insights from exploratory and confirmatory factor analyses.

Aim: This study aimed to evaluate the factor structure of the Oral Behaviors Checklist (OBC) in Chinese temporomandibular disorder (TMDs) patients and compare the outcomes with those of Western patients. Additionally, it examined the correlations between different OBC subscale scoring methods.

Methods: A total of 869 patients completed a survey that included demographic information, the Symptom Questionnaire, and OBC.

Metastatic Status and Dissection Effect of Regional/Extraregional Lymph Nodes in Japanese Patients with Squamous Cell Carcinoma of the Anal Canal: A Multicenter Retrospective Cohort Study.

Objectives: Squamous cell carcinoma of the anal canal (SCCA) is a rare condition. Standard treatment includes chemoradiotherapy, with surgical treatment reserved for limited cases. In the future, the decrease in surgical frequency makes it more difficult to pathologically assess the depth of tumor invasion and lymph node status; therefore, those studies based on relatively recent surgical cases may offer valuable insights into diagnosing and treating SCCA.

Factors Affecting the Prognosis after Primary Tumor Resection for Patients with Metastatic Colorectal Cancer with Synchronous Peritoneal Metastasis: A Multi-center, Prospective, Observational Study.

Objectives: To clarify the risk factors affecting prognosis after primary tumor resection (PTR) in patients with metastatic colorectal cancer with synchronous peritoneal metastasis (mCRC-SPM).

Methods: Patients were enrolled prospectively in the JSCCR project "Grading of Peritoneal Seeding in Colorectal Cancer." Factors that may influence overall survival-age, sex, location of the primary tumor, lymph node metastasis, presence of liver metastasis, degree of peritoneal metastasis, peritoneal cancer index (PCI), cancer cure, and postoperative chemotherapy-in the PTR group were examined using multivariate analysis.

Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects.

Background: The tooth exhibits increased sensitivity to noxious stimuli due to the dense innervation of thin myelinated Aδ fibers and unmyelinated C fibers within the dental pulp. While prior research has identified dynorphin expression in layers I-II of the dorsal horn across the spinal cord in various pain models, its functional role in trigeminal nociception, including tooth pain, remains underexplored. This study examines the potential role of dynorphin in the nociceptive processing of dental stimuli.

Developing a codesigned text message-based digital oral health education resource (TOOTH).

Objective: Digital health technologies offer a more equitable way of providing access to health education. This study engaged consumers and clinicians from two Australian regions with a high burden of oral disease to develop a digital oral health resource called "TOOTH" tailored for adults.

Methods: A total of three focus groups (one clinician and two consumers) were conducted to identify themes that were used to draft text message content.

Intravenous Sedation in a Patient With Sotos Syndrome and Intellectual Disability: A Case Report.

Sotos syndrome is a genetic disorder characterized by distinct facial features, intellectual disability, and overgrowth. In this case, a patient with Sotos syndrome presented with severe intellectual disability, for which general anesthesia was initially considered. However, at the request of the patient's guardian, the treatment was performed under intravenous sedation.

Reconstruction of feeding behaviour and diet in Devonian ctenacanth chondrichthyans using dental microwear texture and finite element analyses.

Devonian ctenacanth chondrichthyans reached body sizes similar to modern great white sharks and therefore might have been apex predators of the Devonian seas. However, very little is known about the diet and feeding behaviours of these large ancestral sharks. To reconstruct their ecological properties, teeth of the large Famennian (Late Devonian) chondrichthyan from the Anti-Atlas, Morocco, were analysed.

Mechanical resistance of a mandibular first molar under the influence of different endodontic access cavity design: a 3D finite element analysis study.

Biomechanical properties of a mandibular first molar with different cavity designs [traditional access cavities (TEC-I & TEC-II), ninja access cavity (NEC), conservative access cavity (CEC), truss access cavity (Tr-EC), caries-driven access cavity (Cd-EC), caries-driven truss access cavity (Cd-TrEC)] were compared using finite element (FE) analysis. Models were subjected to three different loads. The highest stress distribution was observed on the enamel surface of the Cd-EC design and the dentin surface of the TEC-II.

Comparative evaluation of calretinin immunohistochemical expression in calcifying odontogenic cyst and ameloblastoma.

Background: Calretinin is a 29 kilodalton (KDa) calcium-binding protein that is expressed in normal and tumoral tissues. The expression of calretinin has been shown in the dental epithelium during odontogenesis and in different odontogenic cysts and tumors such as ameloblastoma. Since the epithelium of calcifying odontogenic cyst (COC) is similar to ameloblastoma and in both lesions, an arrangement of loose cells similar to stellate reticulum is seen, we aimed to investigate the comparative expression of calretinin in COC and ameloblastoma.

Cannabis consumption and risk of asthma: a systematic review and meta-analysis.

Background: Cannabis is the third most widely used psychoactive substance globally, and its consumption has been increasing, particularly with the growing trend of legalization for medicinal and recreational use. Recent studies have raised concerns about the potential impact of cannabis on respiratory health, specifically the risk of asthma, a significant public health concern. This systematic review aimed to consolidate research on the association between cannabis use and the risk of asthma.

A case series on the basic concept and design of removable partial dentures: support and bracing considerations.

Background: When designing removable partial dentures, maximizing the effectiveness of support and bracing is necessary to minimize denture movement. Therefore, it is essential to emphasize the importance of providing patients with appropriate, safe, and secure removable partial dentures and have clinicians rerecognize the concept and importance of support and bracing. This study aimed to present extension-base removable partial dentures through six specific clinical case series and describe the effect of support and bracing action on denture design, which is essential for denture movement minimization.

Determinants of rural practice among a cohort of dental professionals in Australia.

Background: Most research on tracking practice locations of health students has focused on medical students, particularly the factors influencing their choice to work in rural and remote areas. However, there is limited research on how rural origin and training in regional or rural settings affect the employment destinations of dental and oral health graduates. This paper explores the practice locations of dentistry and oral health therapy (OHT) graduates from rural backgrounds compared to those from metropolitan areas in Australia.

RNAseq of peripheral blood mononucleated cells exposed to platelet-rich fibrin and enamel matrix derivatives.

Platelet-rich fibrin (PRF) and Enamel Matrix Derivatives (EMD) can support the local regenerative events in periodontal defects. There is reason to suggest that PRF and EMD exert part of their activity by targeting the blood-derived cells accumulating in the early wound healing blastema. However, the impact of PRF and EMD on blood cell response remains to be discovered.

Periapical bone edema volume in 3D MRI is positively correlated with bone architecture changes.

Objectives: To compare and correlate bone edema volume detected by 3D-short-tau-inversion-recovery (STIR) sequence to osseous decay detected by a T1-based sequence and conventional panoramic radiography (OPT).

Materials And Methods: Patients with clinical evidence of apical periodontitis were included retrospectively and received OPT as well as MRI of the viscerocranium including a 3D-STIR and a 3D-T1 gradient echo sequence. Bone edema was visualized using the 3D-STIR sequence and periapical hard tissue changes were evaluated using the 3D-T1 sequence.

Perioperative outcomes of robotic vs laparoscopic pancreatoduodenectomy: a meta-analysis and trial sequential analysis.

Background: Minimally invasive pancreatoduodenectomy has gained widespread acceptance among hepatopancreatobiliary surgeons due to its demonstrated advantages in perioperative outcomes compared to the conventional open approach. This meta-analysis, along with trial sequential analysis, aimed to compare the outcomes of robotic pancreatoduodenectomy and laparoscopic pancreatoduodenectomy based on the current available evidence.

Methods: A systematic search of PubMed, Cochrane, Scopus, and Web of Science was conducted from inception to July 2024.

Optimizing dental implant identification using deep learning leveraging artificial data.

This study aims to evaluate the potential enhancement in implant classification performance achieved by incorporating artificially generated images of commercially available products into a deep learning process of dental implant classification using panoramic X-ray images. To supplement an existing dataset of 7,946 in vivo dental implant images, a three-dimensional scanner was employed to create implant surface models. Subsequently, implant surface models were used to generate two-dimensional X-ray images, which were compiled along with original images to create a comprehensive dataset.

BRCC3 aggravates pulpitis by activating the NF-κB signaling pathway in dental pulp cells.

BRCA1/BRCA2-containing complex subunit 3 (BRCC3) has been proved to exert pro-inflammatory effect in various inflammatory diseases through different mechanisms, but its involvement in pulpitis remains unclear. This study aims to investigate the regulatory role and mechanisms of BRCC3 in modulating dental pulp cell inflammation and pulpitis progression. The expression of BRCC3 was observed to be elevated in human/mouse pulpitis samples and lipopolysaccharide-stimulated human dental pulp cells (hDPCs).

Robot-assisted Endodontic Retreatment: A Case Report with Clinical Considerations.

Introduction: Fiber posts present significant challenges for nonsurgical endodontic retreatment, as improper removal may result in iatrogenic root perforation or even root fracture. Recently, robotic technology has attracted considerable attention in dentistry and active dental robotic (ADR) systems can perform procedures based on preset instructions, minimizing reliance on the dentist's experience. This case report describes the application of an ADR system for fiber post removal through an existing zirconia crown.

Enhancing Titanium Dioxide Nanotube Array Stability on Dental Implants through Laser Lithography-Assisted Microline Patterning.

Titanium dioxide nanotube arrays (TNTs) generated in situ on the surface of dental implants have been shown to enhance bone integration for load-bearing support while managing load distribution and energy dissipation to prevent bone resorption from overload. However, their inadequate stability limits the clinical use of conventional TNTs. This study introduces an innovative approach to improve the mechanical stability of TNTs while maintaining their bone-integration efficiency.

Prolonged high Myl9 levels are associated with the pathogenesis and respiratory symptom of post-acute COVID-19 syndrome: A 6-month follow-up study.

Background: Post-acute COVID-19 Syndrome (PACS) occurs in some COVID-19 patients long after acute infection and significantly affects patients' health. However, the mechanism by which PACS develops is unknown. Myosin light chain 9 (Myl9), produced by activated platelets, plays a role in immune dysregulation and microthrombi formation during acute COVID-19.

Clinical implications of disappearing pancreatic cancer liver metastases: Lessons from colorectal liver metastases.

Background: The efficacy of local control for pancreatic cancer liver metastases (PCLM), including surgical treatment, remains controversial, with no consensus on the management and clinical significance of disappearing liver metastases (DLMs). This study aimed to evaluate the clinical implications of DLMs in treating PCLM after multi-agent chemotherapy, utilizing contrast-enhanced imaging modalities.

Methods: A retrospective analysis was conducted on patients who underwent curative resection for pancreatic cancer with synchronous or metachronous liver metastases between 2014 and 2023.

Administering the Lidcombe Program to children who stutter with concomitant disorders: Insights from an exploratory retrospective chart review study.

Purpose: Children who stutter (CWS) in clinical settings may present with concomitant disorders (CDs), which can complexify the delivery of the Lidcombe Program (LP). However, there is limited evidence on how CDs influence treatment outcomes in CWS, leaving clinicians with little guidance regarding best practices with these children. This exploratory study, conducted in partnership with a rehabilitation center's clinical team, aims to understand which CDs and suspected CDs speech-language pathologists document when treating CWS with the LP and their relationship to treatment characteristics and outcomes.