Efficacy of P-4 for the treatment of initial buccal caries: a randomized clinical trial.

To investigate the safety and efficacy of Self-Assembling Peptide P-4 (SAP P-4) compared to placebo or fluoride varnish (FV), a randomized, controlled, blinded, split-mouth study with sequential design was conducted. Subjects presenting two teeth with White-Spot-Lesions (WSLs) were included and teeth were randomly assigned to test or control. Control received placebo at baseline (D0) and test SAP P-4, all received FV at Day 90 (D90).