Pan African Vivax and Ovale Network (PAVON) Malaria Diagnostic Competency Training: Offering Training Opportunities to Impact Malaria Elimination Strategies in Sub-Saharan Africa.

PAVON has developed a malaria microscopy competency training scheme to augment competency in malaria microscopy. Here, data accrued from training activities between 2020 and 2023 in Botswana are presented. Three trainings were done for 37 central and peripheral level technicians for a two-week period.

GC-MS Analysis, Neuropharmacological and Antidiarrheal Activities of the Acetone Extract of Najas gracillima Seaweed: In Vivo and In Silico Study.

Najas gracillima, a marine seaweed found in North America and Asia, was investigated for its neuropharmacological and antidiarrheal properties. Acetone extracts of N. gracillima (ANG) were analyzed using both in vivo and in silico methods.

Cooperation of Multifunctional Redox Mediator and Separator Modification to Enhance Li-S Batteries Performance under Low Electrolyte/Sulfur Ratio.

Sluggish reaction kinetics of sulfur species fundamentally trigger the incomplete conversion of S8↔Li2S and restricted lifespan of lithium-sulfur batteries, especially under high sulfur loading and/or low electrolyte/sulfur (E/S) ratio. Introducing redox mediators (RMs) is an effective strategy to boost the battery reaction kinetics, yet their multifunctionality and shuttle inhibition are still not available. Here, a unique ethyl viologen (EtV²⁺) RM with two highly reversible redox couples (EtV²⁺/EtV⁺, EtV⁺/EtV0) is demonstrated to well match the redox chemistry of sulfur species, in terms of accelerating the electron transfer in S8 reduction, Li2S nucleation and the Li2S oxidation.

Essential Oil from Tetrapanax papyrifer (Hook.) K. Koch: Chemical Composition, Antioxidant Activity, α-Glucosidase Inhibitory Effect Integrating Molecular Docking Analysis.

The present study investigated the chemical composition of essential oil from Tetrapanax papyrifer and evaluated its antioxidant and anti-α-glucosidase activity. Sixty-one essential oil compounds from Tetrapanax papyrifer were identified by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detector (GC-FID). The essential oil is rich in sesquiterpenoids (96.

Psychological stress among hypertensive male patients in Jordan: prevalence and associated factors.

Background: Hypertension is a global, modifiable risk factor for cardiovascular and cerebrovascular disorders, imposing a significant burden due to its high mortality and morbidity rates. This study aimed to assess the prevalence and severity of psychological stress among hypertensive patients in Jordan and identify the factors associated with psychological stress.

Methods: This descriptive, cross-sectional study was conducted on hypertensive patients at three community healthcare clinics in Jordan from May to July 2024.

Whole-genome sequencing of three extremophile sp. strains isolated from the Atacama Desert.

The Atacama Desert is home to bacteria that use biofilms as a means of protecting themselves against the harsh environment. To inform research regarding this survival mechanism, we cultured and sequenced the genomes of three sp. isolates from Atacama Desert soil.

The burden of acute malnutrition among children under five in conflict-afflicted Gaza strip: prevalence and associated factors.

Background: This study aims to assess the prevalence and associated factors of Severe Acute Malnutrition (SAM) and Moderate Acute Malnutrition (MAM) among children in this region during a period of conflict.

Methods: A cross-sectional study was conducted with a sample of 1,200 children under 5 years old, selected through stratified random sampling from three governorates in the Gaza Strip. Data were collected using structured interviews and physical examinations, including Mid-Upper Arm Circumference (MUAC) measurements to determine nutritional status based on established cut-off points.

Discovery of Novel Low Bee-Toxicity Aphicidal α-Butenolide: Design and Optimization Based on A Progressive Strategy of AChBP and ClogP.

The development of novel insecticides with low bee-toxicity has become increasingly urgent as many high bee-toxicity neonicotinoids have been progressively restricted. In this study, novel halogenated phenyl-substituted α-butenolide compounds were designed, optimized and synthesized through a progressive strategy based on insect nicotinic acetylcholine receptor (nAChR) and the calculated oil-water partition coefficient (ClogP) of compounds. Among these, the difluorophenyl-substituted compound 3cj (LC50 = 40.

Design and Synthesis of Novel Thiazole Linked Tetrahydropyridine Analogues as Anticancer Agents.

A library of new thiazole linked tetrahydropyridines (6a-q) synthesized and screened for their invitro anticancer activity against human breast adeno carcinoma cell viz. MCF-7 and MDA-MB-231. The two compounds 6d containing -F and -Cl functions in para and meta position of phenyl ring (9.

Screening for antimicrobial and antioxidant activities of quinazolinone based isoxazole and isoxazoline derivatives, synthesis and In silico studies.

Two novel series of quinazolinone based isoxazole and isoxazoline hybrid compounds were synthesized from 6-aminoquinazolinone as a key precursor. The title compounds were achieved in synthetic routes via propargylation and allylation reactions of the precursor followed by cyclization with various chloroximes. The new compounds 4a-g and 6a-g were screened for their antimicrobial activity against two Gram-positive bacteria, two Gram-negative bacteria and two fungi by employing Ampicillin and Itraconazole as standard reference.

MCM-41 from rice husk silica as a support for Ni catalyst in the emission-free production of H by CH cracking.

Selecting a sustainable source of silica from biomass waste was the research challenge that was put forth in this investigation. Herein, the MCM-41 support has been synthesized using a renewable rice husk and explored as a support for Ni-Cu catalyst in the production of zero-emission H through CH pyrolysis. The role of Cu promoter was investigated by doping different amounts of Cu loading to 30wt%Ni/R-MCM-41catalyst, which improved the catalytic performance in terms of CH conversion and stability.

Review perspective on advanced nutrachemicals and anterior cruciate ligament rehabilitation.

Anterior cruciate ligament (ACL) injuries are prevalent among athletes, necessitating surgical intervention followed by comprehensive rehabilitation. Recently, the integration of nutraceuticals - bioactive compounds from food sources - into rehabilitation protocols has shown promise in enhancing recovery outcomes. This review explores the potential benefits of various nutraceuticals, including omega-3 fatty acids, collagen supplements, vitamin D, glucosamine and chondroitin, curcumin, and branched-chain amino acids (BCAAs), in ACL rehabilitation.

Detection of human drowsiness by the vestibulo-ocular reflex compensating for heartbeat-induced head perturbations.

The vestibulo-ocular reflex (VOR) stabilizes vision during head movements by counter-rotating the eyes in the orbits. Although considered one of the simplest reflexes due to its minimal neuronal circuity comprising a 3-neuron arc, previous studies have shown that VOR performance deteriorates in both monkeys and humans when they are drowsy. Given constant head perturbations under dynamic environments, the VOR has been proposed as a viable biomarker for detecting human drowsiness in automobiles and other moving vehicles.

A Pilot Study Based on the Correlation Between Whole Exome and Transcriptome Reveals Potent Variants in the Indian Population of Cervical Cancer.

Cervical malignancy (CC) is the 2nd most prevalent malignancy among females, leading to cancer mortality. Primary detection of CC tumors results in an improved prognosis. CC is a malignant gynecological tumor, with few treatment options.

Aurantiochytrium mutant strains exhibiting different colony colors altered the contents of squalene.

Aurantiochytrium sp. 18W-13a, a marine heterotrophic protist belonging to the genus thraustochytrid, is known to accumulate high levels of squalene and carotenoids. Nowadays, the mutagenesis breeding of microorganisms is still widely practiced because the induced mutations of DNA do not involve the permanent integration of heterologous DNA sequences.

Anticancer and Antibacterial Activeness of Fused Pyrimidines: Newfangled Updates.

Pyrimidine-based heterocyclic compounds are garnering substantial interest due to their essential role as a class of natural and synthetic molecules. These compounds show a diverse array of biologically relevant activities, making them highly prospective candidates for clinical translation as therapeutic agents in combating various diseases. Pyrimidine derivatives and their fused analogues, such as thienopyrimidines, pyrazolopyrimidines, pyridopyrimidines, and pyrimidopyrimidines, hold immense possibility in both anticancer and antibacterial research.

Greener and whiter analytical method development and validation for determining the presence of zolpidem tartrate infused in apple juice using RP-HPLC magnetic solid-phase extraction followed by LC-MS confirmatory analysis.

The research work entails a newly developed RP-HPLC method, aimed at analyzing the modern date rape drug, zolpidem tartrate (ZT), infused in apple juice matrix. The work relies on dispersive solid-phase extraction (DSPE) with polyethylene imine (PEI)-coated magnetic nanoparticles to preconcentrate zolpidem from the matrix, in the presence of trifluoroacetic acid (TFA) for matrix isolation, for the first time. The optimized conditions emphasize the use of an environmentally preferable mobile phase [methanol: 0.

Analytical methods for the determination of xylazine in pharmaceutical, clinical and forensic matrices - A review.

Xylazine, a non-opioid veterinary anaesthetic tranquillizer that is not licensed for human use, has been linked to an increase in overdose fatalities worldwide. The study delves into the forensic aspects of xylazine usage, emphasizing on chemical, clinical and toxicological analyses of drug seizures, bodily fluids and tissues. It advocates for validated analytical methods for determining xylazine.

Role of melatonin in mitigation of insulin resistance and ensuing diabetic cardiomyopathy.

Addressing insulin resistance or hyperinsulinemia might offer a viable treatment approach to stop the onset of diabetic cardiomyopathy, as these conditions independently predispose to the development of the disease, which is initially characterized by diastolic abnormalities. The development of diabetic cardiomyopathy appears to be driven mainly by insulin resistance or impaired insulin signalling and/or hyperinsulinemia. Oxidative stress, hypertrophy, fibrosis, cardiac diastolic dysfunction, and, ultimately, systolic heart failure are the outcomes of these pathophysiological alterations.

Is it safe? Health promotion videos on YouTube and the safety of viewers - Views from Ghana.

Objectives: Health promotion videos are trending and abundant. Information provided in these videos is not verified by any designated experts but is popular. In this paper we discuss the prevalence of such videos and guide patients on how to verify their authenticity.

Climate Change and Health: Perspectives From Ghana.

Climate change is impacting many aspects of human life in many ways. In Ghana, climate change knowledge remains low and discussions linking climate change and health are scarce. In this paper, authors contribute to the shaping of discussions about climate and health with a focus on how climate change increases certain ailments.

N-Ended Walker PCR: An Efficient Genome-Walking Tool.

As a tool for acquiring uncharacterized genomic DNA adjacent to characterized DNA, genome-walking is integral to bioscience-related research works. Herein, a new genome-walking tool known as N-ended walker PCR (polymerase chain reaction) is presented. The key aspect for this method is the use of a degenerate walker primer in secondary/tertiary PCR.