18 results match your criteria: "University College of MAIWP International[Affiliation]"

Black seed oil (BSO), derived from the seeds of the Nigella sativa plant, has garnered attention for its potential anti-cancer properties, particularly in the context of colon cancer. Its active compound, thymoquinone, may help inhibit cancer cell growth and induce apoptosis in colon cancer cells. Additionally, black seed oil's anti-inflammatory and antioxidant effects could contribute to a healthier gut environment, potentially reducing cancer risk.

View Article and Find Full Text PDF
Article Synopsis
  • * The study identified key risk factors for peripheral neuropathy, including diabetes, age over 50, low education level, male gender, and hypertension.
  • * Researchers emphasize the importance of proactive screening for peripheral neuropathy among healthcare providers to avoid complications, especially in those at higher risk.
View Article and Find Full Text PDF

The approach of ionic gelation was employed at the pilot scale of the 50 kg batch size to manufacture black seed oil (BSO)-loaded alginate (ALG) beads as a natural source supplementing the main bioactive compound of BSO, i.e., thymoquinone (TQ).

View Article and Find Full Text PDF
Article Synopsis
  • Metallic nanoparticles (MNPs) enhance medication effectiveness by overcoming drug resistance and enabling targeted delivery of therapeutic agents.
  • They have a range of medical uses beyond drug delivery, such as diagnostics and improving materials' biocompatibility, while also offering benefits like increased stability and targeted delivery.
  • The review aims to discuss recent developments in MNP preparation, their applications in drug and gene delivery, and the challenges faced in clinical trial implementation.
View Article and Find Full Text PDF

Artificial intelligence (AI) has played a vital role in computer-aided drug design (CADD). This development has been further accelerated with the increasing use of machine learning (ML), mainly deep learning (DL), and computing hardware and software advancements. As a result, initial doubts about the application of AI in drug discovery have been dispelled, leading to significant benefits in medicinal chemistry.

View Article and Find Full Text PDF

This study discusses the micro-level structural details of Cichorieae pollen sources elucidated by scanning electron microscopy (SEM) and explains their symmetry and morphometry. The in-depth knowledge from the electron ultrastructure of Asteraceae pollen has provided insights into enhanced pollen morphology, and the antimicrobial significance of species under study presents novel avenues for their natural defense mechanisms in the development of antimicrobial agents. In this research, both quantitative and qualitative features of pollen were examined.

View Article and Find Full Text PDF
Article Synopsis
  • This research investigates the epidermal anatomy of Lamiales plants, revealing important structural traits and their potential antimicrobial properties, which could lead to new natural medicine developments.
  • Using scanning microscopy, the study analyzed nine species from seven genera and four families within Lamiales, examining various aspects like epidermal cell shapes, stomata, and trichomes for taxonomic significance.
  • Findings highlight a diversity of trichome structures and variabilities in epidermal cell architecture, suggesting significant implications for pharmacological research and sustainable agricultural practices.
View Article and Find Full Text PDF

Genetic Susceptibility Variants of Vascular Dementia among Asians: A Systematic Review and Meta-Analysis.

Dement Geriatr Cogn Disord

August 2024

Department of Environmental and Water Resources Engineering, School of Civil Engineering (SCE), Vellore Institute of Technology, Vellore, India.

Introduction: Vascular dementia (VaD), a neurocognitive impairment directly related to vascular injury, is the second most common cause of age-related dementia. Although numerous studies have investigated candidate genetic polymorphisms associated with VaD in Asia, the genetics of VaD remains unclear.

Methods: This review provides an updated meta-analysis of genetic polymorphisms associated with VaD in Asians, using the PRISMA guidelines.

View Article and Find Full Text PDF

The increasing demand for honey purification and authentication necessitates the global utilization of advanced processing tools. Common honey processing techniques, such as chromatography, are commonly used to assess the quality and quantity of valuable honey. In this study, 15 honey samples were authenticated using HPLC and GC-MS chromatographic methods to analyze their pollen spectrum.

View Article and Find Full Text PDF

Alginate is a natural biopolymer widely studied for pharmaceutical applications due to its biocompatibility, low toxicity, and mild gelation abilities. This review summarizes recent advances in alginate-based encapsulation systems for targeted drug delivery. Alginate formulations like microparticles, nanoparticles, microgels, and composites fabricated by methods including ionic gelation, emulsification, spray drying, and freeze drying enable tailored drug loading, enhanced stability, and sustained release kinetics.

View Article and Find Full Text PDF

5-Fluorouracil (5-FU) has been the primary drug used in chemotherapy for colorectal carcinoma, and localizing the drug would be effective in avoiding its side effects and improving therapeutic outcomes. One approach to achieve this is by encapsulating the drug in microbeads. Alginate microbeads, in particular, exhibit promising pH-sensitive properties, making them an attractive option for colon targeting.

View Article and Find Full Text PDF

The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present.

Pharmaceutics

January 2024

Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.

Article Synopsis
  • Turmeric contains curcumin, which has anti-inflammatory and antioxidant properties that may help combat cancer; it is safe, nontoxic, and affordable with minimal side effects when taken in high doses.
  • Despite its benefits, curcumin suffers from poor bioavailability and biodistribution, making it less effective in clinical applications.
  • Ongoing research focuses on developing polymer-based formulations of curcumin to enhance its absorption and therapeutic effects against cancer and other diseases.
View Article and Find Full Text PDF

There are two main ways to discover or design small drug molecules. The first involves fine-tuning existing molecules or commercially successful drugs through quantitative structure-activity relationships and virtual screening. The second approach involves generating new molecules through drug design or inverse quantitative structure-activity relationship.

View Article and Find Full Text PDF

The widespread use of synthetic pesticides has resulted in a number of issues, including a rise in insecticide-resistant organisms, environmental degradation, and a hazard to human health. As a result, new microbial derived insecticides that are safe for human health and the environment are urgently needed. In this study, rhamnolipid biosurfactants produced from Enterobacter cloacae SJ2 was used to evaluate the toxicity towards mosquito larvae (Culex quinquefasciatus) and termites (Odontotermes obesus).

View Article and Find Full Text PDF
Article Synopsis
  • A study was conducted to evaluate the factors contributing to burnout among healthcare providers in primary care settings in Selangor, Malaysia, involving 1280 participants and using the Copenhagen Burnout Inventory.
  • Findings revealed that personal burnout affected 41.7% of participants, work-related burnout 32.2%, and client-related burnout 14.5%, with various determinants identified for each type of burnout, such as age, occupation, stress levels, and sleep quality.
  • The study emphasizes the importance of addressing the mental and emotional health of healthcare workers, especially during the COVID-19 pandemic, to mitigate burnout risks.
View Article and Find Full Text PDF

The Zingiberaceae family possess various phenolic compounds that have significant systemic bioactivities in the brain, including in age-related neurodegenerative diseases. Neurotrophins are growth factors that protect neurons from oxidative stress, and dysregulation of the neurotrophic system may result in neurocognitive disease. Phenolic compounds from the Zingiberaceae family have been used in traditional and complementary medicine (TCM) to improve cognitive functions.

View Article and Find Full Text PDF

This study showed that bio-functional silver nanoparticles (AgNPs) and zinc oxide nanoparticles (ZnONPs) were synthesized in aqueous extracts of Gymnema sylvestre leaves and tested for toxicity assessment against triple-negative breast cancer cells (TNBC). Biofunctional nanoparticle (NPs) samples were characterized using UV-Vis spectroscopy, FT-IR, XRD, SEM, and TEM. The results showed that the phytofabrication of AgNPs resulted in a dark brown, UV-vis maximum absorbance peak at 413 nm.

View Article and Find Full Text PDF

Ginger ( Roscoe) can scavenge free radicals, which cause oxidative damage and inflamm-ageing. This study aimed to evaluate the antioxidant and anti-inflammatory effects of soil ginger's sub-critical water extracts (SWE) on different ages of Sprague Dawley (SD) rats. The antioxidant properties and yield of SWE of soil- and soilless-grown ginger (soil ginger and soilless ginger will be used throughout the passage) were compared and evaluated.

View Article and Find Full Text PDF