4 results match your criteria: "University College London Foundation Hospital[Affiliation]"
Diverse imaging features of adolescent glioblastoma.
BJR Case Rep
March 2022
Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
We highlight an unusual case of multifocal glioblastoma in an adolescent patient, manifesting as four discrete brain lesions, each distinct in appearance. Familiarity with the diverse imaging features of glioblastoma can reduce misdiagnosis and avoid treatment delays.
View Article and Find Full Text PDFRegional and Volumetric Parameters for Diffusion-Weighted WHO Grade II and III Glioma Genotyping: A Method Comparison.
AJNR Am J Neuroradiol
March 2021
From the Neuroradiological Academic Unit (S.C.T., J.A.M, S.J.W., L.M., H.R.J.), Department of Brain, Repair and Rehabilitation, UCL Institute of Neurology, London, UK.
Background And Purpose: Studies consistently report lower ADC values in () wild-type gliomas than in mutant tumors, but their methods and thresholds vary. This research aimed to compare volumetric and regional ADC measurement techniques for glioma genotyping, with a focus on status prediction.
Materials And Methods: Treatment-naïve World Health Organization grade II and III gliomas were analyzed by 3 neuroradiologist readers blinded to tissue results.
World Health Organization Grade II/III Glioma Molecular Status: Prediction by MRI Morphologic Features and Apparent Diffusion Coefficient.
Radiology
July 2020
From the Neuroradiological Academic Unit, Department of Brain, Repair and Rehabilitation, UCL Institute of Neurology, London, England (J.M., S.O., S.W., L.M., R.J., S.T.); Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, England (S.W., A.A.B., W.M., A.M.K., L.M., R.J., S.T.); Population, Policy and Practice Research Unit, UCL Great Ormond Street Institute of Child Health, London, England (O.A.); Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, England (S.B., Z.J.); Department of Radiology, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey (A.M.K.); and Department of Imaging, University College London Foundation Hospital, London, England (R.J., S.T.).
Background A readily implemented MRI biomarker for glioma genotyping is currently lacking. Purpose To evaluate clinically available MRI parameters for predicting isocitrate dehydrogenase () status in patients with glioma. Materials and Methods In this retrospective study of patients studied from July 2008 to February 2019, untreated World Health Organization (WHO) grade II/III gliomas were analyzed by three neuroradiologists blinded to tissue results.
View Article and Find Full Text PDFApparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis.
Eur Radiol
September 2018
Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK.
Objectives: To investigate if quantitative apparent diffusion coefficient (ADC) measurements can predict genetic subtypes of non-gadolinium-enhancing gliomas, comparing whole tumour against single slice analysis.
Methods: Volumetric T2-derived masks of 44 gliomas were co-registered to ADC maps with ADC mean (ADC) calculated. For the slice analysis, two observers placed regions of interest in the largest tumour cross-section.