8,014 results match your criteria: "University College Hospital.[Affiliation]"

Introduction: Low research output is hindering efforts to improve health services in Sub-Saharan Africa (SSA). AfriWon Research Group of WONCA Africa has established an online collaborative research mentorship and training programme to boost research capacity among Family Physicians in SSA. This study aims to assess the effectiveness of the programme in achieving this goal.

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Article Synopsis
  • - The
  • Mega-ROX HIE trial
  • is an international study designed to compare conservative versus liberal oxygen therapy in adults with hypoxic ischaemic encephalopathy (HIE) after cardiac arrest who are on mechanical ventilation in ICU settings.
  • - The
  • trial aims to enroll around 4,000 participants
  • and will measure all-cause mortality within 90 days from randomization as its primary outcome, alongside several secondary outcomes related to survival and hospital stay.
  • - The study is structured to reduce any potential analysis bias by clearly outlining its
  • protocol and statistical analysis plan
  • , and aims to provide insights into effective oxygen therapies for this population.
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Brain health is the complete functioning of the brain across the life course to support the full physical, mental, social, and spiritual well-being and quality of life of an individual towards attaining and maintaining the epitome of a meaningful, impactful, purposeful, and productive life. The determinants of brain health are complex and include at least in part, non-traditional risks such as interactions among social, economic, physical, and internal factors (e.g.

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Introduction: Reduction in salt intake improves blood pressure control and reduces the risk of hypertension and other noncommunicable diseases (NCDs). However, salt intake remains high among Nigerians. This study aimed to identify barriers and facilitators to salt reduction among hypertensive patients attending a family medicine clinic in southern Nigeria.

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Impact of on-trial IGRT quality assurance in an international adaptive radiotherapy trial for participants with bladder cancer.

Radiother Oncol

October 2024

The Royal Marsden NHS Foundation Trust, Downs Road, Sutton SM2 5PT, United Kingdom; Division of Radiotherapy and Imaging, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom.

Article Synopsis
  • Radiotherapy trial quality assurance (RT QA) is essential for ensuring safe and consistent radiation treatment across different institutions, focusing on adaptive methods like Image-Guided Radiotherapy (IGRT) in the RAIDER trial for bladder cancer.
  • This study analyzed data from 72 participants over 884 Cone-Beam Computed Tomography (CBCT) scans to compare online and offline treatment plan selections, revealing an overall concordance rate of 83%.
  • Results showed an improvement in concordance from 75% in the first stage of the trial to 91% in the second stage, emphasizing the importance of ongoing QA support during the introduction of new radiotherapy techniques.
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Second Primary Lung Cancer - An Emerging Issue in Lung Cancer Survivors.

J Thorac Oncol

October 2024

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom; Department of Oncology, University of Cambridge, Cambridge, United Kingdom; Department of Thoracic Oncology, Royal Papworth Hospital, Cambridge, United Kingdom. Electronic address:

As a result of an increased focus on early detection including lung cancer screening, combined with more curative treatment options, the 5-year survival rates for lung cancer are improving. Welcome though this is, it brings new, hitherto unseen challenges. As more patients are cured and survive longer, they are at risk of developing second primary cancers, particularly lung cancer.

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There is a need to constantly assess the awareness, treatment, and control of hypertension in Nigeria. This study determined the frequency of undiagnosed hypertension across the six geopolitical zones of Nigeria. We conducted an opportunistic screening of adults aged at least 18 years in the month of May 2021.

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  • * The study revealed that the majority of those with CRE had received antibiotics, particularly third-generation cephalosporins, within the past month, indicating potential links between antibiotic use and CRE colonization.
  • * Antimicrobial resistance was prominent, with a high percentage of CRE isolates showing resistance to multiple classes of antibiotics, though susceptibility to tigecycline and colistin was comparatively lower.
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Objectives: To understand the facilitators and barriers to the implementation of renal tumour biopsy (RTB) in the diagnostic pathway for renal tumours in England.

Patients And Methods: Participants consisted of patients who had a renal tumour diagnosed and/or treated at one of five tertiary centres in England, healthcare professionals involved in the direct care of patients diagnosed with renal tumours, and clinical service managers and commissioners. The study employed a mixed-methods research methodology consisting of individual interviews and an on-line survey that explored the types of facilitators and barriers individuals perceived and experienced and the frequency in which these were reported.

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Background: Hypertension is the number one risk factor for cardiovascular death worldwide and its prevalence has been on the increase in LMICs including Nigeria. There is an increasing awareness and recognition of the contributions of the community health workers (CHWs) in the healthcare system. This study assessed their current role in the management of hypertension and patient satisfaction with the care received.

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  • This study focused on the use of admission cardiotocography (CTG), a noninvasive method for assessing fetal oxygenation, and its correlation with neonatal outcomes.
  • Researchers analyzed data from 206 pregnant women and found that 73.3% had normal CTG results; however, those with pathological CTG faced higher risks such as low birth weight and neonatal death.
  • The findings highlight the importance of admission CTG for identifying at-risk pregnancies, recommending prompt intervention for delivery if results are abnormal to improve neonatal outcomes.
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Context: A major indication for referrals for bone scans (BS) to establish or exclude skeletal metastases. Few patients are referred with clinically indeterminate diagnosis or cancer of unknown primary (CUP), to search for bony metastases or primary tumor.

Aims: This study aimed to assess the usefulness or otherwise for BS in such instances.

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Invasive infection in a neutropaenic patient.

Med Mycol Case Rep

September 2024

University College London Hospital NHS Foundation Trust, University College Hospital, 235 Euston Road, London, NW1 2BU, United Kingdom.

Article Synopsis
  • Invasive fungal infections can be severe complications for patients undergoing chemotherapy, especially those with a weakened immune system like neutropenia.
  • Some fungal species, while uncommon, can lead to serious infections in immunosuppressed individuals.
  • The case discussed involves a patient with acute myeloid leukemia who suffered a fatal outcome due to an invasive pulmonary fungal infection.
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  • Retained intra-abdominal foreign bodies are uncommon and typically result from previous abdominal or gynecological surgeries, with sponges being the most frequently retained items.!
  • The types of foreign bodies can include surgical instruments, pads, gauze, and even items like pen caps, as well as objects that individuals may self-insert.!
  • The study reports on a case series from University College Hospital, Ibadan, detailing the outcomes of patients with retained foreign bodies over a 12-year period in their general surgery service.!
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Factors affecting shared decision-making concerning menopausal hormone therapy.

Ann N Y Acad Sci

August 2024

Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.

Menopausal hormone therapy (MHT) is an effective treatment for menopause-related symptoms. Menopause management guidelines recommend a personalized approach to menopause care, including MHT use. Decision-making around menopause care is a complex, iterative process influenced by multiple factors framed by perspectives from both women and healthcare providers (HCPs).

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The COVID-19 pandemic challenged health systems globally. Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for detecting the presence of SARS-CoV-2 in clinical samples. Rapid diagnostic test (RDT) kits for COVID-19 have been widely used in Nigeria.

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Background: Aminoglycosides, such as Streptomycin, are cheap, potent antibiotics widely used Sub-Saharan Africa. However, aminoglycosides are the commonest cause of ototoxicity. The limited prospective epidemiological studies on aminoglycoside ototoxicity from Sub-Saharan Africa motivated this study to provide epidemiological information on Streptomycin-induced ototoxicity, identify risk factors and predictors of ototoxicity.

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Background: Multiple trichoepitheliomas are rare benign adnexal tumours that present a unique challenge both to the patient and the managing physician. The multiple nature of the lesion and face being a common location often causes cosmetic concern and psychosocial challenges. Physicians on the other hand face the challenge of providing an ideal treatment with a satisfactory outcome.

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The accuracy of multiparametric magnetic resonance imaging (mpMRI) heavily relies on image quality, as evidenced by the evolution of the prostate imaging quality (PI-QUAL) scoring system for the evaluation of clinically significant prostate cancer (csPC). This study aims to evaluate the impact of PI-QUAL scores in detecting csPC within PI-RADS 4 and 5 lesions. We retrospectively selected from our database all mpMRI performed from January 2019 to March 2022.

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Background: Telerehabilitation as a new subdiscipline of telehealth is the application of information technology to support and deliver rehabilitation services via two-way or multipoint interactive online telecommunication technology. This enables the therapist to optimize the timing, intensity, and duration of therapy which is often not possible within the constraints of face-to-face treatment protocols in current health systems.

Objective: To review the historical perspective and conceptual framework of telerehabilitation in neurological disorders.

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Estimation of inflammatory cytokines in maternal serum for assessing the outcome of threatened miscarriage.

J West Afr Coll Surg

May 2024

Department of Obstetrics and Gynaecology, Faculty of Clinical Sciences, College of Medicine/University College Hospital Ibadan, University of Ibadan, Nigeria.

Objectives: This study investigates the use of pro- and anti-inflammatory cytokines in predicting the outcome of pregnancy complicated by threatened miscarriage.

Materials And Methods: Of the 140 eligible pregnant women recruited for the study, maternal serum levels of selected inflammatory cytokines (IL-2, IFNγ, IL-4, and IL-13) for 70 women with threatened miscarriage were analysed for this study. Serum concentrations were measured using the enzyme-linked immunosorbent assay (ELISA) kit.

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Attitude and concerns on antenatal pelvic floor exercises among pregnant women in Ibadan, Nigeria.

J West Afr Coll Surg

May 2024

Department of Obstetrics and Gynaecology, Faculty of Clinical Sciences, College of Medicine/University College Hospital Ibadan, University of Ibadan, Ibadan, Nigeria.

Aim: Several studies had investigated the importance and benefit of pelvic floor exercises (PFEs) to the pregnant women and their unborn babies, however, the concerns of antenatal women on the exercise have been sparsely investigated. This study examined the attitude and concerns of pregnant women towards engaging in PFEs in Ibadan, Nigeria.

Materials And Methods: This was cross-sectional study of pregnant women aged ≥15 years.

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Article Synopsis
  • Giant condylomata acuminatum (GCA), also known as Buschke-Lowenstein tumor (BLT), is a rare, slow-growing tumor linked to low-risk HPV types 6 and 11, with low chances of becoming invasive cancer.
  • The study involved three patients (one woman and two men) who underwent surgical excision for their BLT, with two also receiving surgical reconstruction and achieving positive outcomes.
  • The authors emphasize the need for early symptom recognition, effective treatment options, awareness of recurrence risks, and preventive strategies against HPV.
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