7,984 results match your criteria: "University College Hospital[Affiliation]"

Background: The postpartum period is associated with an increased risk of maternal mental disorders. The combined effect of having the mother's infant admitted to a tertiary hospital in a low-resource setting and the need to exclusively breastfeed the infant may exaggerate this risk. This study aimed to determine the breastfeeding support provided to mothers whose infants were hospitalised in Nigerian tertiary hospital nurseries and the prevalence of common mental health disorders among this population.

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Vulnerable populations, such as the elderly, children, displaced people, and refugees, often encounter challenges in accessing healthcare. In this study, we used data from the third iteration of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) to describe kidney care access and delivery to vulnerable populations across countries and regions. Using data from an international survey of clinicians, policymakers, and patient advocates, we assessed the funding and coverage of vulnerable populations on all aspects of kidney replacement therapies (KRT).

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Objective: To describe postnatal outcome following the prenatal diagnosis of an abnormal fetal gallbladder.

Methods: We conducted a systematic review of studies from January 1980 to January 2023 that described FGB abnormalities, which included agenesis or non-visualisation, abnormal content presence of sludge, abnormal shape or size and abnormal position, and postnatal outcome to determine the association with pathology.

Results: In 51 studies, 842 fetuses had abnormal FGB.

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Background: In proximal hypospadias, ventral curvature is invariable and most have penoscrotal transposition, and we observed that the base of the penis (BOP) was located on the inferior aspect of the pubic bones in those, in contrast to the location of the BOP at the anterior end in normal penises. We also observed an unfused bulbospongiosus muscle (BSM) at surgery in those. The aim was to assess the impact of repairing the unfused BSM or transection and straightening of the urethral plate at the first operation on the low BOP.

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We profiled a large heterogenous cohort of matched diagnostic-relapse tumour tissue and paired plasma-derived cell free DNA (cfDNA) from patients with relapsed and progressive solid tumours of childhood. Tissue and cfDNA sequencing results were concordant, with a wider spectrum of mutant alleles and higher degree of intra-tumour heterogeneity captured by the latter, if sufficient circulating tumour-derived DNA (ctDNA) was present. Serial tumour sequencing identified putative drivers of relapse, with alterations in epigenetic drivers being a common feature.

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Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy is highly effective in B-cell blood cancers, but there is limited data on its safety and efficacy in intra-cardiac lymphoma, due to the potential risks of cardiotoxicity and pseudo-progression.

Discussion: We discuss four high-risk cases that were managed with a multi-disciplinary approach, including baseline cardiac risk assessment and surveillance with multimodal cardiac imaging and serum cardiac biomarkers, elective supportive care in the intensive care unit, and early treatment of cytokine release syndrome.

Conclusion: CAR-T therapy can be effective and safe in the treatment of B-cell blood cancers with intra-cardiac disease.

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Sodium-glucose cotransporter-2 inhibitors (SGLT2-i) have been shown to reduce risks of clinical events in patients with heart failure (HF). However, data on the use of SGLT2-i in patients with left ventricular assist devices (LVADs) are scarce. We thought to assess the efficacy and safety of SGLT2-i in patients with LVADs.

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Genomic and transcriptomic analysis of ameloblastoma reveals distinct molecularly aggressive phenotypes.

Mod Pathol

December 2024

Liverpool Head and Neck Centre, Molecular and Clinical Cancer Medicine, University of Liverpool, 6 West Derby Street, Liverpool, L6 8TX. Electronic address:

Ameloblastoma (AM) is a benign but locally infiltrative epithelial odontogenic neoplasm of the jawbones that may reach grotesque proportions and be highly recurrent if inadequately removed. The BRAF mutation has been demonstrated as key molecular event in its development, nevertheless, there are many queries about its aetiopathogenesis that are yet to be answered. In this study, we aimed to integrate results from whole-exome sequencing (WES) and RNA-sequencing in AM samples to identify novel candidate genes that may be relevant to its pathogenesis.

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Using theory to understand how interventions work and inform future implementation.

Lancet Glob Health

December 2024

Health Services Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya; Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

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Viral suppression with antiretroviral therapy (ART) is a critical component of UNAIDS objectives to end the HIV epidemic. Youth living with HIV (YLH) have worse viral suppression rates than adults. The aim of this study was to identify risk factors for viral non-suppression among YLH in Nigeria.

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Article Synopsis
  • A study in Nigeria examined primary healthcare workers' knowledge and perception of mpox, noting limited research on the topic despite rising cases from 2017 to 2022.
  • The survey assessed knowledge across various areas, revealing that while 78.3% were aware of mpox, understanding of its transmission was notably low, especially in Lagos compared to other regions.
  • Most healthcare workers recognized that mpox could affect anyone, but nearly half felt that they couldn't protect themselves from it, highlighting gaps in knowledge and perceived vulnerability.
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Background: The capacity to anticipate future health issues is important for both policy makers and practitioners in the USA, as such insights can facilitate effective planning, investment, and implementation strategies. Forecasting trends in disease and injury burden is not only crucial for policy makers but also garners substantial interest from the general populace and leads to a better-informed public. Through the integration of new data sources, the refinement of methodologies, and the inclusion of additional causes, we have improved our previous forecasting efforts within the scope of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to produce forecasts at the state and national levels for the USA under various possible scenarios.

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Second Primary Lung Cancer-Potential Areas of Ambiguity.

J Thorac Oncol

December 2024

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom; Department of Oncology, University of Cambridge, Cambridge, United Kingdom; Department of Thoracic Oncology, Royal Papworth Hospital, Cambridge, United Kingdom. Electronic address:

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Background: Sickle cell disease (SCD) is of serious public health concern. Paucity of literature exists on qualitative experiences of people with SCD, despite substantial research on the clinical signs and management of the disease. This study examined how SCD affects a range of undergraduate students' experiences, their academic achievements, relationships, mental health and healthcare utilization.

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Consensus Guidelines on Constipation in Adults in Pakistan.

Pak J Med Sci

December 2024

Prof. Dr. Zahid Azam, MBBS, FCPS (Gastro), FCPS (Med), FACG, M.Sc (Clinical Research) Professor of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

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Article Synopsis
  • * Using a cross-sectional design, researchers assessed nutritional status through anthropometric measurements and the Mini Nutritional Assessment tool, along with a structured questionnaire for socio-demographic data.
  • * Results showed no cases of malnutrition among participants, but 27.3% were at risk; males aged 60-69 and seniors over 80 were less likely to be at risk compared to females, highlighting the need for focused nutritional support for at-risk groups.
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Automated analysis of lung ultrasound for pneumothorax detection is an emerging technology with potential applications across various clinical settings. This systematic review aims to evaluate the current evidence for the efficacy of automated analysis techniques in diagnosing pneumothorax using lung ultrasound images and videos. A literature search was conducted in the MEDLINE (Medical Literature Analysis and Retrieval System Online), Embase (Excerpta Medica Database), Web of Science, and Scopus databases up to July 5, 2024.

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Article Synopsis
  • - The study examines the epidemiology and management of maxillofacial trauma in Africa, highlighting the social, psychological, and economic impacts of such injuries, particularly due to high rates of road crashes.
  • - Conducted over six months in five major hospitals, the study involved 195 patients, primarily middle-aged males, with lacerations being the most common injury; delays in treatment were more prevalent among unemployed individuals.
  • - The findings stress the urgent need for improved road safety measures and efforts to address socioeconomic inequalities to enhance timely treatment for maxillofacial injuries in the African region.
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Introduction: Diagnosing the specific causes of young adult hip pain remains challenging due to non-specific symptoms. Fluoroscopy-guided injections are useful for confirming intra-articular hip pain and differentiating it from extra-articular pathology. When performing injections, accurate needle placement into the hip joint is critical.

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