Pulmonary vascular manifestations of hereditary haemorrhagic telangiectasia.

Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant, multisystem disorder that manifests with a spectrum of disease including cardiopulmonary complications. HHT is characterised by aberrant signalling via the transforming growth factor β (TGFβ) pathway, with loss of vascular integrity, angiogenesis and vascular dysplasia. The disease has an estimated prevalence of 1 in 5000 persons and the penetrance increases with increasing age.

Irish general practitioner (GP) perspectives on impact of direct access radiology on patient care in the community: results from a mixed-methods study.

Background: Since winter 2020/21, general practitioners (GPs) in the Republic of Ireland (RoI) have been granted access to diagnostic imaging studies on a new publicly funded pathway, expediting access to services previously obtained via hospital-based doctors.

Aims: Outline GP perspectives on imaging studies obtained via the new "GP Access to Community Diagnostics" initiative.

Methods: A mixed-methods design was employed.

Rapid degradation behavior of encapsulated perovskite solar cells under light, bias voltage or heat fields.

When the power conversion efficiency (PCE) of perovskite solar cells (PSCs) rapidly approaches that of commercial solar cells, the stability becomes the most important obstacle for the commercialization of PSCs. Aside from the widely studied slow PCE degradation, the PSCs also show a unique rapid PCE degradation. Although the degradation due to oxygen and humidity can be avoided by encapsulation, that due to bias voltage, light and heat could not be effective suppressed and will lead to considerable degradation.

[Prospects of use of research results for drugs with anitihypoxic and antioxidative properties in neuroprotective treatment strategies (Opinion of the Council of Experts dated 26 March 2022)].

Cerebrovascular diseases are one of the main causes of death and permanent disability. Effective and timely neuroprotective therapy can reduce the burden of cerebrovascular disease. The possibilities of neuroprotection as a method of prevention and medical rehabilitation of acute and chronic cerebrovascular diseases are addressed.

The management of delirium in the older adult in advanced nursing practice.

Delirium is a term used to describe an array of symptoms that indicate a disruption in cerebral metabolism, a condition that is often under-recognised, leading to delayed interventions. The condition is a common cause of older adults presenting in hospital, with significant morbidity and mortality associated with increased length of stay. A case study is used to illustrate the use of a diagnostic algorithm for older adults presenting with delirium to an advanced nurse practitioner (ANP)-led service.

Ondine's Curse in Frontotemporal Dementia with Parkinsonism Linked to Chromosome 17 Caused by Variants.

Background: "Ondine's curse" or central hypoventilation, induces an apparently spontaneous failure of automatic respiratory drive, henceforth necessitating a conscious effort to breathe and sleep induced hypoventilation. It is typically seen in congenital central hypoventilation syndrome, but may be acquired.

Objectives: To highlight Ondine's curse as part of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) secondary to microtubule associated protein tau () variants.

On mothering and being mothered: A personal reflection on women's productivity during COVID-19.

This is a personal reflection, as a female academic during COVID-19, on how women's academic productivity seems primarily to be discussed in relation to a different kind of productivity - motherhood. A recent procedure in a maternity hospital evoked feelings and associations of mothering and being mothered, and how these associations hover over relationships regardless of whether wombs are productive or not. My hope in writing this piece is that every woman's fear and anxiety may be productively contained (regardless of how she is seen from the outside or momentarily construed from within) during this time of extraordinary turmoil.

Poly(ethylene glycol) based nanotubes for tuneable drug delivery to glioblastoma multiforme.

Glioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumour, which is associated with a poor two-year survival rate and a high rate of fatal recurrence near the original tumour. Focal/local drug delivery devices hold promise for improving therapeutic outcomes for GBM by increasing drug concentrations locally at the tumour site, or by facilitating the use of potent anti-cancer drugs that are poorly permeable across the blood brain barrier (BBB). For inoperable tumours, stereotactic delivery to the tumour necessitates the development of nanoscale/microscale injectable drug delivery devices.

The Dynamics of Fear at the Time of Covid-19: A Contextual Behavioral Science Perspective.

COVID-19 is the relevant disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmitted via close contact between persons. On March 12th, 2020, WHO announced COVID-19 outbreak a pandemic, in view of its worldwide escalation. As the pandemic disease explodes, a parallel outbreak of fear and worry is also spreading.

Enhancing curcumin's solubility and antibiofilm activity silica surface modification.

Bacterial biofilms are microbial communities in which bacterial cells in sessile state are mechanically and chemically protected against foreign agents, thus enhancing antibiotic resistance. The delivery of active compounds to the inside of biofilms is often hindered due to the existence of the biofilm extracellular polymeric substances (EPS) and to the poor solubility of drugs and antibiotics. A possible strategy to overcome the EPS barrier is the incorporation of antimicrobial agents into a nanocarrier, able to penetrate the matrix and deliver the active substance to the cells.

Managing acute shoulder injuries in the emergency department.

Patients with shoulder injuries commonly present to emergency departments (EDs) and minor injury units and it is vital that they receive the same high standard of care regardless of where they receive it or who delivers it. The author, therefore, developed an algorithm to help standardise diagnosis and management of shoulder injuries. This article describes acute shoulder injuries often seen in EDs and advanced health assessments of these injuries, including specific tests, and uses a case study to illustrate how the algorithm helped diagnose and manage care of a patient with a dislocated shoulder.

The effects of administration of gonadotrophins and estrogens on prenatal survival in gilts.

In gilts ovulation occurs over a 4 to 8-hour period, with 70% of the ova being shed over a relatively short span of time. These oocytes supposedly give rise to more developed embryos at Days 10 to 12 which advance the uterine environment and reduce survival rates of less developed embryos because of an asynchronous environment. The aim of this experiment was to reduce embryo mortality by influencing the duration and pattern of ovulation.