30 results match your criteria: "University Clinics for Child and Adolescent Psychiatry[Affiliation]"

Background: Today, online communication is shaped by a billion-dollar social media (SM) and social networking site (SNS) industry. Visual content consumed by children and adolescents has been shown to influence behavioral patterns, state emotions, and self-esteem (SE). In this study, we introduced a novel intervention creating visual content through a professional photoshoot and investigated its impact on state emotions and SE in child and adolescent psychiatric (CAP) patients.

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Problematic Internet Use Among Adolescent Male and Female Psychiatric Inpatients: A Gender Perspective.

Child Psychiatry Hum Dev

April 2024

Christian-Doppler-Clinic, University Clinics for Child and Adolescent Psychiatry, Paracelsus Medical University, Ignaz-Harrer-Straße 79, 5020, Salzburg, Austria.

Problematic internet use (PIU) is of treatment interest in adolescent clinical samples. Gender specific differences in terms of personality traits and psychopathological symptoms remain unclear. In an adolescent clinical sample (n = 104; 69 girls) PIU, psychopathology, temperament and character traits as well as emotional and behavioral problems were assessed.

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Temperament and Offending Behaviors in Male Adolescents.

Int J Offender Ther Comp Criminol

September 2024

University Clinics for Child and Adolescent Psychiatry and Psychotherapy, Salzburger Landeskliniken, Paracelsus Medical University, Salzburg, Austria.

The aim of the current paper was to examine temperament profiles and temperament dimensions as risk factors for persistent criminal behavior in juveniles who offended (JOs). A sample of 137 male adolescents from a Swiss detention center and 137 age and sex matched community controls were included in the present study. Temperament was measured with the Junior Temperament and Character Inventory (JTCI).

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Background: Adverse childhood experiences (ACEs) and psychiatric disorders are common in juvenile detainees. Emotional dysregulation resulting from cumulated ACEs may be characterized by symptoms of irritability. The present study examined whether the accumulation of ACEs, irritability, or both predicted mental disorders in incarcerated adolescents with and without controlling for one another and for socio-demographic factors.

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High-density electroencephalographic recordings during sleep in children with disorders of consciousness.

Neuroimage Clin

December 2016

Child Development Centre and Paediatric Sleep Disorders Centre, University Children's Hospital Zurich, Switzerland; Children's Research Centre, University Children's Hospital Zurich, Switzerland; University Clinics for Child and Adolescent Psychiatry, University of Zurich, Switzerland. Electronic address:

Article Synopsis
  • A study investigates brain function in children with disorders of consciousness (DOC) using EEG recordings during sleep, focusing on sleep slow waves (SWA).
  • Children with DOC exhibited lower SWA build-up compared to healthy peers and those with injuries but without DOC, particularly in the parietal brain area.
  • The findings indicate that reduced SWA regulation could serve as a marker for brain dysfunction in children with DOC, suggesting its potential for future assessments in both adults and children.
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Increased frontal sleep slow wave activity in adolescents with major depression.

Neuroimage Clin

October 2016

Child Development Center, University Children's Hospital Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich, Switzerland; University Clinics for Child and Adolescent Psychiatry, University of Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland.

Sleep slow wave activity (SWA), the major electrophysiological characteristic of deep sleep, mirrors both cortical restructuring and functioning. The incidence of Major Depressive Disorder (MDD) substantially rises during the vulnerable developmental phase of adolescence, where essential cortical restructuring is taking place. The goal of this study was to assess characteristics of SWA topography in adolescents with MDD, in order to assess abnormalities in both cortical restructuring and functioning on a local level.

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Sleep to grow smart?

Arch Ital Biol

September 2016

University Children's Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland - Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190,8057 Zurich, Switzerland - University Clinics for Child and Adolescent Psychiatry, University of Zurich, Neumansterallee 9, CH-8032 Zurich, Switzerland. Email:

Sleep is undisputable an essential part of our life, if we do not sleep enough we feel the consequences the next day. The importance of sleep for healthy brain functioning has been well studied in adults, but less is known for the role of sleep in the paediatric age. Childhood and adolescence is a critical phase for brain development.

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Background: The attenuated positive symptoms syndrome (APSS) is considered an at-risk indicator for psychosis. However, the characteristics and developmental aspects of the combined or enriched risk criteria of APSS and basic symptom (BS) criteria, including self-experienced cognitive disturbances (COGDIS) remain under-researched.

Method: Based on the Structured Interview of Prodromal Syndromes (SIPS), the prevalence of APSS in 13- to 35-year-old individuals seeking help in an early recognition program for schizophrenia and bipolar-spectrum disorders was examined.

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Very preterm adolescents show impaired performance with increasing demands in executive function tasks.

Early Hum Dev

January 2016

Department of Neonatology, University Hospital Zurich, Switzerland; Child Development Center, University Children's Hospital Zurich, Switzerland. Electronic address:

Background: Very preterm birth is often associated with executive function deficits later in life. The transition to adolescence increases personal autonomy, independence and, in parallel, the demands placed on executive functions at home and in school.

Aim: To assess the impact of increasing demands on executive function performance in very preterm children and adolescents with normal intellectual and motor functions.

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Objectives: DSM-5 conceptualized attenuated psychosis syndrome (APS) as self-contained rather than as a risk syndrome, including it under "Conditions for Further Study," but also as a codable/billable condition in the main section. Since many major mental disorders emerge during adolescence, we assessed the frequency and characteristics of APS in adolescent psychiatric inpatients.

Methods: Consecutively recruited adolescents hospitalized for nonpsychotic disorders (September 2009-May 2013) were divided into APS youth versus non-APS youth, based on the Structured Interview of Prodromal Syndromes (SIPS) and according to DSM-5 criteria, and compared across multiple characteristics.

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Article Synopsis
  • Ambiguous situations are often interpreted negatively by individuals, and this tendency is linked to mental disorders, especially noticeable during adolescence.
  • The study explored whether stabilizing memories of positive or negative images through sleep cueing could influence how similar images are interpreted later.
  • Results showed that cueing with positive words led to more optimistic interpretations, while negative cueing resulted in pessimistic interpretations, and this effect was consistent across both adolescents and adults.
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Caffeine is the most commonly ingested psychoactive drug worldwide with increasing consumption rates among young individuals. While caffeine leads to decreased sleep quality in adults, studies investigating how caffeine consumption affects children's and adolescents' sleep remain scarce. We explored the effects of regular caffeine consumption on sleep behavior and the sleep electroencephalogram (EEG) in children and adolescents (10-16 years).

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Reduced sleep spindle density in early onset schizophrenia: a preliminary finding.

Schizophr Res

August 2015

Child Development Center, University Children's Hospital Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich, Switzerland; University Clinics for Child and Adolescent Psychiatry, University of Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland. Electronic address:

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Biological correlates of complex posttraumatic stress disorder-state of research and future directions.

Eur J Psychotraumatol

April 2015

Department of Psychology, Division of Psychopathology and Clinical Intervention, University of Zürich, Zürich, Switzerland.

Complex posttraumatic stress disorder (PTSD) presents with clinical features of full or partial PTSD (re-experiencing a traumatic event, avoiding reminders of the event, and a state of hyperarousal) together with symptoms from three additional clusters (problems in emotional regulation, negative self-concept, and problems in interpersonal relations). Complex PTSD is proposed as a new diagnostic entity in ICD-11 and typically occurs after prolonged and complex trauma. Here we shortly review current knowledge regarding the biological correlates of complex PTSD and compare it to the relevant findings in PTSD.

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Study Objectives: Several studies proposed a link between sleep spindles and sleep dependent memory consolidation in declarative learning tasks. In addition to these state-like aspects of sleep spindles, they have also trait-like characteristics, i.e.

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When problem size matters: differential effects of brain stimulation on arithmetic problem solving and neural oscillations.

PLoS One

December 2015

Section of Educational Neuroscience, Department of Psychology, University of Graz, Graz, Austria; Department of Educational Psychology, Institute of Psychology, Georg-August-University of Göttingen, Göttingen, Germany.

The problem size effect is a well-established finding in arithmetic problem solving and is characterized by worse performance in problems with larger compared to smaller operand size. Solving small and large arithmetic problems has also been shown to involve different cognitive processes and distinct electroencephalography (EEG) oscillations over the left posterior parietal cortex (LPPC). In this study, we aimed to provide further evidence for these dissociations by using transcranial direct current stimulation (tDCS).

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Conflict monitoring and error processing: new insights from simultaneous EEG-fMRI.

Neuroimage

January 2015

University Clinics for Child and Adolescent Psychiatry (UCCAP), University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland. Electronic address:

Error processing and conflict monitoring are essential executive functions for goal directed actions and adaptation to conflicting information. Although medial frontal regions such as the anterior cingulate cortex (ACC) and the pre-supplementary motor area (pre-SMA) are known to be involved in these functions, there is still considerable heterogeneity regarding their spatio-temporal activations. The timing of these functions has been associated with two separable event-related potentials (ERPs) usually localized to the medial frontal wall, one during error processing (ERN--error related negativity) and one during conflict monitoring (N2).

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Ascent to moderate altitude impairs overnight memory improvements.

Physiol Behav

February 2015

University Children's Hospital Zurich, Switzerland; Neuroscience Center Zurich (ZNZ), Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland; University Clinics for Child and Adolescent Psychiatry, Zurich, Switzerland. Electronic address:

Several studies showed beneficial effects of sleep on memory performance. Slow waves, the electroencephalographic characteristic of deep sleep, reflected on the neuronal level by synchronous slow oscillations, seem crucial for these benefits. Traveling to moderate altitudes decreases deep sleep.

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The objective of the present study was to analyse patterns of emotional, physical and sexual maltreatment in detained male juvenile offenders using latent class analysis (LCA). The association of maltreatment related LCA profiles with psychopathology and criminal behaviors was also studied. LCA based on the items of the Child Trauma Questionnaire (CTQ) assessing childhood emotional, physical, and sexual abuse was performed in a sample of 260 male adolescent offenders (mean age = 16.

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Cognitive flexibility in adolescence: neural and behavioral mechanisms of reward prediction error processing in adaptive decision making during development.

Neuroimage

January 2015

University Clinics for Child and Adolescent Psychiatry (UCCAP), University of Zurich, Neumünsterallee 9, 8032 Zürich, Switzerland; Neuroscience Center Zurich, University and ETH Zurich, Switzerland.

Adolescence is associated with quickly changing environmental demands which require excellent adaptive skills and high cognitive flexibility. Feedback-guided adaptive learning and cognitive flexibility are driven by reward prediction error (RPE) signals, which indicate the accuracy of expectations and can be estimated using computational models. Despite the importance of cognitive flexibility during adolescence, only little is known about how RPE processing in cognitive flexibility deviates between adolescence and adulthood.

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Sleep slow-wave activity reveals developmental changes in experience-dependent plasticity.

J Neurosci

September 2014

Child Development Center and Children's Research Center, University Children's Hospital Zürich, 8032 Zürich, Switzerland, University Clinics for Child and Adolescent Psychiatry, 8032 Zürich, Switzerland

Article Synopsis
  • Experience-dependent plasticity allows the brain to adapt based on experiences, peaking in childhood and declining with age, although evidence is limited.
  • Slow-wave activity (SWA) during deep sleep indicates experience-dependent plasticity, shown to increase in adults after visuomotor tasks, particularly in the right parietal cortex.
  • A study of children, adolescents, and adults revealed that children showed the highest increase in SWA after learning tasks, linking brain maturation to the sensitivity of regions involved in learning.
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Many brain-related disorders have neuronal cell death involved in their pathophysiology. Improved in vitro models to study neuroprotective or neurotoxic effects of drugs and downstream pathways involved would help gain insight into the molecular mechanisms of neuroprotection/neurotoxicity and could potentially facilitate drug development. However, many existing in vitro toxicity assays have major limitations - most assess neurotoxicity and neuroprotection at a single time point, not allowing to observe the time-course and kinetics of the effect.

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Role of the medial prefrontal cortex in impaired decision making in juvenile attention-deficit/hyperactivity disorder.

JAMA Psychiatry

October 2014

University Clinics for Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland2Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.

Importance: Attention-deficit/hyperactivity disorder (ADHD) has been associated with deficient decision making and learning. Models of ADHD have suggested that these deficits could be caused by impaired reward prediction errors (RPEs). Reward prediction errors are signals that indicate violations of expectations and are known to be encoded by the dopaminergic system.

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Despite compelling evidence for major genetic contributions to the etiology of obsessive-compulsive disorder (OCD), few genetic variants have been consistently associated with this debilitating illness. Molecular genetic studies in children and adolescents with OCD are of particular interest, since early onset of the disease has been observed to be associated with increased familiality. We replicate here for the first time in early-onset OCD patients, a previously reported association of OCD with the common gain-of-function LA allele at the serotonin transporter linked polymorphic region known as 5-HTTLPR in a collection of parent-offspring trios.

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Sleep spindles are related to schizotypal personality traits and thalamic glutamine/glutamate in healthy subjects.

Schizophr Bull

March 2015

Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland; Children Research Center, University Children's Hospital Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland; University Clinics for Child and Adolescent Psychiatry, Zurich, Switzerland

Background: Schizophrenia is a severe mental disorder affecting approximately 1% of the worldwide population. Yet, schizophrenia-like experiences (schizotypy) are very common in the healthy population, indicating a continuum between normal mental functioning and the psychosis found in schizophrenic patients. A continuum between schizotypy and schizophrenia would be supported if they share the same neurobiological origin.

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