14 results match your criteria: "University Clinic of Endocrinology and Internal Medicine[Affiliation]"
Eur J Clin Invest
December 1996
University Clinic of Endocrinology and Internal Medicine, Aarhus Amtssygehus, Denmark.
Steroids have the ability to alter adipose tissue distribution. Controversy exists as to whether these effects of sex hormones (oestrogen, progesterone and testosterone) on human adipose tissue are indirect or direct, as only very few studies have focused on steroid receptor status in human adipose tissue. In the present study, we reinvestigated steroid receptor status in human mature adipose tissue and human preadipocytes.
View Article and Find Full Text PDFEur J Clin Invest
April 1996
University Clinic of Endocrinology and Internal Medicine, Aarhus Amtssygehus, Tage Hansensgade, Denmark.
The distribution of adipose tissue has a major impact on the morbidity and mortality associated with obesity. Furthermore, the distribution of adipose tissue seems to be regulated by sex hormones. Controversy exists over whether the effects of sex hormones (oestrogen and testosterone) on human adipose tissue are an indirect or a direct effect as contradictory results have been obtained when investigating the existence of these receptors in human adipose tissue.
View Article and Find Full Text PDFEur J Endocrinol
August 1995
University Clinic of Endocrinology and Internal Medicine, Aarhus Amtssygehus, Denmark.
The metabolic complications associated with obesity are dependent upon the degree of obesity and the distribution of adipose tissue. In order to evaluate the associations between sex hormone status, metabolic risk parameters, obesity and distribution of adipose tissue, 25 premenopausal women with a wide range of body mass index (19.3-48.
View Article and Find Full Text PDFMetabolism
August 1993
University Clinic of Endocrinology and Internal Medicine, Aarhus Amtssygehus, Tage Hansensgade, Denmark.
Insulin resistance is commonly associated with obesity. The present study was performed to investigate the relative importance of total fat mass versus localization of adipose tissue in insulin-stimulated glucose disposal (Rd) and skeletal muscle glycogen synthase (GS) activity in obese individuals. Twenty obese women with an average body mass index (BMI) of 37.
View Article and Find Full Text PDFProstaglandins Leukot Essent Fatty Acids
November 1992
University Clinic of Endocrinology and Internal Medicine, Aarhus Amtssygehus, Denmark.
Mol Cell Endocrinol
May 1992
University Clinic of Endocrinology and Internal Medicine, Aarhus Amtssygehus, Denmark.
In contrast to previous studies, Parker et al. (Diabetes (1989) 38, 1123) have recently found that isolated rat adipocytes alone were unable to synthesize prostaglandins (PG) and that the PG measured in adipocyte suspensions were due to contaminating non-adipocyte cells. In the present study the capacity of adipocytes to produce PGE2 has further been explored.
View Article and Find Full Text PDFMol Cell Endocrinol
May 1992
University Clinic of Endocrinology and Internal Medicine, Aarhus Amtssygehus, Denmark.
We have previously demonstrated the existence of nuclear estrogen receptors in isolated adipocytes (Pedersen et al. (1991) Biochim. Biophys.
View Article and Find Full Text PDFBiochim Biophys Acta
April 1992
University Clinic of Endocrinology and Internal Medicine, Aarhus Amtssygehus, Denmark.
The corticosteroid receptor was investigated in isolated rat adipocytes with a new technique which characterizes the corticosteroid receptors that can be activated and tightly bound to the nucleus. The binding reaction with [3H]triamcinolone was performed with intact isolated adipocytes and the radioactivity associated with nucleus was subsequently determined after cell lysis. Scatchard analysis revealed a homogeneous class of nuclear corticosteroid receptors in rat epididymal adipocytes with an apparent Kd of 4.
View Article and Find Full Text PDFBiochim Biophys Acta
June 1991
University Clinic of Endocrinology and Internal Medicine, Aarhus Amtssygehus, Denmark.
The nuclear estrogen receptor was characterised in isolated rat adipocytes. The binding reaction with [3H]estradiol was performed with intact isolated rat adipocytes and the radioactivity associated with the nucleus was subsequently determined after cell lysis. The nuclear uptake of [3H]estrogen in rat adipocytes was temperature dependent and steroid specific.
View Article and Find Full Text PDFEur J Pharmacol
February 1991
University Clinic of Endocrinology and Internal Medicine, Aarhus amtssygehus, Denmark.
The effect of hypothyroidism on insulin- and epinephrine-stimulated phosphoinositide metabolism was investigated in rat adipocytes. Insulin-mediated phosphoinositide synthesis was enhanced by hypothyroidism (14.5 +/- 1.
View Article and Find Full Text PDFDiabetes Res Clin Pract
April 1992
University Clinic of Endocrinology and Internal Medicine, Aarhus Amtssygehus, Denmark.
Sulfonylureas are widely used drugs in the treatment of NIDDM when diet treatment is unsuccessful. In addition to their pancreatic effects sulfonylureas have been reported to have insulin-like and insulin-potentiating actions in vitro with respect both to glucose transport and glycogen synthase activation in isolated adipocytes and hepatocytes from rats. Glycogen synthesis in muscle accounts for the major part of non-oxidative glucose metabolism during insulin stimulation.
View Article and Find Full Text PDFBiochem Int
August 1990
University Clinic of Endocrinology and Internal Medicine, Arhus Amtssygehus, Denmark.
Phosphoinositide turnover was investigated in adipocytes from fed and 48 hour fasted rats. Insulin stimulated phosphoinositide synthesis both in adipocytes from fed and fasted rats. Fasting enhanced this effect of insulin 2-fold.
View Article and Find Full Text PDFDiabetes
November 1989
University Clinic of Endocrinology and Internal Medicine, Arhus Amtssygehus, Denmark.
To elucidate the subcellular mechanism of action of sulfonylurea on glucose utilization of skeletal muscle, we studied nine newly diagnosed patients with type II (non-insulin-dependent) diabetes. Examinations were performed before and after 8 wk of gliclazide therapy. Gliclazide treatment was associated with improved glycemic control and enhanced pancreatic beta-cell responses to meal stimulation.
View Article and Find Full Text PDFBiochem Biophys Res Commun
July 1988
University Clinic of Endocrinology and Internal Medicine, Aarhus C, Denmark.
The effects of 12-phorbol 13-myristate acetate (PMA) on glucose transport, glucose metabolism and lipolysis in rat adipocytes were examined. Alone, PMA (100 ng/ml) stimulated 2-deoxyglucose transport, glucose oxidation and lipogenesis by an amount corresponding to about 30-50% of the maximal insulin effect. The effect of PMA on the insulin-stimulated processes was additive at all insulin concentrations.
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