Monitoring individualized glucose levels predicts risk for bradycardia in type 2 diabetes patients with chronic kidney disease: a pilot study.

Patients with diabetes mellitus (DM) and chronic kidney disease (CKD) exhibit an elevated risk for cardiac arrhythmias, such as bradycardia, which may potentially lead to sudden cardiac death (SCD). While hypoglycemia, defined as a critical drop in glucose levels below the normal range, has long been associated with adverse cardiovascular events, recent studies have highlighted the need for a comprehensive reevaluation of its direct impact on cardiovascular outcomes, particularly in high-risk populations such as those with DM and CKD. In this study, we investigated the association between glucose levels and bradycardia by simultaneously monitoring interstitial glucose (IG) and ECG for 7 days in insulin-treated patients with DM and CKD.

Impact of diabetes on epicardial reperfusion and mortality in a contemporary STEMI population undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry.

Background And Aim: Diabetes has been shown in last decades to be associated with a significantly higher mortality among patients with ST-segment elevation myocardial infarction (STEMI) treated with primary PCI (PPCI). Therefore, the aim of current study was to evaluate the impact of diabetes on times delays, reperfusion and mortality in a contemporary STEMI population undergoing PPCI, including treatment during the COVID pandemic.

Methods And Results: The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry involving PPCI centers from Europe, Latin America, South-East Asia and North-Africa, including patients treated from 1st of March until June 30, 2019 and 2020.

Association of anaesthesia-directed sedation with unplanned discharge to a nursing home following non-ambulatory interventional radiology and endoscopic procedures: a retrospective cohort study.

Introduction: Interventional radiology procedures and endoscopies are performed commonly worldwide, often necessitating pharmacological sedation to optimise patient comfort. It is unclear to what extent non-anaesthetists should provide procedural sedation.

Methods: We studied adult patients who previously lived independently and underwent a non-ambulatory interventional radiology or gastroenterology procedure under anaesthetist-directed or non-anaesthetist-directed sedation at a large healthcare network.

Intraosseous Transcutaneous Amputation Prosthesis (ITAP) compared to Exoprosthesis in veterinary medicine - a literature review.

Objective: This literature review aims to provide an overview of the existing literature on intraosseous transcutaneous amputation prosthesis (ITAP) and stump socket prosthesis in amputated animals. The goal is to compare the advantages and disadvantages of ITAP with exoprosthesis use, given the importance of limb-sparing procedures in contemporary veterinary medicine.

Materials And Methods: A systematic research adhering to the PRISMA protocol was conducted using a time span from 2000 to 2023, focusing on papers detailing the clinical application of ITAP or exoprosthesis in small animals.

MRI analysis of relative tumor enhancement in liver metastases and correlation with immunohistochemical features.

Objective: Investigate the association between the relative tumor enhancement (RTE) of gadoxetic acid across various MRI phases and immunohistochemical (IHC) features in patients with liver metastases (LM) from colorectal cancer (CRC), breast cancer (BC), and pancreatic cancer (PC).

Methods: A retrospective analysis was conducted on 68 patients with LM who underwent 1.5-T MRI scans.

Thymic Stromal Lymphopoietin (TSLP): Evidence in Respiratory Epithelial-driven Diseases Including Chronic Rhinosinusitis with Nasal Polyps.

Purpose Of The Review: Thymic stromal lymphopoietin (TSLP) is increasingly recognized for its pivotal role in the pathogenesis of various epithelial-driven chronic inflammatory diseases. This review navigates the existing evidence on TSLP, with a particular focus on asthma, before delving into the current understanding of its role in chronic rhinosinusitis with nasal polyps (CRSwNP). We explore the role of TSLP in the pathogenesis of asthma and CRSwNP, two conditions often interconnected and collectively referred to as"Global Airway Disease".

Invisible walls? Stigma-related perceptions are associated with reduced help-seeking intentions for disordered eating in men.

Background: Eating disorders (EDs) are increasingly prevalent in men, but men remain underrepresented across many ED-specific treatment settings. Based on the idea that persistent stereotypes, prejudice and discrimination, i.e.

Physical Characteristics of Swedish Female Professional Ice Hockey Players Allowed Body Checking.

Lahti, A, Grundberg, A, Stenman, E, and Sundquist, K. Physical characteristics of Swedish female professional ice hockey players allowed body checking. J Strength Cond Res XX(X): 000-000, 2024-In ice hockey, physical characteristics impact sporting performance.

A Glimmer of Hope: The Impact of the Recovery College Bern on Personal Recovery, Well-Being and Self-Stigmatisation-A Mixed Methods Study.

Recovery Colleges are mental health education centres co-produced by experts with lived experience with mental health problems and mental health professionals. The aim of the study was to evaluate the impact of a Recovery College in Switzerland on its students' mental health measured through personal recovery, well-being and self-stigmatisation in a mixed methods approach following the MMARS guideline. Three standardised questionnaires 'Questionnaire about the Process of Recovery', 'WHO-5 Well-Being Index' and 'Self-Stigma of Mental Illness Scale Short Form' were completed by 92 participants as part of a pre-post-evaluation while two focus groups (n = 10) provided further explanations regarding impacts on the three topics.

A core outcome set for best care for the dying person: Results of an international Delphi study and consensus meeting.

Background: Outcome measurement is essential to progress clinical practice and improve patient care.

Aim: To develop a Core Outcome Set for best care for the dying person.

Design: We followed the Core Outcome Measures in Effectiveness Trials (COMET) Initiative guidelines, which involved identifying potential outcomes via a systematic literature review (n = 619 papers) and from participants in the "iLIVE" project (10 countries: 101 patients, 37 family members, 63 clinicians), followed by a two-round Delphi study, and a consensus meeting.

Failure of neuromuscular blockade despite high doses of rocuronium and atracurium in a patient with colorectal carcinoma: A case report.

Resistance to the effects of rocuronium and other neuromuscular blocking agents (NMBA) has been previously reported, including delayed onset of relaxation, rapid recovery and incomplete paralysis under recommended doses. These conditions have been associated with denervation injury, burns, immobilisation, infections, metabolic disorders, and drug interactions. In this report, we describe the case of a young male without any known pre-disposing factor for NMBA resistance, who failed to attain muscle relaxation with non-depolarising NMBA despite high doses of rocuronium and atracurium during two surgeries for colorectal cancer, several months apart.

Proton Pump Inhibitor Use and Worsening Kidney Function: A Retrospective Cohort Study Including 122,606 Acid-Suppressing Users.

Background: The impact of proton pump inhibitors (PPIs) use on worsening renal function is controversial and lacks a solid pathophysiological explanation.

Objective: To assess the risk of worsening renal function and acute kidney injury (AKI) in PPI initiators as compared with H2-blockers initiators.

Design: Retrospective cohort study using longitudinal records from BIGAN, a population-based health database of Aragón (Spain).

Digital scans versus conventional impressions in fixed prosthodontics: An overview of systematic reviews.

Statement Of Problem: Several systematic reviews have compared the accuracy of conventional impression making and digital recording techniques, with sometimes different results. A systematic overview of these studies is lacking.

Purpose: The purpose of this overview of systematic reviews was to examine the accuracy of digital scans and conventional impressions for tooth- or implant-supported fixed restorations in partially and completely edentulous adult patients.

Danish cohort study of tympanic membrane retractions and manifestations of Eustachian tube dysfunction.

Objectives: Our objective is to evaluate the prevalence of tympanic membrane (TM) retractions and management of signs of Eustachian tube dysfunction (ETD) in both children and adults following type 1 tympanoplasty or myringoplasty. Furthermore, to identify potential risk factors for developing ETD and TM retractions.

Methods: Retrospective cohort study of 423 patients (5-86 years of age) undergoing 452 procedures.

Comparing the contents of patient-reported outcome measures for fatigue: EORTC CAT Core, EORTC QLQ-C30, EORTC QLQ-FA12, FACIT, PRO-CTCAE, PROMIS, Brief Fatigue Inventory, Multidimensional Fatigue Inventory, and Piper Fatigue Scale.

Background: To assess fatigue in cancer patients, several patient-reported outcome measures (PROMs) are available that differ in content. To support the selection of suitable measures for specific applications and to evaluate possibilities of quantitative linking, the present study provides a content comparison of common fatigue measures, scales, and item banks. We included the EORTC CAT Core, EORTC QLQ-FA12, EORTC QLQ-C30, FACIT-F, PROMIS Fatigue (Cancer item bank v1.

Neurochemical dynamics during two hypnotic states evidenced by magnetic resonance spectroscopy.

This study explores neurochemical changes in the brain during hypnosis, targeting the parieto-occipital (PO) and posterior superior temporal gyrus (pSTG) regions using proton magnetic resonance spectroscopy (MRS). We examined 52 healthy, hypnosis experienced participants to investigate how two different hypnotic states of varying depth impacted brain neurochemistry in comparison to each other and to their respective non-hypnagogic control conditions. Alongside neurochemical assessments, we recorded respiration and heart rate variability (HRV) to further explore possible associations between physiological correlates of hypnotic depth.

Blood immune profiling of Ethiopian patients with breast cancer highlights different forms of immune escape.

Breast cancer (BC) is a leading cause of death worldwide, particularly also among African woman. In order to better stratify patients for the most effective (immuno-) therapy, an in depth characterization of the immune status of BC patients is required. In this study, a cohort of 65 Ethiopian patients with primary BC underwent immune profiling by multicolor flow cytometry on peripheral blood samples collected prior to surgery and to any other therapy.

Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma.

The transcription factors STAT3, STAT5A, and STAT5B steer hematopoiesis and immunity, but their enhanced expression and activation promote acute myeloid leukemia (AML) or natural killer/T cell lymphoma (NKCL). Current therapeutic strategies focus on blocking upstream tyrosine kinases to inhibit STAT3/5, but these kinase blockers are not selective against STAT3/5 activation and frequent resistance causes relapse, emphasizing the need for targeted drugs. We evaluated the efficacy of JPX-0700 and JPX-0750 as dual STAT3/5 binding inhibitors promoting protein degradation.