15 results match your criteria: "University Children's Hospital Zurich and Childhood Research Center[Affiliation]"
Patient-centred composite scores as tools for assesment of response to biological therapy for paediatric and adult severe asthma.
Eur Respir J
November 2024
Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Article Synopsis
- - The development of the CompOsite iNdexes For Response in asthMa (CONFiRM) aimed to create patient-centered tools that measure responses to biologics for severe asthma in both adults and children, integrating clinical data and quality of life (QoL) indicators.
- - Experts and patients collaborated to identify significant outcome changes and devised CONFiRM scores, which demonstrated high levels of agreement on key factors, with patients emphasizing the importance of quality of life more than healthcare professionals did.
- - The CONFiRM scores effectively measure treatment response, with strong validity metrics indicating their reliability, and they facilitate a comprehensive assessment of biologics’ effectiveness; further studies are required for prospective validation.
Definitions of non-response and response to biological therapy for severe asthma: a systematic review.
ERJ Open Res
July 2023
Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Background: Biologics have proven efficacy for patients with severe asthma but there is lack of consensus on defining response. We systematically reviewed and appraised methodologically developed, defined and evaluated definitions of non-response and response to biologics for severe asthma.
Methods: We searched four bibliographic databases from inception to 15 March 2021 Two reviewers screened references, extracted data, and assessed methodological quality of development, measurement properties of outcome measures and definitions of response based on COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN).
Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA).
Eur Respir J
April 2023
Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Article Synopsis
- - The COMSA Working Group developed standardized Core Outcome Measures (COM) sets for assessing the effectiveness of biological therapies in treating severe asthma in both adults and children to improve data synthesis and evaluation.
- - A collaborative approach involved patients, clinicians, and health regulators across Europe, using extensive evidence reviews and surveys to shape the outcome measures, which include key metrics like forced expiratory volume (FEV) and frequency of severe exacerbations.
- - The resulting COM sets aim to enhance future clinical trial methodologies, improve comparability of treatment outcomes, and provide a framework for understanding responses to biological therapies in severe asthma.
Feasibility of unsedated lung MRI in young children with cystic fibrosis.
Eur Respir J
November 2022
Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Standardization of Reporting Obstructive Airway Disease in Children: A National Delphi Process.
J Allergy Clin Immunol Pract
January 2023
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; Division of Respiratory Medicine, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address:
Background: Pediatric pulmonologists report asthma and obstructive bronchitis in medical records in a variety of ways, and there is no consensus for standardized reporting.
Objective: We investigated which diagnostic labels and features pediatric pulmonologists use to describe obstructive airway disease in children and aimed to reach consensus for standardized reporting.
Methods: We obtained electronic health records from 562 children participating in the Swiss Pediatric Airway Cohort from 2017 to 2018.
Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort.
Clin Transl Med
April 2022
National Heart and Lung Institute, Imperial College London, and Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK.
Background: Exacerbation-prone asthma is a feature of severe disease. However, the basis for its persistency remains unclear.
Objectives: To determine the clinical and transcriptomic features of frequent exacerbators (FEs) and persistent FEs (PFEs) in the U-BIOPRED cohort.
Age and body mass index affect fit of spirometry Global Lung Function Initiative references in schoolchildren.
ERJ Open Res
April 2022
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Background: References from the Global Lung Function Initiative (GLI) are widely used to interpret children's spirometry results. We assessed fit for healthy schoolchildren.
Methods: LuftiBus in the School was a population-based cross-sectional study undertaken in 2013-2016 in the canton of Zurich, Switzerland.
MRI Shows Lung Perfusion Changes after Vaping and Smoking.
Radiology
July 2022
From the Department of Diagnostic, Interventional and Pediatric Radiology (S.N., M.I., J.T.H., A.C., L.E.), Department of Pediatrics, Division of Pediatric Respiratory Medicine and Allergology (I.K.), Department of General Internal Medicine (N.R.), and Department of Pulmonary Medicine (T.G., M.F.C.), Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, Bern 3010, Switzerland; Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland (G.B., O.P., O.B.); Department of Biomedical Engineering, University of Basel, Basel, Switzerland (G.B., O.P., O.B.); Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland (O.P.); Division of Paediatric Pulmonology and Allergology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria (F.S.); Department of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, Zurich, Switzerland (F.S.); Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland (C.G., A.S., N.R., R.A.); and Center for Primary Care and Public Health, Unisanté, Lausanne, Switzerland (R.A.).
Article Synopsis
- A study investigated the immediate impacts of electronic nicotine delivery systems (ENDS) and tobacco smoke on lung ventilation and perfusion using functional MRI and lung function tests, involving 44 healthy adults.
- Results showed that lung perfusion decreased after END exposure but showed no significant change for tobacco smokers, while ENDS users experienced a slight increase in perfusion post-exposure.
- The research highlights the need for more evidence on the short-term effects of ENDS versus tobacco smoke on lung function.
Agreement of parent- and child-reported wheeze and its association with measurable asthma traits.
Pediatr Pulmonol
December 2021
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Objectives: In epidemiological studies, childhood asthma is usually assessed with questionnaires directed at parents or children, and these may give different answers. We studied how well parents and children agreed when asked to report symptoms of wheeze and investigated whose answers were closer to measurable traits of asthma.
Methods: LuftiBus in the school is a cross-sectional survey of respiratory health among Swiss schoolchildren aged 6-17 years.
Biologicals in childhood severe asthma: the European PERMEABLE survey on the .
ERJ Open Res
July 2021
Dept of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO) at the Hospital St Hedwig of the Order of St John, University of Regensburg, Regensburg, Germany.
Introduction: Severe asthma is a rare disease in children, for which three biologicals, anti-immunoglobulin E, anti-interleukin-5 and anti-IL4RA antibodies, are available in European countries. While global guidelines exist on who should receive biologicals, knowledge is lacking on how those guidelines are implemented in real life and which unmet needs exist in the field. In this survey, we aimed to investigate the and identify open questions in biological therapy of childhood asthma across Europe.
View Article and Find Full Text PDFAssociation of transportation noise with sleep during the first year of life: A longitudinal study.
Environ Res
January 2022
Division of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, University of Zurich, Zurich, Switzerland; University Children's Hospital Basel (UKBB), Basel, Switzerland. Electronic address:
Study Objectives: During infancy, adequate sleep is crucial for physical and neurocognitive development. In adults and children, night-time noise exposure is associated with sleep disturbances. However, whether and to what extent infants' sleep is affected, is unknown.
View Article and Find Full Text PDFAssociations of air pollution and greenness with the nasal microbiota of healthy infants: A longitudinal study.
Environ Res
November 2021
University Children's Hospital Basel, University of Basel, Basel, Switzerland; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Division of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, University of Zurich, Zurich, Switzerland. Electronic address:
Background: Air pollution and greenness are associated with short- and long-term respiratory health in children but the underlying mechanisms are only scarcely investigated. The nasal microbiota during the first year of life has been shown to be associated with respiratory tract infections and asthma development. Thus, an interplay between greenness, air pollution and the early nasal microbiota may contribute to short- and long-term respiratory health.
View Article and Find Full Text PDFEvidence-based European guidelines for the diagnosis of asthma in children aged 5-16 years.
Lancet Respir Med
June 2021
Division of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, Zurich, Switzerland.
European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years.
Eur Respir J
October 2021
Division of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, Zurich, Switzerland.
Background: Diagnosing asthma in children represents an important clinical challenge. There is no single gold-standard test to confirm the diagnosis. Consequently, over- and under-diagnosis of asthma is frequent in children.
View Article and Find Full Text PDFCigarette, shisha, and electronic smoking and respiratory symptoms in Swiss children: The LUIS study.
Pediatr Pulmonol
October 2020
Division of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, University of Zurich, Zurich, Switzerland.
Background: Smoking habits in adolescents are changing. We assessed active smoking of conventional cigarettes, e-cigarettes and shishas in Swiss schoolchildren, studied risk factors and compared respiratory problems between smokers and non-smokers.
Methods: We used data from LuftiBus in the school (LUIS), a school-based survey of respiratory health of children carried out 2013 to 2016 in the canton of Zurich, Switzerland.