Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization.

Bacterial second messengers c-di-GMP and (p)ppGpp have broad functional repertoires ranging from growth and cell cycle control to the regulation of biofilm formation and virulence. The recent identification of SmbA, an effector protein from Caulobacter crescentus that is jointly targeted by both signaling molecules, has opened up studies on how these global bacterial networks interact. C-di-GMP and (p)ppGpp compete for the same SmbA binding site, with a dimer of c-di-GMP inducing a conformational change that involves loop 7 of the protein that leads to downstream signaling.

Clinical guidance for maintaining oral hygiene in patients undergoing chemotherapy or radiation therapy: a scoping review.

The aim of this scoping review was to identify clinical guidance for maintaining oral hygiene in patients undergoing chemotherapy, radiation therapy, or both. Electronic searches were conducted in PubMed, Embase, Cochrane Library, and Google Scholar for articles published between January 2000 and May 2020. Systematic reviews, meta-analyses, clinical trials, case series, and expert consensus reports were considered eligible for inclusion.

Effects of different grafting materials on volumetric changes in the Schneiderian membrane following lateral maxillary sinus floor elevation: a preliminary study.

Objectives: To investigate the potential influence of different grafting materials on maxillary sinus membrane dimensions and ostium patency following lateral sinus floor elevation (SFE) as assessed using cone-beam computed tomography (CBCT).

Materials And Methods: A total of 40 sinuses in 40 patients were included. Twenty sinuses were referred for SFE with deproteinized bovine bone mineral (DBBM), and the remaining 20 sinuses were grafted with calcium phosphate (CP).

The effect of orthodontic treatment on smile attractiveness: a systematic review.

Background: Smile attractiveness is a primary factor for patients to seek orthodontic treatment, however, there is yet no systematic evaluation of this topic in the literature.

Objectives: To assess the current evidence on the effect of orthodontic treatment on smile attractiveness.

Search Methods: Seven electronic databases (MEDLINE, Cochrane Library, Virtual Health Library, SCOPUS, Web of Science, Google Scholar and Embase) were searched on 14 September 2022.

Accuracy of a dynamic navigation system for dental implantation with two different workflows and intraoral markers compared to static-guided implant surgery: An in-vitro study.

Purpose: To investigate the accuracy of a miniaturized dynamic navigation system with intraoral markers and two different workflows for dental implantation and to compare with static computer-assisted implant surgery (sCAIS) surgery.

Materials And Methods: Two operators performed a total of 270 implant insertions in polyurethane mandibular models under simulated clinical conditions. Implants were placed after CBCT-based virtual planning in three different groups: two workflows utilizing dynamic computer-assisted implant surgery (dCAIS; DG1: marker in CBCT; DG2: 3D-printed marker) and the others with sCAIS (TG: template guided).

Quality of CAD-CAM inlays placed on aged resin-based composite restorations used as deep margin elevation: a laboratory study.

Objectives: To assess the impact of the age of resin-based composite (RBC) restorations used for deep margin elevation (DME) on the marginal quality and fracture resistance of inlays.

Materials And Methods: Permanent human molars with direct RBC restorations, involving the mesial, occlusal, and distal surface (MOD), were allocated to four groups (each n = 12). Half of the teeth underwent thermomechanical loading including 240,000 occlusal load cycles and 534 thermal cycles (TML, 5 °C/55 °C; 49 N, 1.

Personalized dental medicine, artificial intelligence, and their relevance for dentomaxillofacial imaging.

Personalized medicine refers to the tailoring of diagnostics and therapeutics to individuals based on one's biological, social, and behavioral characteristics. While personalized dental medicine is still far from being a reality, advanced artificial intelligence (AI) technologies with improved data analytic approaches are expected to integrate diverse data from the individual, setting, and system levels, which may facilitate a deeper understanding of the interaction of these multilevel data and therefore bring us closer to more personalized, predictive, preventive, and participatory dentistry, also known as P4 dentistry. In the field of dentomaxillofacial imaging, a wide range of AI applications, including several commercially available software options, have been proposed to assist dentists in the diagnosis and treatment planning of various dentomaxillofacial diseases, with performance similar or even superior to that of specialists.

Evaluation of antibacterial properties of fluoride-containing mouth rinses differing in their acidic compound using a Streptococcus mutans biofilm.

This in vitro study assessed the antibacterial effect on Streptococcus mutans biofilms of mouth rinses with 700 ppm F- (derived from NaF) that differed only in their acid compounds (malic (A), citric (B), tartaric (C), fumaric (D), hydrochloric (E), phosphoric (F), and lactic (G) acid) used to adjust pH. S. mutans (ATCC 25175) was grown for 22 h at 37°C, harvested, resuspended in simulated body fluid and biofilm formation followed for 24 h at 37°C.

Self-reported injuries to oral tissues through resistance training in bodybuilders.

Lifting heavy weights almost automatically elicits teeth clenching, which, if performed regularly, may lead to chronic trauma. This study assessed self-reported injuries to oral tissues in athletes and bodybuilders caused by resistance training and determined the association between self-reported trauma, performance level and the duration of practicing resistance training. A standardized questionnaire was used to gather information about the respondents (age and gender), their performance level (hobby versus competition athlete), experience with oral tissue trauma, the use of mouthguards, and dietary habits.

Head and dental injuries among farriers and hoof care practitioners: A nationwide survey in Switzerland.

Background/aim: There is a paucity of evidence on injuries sustained by farriers and hoof care practitioners, two professions exposed to unique occupational hazards. The aim of this study was to collect and examine data on occupational head/face and dental injuries among farriers and hoof care practitioners in a nationwide survey in Switzerland.

Materials And Methods: Data on occupational head/face and dental injuries were gathered in a questionnaire-based, voluntary survey, which was mailed to all farriers and hoof care practitioners in Switzerland.

Biomimetic, mussel-inspired surface modification of 3D-printed biodegradable polylactic acid scaffolds with nano-hydroxyapatite for bone tissue engineering.

Polylactic acid (PLA) has been widely used as filaments for material extrusion additive manufacturing (AM) to develop patient-specific scaffolds in bone tissue engineering. Hydroxyapatite (HA), a major component of natural bone, has been extensively recognized as an osteoconductive biomolecule. Here, inspired by the mussel-adhesive phenomenon, in this study, polydopamine (PDA) coating was applied to the surface of 3D printed PLA scaffolds (PLA@PDA), acting as a versatile adhesive platform for immobilizing HA nanoparticles (nHA).

Artificial intelligence in medico-dental diagnostics of the face: a narrative review of opportunities and challenges.

Objectives: This review aims to share the current developments of artificial intelligence (AI) solutions in the field of medico-dental diagnostics of the face. The primary focus of this review is to present the applicability of artificial neural networks (ANN) to interpret medical images, together with the associated opportunities, obstacles, and ethico-legal concerns.

Material And Methods: Narrative literature review.

General and dental injuries sustained at concerts: A questionnaire-based study.

Background/aim: Evidence on the risk of injury at concerts is scant. The aim of this study was to collect data on general and dental injuries incurred by concertgoers in Switzerland and to investigate whether the frequency of accidents was related to music genre, gender and consumption of alcohol.

Materials And Methods: A questionnaire-based, cross-sectional study comprising 451 concertgoers in Switzerland was conducted on the timeframe January 2019 to February 2021.

The use of protection measures in dento-maxillofacial radiology in Europe: a survey among experts.

Patient contact shielding to reduce radiation exposure to radiosensitive organs of patients is known to be used inconsistently in the field of dento-maxillofacial radiology (DMFR). There is an ongoing discussion if its use is still justified with regard to recent technical enhancements in the field. Thus, the aim of this study was to investigate the recommended and applied safety standards regarding dose protection measures in dental radiology within European countries.

Cytokines Activate JAK-STAT Signaling Pathway in MG-63 Cells on Titanium and Zirconia.

Although titanium has been traditionally used as the gold standard for dental implants, recent years have seen the widespread application of zirconia implants given their superiority with regards to reduced bacterial adhesion, inflammation and cellular-interaction in terms of bio-compatibility. The JAK-STAT signaling pathway plays an important role in bone remodeling and formation. The aim of the study was to investigate the activation of the JAK-STAT pathway through different cytokines in osteoblast-like cells (MG-63) on zirconia in comparison to titanium discs.

The effect of orthodontic treatment on facial attractiveness: a systematic review and meta-analysis.

Background: Facial and smile attractiveness are significant motivating factor for patients to seek orthodontic treatment. Although there is a general belief that orthodontic treatment improves facial appearance, this has yet not been systematically evaluated.

Objective: The objective of this study was to assess the current evidence on the effect of orthodontic treatment on facial attractiveness.

Detection and Removal of Tooth-Colored Composite Resin using the Fluorescence-Aided Identification Technique.

The detection and removal of tooth-colored filling materials is a major challenge for every dentist. The Fluorescence-aided Identification Technique (FIT) is a noninvasive tool to facilitate the distinction of composite resin material from sound tooth substance. Compared to conventional illumination, FIT is a very accurate, reliable, and fast diagnostic method.

Evaluation of five methods to identify composite restorations in human teeth on a forensic purpose-an ex vivo comparative study.

The use of tooth-colored composite resin materials in dentistry is increasing. As composite restorations appear similar to the natural tooth structure, their detection is becoming more challenging. The aim of this study was to compare five diagnostic methods for detection of dental restorations and to create reliable postmortem dental records for forensic purposes.

Prevalence of and factors associated with molar-incisor hypomineralisation in schoolchildren in the canton of Basel-Landschaft, Switzerland.

Objectives: As prevalence of molar-incisor hypomineralisation varies considerably in different countries and regions, the aim of this study was to obtain representative epidemiological data for schoolchildren living in the canton of Basel-Landschaft, Switzerland.

Material And Methods: A representative population of schoolchildren of three different age groups, i.e.

Is perioperative antibiotic prophylaxis in the case of routine surgical removal of the third molar still justified? A randomized, double-blind, placebo-controlled clinical trial with a split-mouth design.

Introduction: Since antimicrobial resistance, caused by various factors including antibiotic overuse and abuse, is a severe challenge, the necessity of perioperative antibiotic prophylactic for surgical third molar removal remains a contentious topic. This study determined whether perioperative antibiotic prophylaxis can reduce surgical site infections (SSIs), swelling, and pain in the case of surgical removal of wisdom teeth.

Material And Methods: A randomized, double-blind, placebo-controlled clinical trial with a split-mouth design.