Intermuscular adipose tissue affected muscle density more than intramuscular adipose tissue content with opportunistic screening at abdominal CT.

This study aimed to determine whether intermuscular adipose tissue (IMAT) or intramuscular adipose tissue content (IMAC) has a greater effect on skeletal muscle density (SMD) and to explore the underlying mechanisms. We recruited 292 inpatients without musculoskeletal system disease, all of whom underwent abdominal CT. Muscle parameters, including skeletal muscle area (SMA), skeletal muscle index (SMI), SMD, IMAC, and IMAT, as well as fat parameters-subcutaneous fat area (SFA) and subcutaneous fat density (SFD) in the abdominal wall-were measured by two musculoskeletal radiologists using ImageJ software at the third lumbar vertebra (L3) level.

Association and interaction between resilience and psychological distress in disabled elderly-caregiver dyads: An actor-partner interdependence model.

Objectives: This study examined the association and interaction between resilience and psychological distress in disabled elderly-caregiver dyads.

Methods: A total of 246 disabled elderly individuals and their family caregivers were studied using the Resilience Scale and the Distress Thermometer and Problem List. The data analysis employed the actor-partner interdependence model (APIM) method based on structural equation modelling.

Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): a randomised, double-blind, phase 3 study in China.

Background: Ivonescimab is a bispecific antibody against programmed cell death protein 1 and vascular endothelial growth factor, yielding promising clinical outcomes for patients with advanced non-small cell lung cancer in early-phase studies. We compared the efficacy and safety of ivonescimab with pembrolizumab in patients with programmed cell death ligand-1 (PD-L1)-positive advanced non-small cell lung cancer.

Methods: HARMONi-2 is a randomised, double-blind, phase 3 trial across 55 hospitals in China.

Sensory Processing Sensitivity and Quality of Life Among Cancer Patients and Their Family Caregivers: An Actor-Partner Interdependence Model Analysis.

Objective: Studies report a negative impact of sensory processing sensitivity (SPS) on health outcomes, but evidence from patient-caregiver dyads is scarce. This study aimed to simultaneously examine the independent and interdependent impact of SPS on quality of life (QoL) among cancer patients and their family caregivers.

Methods: In this two-stage random sampling cross-sectional study, we conducted a dyadic analysis of data collected from cancer patients and their family caregivers in southwest China.

A method of matching nodes between MRI and pathology with MRI-based 3D node map in rectal cancer.

Purpose: To propose a node-by-node matching method between MRI and pathology with 3D node maps based on preoperative MRI for rectal cancer patients to improve the yet unsatisfactory diagnostic performance of nodal status in rectal cancer.

Methods: This methodological study prospectively enrolled consecutive participants with rectal cancer who underwent preoperative MRI and radical surgery from December 2021 to August 2023. All nodes with short-axis diameters of ≥ 3 mm within the mesorectum were regarded as target nodes and were localized in three directions based on the positional relationship on MRI and drawn on a node map with the primary tumor as the main reference, which was used as a template for node-by-node matching with pathological evaluation.

Effectiveness, safety, and patterns of use of camrelizumab in advanced esophageal cancer: an individual patient data pooled analysis of 987 patients from three prospective cohort studies.

Background And Aims: This individual patient data pooled analysis aimed to evaluate the effectiveness, safety, and patterns of use of camrelizumab in a large cohort of advanced esophageal cancer (AEC) patients.

Approach And Results: Adult patients (≥ 18 years) who had received camrelizumab as part of AEC treatment were pooled from three independent, prospective observational cohort studies (NCT04616040, ChiCTR1900027275, and ChiCTR2000039499). The main outcomes were patterns of camrelizumab use, progression-free survival (PFS), overall survival (OS), and safety in the overall population and specific subgroups of underrepresented patients.

Chemoradiation treatment with or without concurrent tumor-treating fields (TTFields) therapy in newly diagnosed glioblastoma (GBM) patients in China.

Background: Tumor-treating fields (TTFields) therapy and radiotherapy may have synergistic anti-glioma effect based on preclinical studies. The combination of chemoradiation therapy (CRT) with TTFields therapy has noticeably attracted clinicians' attention. This study aimed to provide insights into the clinical outcomes of patients with newly diagnosed glioblastoma who received either concurrent CRT and TTFields therapy or adjuvant TTFields therapy following CRT.

Disease burden of lung cancer attributable to metabolic and behavioral risks in China and globally from 1990 to 2021.

Background: There are differences between China and globally in the burden of lung cancer attributed to behavioral and metabolic risks.

Methods: This research utilized the Global Burden of Disease (GBD) 2021 database to extract the deaths and disability-adjusted life-years (DALYs) of lung cancer attributed to metabolic and behavioral risks in China and globally, along with the age-standardized mortality rates (ASMR) and age-standardized DALYs rates (ASDR). The age-period-cohort model was used to identify age effects, period effects, cohort effects, as well as local and net drift.

Prediction of postpartum depression in women: development and validation of multiple machine learning models.

Background: Postpartum depression (PPD) is a significant public health issue. This study aimed to develop and validate machine learning (ML) models using biopsychosocial predictors to predict the risk of PPD for perinatal women and to provide several risk assessment tools for the early detection of PPD.

Methods: Candidate predictors, including history of mental illness and demographic, psychosocial, and physiological factors, were obtained from 1138 perinatal women between August 2021 and August 2022.

Factors influencing clinical decision-making and health-related quality of life changes in colorectal cancer patients receiving targeted therapy: a multicenter study in China.

Objectives: The aim of this paper is to assess the current clinical application of targeted therapy in colorectal cancer (CRC), identify factors influencing patients' acceptance of targeted therapy, and evaluate its impact of targeted therapy on patients' health-related quality of life (HRQoL).

Methods: This study was based on a national multi-center survey. From March 2020 to March 2021, involved 19 tertiary hospitals across seven regions in China through multi-stage stratified sampling.

Nivolumab plus chemotherapy or ipilimumab in gastroesophageal cancer: exploratory biomarker analyses of a randomized phase 3 trial.

First-line nivolumab-plus-chemotherapy demonstrated superior overall survival (OS) and progression-free survival versus chemotherapy for advanced gastroesophageal adenocarcinoma with programmed death ligand 1 combined positive score ≥ 5, meeting both primary end points of the randomized phase 3 CheckMate 649 trial. Nivolumab-plus-ipilimumab provided durable responses and higher survival rates versus chemotherapy; however, the prespecified OS significance boundary was not met. To identify biomarkers predictive of differential efficacy outcomes, post hoc exploratory analyses were performed using whole-exome sequencing and RNA sequencing.

Development and Validation of a Nomogram Based on the Different Grades of Cervical Lymph Node Necrosis to Predict Overall Survival in Patients with Lymph Node-Positive Locally Advanced Nasopharyngeal Carcinoma.

Rationale And Objectives: This study aims to quantitatively evaluate the clinical significance of different grades of cervical lymph node necrosis (CNN). Furthermore, a nomogram was developed and validated to predict overall survival (OS) in patients with lymph node-positive (LN-positive) locally advanced nasopharyngeal carcinoma (LA-NPC), incorporating the different grades of CNN.

Patients And Methods: We retrospectively analyzed patients with newly diagnosed, LN-positive LA-NPC at our center from April 2014 to December 2018.

Interleukin-2-inducible T-cell kinase inhibition to block NF-κB signaling exerts anti-tumor effect and enhances chemotherapy in NK/T-cell lymphoma.

Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive non-Hodgkin lymphoma. Relapsed/refractory (R/R) NKTCL patients have dismal prognosis and lack effective treatments, novel therapeutics are urgently needed. Here we found interleukin-2-inducible T-cell kinase (ITK) expression was elevated in NKTCL cells and patient tumors.

Self-assembled patient-derived tumor-like cell clusters for personalized drug testing in diverse sarcomas.

Several patient-derived tumor models have emerged recently. However, soft tissue sarcomas (STSs) present a challenge in developing preclinical drug-testing models due to their non-epithelial and complex nature. Here, we report a model termed patient-derived tumor-like cell clusters (PTCs) derived from STS patients.

The mA reader YTHDC2 restrains endometrial cancer progression through suppressing hedgehog signaling pathway.

N6-methyladenosine (mA) is a prevalent RNA modification involved in different physiological and pathological processes. However, little is known about the role of mA modification in endometrial cancer (EC). In this study, we explored the expression and prognosis of mA-related genes in EC using public databases to screen relevantgenes.

Radiation Dose-Volume Effects on Negative Tumor-Draining Lymph Nodes Impacted T-Cell Activation and Prognosis in Esophageal Cancer with Chemoradiotherapy.

Purpose: Preclinical model found that elective nodal irradiation (ENI) attenuated the efficacy of radiotherapy and radio-immunotherapy. However, limited clinical studies have explored the correlation between radiation dose-volume parameters of negative tumor draining lymph nodes (TDLNs) and T-cell activation/prognosis for cancer patients treated with definitive radio(chemo)therapy.

Experimental Design: Patients with locally advanced esophageal cancer undergoing definitive chemoradiotherapy (CRT) were selected from two prospective trials.

Prognostic analysis and limited efficacy of adjuvant TACE in hepatocellular carcinoma following hepatectomy: a propensity score-matched study.

Background: Postoperative adjuvant transarterial chemoembolization (PA-TACE) is proposed as a potentially effective treatment for hepatocellular carcinoma (HCC), but its benefits may be limited according to recent evidence.

Methods: We analyzed clinicopathologic data from HCC patients who underwent hepatectomy between 2014 and 2019, categorizing them into two groups: surgery alone (non-PA-TACE) and PA-TACE. Propensity score matching (PSM) was used to adjust for selection bias.

An Intervertebral Disc (IVD) Regeneration Model Using Human Nucleus Pulposus Cells (iHNPCs) and Annulus Fibrosus Cells (iHAFCs).

Intervertebral disc (IVD) degeneration (IVDD), primarily caused by nucleus pulposus (NP) dehydration, leads to low back pain. While current treatments focus on symptom management or surgical intervention, tissue engineering using IVD-derived cells, biofactors, and scaffolds offers a promising regenerative approach. Here, human NP cells (NPCs) and annulus fibrosus cells (AFCs) are immortalized with human telomerase reverse transcriptase (hTERT), generating immortalized NPCs (iHNPCs) and AFCs (iHAFCs).

A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resection.

Purpose: This investigation aimed to create a new nomogram based on complement C3 to forecast 1-, 3-, and 5-year overall survival (OS) rates in patients with early-stage hepatocellular carcinoma (HCC) exhibiting microvascular invasion (MVI) post-curative surgery.

Methods: This study encompassed 1234 patients treated with resection at the Affiliated Cancer Hospital of Guangxi Medical University. The cohort for primary included 865 patients from December 2015 to December 2019, while the validation cohort comprised 369 patients.

Influence of CAR T-cell therapy associated complications.

Since the introduction of chimeric antigen receptor (CAR) T-cell therapy, it has elicited an immense response in both targeted and residual cancers. Its clinical efficacy is often accompanied by a group of side effects that may become serious because of factors such as tumor burden, the extent of lymphodepletion, and the type of co-stimulus. It is also crucial to know the common toxicities associated with CAR T-cell therapy, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), cardiotoxicity, metabolic disorders, pulmonary toxicity, macrophage activation syndrome (MAS), prolonged cytopenia, coagulation disorders, and potential off-target effects on various organs.

Adherence to the planetary health diet index and metabolic dysfunction-associated steatotic liver disease: a cross-sectional study.

Backgrounds: Adherence to the Planetary Health Diet Index (PHDI) has been shown to benefit both individual health and the planet. However, its impact on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains unclear. This study aimed to investigate the relationship between PHDI adherence and the MASLD risk.

Surgical Intervention Improves Long-Term Survival in Stage IV Thymic Epithelial Tumors: Insights From a SEER Database Analysis.

Objectives: This research evaluates how surgical intervention affects survival rates in individuals with stage IV thymic epithelial tumors (TET) based on data from the SEER database, offering essential information for clinical decision making.

Methods: The SEER database (2004-2020) provided data on stage IV TET patients, classified into surgical and non-surgical groups. Analytical techniques, including propensity score matching (PSM) and inverse probability treatment weighting (IPTW), were employed.