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Polyamine acetylation and substrate-induced oligomeric states in histone acetyltransferase of multiple drug resistant Acinetobacter baumannii.
Biochimie
January 2020
Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, India; UM-DAE Centre for Excellence in Basic Sciences, University Campus Mumbai, India. Electronic address:
Histone acetyltransferase (Hpa2) is an unusual acetyltransferase, with a wide range of substrates; including histones, polyamines and aminoglycosides antibiotic. Hpa2 belongs to GNAT superfamily and GNATs are well known for the formation of homo-oligomers. However, the reason behind their oligomerization remained unexplored.
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